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UniProtKB - P46939 (UTRO_HUMAN)

Protein

Utrophin

Gene

UTRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3064 – 3111ZZ-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • actin binding Source: BHF-UCL
  • actin filament binding Source: Ensembl
  • integrin binding Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • vinculin binding Source: BHF-UCL
  • zinc ion binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • muscle contraction Source: ProtInc
  • muscle organ development Source: ProtInc
  • neuromuscular junction development Source: Ensembl
  • positive regulation of cell-matrix adhesion Source: UniProtKB
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • response to denervation involved in regulation of muscle adaptation Source: Ensembl
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP46939
SIGNORiP46939

Names & Taxonomyi

Protein namesi
Recommended name:
Utrophin
Alternative name(s):
Dystrophin-related protein 1
Short name:
DRP-1
Gene namesi
Name:UTRN
Synonyms:DMDL, DRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000152818.18
HGNCiHGNC:12635 UTRN
MIMi128240 gene
neXtProtiNX_P46939

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi7402
OpenTargetsiENSG00000152818
PharmGKBiPA37260

Polymorphism and mutation databases

BioMutaiUTRN
DMDMi215274104

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760821 – 3433UtrophinAdd BLAST3433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphotyrosineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei2008PhosphoserineCombined sources1
Modified residuei2211PhosphoserineCombined sources1
Modified residuei3297PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP46939
MaxQBiP46939
PaxDbiP46939
PeptideAtlasiP46939
PRIDEiP46939
ProteomicsDBi55775

PTM databases

iPTMnetiP46939
PhosphoSitePlusiP46939

Expressioni

Tissue specificityi

Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000152818 Expressed in 216 organ(s), highest expression level in kidney
CleanExiHS_UTRN
ExpressionAtlasiP46939 baseline and differential
GenevisibleiP46939 HS

Organism-specific databases

HPAiCAB016348
HPA018894

Interactioni

Subunit structurei

Homodimer. Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM. Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP3CAQ08209-13EBI-295856,EBI-15637215

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi113245, 69 interactors
CORUMiP46939
DIPiDIP-711N
IntActiP46939, 45 interactors
MINTiP46939
STRINGi9606.ENSP00000356515

Structurei

Secondary structure

13433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP46939
SMRiP46939
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46939

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 135Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini150 – 255Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
Repeati312 – 416Spectrin 1Sequence analysisAdd BLAST105
Repeati421 – 525Spectrin 2Sequence analysisAdd BLAST105
Repeati532 – 636Spectrin 3Sequence analysisAdd BLAST105
Repeati690 – 795Spectrin 4Sequence analysisAdd BLAST106
Repeati801 – 901Spectrin 5Sequence analysisAdd BLAST101
Repeati910 – 1012Spectrin 6Sequence analysisAdd BLAST103
Repeati1019 – 1121Spectrin 7Sequence analysisAdd BLAST103
Repeati1128 – 1229Spectrin 8Sequence analysisAdd BLAST102
Repeati1236 – 1333Spectrin 9Sequence analysisAdd BLAST98
Repeati1335 – 1436Spectrin 10Sequence analysisAdd BLAST102
Repeati1438 – 1540Spectrin 11Sequence analysisAdd BLAST103
Repeati1547 – 1648Spectrin 12Sequence analysisAdd BLAST102
Repeati1653 – 1747Spectrin 13Sequence analysisAdd BLAST95
Repeati1748 – 1848Spectrin 14Sequence analysisAdd BLAST101
Repeati1849 – 1968Spectrin 15Sequence analysisAdd BLAST120
Repeati1979 – 2080Spectrin 16Sequence analysisAdd BLAST102
Repeati2087 – 2186Spectrin 17Sequence analysisAdd BLAST100
Repeati2229 – 2332Spectrin 18Sequence analysisAdd BLAST104
Repeati2349 – 2439Spectrin 19Sequence analysisAdd BLAST91
Repeati2446 – 2555Spectrin 20Sequence analysisAdd BLAST110
Repeati2562 – 2687Spectrin 21Sequence analysisAdd BLAST126
Repeati2694 – 2796Spectrin 22Sequence analysisAdd BLAST103
Domaini2812 – 2845WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 246Actin-bindingAdd BLAST246
Regioni268 – 905Interaction with SYNM1 PublicationAdd BLAST638
Regioni1336 – 1768Interaction with SYNM1 PublicationAdd BLAST433
Regioni2798 – 3165Interaction with SYNM1 PublicationAdd BLAST368

