YAP1

Functionⁱ

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).By similarity8 Publications

Isoform 2:

Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).1 Publication

Isoform 3:

Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

PathwayCommonsⁱ	P46937
Reactomeⁱ	R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-2028269, Signaling by Hippo R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination
SignaLinkⁱ	P46937
SIGNORⁱ	P46937

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcriptional coactivator YAP1 Short name: Yes-associated protein 1 Alternative name(s): Protein yorkie homolog Yes-associated protein YAP65 homolog
Gene namesⁱ	Name:YAP1 Synonyms:YAP65
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16262, YAP1
MIMⁱ	606608, gene
neXtProtⁱ	NX_P46937
VEuPathDBⁱ	HostDB:ENSG00000137693.13

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid-frequency hearing loss.

Related information in OMIM

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	61	S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-109; A-127 and A-164. 1 Publication	1
Mutagenesisⁱ	80	V → A: No change in interaction with TEAD4. Reduced interaction with TEAD4 and transforming ability; when associated with A-84 and A-85. 1 Publication	1
Mutagenesisⁱ	84	V → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-85. 1 Publication	1
Mutagenesisⁱ	85	P → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-84. 1 Publication	1
Mutagenesisⁱ	86	M → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	89	R → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	91	L → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	94	S → A: Loss of interaction with TEAD1, TEAD2, TEAD3 and TEAD4. Loss of transcriptional coactivation activity towards TEAD1, TEAD2, TEAD3 and TEAD4 but no effect on its activity towards RUNX2 and ERBB4. Abolishes suppression of ciliogenesis. 2 Publications	1
Mutagenesisⁱ	95	F → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	96	F → A: Loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	109	S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-127 and A-164. 1 Publication	1
Mutagenesisⁱ	122	H → A, R, N or K: Loss of phosphorylation by LATS1. 2 Publications	1
Mutagenesisⁱ	122	H → L or Y: Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB. 2 Publications	1
Mutagenesisⁱ	124	R → A: Loss of phosphorylation by LATS1. 1 Publication	1
Mutagenesisⁱ	127	S → A: Reduced phosphorylation by LATS2, loss of phosphorylation by LATS1, loss of interaction with YWHAB, decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4. In YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109; A-127 and A-164. 4 Publications	1
Mutagenesisⁱ	129	P → D: No effect on phosphorylation but loss of interaction with YWHAB. 1 Publication	1
Mutagenesisⁱ	164	S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109 and A-127. 1 Publication	1
Mutagenesisⁱ	199	W → A: Loss of interaction with ERBB4, loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4; when associated with A-202. 2 Publications	1
Mutagenesisⁱ	202	P → A: Loss of interaction with ERBB4, loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4; when associated with A-199. 2 Publications	1
Mutagenesisⁱ	217	S → A: No effect on interaction with PRRG4. 1 Publication	1
Mutagenesisⁱ	258	W → A: Reduced interaction with PRRG4; when associated with A-261. 1 Publication	1
Mutagenesisⁱ	261	P → A: Reduced interaction with PRRG4; when associated with A-258. 1 Publication	1
Mutagenesisⁱ	397	S → A: Loss of phosphorylation by LATS1. 1 Publication	1
Mutagenesisⁱ	407	Y → E: Enhanced interaction with TP73. 1 Publication	1
Mutagenesisⁱ	407	Y → F: No phosphorylation by ABL1 and partial loss of binding to TP73. 1 Publication	1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10413
MalaCards human disease database More...MalaCardsⁱ	YAP1
MIMⁱ	120433, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000137693
Orphanetⁱ	157791, Epithelioid hemangioendothelioma 1473, Uveal coloboma-cleft lip and palate-intellectual disability
PharmGKBⁱ	PA38103

Miscellaneous databases

Pharosⁱ	P46937, Tbio

Pharosⁱ

P46937, Tbio

Genetic variation databases

BioMutaⁱ	YAP1
DMDMⁱ	294862479

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076071	1 – 504	Transcriptional coactivator YAP1Add BLAST		504

