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Protein

Utrophin

Gene

UTRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3064 – 3111ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: BHF-UCL
  • actin filament binding Source: Ensembl
  • integrin binding Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • vinculin binding Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

  • muscle contraction Source: ProtInc
  • muscle organ development Source: ProtInc
  • neuromuscular junction development Source: Ensembl
  • positive regulation of cell-matrix adhesion Source: UniProtKB
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • response to denervation involved in regulation of muscle adaptation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P46939

SIGNOR Signaling Network Open Resource

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SIGNORi
P46939

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Utrophin
Alternative name(s):
Dystrophin-related protein 1
Short name:
DRP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UTRN
Synonyms:DMDL, DRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152818.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12635 UTRN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
128240 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46939

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7402

Open Targets

More...
OpenTargetsi
ENSG00000152818

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37260

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UTRN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760821 – 3433UtrophinAdd BLAST3433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphotyrosineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei2008PhosphoserineCombined sources1
Modified residuei2211PhosphoserineCombined sources1
Modified residuei3297PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46939

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P46939

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46939

PeptideAtlas

More...
PeptideAtlasi
P46939

PRoteomics IDEntifications database

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PRIDEi
P46939

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55775

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46939

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P46939

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152818 Expressed in 216 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_UTRN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46939 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P46939 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016348
HPA018894

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM. Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PPP3CAQ08209-13EBI-295856,EBI-15637215

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113245, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P46939

Database of interacting proteins

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DIPi
DIP-711N

Protein interaction database and analysis system

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IntActi
P46939, 47 interactors

Molecular INTeraction database

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MINTi
P46939

STRING: functional protein association networks

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STRINGi
9606.ENSP00000356515

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P46939

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46939

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P46939

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 135Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini150 – 255Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati312 – 416Spectrin 1Sequence analysisAdd BLAST105
Repeati421 – 525Spectrin 2Sequence analysisAdd BLAST105
Repeati532 – 636Spectrin 3Sequence analysisAdd BLAST105
Repeati690 – 795Spectrin 4Sequence analysisAdd BLAST106
Repeati801 – 901Spectrin 5Sequence analysisAdd BLAST101
Repeati910 – 1012Spectrin 6Sequence analysisAdd BLAST103
Repeati1019 – 1121Spectrin 7Sequence analysisAdd BLAST103
Repeati1128 – 1229Spectrin 8Sequence analysisAdd BLAST102
Repeati1236 – 1333Spectrin 9Sequence analysisAdd BLAST98
Repeati1335 – 1436Spectrin 10Sequence analysisAdd BLAST102
Repeati1438 – 1540Spectrin 11Sequence analysisAdd BLAST103
Repeati1547 – 1648Spectrin 12Sequence analysisAdd BLAST102
Repeati1653 – 1747Spectrin 13Sequence analysisAdd BLAST95
Repeati1748 – 1848Spectrin 14Sequence analysisAdd BLAST101
Repeati1849 – 1968Spectrin 15Sequence analysisAdd BLAST120
Repeati1979 – 2080Spectrin 16Sequence analysisAdd BLAST102
Repeati2087 – 2186Spectrin 17Sequence analysisAdd BLAST100
Repeati2229 – 2332Spectrin 18Sequence analysisAdd BLAST104
Repeati2349 – 2439Spectrin 19Sequence analysisAdd BLAST91
Repeati2446 – 2555Spectrin 20Sequence analysisAdd BLAST110
Repeati2562 – 2687Spectrin 21Sequence analysisAdd BLAST126
Repeati2694 – 2796Spectrin 22Sequence analysisAdd BLAST103
Domaini2812 – 2845WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 246Actin-bindingAdd BLAST246
Regioni268 – 905Interaction with SYNM1 PublicationAdd BLAST638
Regioni1336 – 1768Interaction with SYNM1 PublicationAdd BLAST433
Regioni2798 – 3165Interaction with SYNM1 PublicationAdd BLAST368

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Actin binding affinity is primarily determined by CH domain 1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3064 – 3111ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4286 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153467