Domaini

Actin binding affinity is primarily determined by CH domain 1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3064 – 3111ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119237
HOGENOMiHOG000231173
HOVERGENiHBG005495
InParanoidiP46939
OMAiNFLKWIQ
OrthoDBiEOG091G001Y
PhylomeDBiP46939
TreeFamiTF320178

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 10 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 18 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46939-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK 
        60         70         80         90        100
PPINDMFTDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL 
       110        120        130        140        150
HQNNVELVNI GGTDIVDGNH KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT 
       160        170        180        190        200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD 
       210        220        230        240        250
KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL 
       260        270        280        290        300
FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET 
       310        320        330        340        350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA 
       360        370        380        390        400
THEAFMMELT AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR 
       410        420        430        440        450
WEALRVESMD RQSRLHDVLM ELQKKQLQQL SAWLTLTEER IQKMETCPLD 
       460        470        480        490        500
DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAILE 
       510        520        530        540        550
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LKAWLTEKEE 
       560        570        580        590        600
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL 
       610        620        630        640        650
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK 
       660        670        680        690        700
DLLETVRVRE QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL 
       710        720        730        740        750
NWILKWKTAI QTTEIKEYMK MQDTSEMKKK LKALEKEQRE RIPRADELNQ 
       760        770        780        790        800
TGQILVEQMG KEGLPTEEIK NVLEKVSSEW KNVSQHLEDL ERKIQLQEDI 
       810        820        830        840        850
NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS CQRELTNLLG 
       860        870        880        890        900
LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL 
       910        920        930        940        950
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK 
       960        970        980        990       1000
KTLDEILENQ KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL 
      1010       1020       1030       1040       1050
KVLVSKDLHL LEEIALTLRA FEADSTVIEK WMDGVKDFLM KQQAAQGDDA 
      1060       1070       1080       1090       1100
GLQRQLDQCS AFVNEIETIE SSLKNMKEIE TNLRSGPVAG IKTWVQTRLG 
      1110       1120       1130       1140       1150
DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW MTQAEEEYLE 
      1160       1170       1180       1190       1200
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG 
      1210       1220       1230       1240       1250
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN 
      1260       1270       1280       1290       1300
TLEERMKSTE VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG 
      1310       1320       1330       1340       1350
GILDDIISEK LEAFNSRYED LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ 
      1360       1370       1380       1390       1400
ESLGELDKQL TTYLTDRIDA FQVPQEAQKI QAEISAHELT LEELRRNMRS 
      1410       1420       1430       1440       1450
QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF EQRMLDCKRV 
      1460       1470       1480       1490       1500
LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR 
      1510       1520       1530       1540       1550
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK 
      1560       1570       1580       1590       1600
KEAASLSEWL SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD 
      1610       1620       1630       1640       1650
LNTITESSAA LQNLIEGSEP ILEERLCVLN AGWSRVRTWT EDWCNTLMNH 
      1660       1670       1680       1690       1700
QNQLEIFDGN VAHISTWLYQ AEALLDEIEK KPTSKQEEIV KRLVSELDDA 
      1710       1720       1730       1740       1750
NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV SQHIKSAKLL 
      1760       1770       1780       1790       1800
IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE 
      1810       1820       1830       1840       1850
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP 
      1860       1870       1880       1890       1900
IQQRKMGQLA SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY 
      1910       1920       1930       1940       1950
EDFSFQEDSL KNIKDQLDKL GEQIAVIHEK QPDVILEASG PEAIQIRDTL 
      1960       1970       1980       1990       2000
TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ FHCDLNDLTQ WITEAEELLV 
      2010       2020       2030       2040       2050
DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD GIVQKLSQAD 
      2060       2070       2080       2090       2100
GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL 
      2110       2120       2130       2140       2150
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK 
      2160       2170       2180       2190       2200
SLSLPERDKI SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH 
      2210       2220       2230       2240       2250
PNVQKVVLVS SASDIPVQSH RTSEISIPAD LDKTITELAD WLVLIDQMLK 
      2260       2270       2280       2290       2300
SNIVTVGDVE EINKTVSRMK ITKADLEQRH PQLDYVFTLA QNLKNKASSS 
      2310       2320       2330       2340       2350
DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ WDDHREETEE 
      2360       2370       2380       2390       2400
LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK 
      2410       2420       2430       2440       2450
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR 
      2460       2470       2480       2490       2500
DLENFLKWIQ EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID 
      2510       2520       2530       2540       2550
AHNDIFKSID GNRQKMVKAL GNSEEATMLQ HRLDDMNQRW NDLKAKSASI 
      2560       2570       2580       2590       2600
RAHLEASAEK WNRLLMSLEE LIKWLNMKDE ELKKQMPIGG DVPALQLQYD 
      2610       2620       2630       2640       2650
HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR NLQSKTELTP 
      2660       2670       2680       2690       2700
EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM 
      2710       2720       2730       2740       2750
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK 
      2760       2770       2780       2790       2800
TVNDLSSQLS PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR 
      2810       2820       2830       2840       2850
DFGPSSQHFL STSVQLPWQR SISHNKVPYY INHQTQTTCW DHPKMTELFQ 
      2860       2870       2880       2890       2900
SLADLNNVRF SAYRTAIKIR RLQKALCLDL LELSTTNEIF KQHKLNQNDQ 
      2910       2920       2930       2940       2950
LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL NVYDTGRTGK 
      2960       2970       2980       2990       3000
IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ 
      3010       3020       3030       3040       3050
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV 
      3060       3070       3080       3090       3100
WLPVLHRVAA AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS 
      3110       3120       3130       3140       3150
GRTAKGHKLH YPMVEYCIPT TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG 
      3160       3170       3180       3190       3200
YLPVQTVLEG DNLETPITLI SMWPEHYDPS QSPQLFHDDT HSRIEQYATR 
      3210       3220       3230       3240       3250
LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES PVSQPQSPAQ 
      3260       3270       3280       3290       3300
ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE 
      3310       3320       3330       3340       3350
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR 
      3360       3370       3380       3390       3400
QLLEQPESDS RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP 
      3410       3420       3430 
PHDTSTDLTE VMEQIHSTFP SCCPNVPSRP QAM
Length:3,433
Mass (Da):394,466
Last modified:November 25, 2008 - v2
Checksum:iC72CADE8CD666993
GO
Isoform 2 (identifier: P46939-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MAKYGEHEASPDNGQNEFSDII → MSGLAATTFHWKKCRLDLPGHVALQAC