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	61	Phosphoserine; by LATS1 and LATS2Combined sources2 Publications	1
Modified residueⁱ	63	PhosphothreonineCombined sources	1
Modified residueⁱ	105	PhosphoserineBy similarity	1
Modified residueⁱ	109	Phosphoserine; by LATS1 and LATS2Combined sources2 Publications	1
Modified residueⁱ	110	PhosphothreonineBy similarity	1
Modified residueⁱ	119	Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	127	Phosphoserine; by LATS1 and LATS2Combined sources4 Publications	1
Modified residueⁱ	128	PhosphoserineCombined sources	1
Modified residueⁱ	131	PhosphoserineCombined sources	1
Modified residueⁱ	138	Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	154	Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	164	Phosphoserine; by LATS1 and LATS22 Publications	1
Modified residueⁱ	274	PhosphoserineCombined sources	1
Modified residueⁱ	289	PhosphoserineCombined sources	1
Modified residueⁱ	367	Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	371	PhosphoserineCombined sources	1
Modified residueⁱ	381	PhosphoserineCombined sources	1
Modified residueⁱ	382	PhosphoserineCombined sources	1
Modified residueⁱ	388	PhosphoserineCombined sources	1
Modified residueⁱ	397	Phosphoserine; by LATS1 and LATS24 Publications	1
Modified residueⁱ	400	Phosphoserine; by CK11 Publication	1
Modified residueⁱ	403	Phosphoserine; by CK11 Publication	1
Modified residueⁱ	407	Phosphotyrosine; by ABL11 Publication	1
Modified residueⁱ	412	Phosphothreonine; by MAPK8 and MAPK91 Publication	1

Post-translational modificationⁱ

Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).4 Publications

Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P46937
jPOSTⁱ	P46937
MassIVEⁱ	P46937
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P46937
PaxDbⁱ	P46937
PeptideAtlas More...PeptideAtlasⁱ	P46937
PRIDEⁱ	P46937
ProteomicsDBⁱ	23425 25812 5134 55772 [P46937-1] 55773 [P46937-2] 55774 [P46937-3]

PTM databases

iPTMnetⁱ	P46937
MetOSiteⁱ	P46937
PhosphoSitePlusⁱ	P46937

Expressionⁱ

Tissue specificityⁱ

Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000137693, Expressed in pigmented layer of retina and 235 other tissues
ExpressionAtlasⁱ	P46937, baseline and differential
Genevisibleⁱ	P46937, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000137693, Low tissue specificity

HPAⁱ

ENSG00000137693, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916).

Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288).

Interacts with LATS2 (PubMed:18158288).

Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908).

Interacts with TP73 (PubMed:18280240).

Interacts with RUNX1 (PubMed:18280240).

Interacts with HCK (PubMed:17535448).

Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).

Interacts (when phosphorylated at Ser-127) with SMAD2, SMAD3 and WWTR1 (By similarity).

Interacts with PRRG2 (via cytoplasmic domain) (PubMed:17502622).

Interacts (via WW domains) with PRRG4 (via cytoplasmic domain) (PubMed:23873930).

By similarity12 Publications

Isoform 3:

Interacts (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2).

1 Publication

Isoform 2:

Interacts (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2).

1 Publication

Binary interactionsⁱ

Hide details

P46937

With	#Exp.	IntAct
AXIN1 [O15169]	11	EBI-1044059,EBI-710484
CTNNB1 [P35222]	13	EBI-1044059,EBI-491549
DDX17 [Q92841]	7	EBI-1044059,EBI-746012
ERBB4 [Q15303]	3	EBI-1044059,EBI-80371
LATS1 [O95835]	9	EBI-1044059,EBI-444209
MAP2K1 [Q02750]	3	EBI-1044059,EBI-492564
PRKAA1 [Q13131]	3	EBI-1044059,EBI-1181405
PRRG2 [O14669]	5	EBI-1044059,EBI-9824765
PTCH1 [Q13635]	3	EBI-1044059,EBI-8775406
PTPN14 [Q15678]	7	EBI-1044059,EBI-1237156
RAB11A [P62491]	2	EBI-1044059,EBI-745098
RUNX1 [Q01196]	3	EBI-1044059,EBI-925904
SCRIB [Q14160]	2	EBI-1044059,EBI-357345
SMAD1 [Q15797]	3	EBI-1044059,EBI-1567153
SMAD7 [O15105]	7	EBI-1044059,EBI-3861591
SOCS6 [O14544]	2	EBI-1044059,EBI-3929549
TBX5 [Q99593]	4	EBI-1044059,EBI-297043
TEAD1 [P28347]	10	EBI-1044059,EBI-529156
TEAD2 [Q15562]	5	EBI-1044059,EBI-6427252
TEAD2 - isoform 2 [Q15562-2]	3	EBI-1044059,EBI-9370956
TEAD4 [Q15561]	10	EBI-1044059,EBI-747736
TP53BP2 - isoform 2 [Q13625-2]	9	EBI-1044059,EBI-287091
TP73 [O15350]	3	EBI-1044059,EBI-389606
TP73 - isoform Alpha [O15350-1]	7	EBI-1044059,EBI-389619
WBP1 [Q96G27]	3	EBI-1044059,EBI-3867685
WBP2 [Q969T9]	7	EBI-1044059,EBI-727055
YWHAB [P31946]	6	EBI-1044059,EBI-359815
YWHAE [P62258]	5	EBI-1044059,EBI-356498
YWHAZ [P63104]	9	EBI-1044059,EBI-347088
Axin1 [O35625] from Mus musculus.	3	EBI-1044059,EBI-2365912
Prkaa1 [Q5EG47] from Mus musculus.	2	EBI-1044059,EBI-7282395
Wbp1 [P97764] from Mus musculus.	13	EBI-1044059,EBI-6304160

