UniProtKB - P46939 (UTRN_HUMAN)
Utrophin
UTRN
Functioni
May play a role in anchoring the cytoskeleton to the plasma membrane.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 3070 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 3073 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 3094 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 3097 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 3065 – 3121 | ZZ-type; degeneratePROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- actin binding Source: BHF-UCL
- actin filament binding Source: GO_Central
- integrin binding Source: BHF-UCL
- protein kinase binding Source: BHF-UCL
- vinculin binding Source: BHF-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- muscle contraction Source: ProtInc
- muscle organ development Source: ProtInc
- positive regulation of cell-matrix adhesion Source: UniProtKB
- regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Keywordsi
Molecular function | Actin-binding |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P46939 |
Reactomei | R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P46939 |
SIGNORi | P46939 |
Names & Taxonomyi
Protein namesi | Recommended name: UtrophinCuratedAlternative name(s): Dystrophin-related protein 1 Short name: DRP-1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12635, UTRN |
MIMi | 128240, gene |
neXtProti | NX_P46939 |
VEuPathDBi | HostDB:ENSG00000152818 |
Subcellular locationi
Plasma membrane
Cytoskeleton
Note: Neuromuscular junction.
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
- cytoskeleton Source: ProtInc
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- dystrophin-associated glycoprotein complex Source: Ensembl
- filopodium membrane Source: BHF-UCL
- plasma membrane Source: HPA
- postsynaptic membrane Source: UniProtKB-SubCell
- sarcolemma Source: Ensembl
Other locations
- cell junction Source: GO_Central
- cell projection Source: GO_Central
- cytoplasm Source: UniProtKB
- filopodium Source: BHF-UCL
- membrane Source: ProtInc
- neuromuscular junction Source: Ensembl
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 7402 |
OpenTargetsi | ENSG00000152818 |
PharmGKBi | PA37260 |
Miscellaneous databases
Pharosi | P46939, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4523230 |
DrugBanki | DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | UTRN |
DMDMi | 215274104 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076082 | 1 – 3433 | UtrophinAdd BLAST | 3433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2008 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2211 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3297 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P46939 |
jPOSTi | P46939 |
MassIVEi | P46939 |
MaxQBi | P46939 |
PaxDbi | P46939 |
PeptideAtlasi | P46939 |
PRIDEi | P46939 |
ProteomicsDBi | 55775 [P46939-1] 64041 |
PTM databases
GlyGeni | P46939, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P46939 |
MetOSitei | P46939 |
PhosphoSitePlusi | P46939 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000152818, Expressed in calcaneal tendon and 228 other tissues |
ExpressionAtlasi | P46939, baseline and differential |
Genevisiblei | P46939, HS |
Organism-specific databases
HPAi | ENSG00000152818, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with the syntrophins SNTA1; SNTB1 and SNTB2.
Interacts with SYNM.
Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1.
Interacts with DTNB (By similarity).
Interacts with PGM5 (By similarity).
By similarity6 PublicationsBinary interactionsi
P46939
With | #Exp. | IntAct |
---|---|---|
PPP3CA - isoform 1 [Q08209-1] | 3 | EBI-295856,EBI-15637215 |
GO - Molecular functioni
- actin binding Source: BHF-UCL
- actin filament binding Source: GO_Central
- integrin binding Source: BHF-UCL
- protein kinase binding Source: BHF-UCL
- vinculin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 113245, 148 interactors |
CORUMi | P46939 |
DIPi | DIP-711N |
IntActi | P46939, 93 interactors |
MINTi | P46939 |
STRINGi | 9606.ENSP00000356515 |
Chemistry databases
BindingDBi | P46939 |
Miscellaneous databases
RNActi | P46939, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P46939 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46939 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 135 | Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 150 – 255 | Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST | 106 | |
Repeati | 312 – 416 | Spectrin 1Sequence analysisAdd BLAST | 105 | |