Note: Produced by alternative promoter usage.
Show »
Length:3,438
Mass (Da):394,969
Checksum:i9242095AE3CD5F48
GO
Isoform Up71 (identifier: P46939-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MAKYGEHEASPDNGQNEFSDIIK → MKFFDFLFIFKILPPYYINFFSS
     24-2832: Missing.

Note: =Produced by alternative promoter usage.Curated
Show »
Length:624
Mass (Da):71,417
Checksum:i0479238E557B0CEA
GO
Isoform Up140 (identifier: P46939-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2086: Missing.

Note: =Produced by alternative promoter usage.
Show »
Length:1,347
Mass (Da):155,026
Checksum:iFDB1EF2EDB5092BC
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T097Q5T097_HUMAN
Utrophin
UTRN
988Annotation score:
Q5JT49Q5JT49_HUMAN
Utrophin
UTRN
186Annotation score:
H0Y337H0Y337_HUMAN
Utrophin
UTRN
251Annotation score:
A0A0A0MSM3A0A0A0MSM3_HUMAN
Utrophin
UTRN
154Annotation score:
Q5JT45Q5JT45_HUMAN
Utrophin
UTRN
180Annotation score:
Q5JT44Q5JT44_HUMAN
Utrophin
UTRN
184Annotation score:
A0A0D9SG57A0A0D9SG57_HUMAN
Utrophin
UTRN
150Annotation score:
Q5SYY2Q5SYY2_HUMAN
Utrophin
UTRN
47Annotation score:
Q5T098Q5T098_HUMAN
Utrophin
UTRN
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236Q → R in CAA48829 (PubMed:1461283).Curated1
Isoform Up71 (identifier: P46939-3)
Sequence conflicti5D → N no nucleotide entry (PubMed:10369873).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0477941880L → I. Corresponds to variant dbSNP:rs12204715Ensembl.1
Natural variantiVAR_0477951974A → T. Corresponds to variant dbSNP:rs12204734Ensembl.1
Natural variantiVAR_0477962060G → D. Corresponds to variant dbSNP:rs35676466Ensembl.1
Natural variantiVAR_0477972202N → S. Corresponds to variant dbSNP:rs1534443Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0549421 – 2086Missing in isoform Up140. 1 PublicationAdd BLAST2086
Alternative sequenceiVSP_0549431 – 23MAKYG…SDIIK → MKFFDFLFIFKILPPYYINF FSS in isoform Up71. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0479251 – 22MAKYG…FSDII → MSGLAATTFHWKKCRLDLPG HVALQAC in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_05494424 – 2832Missing in isoform Up71. 1 PublicationAdd BLAST2809