Isoform 3 [P46937-3]

With	#Exp.	IntAct
CTNNB1 [P35222]	2	EBI-6558686,EBI-491549

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	115684, 665 interactors
ComplexPortalⁱ	CPX-256, YAP1-TEAD1 complex
CORUMⁱ	P46937
Database of interacting proteins More...DIPⁱ	DIP-40839N
ELMⁱ	P46937
IntActⁱ	P46937, 114 interactors
Molecular INTeraction database More...MINTⁱ	P46937
STRINGⁱ	9606.ENSP00000478927

Miscellaneous databases

RNActⁱ	P46937, protein

RNActⁱ

P46937, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	52 – 57	Combined sources	6
Helixⁱ	65 – 73	Combined sources	9
Helixⁱ	75 – 77	Combined sources	3
Helixⁱ	86 – 88	Combined sources	3
Helixⁱ	93 – 95	Combined sources	3
Beta strandⁱ	169 – 171	Combined sources	3
Beta strandⁱ	177 – 181	Combined sources	5
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	187 – 191	Combined sources	5
Turnⁱ	192 – 195	Combined sources	4
Beta strandⁱ	196 – 200	Combined sources	5
Helixⁱ	202 – 206	Combined sources	5
Beta strandⁱ	233 – 235	Combined sources	3
Beta strandⁱ	238 – 241	Combined sources	4
Turnⁱ	242 – 244	Combined sources	3
Beta strandⁱ	245 – 250	Combined sources	6
Turnⁱ	251 – 254	Combined sources	4
Beta strandⁱ	255 – 259	Combined sources	5
Beta strandⁱ	261 – 263	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P46937
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P46937

EvolutionaryTraceⁱ

P46937

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	171 – 204	WW 1PROSITE-ProRule annotationAdd BLAST		34
Domainⁱ	230 – 263	WW 2PROSITE-ProRule annotationAdd BLAST		34

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	291 – 504	Transactivation domainAdd BLAST		214

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	86 – 100	1 PublicationAdd BLAST		15
Coiled coilⁱ	298 – 359	Sequence analysisAdd BLAST		62

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	3 – 49	Pro-richAdd BLAST		47

Domainⁱ

The first coiled-coil region mediates most of the interaction with TEAD transcription factors.1 Publication

Sequence similaritiesⁱ

Belongs to the YAP1 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0940, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046760
HOGENOMⁱ	CLU_041917_0_1_1
InParanoidⁱ	P46937
OMAⁱ	PKNTIVP
Database of Orthologous Groups More...OrthoDBⁱ	1006566at2759
PhylomeDBⁱ	P46937
TreeFamⁱ	TF326941

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201, WW, 2 hits
Database of protein disorder More...DisProtⁱ	DP00702
IDEALⁱ	IID00304
InterProⁱ	View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00397, WW, 2 hits
SMARTⁱ	View protein in SMART SM00456, WW, 2 hits
SUPFAMⁱ	SSF51045, SSF51045, 2 hits
PROSITEⁱ	View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Isoforms of the YAP1-1 form contain only one WW domain.

This entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P46937-1) [UniParc]FASTA Add to basket

Also known as: YAP1-2gamma, YAP2L

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS 
       360        370        380        390        400
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS 
       410        420        430        440        450
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG 
       460        470        480        490        500
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF 

LTWL

Length:504

Mass (Da):54,462

Last modified:April 20, 2010 - v2

Checksum:ⁱ6145F7049ED338AE

GO

Isoform 2 (identifier: P46937-2) [UniParc]FASTA Add to basket

Also known as: YAP1-2alpha, YAP2

The sequence of this isoform differs from the canonical sequence as follows:
328-343: Missing.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQEL ALRSQLPTLE QDGGTQNPVS 
       360        370        380        390        400
SPGMSQELRT MTTNSSDPFL NSGTYHSRDE STDSGLSMSS YSVPRTPDDF 
       410        420        430        440        450
LNSVDEMDTG DTINQSTLPS QQNRFPDYLE AIPGTNVDLG TLEGDGMNIE 
       460        470        480 
GEELMPSLQE ALSSDILNDM ESVLAATKLD KESFLTWL

Show »

Length:488

Mass (Da):52,748

Checksum:ⁱ675CC207C83A311E

GO

Isoform 3 (identifier: P46937-3) [UniParc]FASTA Add to basket

Also known as: YAP1-1beta

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.
329-343: AMRNINPSTANSPKC → VRP

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ VRPQELALRS 
       310        320        330        340        350
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS 
       360        370        380        390        400
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG 
       410        420        430        440        450
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF 

LTWL

Show »

Length:454

Mass (Da):48,755

Checksum:ⁱ87CB840D3393EFC0

GO

Isoform 4 (identifier: P46937-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-178: Missing.

« Hide

        10         20         30         40         50
MAKTSSGQRY FLNHIDQTTT WQDPRKAMLS QMNVTAPTSP PVQQNMMNSA 
        60         70         80         90        100
SGPLPDGWEQ AMTQDGEIYY INHKNKTTSW LDPRLDPRFA MNQRISQSAP 
       110        120        130        140        150
VKQPPPLAPQ SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ 
       160        170        180        190        200
AMRNINPSTA NSPKCQELAL RSQLPTLEQD GGTQNPVSSP GMSQELRTMT 
       210        220        230        240        250
TNSSDPFLNS GTYHSRDEST DSGLSMSSYS VPRTPDDFLN SVDEMDTGDT 
       260        270        280        290        300
INQSTLPSQQ NRFPDYLEAI PGTNVDLGTL EGDGMNIEGE ELMPSLQEAL 
       310        320 
SSDILNDMES VLAATKLDKE SFLTWL

Show »

Length:326

Mass (Da):36,232

Checksum:ⁱ5C94DABAC6D74ABA

GO

Isoform 5 (identifier: P46937-5) [UniParc]FASTA Add to basket

Also known as: YAP1-1alpha

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.
328-343: Missing.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ ELALRSQLPT 
       310        320        330        340        350
LEQDGGTQNP VSSPGMSQEL RTMTTNSSDP FLNSGTYHSR DESTDSGLSM 
       360        370        380        390        400
SSYSVPRTPD DFLNSVDEMD TGDTINQSTL PSQQNRFPDY LEAIPGTNVD 
       410        420        430        440        450
LGTLEGDGMN IEGEELMPSL QEALSSDILN DMESVLAATK LDKESFLTWL

Show »

Length:450

Mass (Da):48,275

Checksum:ⁱ295934FD185E7C59

GO

Isoform 6 (identifier: P46937-6) [UniParc]FASTA Add to basket

Also known as: YAP1-1gamma

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ AMRNINPSTA 
       310        320        330        340        350
NSPKCQELAL RSQLPTLEQD GGTQNPVSSP GMSQELRTMT TNSSDPFLNS 
       360        370        380        390        400
GTYHSRDEST DSGLSMSSYS VPRTPDDFLN SVDEMDTGDT INQSTLPSQQ 
       410        420        430        440        450
NRFPDYLEAI PGTNVDLGTL EGDGMNIEGE ELMPSLQEAL SSDILNDMES 
       460 
VLAATKLDKE SFLTWL

Show »

Length:466

Mass (Da):49,989

Checksum:ⁱF1E76E6DEB3F93C0

GO

Isoform 7 (identifier: P46937-7) [UniParc]FASTA Add to basket

Also known as: YAP1-1delta

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.
328-328: Q → QVRPQ

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ VRPQAMRNIN 
       310        320        330        340        350
PSTANSPKCQ ELALRSQLPT LEQDGGTQNP VSSPGMSQEL RTMTTNSSDP 
       360        370        380        390        400
FLNSGTYHSR DESTDSGLSM SSYSVPRTPD DFLNSVDEMD TGDTINQSTL 
       410        420        430        440        450
PSQQNRFPDY LEAIPGTNVD LGTLEGDGMN IEGEELMPSL QEALSSDILN 
       460        470
DMESVLAATK LDKESFLTWL