Repeati | 421 – 525 | Spectrin 2Sequence analysisAdd BLAST | 105 | |
Repeati | 532 – 636 | Spectrin 3Sequence analysisAdd BLAST | 105 | |
Repeati | 690 – 795 | Spectrin 4Sequence analysisAdd BLAST | 106 | |
Repeati | 801 – 901 | Spectrin 5Sequence analysisAdd BLAST | 101 | |
Repeati | 910 – 1012 | Spectrin 6Sequence analysisAdd BLAST | 103 | |
Repeati | 1019 – 1121 | Spectrin 7Sequence analysisAdd BLAST | 103 | |
Repeati | 1128 – 1229 | Spectrin 8Sequence analysisAdd BLAST | 102 | |
Repeati | 1236 – 1333 | Spectrin 9Sequence analysisAdd BLAST | 98 | |
Repeati | 1335 – 1436 | Spectrin 10Sequence analysisAdd BLAST | 102 | |
Repeati | 1438 – 1540 | Spectrin 11Sequence analysisAdd BLAST | 103 | |
Repeati | 1547 – 1648 | Spectrin 12Sequence analysisAdd BLAST | 102 | |
Repeati | 1653 – 1747 | Spectrin 13Sequence analysisAdd BLAST | 95 | |
Repeati | 1748 – 1848 | Spectrin 14Sequence analysisAdd BLAST | 101 | |
Repeati | 1849 – 1968 | Spectrin 15Sequence analysisAdd BLAST | 120 | |
Repeati | 1979 – 2080 | Spectrin 16Sequence analysisAdd BLAST | 102 | |
Repeati | 2087 – 2186 | Spectrin 17Sequence analysisAdd BLAST | 100 | |
Repeati | 2229 – 2332 | Spectrin 18Sequence analysisAdd BLAST | 104 | |
Repeati | 2349 – 2439 | Spectrin 19Sequence analysisAdd BLAST | 91 | |
Repeati | 2446 – 2555 | Spectrin 20Sequence analysisAdd BLAST | 110 | |
Repeati | 2562 – 2687 | Spectrin 21Sequence analysisAdd BLAST | 126 | |
Repeati | 2694 – 2796 | Spectrin 22Sequence analysisAdd BLAST | 103 | |
Domaini | 2812 – 2845 | WWPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 246 | Actin-bindingAdd BLAST | 246 | |
Regioni | 268 – 905 | Interaction with SYNM1 PublicationAdd BLAST | 638 | |
Regioni | 284 – 303 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1336 – 1768 | Interaction with SYNM1 PublicationAdd BLAST | 433 | |
Regioni | 2798 – 3165 | Interaction with SYNM1 PublicationAdd BLAST | 368 | |
Regioni | 3357 – 3390 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 284 – 299 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 3357 – 3381 | Polar residuesSequence analysisAdd BLAST | 25 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 3065 – 3121 | ZZ-type; degeneratePROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4286, Eukaryota |
GeneTreei | ENSGT00940000153467 |
HOGENOMi | CLU_000246_2_0_1 |
InParanoidi | P46939 |
OMAi | NQRWDAI |
OrthoDBi | 72477at2759 |
PhylomeDBi | P46939 |
TreeFami | TF320178 |
Family and domain databases
CDDi | cd00014, CH, 2 hits cd00176, SPEC, 9 hits cd00201, WW, 1 hit |
Gene3Di | 1.10.418.10, 2 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR035436, Dystrophin/utrophin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat IPR001202, WW_dom IPR036020, WW_dom_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00435, Spectrin, 10 hits PF00397, WW, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF002341, Dystrophin/utrophin, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 18 hits SM00456, WW, 1 hit SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF47576, SSF47576, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative promoter usage. AlignAdd to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
60 70 80 90 100
PPINDMFTDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
110 120 130 140 150
HQNNVELVNI GGTDIVDGNH KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT
160 170 180 190 200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD
210 220 230 240 250
KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL
260 270 280 290 300
FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET
310 320 330 340 350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA
360 370 380 390 400
THEAFMMELT AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR
410 420 430 440 450
WEALRVESMD RQSRLHDVLM ELQKKQLQQL SAWLTLTEER IQKMETCPLD
460 470 480 490 500
DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAILE
510 520 530 540 550
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LKAWLTEKEE
560 570 580 590 600
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
610 620 630 640 650
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
660 670 680 690 700
DLLETVRVRE QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL
710 720 730 740 750
NWILKWKTAI QTTEIKEYMK MQDTSEMKKK LKALEKEQRE RIPRADELNQ
760 770 780 790 800
TGQILVEQMG KEGLPTEEIK NVLEKVSSEW KNVSQHLEDL ERKIQLQEDI
810 820 830 840 850
NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS CQRELTNLLG
860 870 880 890 900
LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL
