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UniProtKB - P46996 (YJQ3_YEAST)

Entry version 123 (23 Feb 2022)
Sequence version 1 (01 Feb 1996)
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Protein

Uncharacterized membrane protein YJL163C

Gene

YJL163C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-196757, Metabolism of folate and pterines
R-SCE-917937, Iron uptake and transport
R-SCE-9707616, Heme signaling

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.11.4, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized membrane protein YJL163C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YJL163C
ORF Names:J0544
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000003699, YJL163C

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YJL163C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 83ExtracellularSequence analysisAdd BLAST83
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 125CytoplasmicSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 188ExtracellularSequence analysisAdd BLAST42
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 229CytoplasmicSequence analysisAdd BLAST20
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 257ExtracellularSequence analysis7
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 356CytoplasmicSequence analysisAdd BLAST78
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 386ExtracellularSequence analysis9
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 428CytoplasmicSequence analysisAdd BLAST21
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 459ExtracellularSequence analysis10
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 491CytoplasmicSequence analysisAdd BLAST11
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 523ExtracellularSequence analysisAdd BLAST11
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 555CytoplasmicSequence analysisAdd BLAST11

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002030271 – 555Uncharacterized membrane protein YJL163CAdd BLAST555

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46996

PRoteomics IDEntifications database

More...PRIDEi		P46996

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P46996

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		33596, 115 interactors

Database of interacting proteins

More...DIPi		DIP-8000N

STRING: functional protein association networks

More...STRINGi		4932.YJL163C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P46996, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P46996

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 311DisorderedSequence analysisAdd BLAST23

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2816, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183096

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017517_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46996

Identification of Orthologs from Complete Genome Data

More...OMAi		NWSEVEF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46996-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNEDETTRL MSSDEMDYLL ETAGINALEE IISQNDSTGI NLDTNETAQD 
        60         70         80         90        100
SSYDSIRRSP SILSVAKSVE GEHGRRKLLC LYGLVMIICI AESISMTATI 
       110        120        130        140        150
PLVMDKVAEG ISDENGHYDS VAVQTIVSSI SSSTMMIAGA ISIFMAGKWG 
       160        170        180        190        200
ELSDRIGRVR VFKYMSGIRV IGLLTHVFTL SSKMKYHKWA IVLTACIVPS 
       210        220        230        240        250
FGGLFALVAN GNSYVSDIVK TEHRMVTIGI MMSCIYATMG VGPMFGSFLV 
       260        270        280        290        300
KWTHGNGFIP IYTSIAFVIL ALIICETIMV EPRHETQMAH SQSTYTKRRE 
       310        320        330        340        350
KLRSQSGSDD ARNYQSVTYG KFQIMRLMDL LAPVKKLWLK PDSAGSLVPR 
       360        370        380        390        400
HTVILLIVLD ILFVCGTTSC MPALILFSTY EYKWHAVELG YFISILGIGR 
       410        420        430        440        450
GVVLLVVSPT LLYTLKRIYQ HLNHSIDKID IFCIQFSMIV ITLSLFVMIR 
       460        470        480        490        500
FGEKTPTSMI IFALLQALSA FCSPTLQSGI IKYTSKKHTG EMFGAMALVR 
       510        520        530        540        550
SCVMLVIPPI LLKLYGSTVS VNPSLFMYIP FSTSIVAILL TFFLRIYKNP 

PLDGP
Length:555
Mass (Da):61,525
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA72400A0BB80A533
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z49438 Genomic DNA Translation: CAA89458.1
BK006943 Genomic DNA Translation: DAA08640.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56946

NCBI Reference Sequences

More...RefSeqi		NP_012372.1, NM_001181596.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YJL163C_mRNA; YJL163C; YJL163C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		853276

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YJL163C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49438 Genomic DNA Translation: CAA89458.1
BK006943 Genomic DNA Translation: DAA08640.1
PIRiS56946
RefSeqiNP_012372.1, NM_001181596.1

3D structure databases

SMRiP46996
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33596, 115 interactors
DIPiDIP-8000N
STRINGi4932.YJL163C

Protein family/group databases

TCDBi2.A.1.11.4, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP46996

Proteomic databases

PaxDbiP46996
PRIDEiP46996

Genome annotation databases

EnsemblFungiiYJL163C_mRNA; YJL163C; YJL163C
GeneIDi853276
KEGGisce:YJL163C

Organism-specific databases

SGDiS000003699, YJL163C
VEuPathDBiFungiDB:YJL163C

Phylogenomic databases

eggNOGiKOG2816, Eukaryota
GeneTreeiENSGT00950000183096
HOGENOMiCLU_017517_2_1_1
InParanoidiP46996
OMAiNWSEVEF

Enzyme and pathway databases

ReactomeiR-SCE-196757, Metabolism of folate and pterines
R-SCE-917937, Iron uptake and transport
R-SCE-9707616, Heme signaling

Miscellaneous databases

Protein Ontology

More...PROi		PR:P46996
RNActiP46996, protein

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYJQ3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46996
Secondary accession number(s): D6VW24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 23, 2022
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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