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UniProtKB - P46939 (UTRO_HUMAN)

Entry version 210 (07 Apr 2021)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
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Protein

Utrophin

Gene

UTRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3064 – 3111ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P46939

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P46939

SIGNOR Signaling Network Open Resource

More...SIGNORi		P46939

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Utrophin
Alternative name(s):
Dystrophin-related protein 1
Short name:
DRP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UTRN
Synonyms:DMDL, DRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12635, UTRN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		128240, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P46939

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152818.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7402

Open Targets

More...OpenTargetsi		ENSG00000152818

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37260

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P46939, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UTRN

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760821 – 3433UtrophinAdd BLAST3433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphotyrosineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei2008PhosphoserineCombined sources1
Modified residuei2211PhosphoserineCombined sources1
Modified residuei3297PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P46939

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P46939

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P46939

MaxQB - The MaxQuant DataBase

More...MaxQBi		P46939

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46939

PeptideAtlas

More...PeptideAtlasi		P46939

PRoteomics IDEntifications database

More...PRIDEi		P46939

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55775 [P46939-1]
64041

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P46939

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P46939

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P46939

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152818, Expressed in calcaneal tendon and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P46939, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P46939, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152818, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the syntrophins SNTA1; SNTB1 and SNTB2.

Interacts with SYNM.

Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113245, 107 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P46939

Database of interacting proteins

More...DIPi		DIP-711N

Protein interaction database and analysis system

More...IntActi		P46939, 77 interactors

Molecular INTeraction database

More...MINTi		P46939

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356515

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P46939, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P46939

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P46939

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 135Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini150 – 255Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati312 – 416Spectrin 1Sequence analysisAdd BLAST105
Repeati421 – 525Spectrin 2Sequence analysisAdd BLAST105
Repeati532 – 636Spectrin 3Sequence analysisAdd BLAST105
Repeati690 – 795Spectrin 4Sequence analysisAdd BLAST106
Repeati801 – 901Spectrin 5Sequence analysisAdd BLAST101
Repeati910 – 1012Spectrin 6Sequence analysisAdd BLAST103
Repeati1019 – 1121Spectrin 7Sequence analysisAdd BLAST103
Repeati1128 – 1229Spectrin 8Sequence analysisAdd BLAST102
Repeati1236 – 1333Spectrin 9Sequence analysisAdd BLAST98
Repeati1335 – 1436Spectrin 10Sequence analysisAdd BLAST102
Repeati1438 – 1540Spectrin 11Sequence analysisAdd BLAST103
Repeati1547 – 1648Spectrin 12Sequence analysisAdd BLAST102
Repeati1653 – 1747Spectrin 13Sequence analysisAdd BLAST95
Repeati1748 – 1848Spectrin 14Sequence analysisAdd BLAST101
Repeati1849 – 1968Spectrin 15Sequence analysisAdd BLAST120
Repeati1979 – 2080Spectrin 16Sequence analysisAdd BLAST102
Repeati2087 – 2186Spectrin 17Sequence analysisAdd BLAST100
Repeati2229 – 2332Spectrin 18Sequence analysisAdd BLAST104
Repeati2349 – 2439Spectrin 19Sequence analysisAdd BLAST91
Repeati2446 – 2555Spectrin 20Sequence analysisAdd BLAST110
Repeati2562 – 2687Spectrin 21Sequence analysisAdd BLAST126
Repeati2694 – 2796Spectrin 22Sequence analysisAdd BLAST103
Domaini2812 – 2845WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 246Actin-bindingAdd BLAST246
Regioni268 – 905Interaction with SYNM1 PublicationAdd BLAST638
Regioni1336 – 1768Interaction with SYNM1 PublicationAdd BLAST433
Regioni2798 – 3165Interaction with SYNM1 PublicationAdd BLAST368

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Actin binding affinity is primarily determined by CH domain 1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3064 – 3111ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4286, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153467

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000246_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46939

Identification of Orthologs from Complete Genome Data

More...OMAi		KARIHQQ

Database of Orthologous Groups

More...OrthoDBi		72477at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46939