910 920 930 940 950
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK
960 970 980 990 1000
KTLDEILENQ KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL
1010 1020 1030 1040 1050
KVLVSKDLHL LEEIALTLRA FEADSTVIEK WMDGVKDFLM KQQAAQGDDA
1060 1070 1080 1090 1100
GLQRQLDQCS AFVNEIETIE SSLKNMKEIE TNLRSGPVAG IKTWVQTRLG
1110 1120 1130 1140 1150
DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW MTQAEEEYLE
1160 1170 1180 1190 1200
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG
1210 1220 1230 1240 1250
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN
1260 1270 1280 1290 1300
TLEERMKSTE VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG
1310 1320 1330 1340 1350
GILDDIISEK LEAFNSRYED LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ
1360 1370 1380 1390 1400
ESLGELDKQL TTYLTDRIDA FQVPQEAQKI QAEISAHELT LEELRRNMRS
1410 1420 1430 1440 1450
QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF EQRMLDCKRV
1460 1470 1480 1490 1500
LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR
1510 1520 1530 1540 1550
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK
1560 1570 1580 1590 1600
KEAASLSEWL SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD
1610 1620 1630 1640 1650
LNTITESSAA LQNLIEGSEP ILEERLCVLN AGWSRVRTWT EDWCNTLMNH
1660 1670 1680 1690 1700
QNQLEIFDGN VAHISTWLYQ AEALLDEIEK KPTSKQEEIV KRLVSELDDA
1710 1720 1730 1740 1750
NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV SQHIKSAKLL
1760 1770 1780 1790 1800
IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE
1810 1820 1830 1840 1850
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP
1860 1870 1880 1890 1900
IQQRKMGQLA SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY
1910 1920 1930 1940 1950
EDFSFQEDSL KNIKDQLDKL GEQIAVIHEK QPDVILEASG PEAIQIRDTL
1960 1970 1980 1990 2000
TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ FHCDLNDLTQ WITEAEELLV
2010 2020 2030 2040 2050
DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD GIVQKLSQAD
2060 2070 2080 2090 2100
GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL
2110 2120 2130 2140 2150
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK
2160 2170 2180 2190 2200
SLSLPERDKI SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH
2210 2220 2230 2240 2250
PNVQKVVLVS SASDIPVQSH RTSEISIPAD LDKTITELAD WLVLIDQMLK
2260 2270 2280 2290 2300
SNIVTVGDVE EINKTVSRMK ITKADLEQRH PQLDYVFTLA QNLKNKASSS
2310 2320 2330 2340 2350
DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ WDDHREETEE
2360 2370 2380 2390 2400
LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK
2410 2420 2430 2440 2450
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR
2460 2470 2480 2490 2500
DLENFLKWIQ EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID
2510 2520 2530 2540 2550
AHNDIFKSID GNRQKMVKAL GNSEEATMLQ HRLDDMNQRW NDLKAKSASI
2560 2570 2580 2590 2600
RAHLEASAEK WNRLLMSLEE LIKWLNMKDE ELKKQMPIGG DVPALQLQYD
2610 2620 2630 2640 2650
HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR NLQSKTELTP
2660 2670 2680 2690 2700
EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM
2710 2720 2730 2740 2750
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK
2760 2770 2780 2790 2800
TVNDLSSQLS PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR
2810 2820 2830 2840 2850
DFGPSSQHFL STSVQLPWQR SISHNKVPYY INHQTQTTCW DHPKMTELFQ
2860 2870 2880 2890 2900
SLADLNNVRF SAYRTAIKIR RLQKALCLDL LELSTTNEIF KQHKLNQNDQ
2910 2920 2930 2940 2950
LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL NVYDTGRTGK
2960 2970 2980 2990 3000
IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ
3010 3020 3030 3040 3050
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV
3060 3070 3080 3090 3100
WLPVLHRVAA AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS
3110 3120 3130 3140 3150
GRTAKGHKLH YPMVEYCIPT TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG
3160 3170 3180 3190 3200
YLPVQTVLEG DNLETPITLI SMWPEHYDPS QSPQLFHDDT HSRIEQYATR
3210 3220 3230 3240 3250
LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES PVSQPQSPAQ
3260 3270 3280 3290 3300
ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE
3310 3320 3330 3340 3350
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR
3360 3370 3380 3390 3400
QLLEQPESDS RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP
3410 3420 3430
PHDTSTDLTE VMEQIHSTFP SCCPNVPSRP QAM
The sequence of this isoform differs from the canonical sequence as follows:
1-23: MAKYGEHEASPDNGQNEFSDIIK → MKFFDFLFIFKILPPYYINFFSS
24-2832: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-2086: Missing.
