GYG1

Functionⁱ

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

Catalytic activityⁱ

UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.

Cofactorⁱ

Mn²⁺Note: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.

Pathwayⁱ: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	86	By similarity	1
Metal bindingⁱ	102	ManganeseBy similarity	1
Metal bindingⁱ	104	ManganeseBy similarity	1
Siteⁱ	160	Important for catalytic activityBy similarity	1
Siteⁱ	163	Important for catalytic activityBy similarity	1
Metal bindingⁱ	212	ManganeseBy similarity	1

GO - Molecular functionⁱ

glycogenin glucosyltransferase activity
Source: Reactome
Inferred from experimentⁱ
- 20357282
metal ion binding Source: UniProtKB-KW
UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycogen biosynthetic process Source: Reactome
neutrophil degranulation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Glycogen biosynthesis
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS08931-MONOMER
BRENDAⁱ	2.4.1.186 2681
Reactomeⁱ	R-HSA-3322077 Glycogen synthesis R-HSA-3785653 Myoclonic epilepsy of Lafora R-HSA-3814836 Glycogen storage disease type XV (GYG1) R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) R-HSA-5357609 Glycogen storage disease type II (GAA) R-HSA-6798695 Neutrophil degranulation R-HSA-70221 Glycogen breakdown (glycogenolysis)
UniPathwayⁱ	UPA00164

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT8 Glycosyltransferase Family 8

CAZyⁱ

GT8 Glycosyltransferase Family 8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycogenin-1 (EC:2.4.1.186) Short name: GN-1 Short name: GN1
Gene namesⁱ	Name:GYG1 Synonyms:GYG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163754.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4699 GYG1
MIMⁱ	603942 gene
neXtProtⁱ	NX_P46976

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Glycogen storage disease 15 (GSD15)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA metabolic disorder resulting in muscle weakness, associated with the glycogen depletion in skeletal muscle, and cardiac arrhythmia, associated with the accumulation of abnormal storage material in the heart. The skeletal muscle shows a marked predominance of slow-twitch, oxidative muscle fibers and mitochondrial proliferation.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063768	83	T → M in GSD15; inactivation of the autoglucosylation. 1 PublicationCorresponds to variant dbSNP:rs267606858EnsemblClinVar.		1

Polyglucosan body myopathy 2 (PGBM2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA glycogen storage disease characterized by polyglucosan accumulation in muscle, and skeletal myopathy without cardiac involvement. Most patients manifest slowly progressive, hip girdle, shoulder girdle, and/or hand and leg muscle weakness. Polyglucosan contains abnormally long and poorly branched glucosyl chains and is variably resistant to digestion by alpha-amylase.

Keywords - Diseaseⁱ

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2992
MalaCards human disease database More...MalaCardsⁱ	GYG1
MIMⁱ	613507 phenotype 616199 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163754
Orphanetⁱ	263297 Glycogen storage disease due to glycogenin deficiency
PharmGKBⁱ	PA29077

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB01861 Uridine diphosphate glucose DB03435 Uridine-5'-Diphosphate

DrugBankⁱ

DB01861 Uridine diphosphate glucose
DB03435 Uridine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaⁱ	GYG1

BioMutaⁱ

GYG1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000215176	2 – 350	Glycogenin-1CuratedAdd BLAST		349

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineCombined sources	1
Modified residueⁱ	44	PhosphoserineBy similarity	1
Glycosylationⁱ	195	O-linked (Glc...) tyrosineBy similarity	1

Post-translational modificationⁱ

Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.

Phosphorylated.By similarity

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P46976
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P46976
PaxDbⁱ	P46976
PeptideAtlas More...PeptideAtlasⁱ	P46976
PRIDEⁱ	P46976
ProteomicsDBⁱ	55779 55780 [P46976-2] 55781 [P46976-3]

PTM databases

iPTMnetⁱ	P46976
PhosphoSitePlusⁱ	P46976

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163754 Expressed in 242 organ(s), highest expression level in deltoid
CleanExⁱ	HS_GYG1
ExpressionAtlasⁱ	P46976 baseline and differential
Genevisibleⁱ	P46976 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030497

HPAⁱ

HPA030497

Interactionⁱ

Subunit structureⁱ

Homodimer tightly complexed to the 86 kDa catalytic subunit of glycogen synthase GYS1 (By similarity). Interacts (via C-terminus) with GYS2 (PubMed:17055998). This interaction is required for GYS2-mediated glycogen synthesis (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GYS1	P13807	7	EBI-740533,EBI-740553

With

Entry

#Exp.

