UniProtKB - P46937 (YAP1_HUMAN)
Transcriptional coactivator YAP1
YAP1
Functioni
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097).
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288).
Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702).
Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288).
The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).
In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).
By similarity8 PublicationsActivates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
1 PublicationActivates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
1 PublicationGO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription factor binding Source: CAFA
- proline-rich region binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- transcription cis-regulatory region binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- bud elongation involved in lung branching Source: Ensembl
- cardiac muscle tissue regeneration Source: Ensembl
- cell morphogenesis Source: Ensembl
- cell population proliferation Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to gamma radiation Source: UniProtKB
- cellular response to retinoic acid Source: Ensembl
- contact inhibition Source: UniProtKB
- embryonic heart tube morphogenesis Source: Ensembl
- heart process Source: Ensembl
- hippo signaling Source: GO_Central
- interleukin-6-mediated signaling pathway Source: UniProtKB
- intestinal epithelial cell development Source: UniProtKB
- keratinocyte differentiation Source: Ensembl
- lateral mesoderm development Source: Ensembl
- lung epithelial cell differentiation Source: Ensembl
- negative regulation of cilium assembly Source: UniProtKB
- negative regulation of epithelial cell apoptotic process Source: CACAO
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of fat cell differentiation Source: ARUK-UCL
- negative regulation of gene expression Source: CACAO
- negative regulation of stem cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- notochord development Source: Ensembl
- paraxial mesoderm development Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of cardiac muscle cell proliferation Source: Ensembl
- positive regulation of cell growth Source: ComplexPortal
- positive regulation of epithelial cell proliferation Source: CACAO
- positive regulation of gene expression Source: CACAO
- positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of osteoblast differentiation Source: ARUK-UCL
- positive regulation of protein localization to nucleus Source: UniProtKB
- positive regulation of stem cell population maintenance Source: Ensembl
- positive regulation of transcription, DNA-templated Source: CAFA
- positive regulation of transcription by RNA polymerase II Source: CAFA
- progesterone receptor signaling pathway Source: UniProtKB
- protein-containing complex assembly Source: CAFA
- regulation of keratinocyte proliferation Source: Ensembl
- regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
- regulation of neurogenesis Source: MGI
- regulation of stem cell proliferation Source: MGI
- response to progesterone Source: UniProtKB
- somatic stem cell population maintenance Source: Ensembl
- tissue homeostasis Source: Ensembl
- trophectodermal cell differentiation Source: Ensembl
- vasculogenesis Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P46937 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-2028269, Signaling by Hippo R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P46937 |
SIGNORi | P46937 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional coactivator YAP1Short name: Yes-associated protein 1 Alternative name(s): Protein yorkie homolog Yes-associated protein YAP65 homolog |
Gene namesi | Name:YAP1 Synonyms:YAP65 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16262, YAP1 |
MIMi | 606608, gene |
neXtProti | NX_P46937 |
VEuPathDBi | HostDB:ENSG00000137693 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 5 Publications
Nucleus
- Nucleus 9 Publications
Note: Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity).By similarity4 Publications
Cytosol
- cytosol Source: FlyBase
Nucleus
- female germ cell nucleus Source: Ensembl
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- TEAD-YAP complex Source: CAFA
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 61 | S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-109; A-127 and A-164. 1 Publication | 1 | |
Mutagenesisi | 80 | V → A: No change in interaction with TEAD4. Reduced interaction with TEAD4 and transforming ability; when associated with A-84 and A-85. 1 Publication | 1 | |
Mutagenesisi | 84 | V → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-85. 1 Publication | 1 | |
Mutagenesisi | 85 | P → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-84. 1 Publication | 1 | |
Mutagenesisi | 86 | M → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
Mutagenesisi | 89 | R → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
Mutagenesisi | 91 | L → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