Show »

Length:470

Mass (Da):50,469

Checksum:ⁱ8935AAD2FA859F62

GO

Isoform 8 (identifier: P46937-8) [UniParc]FASTA Add to basket

Also known as: YAP1-2beta

The sequence of this isoform differs from the canonical sequence as follows:
329-343: AMRNINPSTANSPKC → VRP

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQVR PQELALRSQL PTLEQDGGTQ 
       360        370        380        390        400
NPVSSPGMSQ ELRTMTTNSS DPFLNSGTYH SRDESTDSGL SMSSYSVPRT 
       410        420        430        440        450
PDDFLNSVDE MDTGDTINQS TLPSQQNRFP DYLEAIPGTN VDLGTLEGDG 
       460        470        480        490 
MNIEGEELMP SLQEALSSDI LNDMESVLAA TKLDKESFLT WL

Show »

Length:492

Mass (Da):53,228

Checksum:ⁱ289722956D96193A

GO

Isoform 9 (identifier: P46937-9) [UniParc]FASTA Add to basket

Also known as: YAP1-2delta

The sequence of this isoform differs from the canonical sequence as follows:
328-328: Q → QVRPQ

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQVR PQAMRNINPS TANSPKCQEL 
       360        370        380        390        400
ALRSQLPTLE QDGGTQNPVS SPGMSQELRT MTTNSSDPFL NSGTYHSRDE 
       410        420        430        440        450
STDSGLSMSS YSVPRTPDDF LNSVDEMDTG DTINQSTLPS QQNRFPDYLE 
       460        470        480        490        500
AIPGTNVDLG TLEGDGMNIE GEELMPSLQE ALSSDILNDM ESVLAATKLD 

KESFLTWL

Note: Highest expression in ovary and placenta, lowest in skeletal muscle and brain.Curated

Show »

Length:508

Mass (Da):54,942

Checksum:ⁱCFCC0BD04A27060B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YCI3	H0YCI3_HUMAN		Transcriptional coactivator YAP1 Transcriptional coactivator YAP1	YAP1	258	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071125	139	P → L1 PublicationCorresponds to variant dbSNP:rs1162286204Ensembl.	1
Natural variantⁱVAR_071126	227	S → L1 PublicationCorresponds to variant dbSNP:rs376161041Ensembl.	1
Natural variantⁱVAR_071127	330	M → V1 PublicationCorresponds to variant dbSNP:rs777949318Ensembl.	1
Natural variantⁱVAR_071128	462	G → E1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045190	1 – 178	Missing in isoform 4. 1 PublicationAdd BLAST	178
Alternative sequenceⁱVSP_039053	230 – 267	Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST	38
Alternative sequenceⁱVSP_039054	328 – 343	Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_053483	328	Q → QVRPQ in isoform 7 and isoform 9. 1 Publication	1
Alternative sequenceⁱVSP_039055	329 – 343	AMRNI…NSPKC → VRP in isoform 3 and isoform 8. 1 PublicationAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80507 Genomic DNA Translation: CAA56672.1 AY316529 mRNA Translation: AAP92710.1 AB567720 mRNA Translation: BAJ41471.1 AB567721 mRNA Translation: BAJ41472.1 AK300414 mRNA Translation: BAG62143.1 AK316116 mRNA Translation: BAH14487.1 AP000942 Genomic DNA No translation available. AP001527 Genomic DNA No translation available. AP002777 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67011.1 CH471065 Genomic DNA Translation: EAW67015.1 BC038235 mRNA Translation: AAH38235.1 HE864159 mRNA Translation: CCI79618.1 HE864160 mRNA Translation: CCI79619.1 HE864161 mRNA Translation: CCI79620.1 HE864162 mRNA Translation: CCI79621.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44716.1 [P46937-1] CCDS53699.1 [P46937-2] CCDS53700.1 [P46937-4] CCDS60944.1 [P46937-8] CCDS60945.1 [P46937-3] CCDS73373.1 [P46937-9] CCDS73374.1 [P46937-7] CCDS8314.2 [P46937-5]
PIRⁱ	A56954
NCBI Reference Sequences More...RefSeqⁱ	NP_001123617.1, NM_001130145.2 [P46937-1] NP_001181973.1, NM_001195044.1 [P46937-2] NP_001181974.1, NM_001195045.1 [P46937-4] NP_001269026.1, NM_001282097.1 [P46937-6] NP_001269027.1, NM_001282098.1 [P46937-3] NP_001269028.1, NM_001282099.1 [P46937-7] NP_001269029.1, NM_001282100.1 [P46937-8] NP_001269030.1, NM_001282101.1 [P46937-9]