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T097 | Q5T097_HUMAN | Utrophin | UTRN | 988 | Annotation score: | ||
Q5JT49 | Q5JT49_HUMAN | Utrophin | UTRN | 186 | Annotation score: | ||
A0A0D9SG57 | A0A0D9SG57_HUMAN | Utrophin | UTRN | 150 | Annotation score: | ||
H0Y337 | H0Y337_HUMAN | Utrophin | UTRN | 251 | Annotation score: | ||
A0A0A0MSM3 | A0A0A0MSM3_HUMAN | Utrophin | UTRN | 154 | Annotation score: | ||
Q5JT44 | Q5JT44_HUMAN | Utrophin | UTRN | 184 | Annotation score: | ||
Q5SYY2 | Q5SYY2_HUMAN | Utrophin | UTRN | 47 | Annotation score: | ||
Q5JT45 | Q5JT45_HUMAN | Utrophin | UTRN | 180 | Annotation score: | ||
Q5T098 | Q5T098_HUMAN | Utrophin | UTRN | 66 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 236 | Q → R in CAA48829 (PubMed:1461283).Curated | 1 | ||
Isoform Up71 (identifier: P46939-3) | |||||
Sequence conflicti | 5 | D → N no nucleotide entry (PubMed:10369873).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047794 | 1880 | L → I. Corresponds to variant dbSNP:rs12204715Ensembl. | 1 | |
Natural variantiVAR_047795 | 1974 | A → T. Corresponds to variant dbSNP:rs12204734Ensembl. | 1 | |
Natural variantiVAR_047796 | 2060 | G → D. Corresponds to variant dbSNP:rs35676466EnsemblClinVar. | 1 | |
Natural variantiVAR_047797 | 2202 | N → S. Corresponds to variant dbSNP:rs1534443Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054942 | 1 – 2086 | Missing in isoform Up140. 1 PublicationAdd BLAST | 2086 | |
Alternative sequenceiVSP_054943 | 1 – 23 | MAKYG…SDIIK → MKFFDFLFIFKILPPYYINF FSS in isoform Up71. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_047925 | 1 – 22 | MAKYG…FSDII → MSGLAATTFHWKKCRLDLPG HVALQAC in isoform 2. CuratedAdd BLAST | 22 | |
Alternative sequenceiVSP_054944 | 24 – 2832 | Missing in isoform Up71. 1 PublicationAdd BLAST | 2809 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69086 mRNA Translation: CAA48829.1 AL024474 Genomic DNA No translation available. AL357149 Genomic DNA No translation available. AL513184 Genomic DNA No translation available. AL513475 Genomic DNA No translation available. AL590488 Genomic DNA No translation available. AL590704 Genomic DNA No translation available. AJ250044 Genomic DNA Translation: CAB61826.1 |
CCDSi | CCDS34547.1 [P46939-1] |
PIRi | S28381 |
RefSeqi | NP_009055.2, NM_007124.2 [P46939-1] XP_005267187.1, XM_005267130.2 [P46939-1] XP_011534408.1, XM_011536106.2 [P46939-1] |
Genome annotation databases
Ensembli | ENST00000367545.8; ENSP00000356515.3; ENSG00000152818.19 |
GeneIDi | 7402 |
KEGGi | hsa:7402 |
MANE-Selecti | ENST00000367545.8; ENSP00000356515.3; NM_007124.3; NP_009055.2 |
UCSCi | uc003qkt.4, human [P46939-1] |
Keywords - Coding sequence diversityi
Alternative promoter usageSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Utrophin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69086 mRNA Translation: CAA48829.1 AL024474 Genomic DNA No translation available. AL357149 Genomic DNA No translation available. AL513184 Genomic DNA No translation available. AL513475 Genomic DNA No translation available. AL590488 Genomic DNA No translation available. AL590704 Genomic DNA No translation available. AJ250044 Genomic DNA Translation: CAB61826.1 |
CCDSi | CCDS34547.1 [P46939-1] |
PIRi | S28381 |
RefSeqi | NP_009055.2, NM_007124.2 [P46939-1] XP_005267187.1, XM_005267130.2 [P46939-1] XP_011534408.1, XM_011536106.2 [P46939-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BHD | X-ray | 2.00 | A/B | 144-261 | [»] | |