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231173

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005495

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46939

Identification of Orthologs from Complete Genome Data

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OMAi
NFLKWIQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G001Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46939

TreeFam database of animal gene trees

More...
TreeFami
TF320178

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 10 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002341 Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 18 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46939-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
60 70 80 90 100
PPINDMFTDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
110 120 130 140 150
HQNNVELVNI GGTDIVDGNH KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT
160 170 180 190 200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD
210 220 230 240 250
KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL
260 270 280 290 300
FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET
310 320 330 340 350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA
360 370 380 390 400
THEAFMMELT AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR
410 420 430 440 450
WEALRVESMD RQSRLHDVLM ELQKKQLQQL SAWLTLTEER IQKMETCPLD
460 470 480 490 500
DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAILE
510 520 530 540 550
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LKAWLTEKEE
560 570 580 590 600
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
610 620 630 640 650
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
660 670 680 690 700
DLLETVRVRE QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL
710 720 730 740 750
NWILKWKTAI QTTEIKEYMK MQDTSEMKKK LKALEKEQRE RIPRADELNQ
760 770 780 790 800
TGQILVEQMG KEGLPTEEIK NVLEKVSSEW KNVSQHLEDL ERKIQLQEDI
810 820 830 840 850
NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS CQRELTNLLG
860 870 880 890 900
LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL
910 920 930 940 950
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK
960 970 980 990 1000
KTLDEILENQ KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL
1010 1020 1030 1040 1050
KVLVSKDLHL LEEIALTLRA FEADSTVIEK WMDGVKDFLM KQQAAQGDDA
1060 1070 1080 1090 1100
GLQRQLDQCS AFVNEIETIE SSLKNMKEIE TNLRSGPVAG IKTWVQTRLG
1110 1120 1130 1140 1150
DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW MTQAEEEYLE
1160 1170 1180 1190 1200
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG
1210 1220 1230 1240 1250
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN
1260 1270 1280 1290 1300
TLEERMKSTE VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG
1310 1320 1330 1340 1350
GILDDIISEK LEAFNSRYED LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ
1360 1370 1380 1390 1400
ESLGELDKQL TTYLTDRIDA FQVPQEAQKI QAEISAHELT LEELRRNMRS
1410 1420 1430 1440 1450
QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF EQRMLDCKRV
1460 1470 1480 1490 1500
LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR
1510 1520 1530 1540 1550
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK
1560 1570 1580 1590 1600
KEAASLSEWL SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD
1610 1620 1630 1640 1650
LNTITESSAA LQNLIEGSEP ILEERLCVLN AGWSRVRTWT EDWCNTLMNH
1660 1670 1680 1690 1700
QNQLEIFDGN VAHISTWLYQ AEALLDEIEK KPTSKQEEIV KRLVSELDDA
1710 1720 1730 1740 1750
NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV SQHIKSAKLL
1760 1770 1780 1790 1800
IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE
1810 1820 1830 1840 1850
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP
1860 1870 1880 1890 1900
IQQRKMGQLA SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY
1910 1920 1930 1940 1950
EDFSFQEDSL KNIKDQLDKL GEQIAVIHEK QPDVILEASG PEAIQIRDTL
1960 1970 1980 1990 2000
TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ FHCDLNDLTQ WITEAEELLV
2010 2020 2030 2040 2050
DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD GIVQKLSQAD
2060 2070 2080 2090 2100
GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL
2110 2120 2130 2140 2150
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK
2160 2170 2180 2190 2200
SLSLPERDKI SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH
2210 2220 2230 2240 2250
PNVQKVVLVS SASDIPVQSH RTSEISIPAD LDKTITELAD WLVLIDQMLK
2260 2270 2280 2290 2300
SNIVTVGDVE EINKTVSRMK ITKADLEQRH PQLDYVFTLA QNLKNKASSS
2310 2320 2330 2340 2350
DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ WDDHREETEE
2360 2370 2380 2390 2400
LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK
2410 2420 2430 2440 2450
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR
2460 2470 2480 2490 2500
DLENFLKWIQ EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID
2510 2520 2530 2540 2550
AHNDIFKSID GNRQKMVKAL GNSEEATMLQ HRLDDMNQRW NDLKAKSASI
2560 2570 2580 2590 2600
RAHLEASAEK WNRLLMSLEE LIKWLNMKDE ELKKQMPIGG DVPALQLQYD
2610 2620 2630 2640 2650
HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR NLQSKTELTP
2660 2670 2680 2690 2700
EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM
2710 2720 2730 2740 2750
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK
2760 2770 2780 2790 2800
TVNDLSSQLS PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR
2810 2820 2830 2840 2850
DFGPSSQHFL STSVQLPWQR SISHNKVPYY INHQTQTTCW DHPKMTELFQ
2860 2870 2880 2890 2900
SLADLNNVRF SAYRTAIKIR RLQKALCLDL LELSTTNEIF KQHKLNQNDQ
2910 2920 2930 2940 2950
LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL NVYDTGRTGK
2960 2970 2980 2990 3000
IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ
3010 3020 3030 3040 3050
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV
3060 3070 3080 3090 3100
WLPVLHRVAA AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS
3110 3120 3130 3140 3150
GRTAKGHKLH YPMVEYCIPT TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG
3160 3170 3180 3190 3200
YLPVQTVLEG DNLETPITLI SMWPEHYDPS QSPQLFHDDT HSRIEQYATR
3210 3220 3230 3240 3250
LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES PVSQPQSPAQ
3260 3270 3280 3290 3300
ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE
3310 3320 3330 3340 3350
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR
3360 3370 3380 3390 3400
QLLEQPESDS RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP
3410 3420 3430
PHDTSTDLTE VMEQIHSTFP SCCPNVPSRP QAM
Length:3,433
Mass (Da):394,466
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC72CADE8CD666993
GO
Isoform 2 (identifier: P46939-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MAKYGEHEASPDNGQNEFSDII → MSGLAATTFHWKKCRLDLPGHVALQAC