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69086 mRNA Translation: CAA48829.1
AL024474 Genomic DNA No translation available.
AL357149 Genomic DNA No translation available.
AL513184 Genomic DNA No translation available.
AL513475 Genomic DNA No translation available.
AL590488 Genomic DNA No translation available.
AL590704 Genomic DNA No translation available.
AJ250044 Genomic DNA Translation: CAB61826.1
CCDSiCCDS34547.1 [P46939-1]
PIRiS28381
RefSeqiNP_009055.2, NM_007124.2 [P46939-1]
XP_005267187.1, XM_005267130.2 [P46939-1]
XP_011534408.1, XM_011536106.2 [P46939-1]
UniGeneiHs.133135

Genome annotation databases

EnsembliENST00000367545; ENSP00000356515; ENSG00000152818 [P46939-1]
GeneIDi7402
KEGGihsa:7402
UCSCiuc003qkt.4 human [P46939-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Utrophin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69086 mRNA Translation: CAA48829.1
AL024474 Genomic DNA No translation available.
AL357149 Genomic DNA No translation available.
AL513184 Genomic DNA No translation available.
AL513475 Genomic DNA No translation available.
AL590488 Genomic DNA No translation available.
AL590704 Genomic DNA No translation available.
AJ250044 Genomic DNA Translation: CAB61826.1
CCDSiCCDS34547.1 [P46939-1]
PIRiS28381
RefSeqiNP_009055.2, NM_007124.2 [P46939-1]
XP_005267187.1, XM_005267130.2 [P46939-1]
XP_011534408.1, XM_011536106.2 [P46939-1]
UniGeneiHs.133135

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHDX-ray2.00A/B144-261[»]
1QAGX-ray3.00A/B31-256[»]
ProteinModelPortaliP46939
SMRiP46939
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113245, 69 interactors
CORUMiP46939
DIPiDIP-711N
IntActiP46939, 45 interactors
MINTiP46939
STRINGi9606.ENSP00000356515

PTM databases

iPTMnetiP46939
PhosphoSitePlusiP46939

Polymorphism and mutation databases

BioMutaiUTRN
DMDMi215274104

Proteomic databases

EPDiP46939
MaxQBiP46939
PaxDbiP46939
PeptideAtlasiP46939
PRIDEiP46939
ProteomicsDBi55775

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367545; ENSP00000356515; ENSG00000152818 [P46939-1]
GeneIDi7402
KEGGihsa:7402
UCSCiuc003qkt.4 human [P46939-1]

Organism-specific databases

CTDi7402
DisGeNETi7402
EuPathDBiHostDB:ENSG00000152818.18
GeneCardsiUTRN
HGNCiHGNC:12635 UTRN
HPAiCAB016348
HPA018894
MIMi128240 gene
neXtProtiNX_P46939
OpenTargetsiENSG00000152818
PharmGKBiPA37260
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119237
HOGENOMiHOG000231173
HOVERGENiHBG005495
InParanoidiP46939
OMAiNFLKWIQ
OrthoDBiEOG091G001Y
PhylomeDBiP46939
TreeFamiTF320178

Enzyme and pathway databases

SignaLinkiP46939
SIGNORiP46939

Miscellaneous databases

ChiTaRSiUTRN human
EvolutionaryTraceiP46939
GeneWikiiUtrophin
GenomeRNAii7402
PROiPR:P46939
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152818 Expressed in 216 organ(s), highest expression level in kidney
CleanExiHS_UTRN
ExpressionAtlasiP46939 baseline and differential
GenevisibleiP46939 HS

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 10 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 18 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUTRO_HUMAN
AccessioniPrimary (citable) accession number: P46939
Secondary accession number(s): Q5SYY1, Q5SZ57, Q9UJ40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: October 10, 2018
This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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