1QAG | X-ray | 3.00 | A/B | 31-256 | [»] | |
6M5G | electron microscopy | 3.60 | F/G/H | 1-261 | [»] | |
SMRi | P46939 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113245, 148 interactors |
CORUMi | P46939 |
DIPi | DIP-711N |
IntActi | P46939, 93 interactors |
MINTi | P46939 |
STRINGi | 9606.ENSP00000356515 |
Chemistry databases
BindingDBi | P46939 |
ChEMBLi | CHEMBL4523230 |
DrugBanki | DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
GlyGeni | P46939, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P46939 |
MetOSitei | P46939 |
PhosphoSitePlusi | P46939 |
Genetic variation databases
BioMutai | UTRN |
DMDMi | 215274104 |
Proteomic databases
EPDi | P46939 |
jPOSTi | P46939 |
MassIVEi | P46939 |
MaxQBi | P46939 |
PaxDbi | P46939 |
PeptideAtlasi | P46939 |
PRIDEi | P46939 |
ProteomicsDBi | 55775 [P46939-1] 64041 |
Protocols and materials databases
ABCDi | P46939, 1 sequenced antibody |
Antibodypediai | 4282, 90 antibodies from 20 providers |
DNASUi | 7402 |
Genome annotation databases
Ensembli | ENST00000367545.8; ENSP00000356515.3; ENSG00000152818.19 |
GeneIDi | 7402 |
KEGGi | hsa:7402 |
MANE-Selecti | ENST00000367545.8; ENSP00000356515.3; NM_007124.3; NP_009055.2 |
UCSCi | uc003qkt.4, human [P46939-1] |
Organism-specific databases
CTDi | 7402 |
DisGeNETi | 7402 |
GeneCardsi | UTRN |
HGNCi | HGNC:12635, UTRN |
HPAi | ENSG00000152818, Low tissue specificity |
MIMi | 128240, gene |
neXtProti | NX_P46939 |
OpenTargetsi | ENSG00000152818 |
PharmGKBi | PA37260 |
VEuPathDBi | HostDB:ENSG00000152818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4286, Eukaryota |
GeneTreei | ENSGT00940000153467 |
HOGENOMi | CLU_000246_2_0_1 |
InParanoidi | P46939 |
OMAi | NQRWDAI |
OrthoDBi | 72477at2759 |
PhylomeDBi | P46939 |
TreeFami | TF320178 |
Enzyme and pathway databases
PathwayCommonsi | P46939 |
Reactomei | R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P46939 |
SIGNORi | P46939 |
Miscellaneous databases
BioGRID-ORCSi | 7402, 11 hits in 1086 CRISPR screens |
ChiTaRSi | UTRN, human |
EvolutionaryTracei | P46939 |
GeneWikii | Utrophin |
GenomeRNAii | 7402 |
Pharosi | P46939, Tchem |
PROi | PR:P46939 |
RNActi | P46939, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152818, Expressed in calcaneal tendon and 228 other tissues |
ExpressionAtlasi | P46939, baseline and differential |
Genevisiblei | P46939, HS |
Family and domain databases
CDDi | cd00014, CH, 2 hits cd00176, SPEC, 9 hits cd00201, WW, 1 hit |
Gene3Di | 1.10.418.10, 2 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR035436, Dystrophin/utrophin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat IPR001202, WW_dom IPR036020, WW_dom_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00435, Spectrin, 10 hits PF00397, WW, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF002341, Dystrophin/utrophin, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 18 hits SM00456, WW, 1 hit SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF47576, SSF47576, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UTRN_HUMAN | |
Accessioni | P46939Primary (citable) accession number: P46939 Secondary accession number(s): Q5SYY1, Q5SZ57, Q9UJ40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 214 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references