Note: Produced by alternative promoter usage.
Show »
Length:3,438
Mass (Da):394,969
Checksum:i9242095AE3CD5F48
GO
Isoform Up71 (identifier: P46939-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MAKYGEHEASPDNGQNEFSDIIK → MKFFDFLFIFKILPPYYINFFSS
     24-2832: Missing.

Note: =Produced by alternative promoter usage.Curated
Show »
Length:624
Mass (Da):71,417
Checksum:i0479238E557B0CEA
GO
Isoform Up140 (identifier: P46939-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2086: Missing.

Note: =Produced by alternative promoter usage.
Show »
Length:1,347
Mass (Da):155,026
Checksum:iFDB1EF2EDB5092BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T097Q5T097_HUMAN
Utrophin
UTRN
988Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT49Q5JT49_HUMAN
Utrophin
UTRN
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y337H0Y337_HUMAN
Utrophin
UTRN
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT44Q5JT44_HUMAN
Utrophin
UTRN
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT45Q5JT45_HUMAN
Utrophin
UTRN
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSM3A0A0A0MSM3_HUMAN
Utrophin
UTRN
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG57A0A0D9SG57_HUMAN
Utrophin
UTRN
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SYY2Q5SYY2_HUMAN
Utrophin
UTRN
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T098Q5T098_HUMAN
Utrophin
UTRN
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236Q → R in CAA48829 (PubMed:1461283).Curated1
Isoform Up71 (identifier: P46939-3)
Sequence conflicti5D → N no nucleotide entry (PubMed:10369873).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0477941880L → I. Corresponds to variant dbSNP:rs12204715Ensembl.1
Natural variantiVAR_0477951974A → T. Corresponds to variant dbSNP:rs12204734Ensembl.1
Natural variantiVAR_0477962060G → D. Corresponds to variant dbSNP:rs35676466Ensembl.1
Natural variantiVAR_0477972202N → S. Corresponds to variant dbSNP:rs1534443Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0549421 – 2086Missing in isoform Up140. 1 PublicationAdd BLAST2086
Alternative sequenceiVSP_0549431 – 23MAKYG…SDIIK → MKFFDFLFIFKILPPYYINF FSS in isoform Up71. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0479251 – 22MAKYG…FSDII → MSGLAATTFHWKKCRLDLPG HVALQAC in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_05494424 – 2832Missing in isoform Up71. 1 PublicationAdd BLAST2809