TreeFam database of animal gene trees

More...TreeFami		TF320178

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035436, Dystrophin/utrophin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 10 hits
PF00397, WW, 1 hit
PF00569, ZZ, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002341, Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 18 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46939-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK 
        60         70         80         90        100
PPINDMFTDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL 
       110        120        130        140        150
HQNNVELVNI GGTDIVDGNH KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT 
       160        170        180        190        200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD 
       210        220        230        240        250
KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL 
       260        270        280        290        300
FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET 
       310        320        330        340        350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA 
       360        370        380        390        400
THEAFMMELT AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR 
       410        420        430        440        450
WEALRVESMD RQSRLHDVLM ELQKKQLQQL SAWLTLTEER IQKMETCPLD 
       460        470        480        490        500
DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAILE 
       510        520        530        540        550
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LKAWLTEKEE 
       560        570        580        590        600
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL 
       610        620        630        640        650
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK 
       660        670        680        690        700
DLLETVRVRE QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL 
       710        720        730        740        750
NWILKWKTAI QTTEIKEYMK MQDTSEMKKK LKALEKEQRE RIPRADELNQ 
       760        770        780        790        800
TGQILVEQMG KEGLPTEEIK NVLEKVSSEW KNVSQHLEDL ERKIQLQEDI 
       810        820        830        840        850
NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS CQRELTNLLG 
       860        870        880        890        900
LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL 
       910        920        930        940        950
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK 
       960        970        980        990       1000
KTLDEILENQ KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL 
      1010       1020       1030       1040       1050
KVLVSKDLHL LEEIALTLRA FEADSTVIEK WMDGVKDFLM KQQAAQGDDA 
      1060       1070       1080       1090       1100
GLQRQLDQCS AFVNEIETIE SSLKNMKEIE TNLRSGPVAG IKTWVQTRLG 
      1110       1120       1130       1140       1150
DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW MTQAEEEYLE 
      1160       1170       1180       1190       1200
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG 
      1210       1220       1230       1240       1250
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN 
      1260       1270       1280       1290       1300
TLEERMKSTE VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG 
      1310       1320       1330       1340       1350
GILDDIISEK LEAFNSRYED LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ 
      1360       1370       1380       1390       1400
ESLGELDKQL TTYLTDRIDA FQVPQEAQKI QAEISAHELT LEELRRNMRS 
      1410       1420       1430       1440       1450
QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF EQRMLDCKRV 
      1460       1470       1480       1490       1500
LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR 
      1510       1520       1530       1540       1550
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK 
      1560       1570       1580       1590       1600
KEAASLSEWL SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD 
      1610       1620       1630       1640       1650
LNTITESSAA LQNLIEGSEP ILEERLCVLN AGWSRVRTWT EDWCNTLMNH 
      1660       1670       1680       1690       1700
QNQLEIFDGN VAHISTWLYQ AEALLDEIEK KPTSKQEEIV KRLVSELDDA 
      1710       1720       1730       1740       1750
NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV SQHIKSAKLL 
      1760       1770       1780       1790       1800
IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE 
      1810       1820       1830       1840       1850
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP 
      1860       1870       1880       1890       1900
IQQRKMGQLA SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY 
      1910       1920       1930       1940       1950
EDFSFQEDSL KNIKDQLDKL GEQIAVIHEK QPDVILEASG PEAIQIRDTL 
      1960       1970       1980       1990       2000
TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ FHCDLNDLTQ WITEAEELLV 
      2010       2020       2030       2040       2050
DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD GIVQKLSQAD 
      2060       2070       2080       2090       2100
GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL 
      2110       2120       2130       2140       2150
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK 
      2160       2170       2180       2190       2200
SLSLPERDKI SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH 
      2210       2220       2230       2240       2250
PNVQKVVLVS SASDIPVQSH RTSEISIPAD LDKTITELAD WLVLIDQMLK 
      2260       2270       2280       2290       2300
SNIVTVGDVE EINKTVSRMK ITKADLEQRH PQLDYVFTLA QNLKNKASSS 
      2310       2320       2330       2340       2350
DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ WDDHREETEE 
      2360       2370       2380       2390       2400
LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK 
      2410       2420       2430       2440       2450
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR 
      2460       2470       2480       2490       2500
DLENFLKWIQ EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID 
      2510       2520       2530       2540       2550
AHNDIFKSID GNRQKMVKAL GNSEEATMLQ HRLDDMNQRW NDLKAKSASI 
      2560       2570       2580       2590       2600
RAHLEASAEK WNRLLMSLEE LIKWLNMKDE ELKKQMPIGG DVPALQLQYD 
      2610       2620       2630       2640       2650
HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR NLQSKTELTP 
      2660       2670       2680       2690       2700
EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM 
      2710       2720       2730       2740       2750
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK 
      2760       2770       2780       2790       2800
TVNDLSSQLS PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR 
      2810       2820       2830       2840       2850
DFGPSSQHFL STSVQLPWQR SISHNKVPYY INHQTQTTCW DHPKMTELFQ 
      2860       2870       2880       2890       2900
SLADLNNVRF SAYRTAIKIR RLQKALCLDL LELSTTNEIF KQHKLNQNDQ 
      2910       2920       2930       2940       2950
LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL NVYDTGRTGK 
      2960       2970       2980       2990       3000
IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ 
      3010       3020       3030       3040       3050
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV 
      3060       3070       3080       3090       3100
WLPVLHRVAA AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS 
      3110       3120       3130       3140       3150
GRTAKGHKLH YPMVEYCIPT TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG 
      3160       3170       3180       3190       3200
YLPVQTVLEG DNLETPITLI SMWPEHYDPS QSPQLFHDDT HSRIEQYATR 
      3210       3220       3230       3240       3250
LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES PVSQPQSPAQ 
      3260       3270       3280       3290       3300
ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE 
      3310       3320       3330       3340       3350
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR 
      3360       3370       3380       3390       3400
QLLEQPESDS RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP 
      3410       3420       3430 
PHDTSTDLTE VMEQIHSTFP SCCPNVPSRP QAM
Length:3,433
Mass (Da):394,466
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC72CADE8CD666993
GO
Isoform 2 (identifier: P46939-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MAKYGEHEASPDNGQNEFSDII → MSGLAATTFHWKKCRLDLPGHVALQAC

