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Entry version 145 (07 Apr 2021)
Sequence version 1 (01 Nov 1995)
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Protein

Protein FYV8

Gene

FYV8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for survival upon exposure to K1 killer toxin. Involved in the resistance to unfolded protein response (UPR)-inducing agents.2 Publications

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FYV8
Alternative name(s):
Function required for yeast viability protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FYV8
Ordered Locus Names:YGR196C
ORF Names:G7589
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000003428, FYV8

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
FungiDB:YGR196C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002028421 – 817Protein FYV8Add BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei92PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P46949

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P46949

PRoteomics IDEntifications database

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PRIDEi
P46949

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P46949

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
33449, 215 interactors

Database of interacting proteins

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DIPi
DIP-4795N

Protein interaction database and analysis system

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IntActi
P46949, 6 interactors

Molecular INTeraction database

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MINTi
P46949

STRING: functional protein association networks

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STRINGi
4932.YGR196C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P46949, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46949

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FYV8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QPM9, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_009686_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P46949

Identification of Orthologs from Complete Genome Data

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OMAi
KSYRWVS

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026248, Fyv8

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02076, PROTEINFYV8

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46949-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTEQVGRKK SYRWVSASQA SYDGAGWDSS DEYDYSSEDG TKGSEIHKQK
60 70 80 90 100
ISNLPSLPKL NYTDVNGEHD ENTGENKDSN DNNVSKSDIS PSDKEVGYLS
110 120 130 140 150
DGVPKLMASR ESVELQAKKS SEHSKSDYLS STASLKSPSE NKKSPHTNRA
160 170 180 190 200
VNEDLDNLIE QISREMTPEI RQTSDFRRDS DSCDEIQNEA PLGEAVPSSS
210 220 230 240 250
SPVEEDEKSH SLGVSMDTNE ADTTFNTPTR NGNEHLSSDG DVSEQKDDEF
260 270 280 290 300
KVSERGYLAD ILPAEKEENL QQEDDGEVES SGALEKKEKS EEKTSIRNRN
310 320 330 340 350
STSSGQDKVA KPKPVANETK TSDNGYRNSF FNDYQHSSDS EEDDNNEGNS
360 370 380 390 400
GSSDDDNRSS VSDKHADINR QSKQLDTTDD DALSYTESIK YSTNETEEED
410 420 430 440 450
NEDNESIEDK NEDNESIEDE NEDTDSYKFS NREKGSILLT SDEEEEEKGM
460 470 480 490 500
SSDSDEGSLK APKSGYFSKM IGNDDKGDSA LQPNQIDTIE NTNLSNSGSE
510 520 530 540 550
LENSDGSDEE DHINEDKVLE ESSVKDSTDV DSWKPDSEAL RSGFVQDTAN
560 570 580 590 600
KKAPPGYVID SNGKLVDLTP ASMKPRVVST YSEMESTWDA FPSKGEDDDL
610 620 630 640 650
ETIRDTKTIY DNNTIYNVPG LIGNQSNLPP LPMDAQEQLN AGNDNSTTDN
660 670 680 690 700
DNSNNTANDL AARSASFKSE NRTVSQGEMT SVHEPSTEEM AKLGQQNNLP
710 720 730 740 750
KLDMNKLLNS KTSHAGKIEQ LRNYKRELDE YDTGIQTWIN YTLKSSSNKD
760 770 780 790 800
KDFIAEEYKQ HSHVREAYAN ADDLSKKHTV INTVASVNQN VTHLRRKVFQ
810
HSMKPKDLFA SIGKKKL
Length:817
Mass (Da):90,798
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE52C5D659D63BEBB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82775 Genomic DNA Translation: CAA58019.1
Z72981 Genomic DNA Translation: CAA97222.1
BK006941 Genomic DNA Translation: DAA08289.1

Protein sequence database of the Protein Information Resource

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PIRi
S53919

NCBI Reference Sequences

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RefSeqi
NP_011712.1, NM_001181325.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YGR196C_mRNA; YGR196C; YGR196C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGR196C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82775 Genomic DNA Translation: CAA58019.1
Z72981 Genomic DNA Translation: CAA97222.1
BK006941 Genomic DNA Translation: DAA08289.1
PIRiS53919
RefSeqiNP_011712.1, NM_001181325.1

3D structure databases

SMRiP46949
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33449, 215 interactors
DIPiDIP-4795N
IntActiP46949, 6 interactors
MINTiP46949
STRINGi4932.YGR196C

PTM databases

iPTMnetiP46949

Proteomic databases

MaxQBiP46949
PaxDbiP46949
PRIDEiP46949

Genome annotation databases

EnsemblFungiiYGR196C_mRNA; YGR196C; YGR196C
GeneIDi853110
KEGGisce:YGR196C

Organism-specific databases

SGDiS000003428, FYV8
VEuPathDBiFungiDB:YGR196C

Phylogenomic databases

eggNOGiENOG502QPM9, Eukaryota
HOGENOMiCLU_009686_0_0_1
InParanoidiP46949
OMAiKSYRWVS

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P46949
RNActiP46949, protein

Family and domain databases

InterProiView protein in InterPro
IPR026248, Fyv8
PRINTSiPR02076, PROTEINFYV8

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFYV8_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46949
Secondary accession number(s): D6VUX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 7, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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