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69086 mRNA Translation: CAA48829.1
AL024474 Genomic DNA No translation available.
AL357149 Genomic DNA No translation available.
AL513184 Genomic DNA No translation available.
AL513475 Genomic DNA No translation available.
AL590488 Genomic DNA No translation available.
AL590704 Genomic DNA No translation available.
AJ250044 Genomic DNA Translation: CAB61826.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34547.1 [P46939-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S28381

NCBI Reference Sequences

More...
RefSeqi
NP_009055.2, NM_007124.2 [P46939-1]
XP_005267187.1, XM_005267130.2 [P46939-1]
XP_011534408.1, XM_011536106.2 [P46939-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.133135

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367545; ENSP00000356515; ENSG00000152818 [P46939-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7402

UCSC genome browser

More...
UCSCi
uc003qkt.4 human [P46939-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Utrophin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69086 mRNA Translation: CAA48829.1
AL024474 Genomic DNA No translation available.
AL357149 Genomic DNA No translation available.
AL513184 Genomic DNA No translation available.
AL513475 Genomic DNA No translation available.
AL590488 Genomic DNA No translation available.
AL590704 Genomic DNA No translation available.
AJ250044 Genomic DNA Translation: CAB61826.1
CCDSiCCDS34547.1 [P46939-1]
PIRiS28381
RefSeqiNP_009055.2, NM_007124.2 [P46939-1]
XP_005267187.1, XM_005267130.2 [P46939-1]
XP_011534408.1, XM_011536106.2 [P46939-1]
UniGeneiHs.133135

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHDX-ray2.00A/B144-261[»]
1QAGX-ray3.00A/B31-256[»]
ProteinModelPortaliP46939
SMRiP46939
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113245, 70 interactors
CORUMiP46939
DIPiDIP-711N
IntActiP46939, 47 interactors
MINTiP46939
STRINGi9606.ENSP00000356515

PTM databases

iPTMnetiP46939
PhosphoSitePlusiP46939

Polymorphism and mutation databases

BioMutaiUTRN
DMDMi215274104

Proteomic databases

EPDiP46939
MaxQBiP46939
PaxDbiP46939
PeptideAtlasiP46939
PRIDEiP46939
ProteomicsDBi55775

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367545; ENSP00000356515; ENSG00000152818 [P46939-1]
GeneIDi7402
KEGGihsa:7402
UCSCiuc003qkt.4 human [P46939-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7402
DisGeNETi7402
EuPathDBiHostDB:ENSG00000152818.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UTRN
HGNCiHGNC:12635 UTRN
HPAiCAB016348
HPA018894
MIMi128240 gene
neXtProtiNX_P46939
OpenTargetsiENSG00000152818
PharmGKBiPA37260

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000153467
HOGENOMiHOG000231173
HOVERGENiHBG005495
InParanoidiP46939
OMAiNFLKWIQ
OrthoDBiEOG091G001Y
PhylomeDBiP46939
TreeFamiTF320178

Enzyme and pathway databases

SignaLinkiP46939
SIGNORiP46939

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UTRN human
EvolutionaryTraceiP46939

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Utrophin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7402

Protein Ontology

More...
PROi
PR:P46939

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152818 Expressed in 216 organ(s), highest expression level in kidney
CleanExiHS_UTRN
ExpressionAtlasiP46939 baseline and differential
GenevisibleiP46939 HS

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 10 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 18 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUTRO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46939
Secondary accession number(s): Q5SYY1, Q5SZ57, Q9UJ40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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