UniProtKB - P46990 (RL17B_YEAST)
Protein
60S ribosomal protein L17-B
Gene
RPL17B
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication
Miscellaneous
Present with 21100 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL22 in yeast.Curated
GO - Molecular functioni
- structural constituent of ribosome Source: SGD
GO - Biological processi
- cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- cytoplasmic translation Source: SGD
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L17-B1 PublicationAlternative name(s): L20 Large ribosomal subunit protein uL22-B1 Publication YL17 |
Gene namesi | Ordered Locus Names:YJL177W ORF Names:J0493 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YJL177W |
SGDi | S000003713, RPL17B |
Subcellular locationi
Other locations
- Cytoplasm 2 Publications
Cytosol
- cytosolic large ribosomal subunit Source: SGD
Other locations
- preribosome, large subunit precursor Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000125348 | 2 – 184 | 60S ribosomal protein L17-BAdd BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 46 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 70 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P46990 |
PaxDbi | P46990 |
PRIDEi | P46990 |
PTM databases
CarbonylDBi | P46990 |
iPTMneti | P46990 |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL22 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102).
1 Publication1 PublicationProtein-protein interaction databases
BioGRIDi | 33584, 234 interactors |
IntActi | P46990, 35 interactors |
MINTi | P46990 |
STRINGi | 4932.YJL177W |
Miscellaneous databases
RNActi | P46990, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL22 family.Curated
Phylogenomic databases
eggNOGi | KOG3353, Eukaryota |
GeneTreei | ENSGT00950000183010 |
HOGENOMi | CLU_083987_0_0_1 |
InParanoidi | P46990 |
OMAi | ANAEYKG |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR005721, Ribosomal_L22/L17_euk/arc IPR036394, Ribosomal_L22/L17_sf |
PANTHERi | PTHR11593, PTHR11593, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01038, uL22_arch_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P46990-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARYGATSTN PAKSASARGS YLRVSFKNTR ETAQAINGWE LTKAQKYLDQ
60 70 80 90 100
VLDHQRAIPF RRFNSSIGRT AQGKEFGVTK ARWPAKSVKF VQGLLQNAAA
110 120 130 140 150
NAEAKGLDAT KLYVSHIQVN QAPKQRRRTY RAHGRINKYE SSPSHIELVV
160 170 180
TEKEEAVAKA AEKKVVRLTS RQRGRIAAQK RISA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49452 Genomic DNA Translation: CAA89472.1 BK006943 Genomic DNA Translation: DAA08628.1 |
PIRi | S56960 |
RefSeqi | NP_012358.1, NM_001181610.1 |
Genome annotation databases
EnsemblFungii | YJL177W_mRNA; YJL177W; YJL177W |
GeneIDi | 853262 |
KEGGi | sce:YJL177W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49452 Genomic DNA Translation: CAA89472.1 BK006943 Genomic DNA Translation: DAA08628.1 |
PIRi | S56960 |
RefSeqi | NP_012358.1, NM_001181610.1 |
3D structure databases
SMRi | P46990 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33584, 234 interactors |
IntActi | P46990, 35 interactors |
MINTi | P46990 |
STRINGi | 4932.YJL177W |
PTM databases
CarbonylDBi | P46990 |
iPTMneti | P46990 |
Proteomic databases
MaxQBi | P46990 |
PaxDbi | P46990 |
PRIDEi | P46990 |
Genome annotation databases
EnsemblFungii | YJL177W_mRNA; YJL177W; YJL177W |
GeneIDi | 853262 |
KEGGi | sce:YJL177W |
Organism-specific databases
EuPathDBi | FungiDB:YJL177W |
SGDi | S000003713, RPL17B |
Phylogenomic databases
eggNOGi | KOG3353, Eukaryota |
GeneTreei | ENSGT00950000183010 |
HOGENOMi | CLU_083987_0_0_1 |
InParanoidi | P46990 |
OMAi | ANAEYKG |
Miscellaneous databases
PROi | PR:P46990 |
RNActi | P46990, protein |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR005721, Ribosomal_L22/L17_euk/arc IPR036394, Ribosomal_L22/L17_sf |
PANTHERi | PTHR11593, PTHR11593, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01038, uL22_arch_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL17B_YEAST | |
Accessioni | P46990Primary (citable) accession number: P46990 Secondary accession number(s): D6VW12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - Ribosomal proteins
Ribosomal proteins families and list of entries