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UniProtKB - P47026 (GWT1_YEAST)

Entry version 147 (02 Dec 2020)
Sequence version 2 (31 Oct 2006)
Previous versions | rss
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Protein

GPI-anchored wall transfer protein 1

Gene

GWT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins.2 Publications

Miscellaneous

Target of the antifungal compound 1-[4-butylbenzyl]isoquinoline that inhibits cell wall localization of GPI-anchored mannoproteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glucosaminyl-phosphatidylinositol O-acyltransferase activity Source: SGD
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-162710, Synthesis of glycosylphosphatidylinositol (GPI)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00196

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.315.1.5, the glycoslyphosphatidylinositol (gpi) membrane anchoring protein gwt1 (gwt1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GPI-anchored wall transfer protein 1 (EC:2.3.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GWT1
Ordered Locus Names:YJL091C
ORF Names:J0916
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		FungiDB:YJL091C

Saccharomyces Genome Database

More...SGDi		S000003627, GWT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19LumenalSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 54CytoplasmicSequence analysisAdd BLAST14
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76LumenalSequence analysis1
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 128CytoplasmicSequence analysisAdd BLAST31
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 157LumenalSequence analysis8
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 199CytoplasmicSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 231LumenalSequence analysisAdd BLAST11
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 257CytoplasmicSequence analysis5
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 301LumenalSequence analysisAdd BLAST23
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 356CytoplasmicSequence analysisAdd BLAST34
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 390LumenalSequence analysisAdd BLAST13
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 435CytoplasmicSequence analysisAdd BLAST24
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21
Topological domaini457 – 460LumenalSequence analysis4
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 490CytoplasmicSequence analysis9

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8K → E in gwt1-10; impairs the transport of detergent-resistant microdomain-associated membrane proteins TAT2 and FUR4. 1 Publication1
Mutagenesisi63 – 64WV → RA in gwt1-20; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins. 1 Publication2
Mutagenesisi132G → R: Resistant to the drug 1-[4-butylbenzyl]isoquinoline (BIQ). 1 Publication1
Mutagenesisi209L → P in gwt1-28; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with D-259. 1 Publication1
Mutagenesisi259V → D in gwt1-28; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with P-209. 1 Publication1
Mutagenesisi330N → S in gwt1-16; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with P-362 and A-479. 1 Publication1
Mutagenesisi362L → P in gwt1-16; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with S-330 and A-479. 1 Publication1
Mutagenesisi397V → I: Resistant to the drug 1-[4-butylbenzyl]isoquinoline (BIQ). 1 Publication1
Mutagenesisi479V → A in gwt1-16; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with S-330 and P-362. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002151881 – 490GPI-anchored wall transfer protein 1Add BLAST490

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P47026

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P47026

PRoteomics IDEntifications database

More...PRIDEi		P47026

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		33666, 457 interactors

Database of interacting proteins

More...DIPi		DIP-4481N

Protein interaction database and analysis system

More...IntActi		P47026, 9 interactors

Molecular INTeraction database

More...MINTi		P47026

STRING: functional protein association networks

More...STRINGi		4932.YJL091C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P47026, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIGW family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0411, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013520

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020802_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P47026

Identification of Orthologs from Complete Genome Data

More...OMAi		INLMVDT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009447, PIGW/GWT1

The PANTHER Classification System

More...PANTHERi		PTHR20661, PTHR20661, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06423, GWT1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF017321, GWT1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLKQRKED FVTGLNGGSI TEINAVTSIA LVTYISWNLL KNSNLMPPGI 
        60         70         80         90        100
SSVQYIIDFA LNWVALLLSI TIYASEPYLL NTLILLPCLL AFIYGKFTSS 
       110        120        130        140        150
SKPSNPIYNK KKMITQRFQL EKKPYITAYR GGMLILTAIA ILAVDFPIFP 
       160        170        180        190        200
RRFAKVETWG TSLMDLGVGS FVFSNGIVSS RALLKNLSLK SKPSFLKNAF 
       210        220        230        240        250
NALKSGGTLL FLGLLRLFFV KNLEYQEHVT EYGVHWNFFI TLSLLPLVLT 
       260        270        280        290        300
FIDPVTRMVP RCSIAIFISC IYEWLLLKDD RTLNFLILAD RNCFFSANRE 
       310        320        330        340        350
GIFSFLGYCS IFLWGQNTGF YLLGNKPTLN NLYKPSTQDV VAASKKSSTW 
       360        370        380        390        400
DYWTSVTPLS GLCIWSTIFL VISQLVFQYH PYSVSRRFAN LPYTLWVITY 
       410        420        430        440        450
NLLFLTGYCL TDKIFGNSSE YYKVAECLES INSNGLFLFL LANVSTGLVN 
       460        470        480        490
MSMVTIDSSP LKSFLVLLAY CSFIAVISVF LYRKRIFIKL
Length:490
Mass (Da):55,466
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BE4AE710DB93A98
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA58476 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA89384 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z49366 Genomic DNA Translation: CAA89384.1 Different initiation.
X83502 Genomic DNA Translation: CAA58476.1 Different initiation.
BK006943 Genomic DNA Translation: DAA08709.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56868

NCBI Reference Sequences

More...RefSeqi		NP_012444.2, NM_001181524.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YJL091C_mRNA; YJL091C; YJL091C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		853354

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YJL091C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49366 Genomic DNA Translation: CAA89384.1 Different initiation.
X83502 Genomic DNA Translation: CAA58476.1 Different initiation.
BK006943 Genomic DNA Translation: DAA08709.1
PIRiS56868
RefSeqiNP_012444.2, NM_001181524.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33666, 457 interactors
DIPiDIP-4481N
IntActiP47026, 9 interactors
MINTiP47026
STRINGi4932.YJL091C

Protein family/group databases

TCDBi9.B.315.1.5, the glycoslyphosphatidylinositol (gpi) membrane anchoring protein gwt1 (gwt1) family

Proteomic databases

MaxQBiP47026
PaxDbiP47026
PRIDEiP47026

Genome annotation databases

EnsemblFungiiYJL091C_mRNA; YJL091C; YJL091C
GeneIDi853354
KEGGisce:YJL091C

Organism-specific databases

EuPathDBiFungiDB:YJL091C
SGDiS000003627, GWT1

Phylogenomic databases

eggNOGiKOG0411, Eukaryota
GeneTreeiENSGT00390000013520
HOGENOMiCLU_020802_2_2_1
InParanoidiP47026
OMAiINLMVDT

Enzyme and pathway databases

UniPathwayiUPA00196
ReactomeiR-SCE-162710, Synthesis of glycosylphosphatidylinositol (GPI)

Miscellaneous databases

Protein Ontology

More...PROi		PR:P47026
RNActiP47026, protein

Family and domain databases

InterProiView protein in InterPro
IPR009447, PIGW/GWT1
PANTHERiPTHR20661, PTHR20661, 1 hit
PfamiView protein in Pfam
PF06423, GWT1, 1 hit
PIRSFiPIRSF017321, GWT1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGWT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47026
Secondary accession number(s): D6VW93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 31, 2006
Last modified: December 2, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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