Genome annotation databases

Ensemblⁱ	ENST00000282441; ENSP00000282441; ENSG00000137693 [P46937-1] ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7] ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4] ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5] ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2] ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8] ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9] ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3]
GeneIDⁱ	10413
KEGGⁱ	hsa:10413
UCSC genome browser More...UCSCⁱ	uc001pgt.3, human [P46937-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P46937	YAP1 isoform 2		PANTR		504	UniRef100_P46937
YAP1 isoform 2		PONAB		504
P46937-2	YAP1 isoform 7		PANTR		488	UniRef100_K7CIP4
YAP1 isoform 8		PONAB		488
Uncharacterized protein		MANLE		442
+2
P46937-3	Yes-associated protein 1, 65kDa, isoform CRA_b		HUMAN		454	UniRef100_A0A024R3E4
YAP1 isoform 7		PONAB		454
YAP1 isoform 6		PANTR		454
P46937-4	Uncharacterized protein		MACFA		506	UniRef100_A0A2K5W4U5
Uncharacterized protein		CERAT		506
Uncharacterized protein		MACNE		506
YAP1 isoform 9		PONAB		326
YAP1 isoform 8		PANTR		326
+4
P46937-5	YAP1 isoform 4		PANTR		450	UniRef100_K7BI95
YAP1 isoform 4		PONAB		450
P46937-7	YAP1 isoform 3		PONAB		470	UniRef100_A0A2J8XX17
YAP1 isoform 3		PANTR		470
Yes1 associated transcriptional regulator		PANTR		470
P46937-8	Yes-associated protein 1		PANTR		492	UniRef100_K7DF44
YAP1 isoform 1		PONAB		492
YAP1 isoform 1		PANTR		492
+1
P46937-9	Yes-associated protein 1		PANTR		508	UniRef100_H2Q4M4
YAP1 isoform 5		PONAB		508
YAP1 isoform 5		PANTR		508

Protein	Similar proteins		Species	Score	Length	Source
P46937	YAP1 isoform 2		PANTR		504	UniRef90_P46937
YAP1 isoform 2		PONAB		504
Uncharacterized protein		PANPA		512
Yes-associated protein isoform 9 (Fragment)		HUMAN		168
transcriptional coactivator YAP1 isoform X3		ZALCA		510
+89
P46937-3	Yes-associated protein 1, 65kDa, isoform CRA_b		HUMAN		454	UniRef90_A0A024R3E4
YAP1 isoform 7		PONAB		454
YAP1 isoform 6		PANTR		454
+2
P46937-4	Uncharacterized protein		PAPAN		506	UniRef90_A0A2I3MM76
Uncharacterized protein		MACFA		506
Uncharacterized protein		CERAT		506
Uncharacterized protein		MACNE		506
YAP1 isoform 9		PONAB		326
+5
P46937-5	WW domain-containing protein		MANLE		439	UniRef90_A0A2K6A3U6
Yorkie homolog isoform 1		CALJA		503
transcriptional coactivator YAP1 isoform X12		PHYMC		451
transcriptional coactivator YAP1 isoform X12		TURTR		451
YAP1 isoform 4		PANTR		450
+21
P46937-6	WW domain-containing protein		MACNE		466	UniRef90_P46937-6
P46937-7	Yes1 associated transcriptional regulator		HORSE		508	UniRef90_F6T8H1
transcriptional coactivator YAP1 isoform X1		ZALCA		514
transcriptional coactivator YAP1 isoform X1		DELLE		511
transcriptional coactivator YAP1 isoform X1		PHYMC		511
transcriptional coactivator YAP1 isoform X1		TURTR		511
+183