Note: Produced by alternative promoter usage.Curated
Show »
Length:3,438
Mass (Da):394,969
Checksum:i9242095AE3CD5F48
GO
Isoform Up71 (identifier: P46939-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MAKYGEHEASPDNGQNEFSDIIK → MKFFDFLFIFKILPPYYINFFSS
     24-2832: Missing.

Note: =Produced by alternative promoter usage.Curated
Show »
Length:624
Mass (Da):71,417
Checksum:i0479238E557B0CEA
GO
Isoform Up140 (identifier: P46939-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2086: Missing.

Note: =Produced by alternative promoter usage.Curated
Show »
Length:1,347
Mass (Da):155,026
Checksum:iFDB1EF2EDB5092BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T097Q5T097_HUMAN
Utrophin
UTRN
988Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT49Q5JT49_HUMAN
Utrophin
UTRN
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG57A0A0D9SG57_HUMAN
Utrophin
UTRN
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y337H0Y337_HUMAN
Utrophin
UTRN
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT44Q5JT44_HUMAN
Utrophin
UTRN
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSM3A0A0A0MSM3_HUMAN
Utrophin
UTRN
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT45Q5JT45_HUMAN
Utrophin
UTRN
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SYY2Q5SYY2_HUMAN
Utrophin
UTRN
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T098Q5T098_HUMAN
Utrophin
UTRN
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236Q → R in CAA48829 (PubMed:1461283).Curated1
Isoform Up71 (identifier: P46939-3)
Sequence conflicti5D → N no nucleotide entry (PubMed:10369873).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0477941880L → I. Corresponds to variant dbSNP:rs12204715Ensembl.1
Natural variantiVAR_0477951974A → T. Corresponds to variant dbSNP:rs12204734Ensembl.1
Natural variantiVAR_0477962060G → D. Corresponds to variant dbSNP:rs35676466EnsemblClinVar.1
Natural variantiVAR_0477972202N → S. Corresponds to variant dbSNP:rs1534443Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0549421 – 2086Missing in isoform Up140. 1 PublicationAdd BLAST2086
Alternative sequenceiVSP_0549431 – 23MAKYG…SDIIK → MKFFDFLFIFKILPPYYINF FSS in isoform Up71. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0479251 – 22MAKYG…FSDII → MSGLAATTFHWKKCRLDLPG HVALQAC in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_05494424 – 2832Missing in isoform Up71. 1 PublicationAdd BLAST2809