IntAct

Notes

GYS1

P13807

7

EBI-740533,EBI-740553

Protein-protein interaction databases

BioGridⁱ	109247, 20 interactors
IntActⁱ	P46976, 15 interactors
STRINGⁱ	9606.ENSP00000340736

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 12	Combined sources	9
Helixⁱ	13 – 28	Combined sources	16
Beta strandⁱ	33 – 39	Combined sources	7
Helixⁱ	45 – 54	Combined sources	10
Beta strandⁱ	55 – 60	Combined sources	6
Helixⁱ	69 – 74	Combined sources	6
Helixⁱ	80 – 91	Combined sources	12
Beta strandⁱ	96 – 101	Combined sources	6
Beta strandⁱ	105 – 107	Combined sources	3
Helixⁱ	112 – 116	Combined sources	5
Beta strandⁱ	119 – 124	Combined sources	6
Beta strandⁱ	126 – 128	Combined sources	3
Beta strandⁱ	131 – 139	Combined sources	9
Helixⁱ	143 – 156	Combined sources	14
Beta strandⁱ	159 – 161	Combined sources	3
Helixⁱ	163 – 170	Combined sources	8
Turnⁱ	171 – 176	Combined sources	6
Helixⁱ	179 – 181	Combined sources	3
Helixⁱ	185 – 187	Combined sources	3
Beta strandⁱ	188 – 190	Combined sources	3
Helixⁱ	191 – 195	Combined sources	5
Helixⁱ	198 – 204	Combined sources	7
Helixⁱ	205 – 207	Combined sources	3
Beta strandⁱ	209 – 212	Combined sources	4
Beta strandⁱ	215 – 217	Combined sources	3
Helixⁱ	219 – 221	Combined sources	3
Beta strandⁱ	222 – 225	Combined sources	4
Turnⁱ	226 – 229	Combined sources	4
Beta strandⁱ	230 – 232	Combined sources	3
Helixⁱ	238 – 240	Combined sources	3
Helixⁱ	244 – 256	Combined sources	13
Helixⁱ	258 – 261	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P46976
SMRⁱ	P46976
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P46976

EvolutionaryTraceⁱ

P46976

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	301 – 333	Interaction with GYS11 PublicationAdd BLAST		33

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1950 Eukaryota COG5597 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004721
HOGENOMⁱ	HOG000008282
HOVERGENⁱ	HBG000681
InParanoidⁱ	P46976
KEGG Orthology (KO) More...KOⁱ	K00750
OMAⁱ	TYNQLLH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09E1
PhylomeDBⁱ	P46976
TreeFamⁱ	TF312839

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR002495 Glyco_trans_8 IPR029044 Nucleotide-diphossugar_trans
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01501 Glyco_transf_8, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform GN-1L (identifier: P46976-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV 
        60         70         80         90        100
LETVFDEVIM VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF 
       110        120        130        140        150
MDADTLVLAN IDDLFDREEL SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL 
       160        170        180        190        200
HLASEQGSFD GGDQGILNTF FSSWATTDIR KHLPFIYNLS SISIYSYLPA 
       210        220        230        240        250
FKVFGASAKV VHFLGRVKPW NYTYDPKTKS VKSEAHDPNM THPEFLILWW 
       260        270        280        290        300
NIFTTNVLPL LQQFGLVKDT CSYVNVLSDL VYTLAFSCGF CRKEDVSGAI 
       310        320        330        340        350
SHLSLGEIPA MAQPFVSSEE RKERWEQGQA DYMGADSFDN IKRKLDTYLQ

Length:350

Mass (Da):39,384

Last modified:January 23, 2007 - v4

Checksum:ⁱABAEEB7160DEC4DF

GO

Isoform GN-1 (identifier: P46976-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
277-293: Missing.