Protein	Similar proteins		Species	Score	Length	Source
P46937	Transcriptional coactivator YAP1		CHICK		448	UniRef50_P46937
Transcriptional coactivator YAP1		ORYLA		459
Transcriptional coactivator YAP1-A		XENLA		459
Transcriptional coactivator YAP1		RAT		469
Transcriptional coactivator YAP1	)	MOUSE		488
+797
P46937-3	Isoform 3 of Transcriptional coactivator YAP1		RAT		366	UniRef50_Q2EJA0-3
Transcriptional coactivator YAP1		MOUSE		369
transcriptional coactivator YAP1 isoform X11		PHYMC		455
transcriptional coactivator YAP1 isoform X11		TURTR		455
transcriptional coactivator YAP1		Austrofundulus limnaeus		438
+155
P46937-4	Uncharacterized protein		ICTTR		397	UniRef50_I3M570
Uncharacterized protein		MARMO		545
transcriptional coactivator YAP1 isoform X5		SHEEP		491
transcriptional coactivator YAP1 isoform X4		pale spear-nosed bat		492
Uncharacterized protein		MACFA		506
+139
P46937-6	Transcriptional coactivator YAP1		DANRE		442	UniRef50_P46937-6
WW domain-containing protein		MACNE		466
WW domain-containing protein		CEBIM		470
transcriptional coactivator YAP1 isoform X9		SAPAP		470
transcriptional coactivator YAP1 isoform X1		ZALCA		514
+366

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Protein Spotlight

Shaping life - Issue 175 of January 2016

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80507 Genomic DNA Translation: CAA56672.1 AY316529 mRNA Translation: AAP92710.1 AB567720 mRNA Translation: BAJ41471.1 AB567721 mRNA Translation: BAJ41472.1 AK300414 mRNA Translation: BAG62143.1 AK316116 mRNA Translation: BAH14487.1 AP000942 Genomic DNA No translation available. AP001527 Genomic DNA No translation available. AP002777 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67011.1 CH471065 Genomic DNA Translation: EAW67015.1 BC038235 mRNA Translation: AAH38235.1 HE864159 mRNA Translation: CCI79618.1 HE864160 mRNA Translation: CCI79619.1 HE864161 mRNA Translation: CCI79620.1 HE864162 mRNA Translation: CCI79621.1
CCDSⁱ	CCDS44716.1 [P46937-1] CCDS53699.1 [P46937-2] CCDS53700.1 [P46937-4] CCDS60944.1 [P46937-8] CCDS60945.1 [P46937-3] CCDS73373.1 [P46937-9] CCDS73374.1 [P46937-7] CCDS8314.2 [P46937-5]
PIRⁱ	A56954
RefSeqⁱ	NP_001123617.1, NM_001130145.2 [P46937-1] NP_001181973.1, NM_001195044.1 [P46937-2] NP_001181974.1, NM_001195045.1 [P46937-4] NP_001269026.1, NM_001282097.1 [P46937-6] NP_001269027.1, NM_001282098.1 [P46937-3] NP_001269028.1, NM_001282099.1 [P46937-7] NP_001269029.1, NM_001282100.1 [P46937-8] NP_001269030.1, NM_001282101.1 [P46937-9]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JMQ	NMR	-	A	165-210	[»]
	1K5R	NMR	-	A	165-204	[»]
	1K9Q	NMR	-	A	165-204	[»]
	1K9R	NMR	-	A	165-204	[»]
	2LAW	NMR	-	A	230-263	[»]
	2LAX	NMR	-	A	170-205	[»]
	2LAY	NMR	-	A	170-205	[»]
	2LTV	NMR	-	A	230-265	[»]
	2LTW	NMR	-	A	170-205	[»]
	3KYS	X-ray	2.80	B/D	50-171	[»]
	3MHR	X-ray	1.15	P	124-133	[»]
	4RE1	X-ray	2.20	C/D	50-171	[»]
	4REX	X-ray	1.60	A	165-209	[»]
	5OAQ	X-ray	1.95	L	60-100	[»]
	5YDX	NMR	-	A	164-218	[»]
	5YDY	NMR	-	A	229-287	[»]
	6G6X	X-ray	1.13	P	124-133	[»]
	6G8I	X-ray	1.60	P	125-133	[»]
	6G8J	X-ray	1.47	P	124-133	[»]
	6G8K	X-ray	1.25	P	124-133	[»]
	6G8L	X-ray	1.37	P	124-133	[»]
	6G8P	X-ray	1.90	P	124-133	[»]
	6G8Q	X-ray	1.85	P	124-132	[»]
	6GE3	X-ray	1.85	L	60-100	[»]
	6GE4	X-ray	1.97	L	60-100	[»]
	6GE5	X-ray	2.05	L	60-100	[»]
	6GE6	X-ray	1.80	L	60-100	[»]
	6GEC	X-ray	1.70	L	60-99	[»]
	6GEE	X-ray	1.96	L	60-99	[»]
	6GEG	X-ray	2.23	L	60-99	[»]
	6GEI	X-ray	1.65	L	60-100	[»]
	6GEK	X-ray	2.28	L/M	60-100	[»]
	6HIK	X-ray	1.65	L	60-99	[»]
	6HIL	X-ray	2.30	L/M/N/O	60-100	[»]
	6Q2X	X-ray	2.10	L	60-100	[»]
SMRⁱ	P46937
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115684, 665 interactors
ComplexPortalⁱ	CPX-256, YAP1-TEAD1 complex
CORUMⁱ	P46937
DIPⁱ	DIP-40839N
ELMⁱ	P46937
IntActⁱ	P46937, 114 interactors
MINTⁱ	P46937
STRINGⁱ	9606.ENSP00000478927