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X69086 mRNA Translation: CAA48829.1
AL024474 Genomic DNA No translation available.
AL357149 Genomic DNA No translation available.
AL513184 Genomic DNA No translation available.
AL513475 Genomic DNA No translation available.
AL590488 Genomic DNA No translation available.
AL590704 Genomic DNA No translation available.
AJ250044 Genomic DNA Translation: CAB61826.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34547.1 [P46939-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S28381

NCBI Reference Sequences

More...RefSeqi		NP_009055.2, NM_007124.2 [P46939-1]
XP_005267187.1, XM_005267130.2 [P46939-1]
XP_011534408.1, XM_011536106.2 [P46939-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367545; ENSP00000356515; ENSG00000152818 [P46939-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7402

UCSC genome browser

More...UCSCi		uc003qkt.4, human [P46939-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Utrophin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69086 mRNA Translation: CAA48829.1
AL024474 Genomic DNA No translation available.
AL357149 Genomic DNA No translation available.
AL513184 Genomic DNA No translation available.
AL513475 Genomic DNA No translation available.
AL590488 Genomic DNA No translation available.
AL590704 Genomic DNA No translation available.
AJ250044 Genomic DNA Translation: CAB61826.1
CCDSiCCDS34547.1 [P46939-1]
PIRiS28381
RefSeqiNP_009055.2, NM_007124.2 [P46939-1]
XP_005267187.1, XM_005267130.2 [P46939-1]
XP_011534408.1, XM_011536106.2 [P46939-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHDX-ray2.00A/B144-261[»]
1QAGX-ray3.00A/B31-256[»]
6M5Gelectron microscopy3.60F/G/H1-261[»]
SMRiP46939
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113245, 107 interactors
CORUMiP46939
DIPiDIP-711N
IntActiP46939, 77 interactors
MINTiP46939
STRINGi9606.ENSP00000356515

Chemistry databases

DrugBankiDB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

PTM databases

iPTMnetiP46939
MetOSiteiP46939
PhosphoSitePlusiP46939

Genetic variation databases

BioMutaiUTRN
DMDMi215274104

Proteomic databases

EPDiP46939
jPOSTiP46939
MassIVEiP46939
MaxQBiP46939
PaxDbiP46939
PeptideAtlasiP46939
PRIDEiP46939
ProteomicsDBi55775 [P46939-1]
64041

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4282, 86 antibodies

Genome annotation databases

EnsembliENST00000367545; ENSP00000356515; ENSG00000152818 [P46939-1]
GeneIDi7402
KEGGihsa:7402
UCSCiuc003qkt.4, human [P46939-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7402
DisGeNETi7402

GeneCards: human genes, protein and diseases

More...GeneCardsi		UTRN
HGNCiHGNC:12635, UTRN
HPAiENSG00000152818, Low tissue specificity
MIMi128240, gene
neXtProtiNX_P46939
OpenTargetsiENSG00000152818
PharmGKBiPA37260
VEuPathDBiHostDB:ENSG00000152818.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4286, Eukaryota
GeneTreeiENSGT00940000153467
HOGENOMiCLU_000246_2_0_1
InParanoidiP46939
OMAiKARIHQQ
OrthoDBi72477at2759
PhylomeDBiP46939
TreeFamiTF320178

Enzyme and pathway databases

PathwayCommonsiP46939
ReactomeiR-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination
SignaLinkiP46939
SIGNORiP46939

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7402, 6 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UTRN, human
EvolutionaryTraceiP46939

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Utrophin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7402
PharosiP46939, Tbio

Protein Ontology

More...PROi		PR:P46939
RNActiP46939, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152818, Expressed in calcaneal tendon and 227 other tissues
ExpressionAtlasiP46939, baseline and differential
GenevisibleiP46939, HS

Family and domain databases

CDDicd00014, CH, 2 hits
cd00201, WW, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035436, Dystrophin/utrophin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 10 hits
PF00397, WW, 1 hit
PF00569, ZZ, 1 hit
PIRSFiPIRSF002341, Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 18 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUTRO_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46939
Secondary accession number(s): Q5SYY1, Q5SZ57, Q9UJ40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: April 7, 2021
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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