« Hide

        10         20         30         40         50
MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV 
        60         70         80         90        100
LETVFDEVIM VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF 
       110        120        130        140        150
MDADTLVLAN IDDLFDREEL SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL 
       160        170        180        190        200
HLASEQGSFD GGDQGILNTF FSSWATTDIR KHLPFIYNLS SISIYSYLPA 
       210        220        230        240        250
FKVFGASAKV VHFLGRVKPW NYTYDPKTKS VKSEAHDPNM THPEFLILWW 
       260        270        280        290        300
NIFTTNVLPL LQQFGLVKDT CSYVNVEDVS GAISHLSLGE IPAMAQPFVS 
       310        320        330 
SEERKERWEQ GQADYMGADS FDNIKRKLDT YLQ

Show »

Length:333

Mass (Da):37,479

Checksum:ⁱCD5E3C16F849FF7C

GO

Isoform GN-1S (identifier: P46976-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
204-350: FGASAKVVHF...IKRKLDTYLQ → KMSQEPYHIC...IHFTSLVSDT

« Hide

        10         20         30         40         50
MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV 
        60         70         80         90        100
LETVFDEVIM VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF 
       110        120        130        140        150
MDADTLVLAN IDDLFDREEL SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL 
       160        170        180        190        200
HLASEQGSFD GGDQGILNTF FSSWATTDIR KHLPFIYNLS SISIYSYLPA 
       210        220        230        240        250
FKVKMSQEPY HICPLGRSQL WHSRLYPRKN GRNDGNRARL IIWEQIPLTT 
       260        270 
SRGNLTLTSS RNTAFFCEHI HFTSLVSDT

Show »

Length:279

Mass (Da):31,467

Checksum:ⁱF8AD62431CBB470E

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E9W8	G5E9W8_HUMAN	Glycogenin 1, isoform CRA_e Glycogenin 1, isoform CRA_e (Glycogenin-1)	GYG1 hCG_21210	193	Annotation score:
C9JQ42	C9JQ42_HUMAN	Glycogenin-1 Glycogenin-1	GYG1	265	Annotation score:
C9J7C7	C9J7C7_HUMAN	Glycogenin-1 Glycogenin-1	GYG1	110	Annotation score:
C9J8R8	C9J8R8_HUMAN	Glycogenin-1 Glycogenin-1	GYG1	60	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072706	16	A → P in PGBM2. 1 Publication	1
Natural variantⁱVAR_063768	83	T → M in GSD15; inactivation of the autoglucosylation. 1 PublicationCorresponds to variant dbSNP:rs267606858EnsemblClinVar.	1
Natural variantⁱVAR_072707	102	D → H in PGBM2. 1 PublicationCorresponds to variant dbSNP:rs143137713EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001768	204 – 350	FGASA…DTYLQ → KMSQEPYHICPLGRSQLWHS RLYPRKNGRNDGNRARLIIW EQIPLTTSRGNLTLTSSRNT AFFCEHIHFTSLVSDT in isoform GN-1S. CuratedAdd BLAST		147
Alternative sequenceⁱVSP_001769	277 – 293	Missing in isoform GN-1. 4 PublicationsAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44131 mRNA Translation: AAB00114.1 U31525 mRNA Translation: AAB09752.1 X79537 mRNA Translation: CAA56073.1 AF065481 AF065480 Genomic DNA Translation: AAD31084.1 AF087942 mRNA Translation: AAD52093.1 CR536547 mRNA Translation: CAG38784.1 AC021059 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78894.1 CH471052 Genomic DNA Translation: EAW78895.1 CH471052 Genomic DNA Translation: EAW78896.1 CH471052 Genomic DNA Translation: EAW78898.1 CH471052 Genomic DNA Translation: EAW78900.1 CH471052 Genomic DNA Translation: EAW78901.1 BC000033 mRNA Translation: AAH00033.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3139.1 [P46976-1] CCDS54654.1 [P46976-2] CCDS54655.1 [P46976-3]
PIRⁱ	JC4695
NCBI Reference Sequences More...RefSeqⁱ	NP_001171649.1, NM_001184720.1 [P46976-2] NP_001171650.1, NM_001184721.1 [P46976-3] NP_004121.2, NM_004130.3 [P46976-1]
UniGeneⁱ	Hs.477892