PTM databases

iPTMnetⁱ	P46937
MetOSiteⁱ	P46937
PhosphoSitePlusⁱ	P46937

Genetic variation databases

BioMutaⁱ	YAP1
DMDMⁱ	294862479

Proteomic databases

EPDⁱ	P46937
jPOSTⁱ	P46937
MassIVEⁱ	P46937
MaxQBⁱ	P46937
PaxDbⁱ	P46937
PeptideAtlasⁱ	P46937
PRIDEⁱ	P46937
ProteomicsDBⁱ	23425 25812 5134 55772 [P46937-1] 55773 [P46937-2] 55774 [P46937-3]

Protocols and materials databases

Antibodypediaⁱ	3994, 916 antibodies

Antibodypediaⁱ

3994, 916 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000282441; ENSP00000282441; ENSG00000137693 [P46937-1] ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7] ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4] ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5] ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2] ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8] ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9] ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3]
GeneIDⁱ	10413
KEGGⁱ	hsa:10413
UCSCⁱ	uc001pgt.3, human [P46937-1]

Organism-specific databases

CTDⁱ	10413
DisGeNETⁱ	10413
GeneCardsⁱ	YAP1
HGNCⁱ	HGNC:16262, YAP1
HPAⁱ	ENSG00000137693, Low tissue specificity
MalaCardsⁱ	YAP1
MIMⁱ	120433, phenotype 606608, gene
neXtProtⁱ	NX_P46937
OpenTargetsⁱ	ENSG00000137693
Orphanetⁱ	157791, Epithelioid hemangioendothelioma 1473, Uveal coloboma-cleft lip and palate-intellectual disability
PharmGKBⁱ	PA38103
VEuPathDBⁱ	HostDB:ENSG00000137693.13
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0940, Eukaryota
GeneTreeⁱ	ENSGT00510000046760
HOGENOMⁱ	CLU_041917_0_1_1
InParanoidⁱ	P46937
OMAⁱ	PKNTIVP
OrthoDBⁱ	1006566at2759
PhylomeDBⁱ	P46937
TreeFamⁱ	TF326941

Enzyme and pathway databases

PathwayCommonsⁱ	P46937
Reactomeⁱ	R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-2028269, Signaling by Hippo R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination
SignaLinkⁱ	P46937
SIGNORⁱ	P46937

Miscellaneous databases

BioGRID-ORCSⁱ	10413, 145 hits in 989 CRISPR screens
ChiTaRSⁱ	YAP1, human
EvolutionaryTraceⁱ	P46937
GeneWikiⁱ	YAP1
GenomeRNAiⁱ	10413
Pharosⁱ	P46937, Tbio
Protein Ontology More...PROⁱ	PR:P46937
RNActⁱ	P46937, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137693, Expressed in pigmented layer of retina and 235 other tissues
ExpressionAtlasⁱ	P46937, baseline and differential
Genevisibleⁱ	P46937, HS

Family and domain databases

CDDⁱ	cd00201, WW, 2 hits
DisProtⁱ	DP00702
IDEALⁱ	IID00304
InterProⁱ	View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf
Pfamⁱ	View protein in Pfam PF00397, WW, 2 hits
SMARTⁱ	View protein in SMART SM00456, WW, 2 hits
SUPFAMⁱ	SSF51045, SSF51045, 2 hits
PROSITEⁱ	View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YAP1_HUMAN
Accessionⁱ	P46937Primary (citable) accession number: P46937 Secondary accession number(s): B4DTY1 Q8IUY9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	April 20, 2010
	Last modified:	April 7, 2021
	This is version 210 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - P46937 (YAP1_HUMAN)

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Transcriptional coactivator YAP1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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P46937

Isoform 3 [P46937-3]

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

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Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