Genome annotation databases

Ensemblⁱ	ENST00000296048; ENSP00000296048; ENSG00000163754 [P46976-2] ENST00000345003; ENSP00000340736; ENSG00000163754 [P46976-1] ENST00000484197; ENSP00000420683; ENSG00000163754 [P46976-3]
GeneIDⁱ	2992
KEGGⁱ	hsa:2992
UCSC genome browser More...UCSCⁱ	uc003ewn.4 human [P46976-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P46976	Glycogenin-1 (Fragment)		HUMAN		110	UniRef100_P46976
P46976-2	GYG1 protein (Fragment)		HUMAN		331	UniRef100_P46976-2
UPI0007DC5528		HUMAN		274

Protein	Similar proteins		Species	Score	Length	Source
P46976	Glycogenin-1 (Fragment)		HUMAN		110	UniRef90_P46976
Uncharacterized protein		MACFA		354
Uncharacterized protein		COLAP		354
Uncharacterized protein		CERAT		354
Uncharacterized protein		MACNE		354
+46
P46976-2	GYG1 protein (Fragment)		HUMAN		331	UniRef90_P46976-2
Glycogenin 1		SAIBB		410
GYG1 isoform 7 (Fragment)		PONAB		157
Glycogenin-1		HETGA		355
Uncharacterized protein		RHIRO		354
+71
P46976-3	Uncharacterized protein		COLAP		283	UniRef90_P46976-3
Glycogenin 1		GORGO		283
Uncharacterized protein		CALJA		279
GYG1 isoform 6		PONAB		279
Uncharacterized protein		MACFA		279
+11

Protein	Similar proteins		Species	Score	Length	Source
P46976	Glycogenin-1	)	RABIT		333	UniRef50_P46976
Glycogenin-1 (Fragment)		HUMAN		110
Glycogenin 1		PANTR		354
Uncharacterized protein		PANPA		354
Glycogenin 1		GORGO		354
+308
P46976-2	Glycogenin-1		MOUSE		333	UniRef50_P46976-2
Glycogenin-1		RAT		333
GYG1 protein (Fragment)		HUMAN		331
Glycogenin 1		SAIBB		410
GYG1 isoform 7 (Fragment)		PONAB		157
+241
P46976-3	Uncharacterized protein		COLAP		283	UniRef50_P46976-3
Glycogenin 1		GORGO		283
GYG1 isoform 6		PONAB		279
Uncharacterized protein		AOTNA		279
Uncharacterized protein		CALJA		279
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44131 mRNA Translation: AAB00114.1 U31525 mRNA Translation: AAB09752.1 X79537 mRNA Translation: CAA56073.1 AF065481 AF065480 Genomic DNA Translation: AAD31084.1 AF087942 mRNA Translation: AAD52093.1 CR536547 mRNA Translation: CAG38784.1 AC021059 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78894.1 CH471052 Genomic DNA Translation: EAW78895.1 CH471052 Genomic DNA Translation: EAW78896.1 CH471052 Genomic DNA Translation: EAW78898.1 CH471052 Genomic DNA Translation: EAW78900.1 CH471052 Genomic DNA Translation: EAW78901.1 BC000033 mRNA Translation: AAH00033.1
CCDSⁱ	CCDS3139.1 [P46976-1] CCDS54654.1 [P46976-2] CCDS54655.1 [P46976-3]
PIRⁱ	JC4695
RefSeqⁱ	NP_001171649.1, NM_001184720.1 [P46976-2] NP_001171650.1, NM_001184721.1 [P46976-3] NP_004121.2, NM_004130.3 [P46976-1]
UniGeneⁱ	Hs.477892

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3Q4S	X-ray	1.98	A	1-262	[»]
	3QVB	X-ray	2.26	A	1-262	[»]
	3RMV	X-ray	1.82	A	1-262	[»]
	3RMW	X-ray	1.93	A	1-262	[»]
	3T7M	X-ray	1.80	A/B	1-262	[»]
	3T7N	X-ray	1.98	A/B	1-262	[»]
	3T7O	X-ray	1.85	A/B	1-262	[»]
	3U2T	X-ray	2.05	A	1-262	[»]
	3U2U	X-ray	1.45	A/B	1-262	[»]
	3U2V	X-ray	1.50	A/B	1-262	[»]
	3U2W	X-ray	1.68	A/B	1-262	[»]
	3U2X	X-ray	1.77	A/B	1-262	[»]
	6EQJ	X-ray	2.18	A	1-262	[»]
	6EQL	X-ray	2.38	A/B	1-262	[»]
ProteinModelPortalⁱ	P46976
SMRⁱ	P46976
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109247, 20 interactors
IntActⁱ	P46976, 15 interactors
STRINGⁱ	9606.ENSP00000340736

Chemistry databases

DrugBankⁱ	DB01861 Uridine diphosphate glucose DB03435 Uridine-5'-Diphosphate

DrugBankⁱ

DB01861 Uridine diphosphate glucose
DB03435 Uridine-5'-Diphosphate

Protein family/group databases

CAZyⁱ	GT8 Glycosyltransferase Family 8

CAZyⁱ

GT8 Glycosyltransferase Family 8

PTM databases

iPTMnetⁱ	P46976
PhosphoSitePlusⁱ	P46976

Polymorphism and mutation databases

BioMutaⁱ	GYG1

BioMutaⁱ

GYG1

Proteomic databases

EPDⁱ	P46976
MaxQBⁱ	P46976
PaxDbⁱ	P46976
PeptideAtlasⁱ	P46976
PRIDEⁱ	P46976
ProteomicsDBⁱ	55779 55780 [P46976-2] 55781 [P46976-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2992
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296048; ENSP00000296048; ENSG00000163754 [P46976-2] ENST00000345003; ENSP00000340736; ENSG00000163754 [P46976-1] ENST00000484197; ENSP00000420683; ENSG00000163754 [P46976-3]
GeneIDⁱ	2992
KEGGⁱ	hsa:2992
UCSCⁱ	uc003ewn.4 human [P46976-1]

Organism-specific databases

CTDⁱ	2992
DisGeNETⁱ	2992
EuPathDBⁱ	HostDB:ENSG00000163754.17
GeneCardsⁱ	GYG1
HGNCⁱ	HGNC:4699 GYG1
HPAⁱ	HPA030497
MalaCardsⁱ	GYG1
MIMⁱ	603942 gene 613507 phenotype 616199 phenotype
neXtProtⁱ	NX_P46976
OpenTargetsⁱ	ENSG00000163754
Orphanetⁱ	263297 Glycogen storage disease due to glycogenin deficiency
PharmGKBⁱ	PA29077
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1950 Eukaryota COG5597 LUCA
GeneTreeⁱ	ENSGT00390000004721
HOGENOMⁱ	HOG000008282
HOVERGENⁱ	HBG000681
InParanoidⁱ	P46976
KOⁱ	K00750
OMAⁱ	TYNQLLH
OrthoDBⁱ	EOG091G09E1
PhylomeDBⁱ	P46976
TreeFamⁱ	TF312839

Enzyme and pathway databases

UniPathwayⁱ	UPA00164
BioCycⁱ	MetaCyc:HS08931-MONOMER
BRENDAⁱ	2.4.1.186 2681
Reactomeⁱ	R-HSA-3322077 Glycogen synthesis R-HSA-3785653 Myoclonic epilepsy of Lafora R-HSA-3814836 Glycogen storage disease type XV (GYG1) R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) R-HSA-5357609 Glycogen storage disease type II (GAA) R-HSA-6798695 Neutrophil degranulation R-HSA-70221 Glycogen breakdown (glycogenolysis)

Miscellaneous databases

ChiTaRSⁱ	GYG1 human
EvolutionaryTraceⁱ	P46976
GenomeRNAiⁱ	2992
Protein Ontology More...PROⁱ	PR:P46976
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163754 Expressed in 242 organ(s), highest expression level in deltoid
CleanExⁱ	HS_GYG1
ExpressionAtlasⁱ	P46976 baseline and differential
Genevisibleⁱ	P46976 HS

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR002495 Glyco_trans_8 IPR029044 Nucleotide-diphossugar_trans
Pfamⁱ	View protein in Pfam PF01501 Glyco_transf_8, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLYG_HUMAN
Accessionⁱ	P46976Primary (citable) accession number: P46976 Secondary accession number(s): D3DNH0 , D3DNH1, D3DNH2, Q6FHZ1, Q9UNV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 172 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P46976 (GLYG_HUMAN)

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Glycogenin-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycogen biosynthesis

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GO - Biological processi

Enzyme and pathway databases

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Diseasei

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Keywords - PTMi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: glycogen biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