Mutagenesisi | 94 | S → A: Loss of interaction with TEAD1, TEAD2, TEAD3 and TEAD4. Loss of transcriptional coactivation activity towards TEAD1, TEAD2, TEAD3 and TEAD4 but no effect on its activity towards RUNX2 and ERBB4. Abolishes suppression of ciliogenesis. 2 Publications | 1 | |
Mutagenesisi | 95 | F → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
Mutagenesisi | 96 | F → A: Loss of interaction with TEAD1. 1 Publication | 1 | |
Mutagenesisi | 109 | S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-127 and A-164. 1 Publication | 1 | |
Mutagenesisi | 122 | H → A, R, N or K: Loss of phosphorylation by LATS1. 2 Publications | 1 | |
Mutagenesisi | 122 | H → L or Y: Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB. 2 Publications | 1 | |
Mutagenesisi | 124 | R → A: Loss of phosphorylation by LATS1. 1 Publication | 1 | |
Mutagenesisi | 127 | S → A: Reduced phosphorylation by LATS2, loss of phosphorylation by LATS1, loss of interaction with YWHAB, decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4. In YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109; A-127 and A-164. 4 Publications | 1 | |
Mutagenesisi | 129 | P → D: No effect on phosphorylation but loss of interaction with YWHAB. 1 Publication | 1 | |
Mutagenesisi | 164 | S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109 and A-127. 1 Publication | 1 | |
Mutagenesisi | 199 | W → A: Loss of interaction with ERBB4, loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4; when associated with A-202. 2 Publications | 1 | |
Mutagenesisi | 202 | P → A: Loss of interaction with ERBB4, loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4; when associated with A-199. 2 Publications | 1 | |
Mutagenesisi | 217 | S → A: No effect on interaction with PRRG4. 1 Publication | 1 | |
Mutagenesisi | 258 | W → A: Reduced interaction with PRRG4; when associated with A-261. 1 Publication | 1 | |
Mutagenesisi | 261 | P → A: Reduced interaction with PRRG4; when associated with A-258. 1 Publication | 1 | |
Mutagenesisi | 397 | S → A: Loss of phosphorylation by LATS1. 1 Publication | 1 | |
Mutagenesisi | 407 | Y → E: Enhanced interaction with TP73. 1 Publication | 1 | |
Mutagenesisi | 407 | Y → F: No phosphorylation by ABL1 and partial loss of binding to TP73. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 10413 |
MalaCardsi | YAP1 |
MIMi | 120433, phenotype |
OpenTargetsi | ENSG00000137693 |
Orphaneti | 157791, Epithelioid hemangioendothelioma 1473, Uveal coloboma-cleft lip and palate-intellectual disability |
PharmGKBi | PA38103 |
Miscellaneous databases
Pharosi | P46937, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3334415 |
Genetic variation databases
BioMutai | YAP1 |
DMDMi | 294862479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076071 | 1 – 504 | Transcriptional coactivator YAP1Add BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | Phosphoserine; by LATS1 and LATS2Combined sources2 Publications | 1 | |
Modified residuei | 63 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 105 | PhosphoserineBy similarity | 1 | |
Modified residuei | 109 | Phosphoserine; by LATS1 and LATS2Combined sources2 Publications | 1 | |
Modified residuei | 110 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 119 | Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
Modified residuei | 127 | Phosphoserine; by LATS1 and LATS2Combined sources4 Publications | 1 | |
Modified residuei | 128 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Modified residuei | 138 | Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
Modified residuei | 154 | Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
Modified residuei | 164 | Phosphoserine; by LATS1 and LATS22 Publications | 1 | |
Modified residuei | 274 | PhosphoserineCombined sources | 1 | |
Modified residuei | 289 | PhosphoserineCombined sources | 1 | |
Modified residuei | 367 | Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
Modified residuei | 381 | PhosphoserineCombined sources | 1 | |
Modified residuei | 382 | PhosphoserineCombined sources | 1 | |
Modified residuei | 388 | PhosphoserineCombined sources | 1 | |
Modified residuei | 397 | Phosphoserine; by LATS1 and LATS24 Publications | 1 | |
Modified residuei | 400 | Phosphoserine; by CK11 Publication | 1 | |
Modified residuei | 403 | Phosphoserine; by CK11 Publication | 1 | |
Modified residuei | 407 | Phosphotyrosine; by ABL11 Publication | 1 | |
Modified residuei | 412 | Phosphothreonine; by MAPK8 and MAPK91 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P46937 |
jPOSTi | P46937 |
MassIVEi | P46937 |
MaxQBi | P46937 |
PaxDbi | P46937 |
PeptideAtlasi | P46937 |
PRIDEi | P46937 |
ProteomicsDBi | 23425 25812 5134 55772 [P46937-1] 55773 [P46937-2] 55774 [P46937-3] |
PTM databases
GlyGeni | P46937, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P46937 |
MetOSitei | P46937 |
PhosphoSitePlusi | P46937 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000137693, Expressed in pigmented layer of retina and 236 other tissues |
ExpressionAtlasi | P46937, baseline and differential |
Genevisiblei | P46937, HS |
Organism-specific databases
HPAi | ENSG00000137693, Low tissue specificity |
Interactioni
Subunit structurei
Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916).
Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288).
Interacts with LATS2 (PubMed:18158288).
Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908).
Interacts with TP73 (PubMed:18280240).
Interacts with RUNX1 (PubMed:18280240).
Interacts with HCK (PubMed:17535448).
Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).
Interacts (when phosphorylated at Ser-127) with SMAD2, SMAD3 and WWTR1 (By similarity).
Interacts with PRRG2 (via cytoplasmic domain) (PubMed:17502622).
Interacts (via WW domains) with PRRG4 (via cytoplasmic domain) (PubMed:23873930).
By similarity12 PublicationsBinary interactionsi
P46937
Isoform 1 [P46937-1]
With | #Exp. | IntAct |
---|---|---|
PRRG4 [Q9BZD6] | 2 | EBI-26604877,EBI-3918643 |
Isoform 3 [P46937-3]
With | #Exp. | IntAct |
---|---|---|
CTNNB1 [P35222] | 2 | EBI-6558686,EBI-491549 |
PRRG4 [Q9BZD6] | 3 | EBI-6558686,EBI-3918643 |
GO - Molecular functioni
- DNA-binding transcription factor binding Source: CAFA
- proline-rich region binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115684, 689 interactors |
ComplexPortali | CPX-256, YAP1-TEAD1 complex |
CORUMi | P46937 |
DIPi | DIP-40839N |
ELMi | P46937 |
IntActi | P46937, 117 interactors |
MINTi | P46937 |
STRINGi | 9606.ENSP00000478927 |
Miscellaneous databases
RNActi | P46937, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P46937 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46937 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 171 – 204 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 230 – 263 | WW 2PROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 59 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 91 – 114 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 133 – 158 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 275 – 309 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 291 – 504 | Transactivation domainAdd BLAST | 214 | |
Regioni | 355 – 407 | DisorderedSequence analysisAdd BLAST | 53 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 86 – 100 | 1 PublicationAdd BLAST | 15 | |
Coiled coili | 298 – 359 | Sequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 36 | Pro residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 292 – 309 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0940, Eukaryota |
GeneTreei | ENSGT00510000046760 |
HOGENOMi | CLU_041917_0_1_1 |
InParanoidi | P46937 |
OMAi | DPNQHNP |
OrthoDBi | 1006566at2759 |
PhylomeDBi | P46937 |
TreeFami | TF326941 |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
DisProti | DP00702 |
IDEALi | IID00304 |
InterProi | View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00397, WW, 2 hits |
SMARTi | View protein in SMART SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA
60 70 80 90 100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE
110 120 130 140 150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG
160 170 180 190 200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ
210 220 230 240 250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN
260 270 280 290 300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS
310 320 330 340 350
NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS
360 370 380 390 400
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS
410 420 430 440 450
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG
460 470 480 490 500
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF
LTWL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YCI3 | H0YCI3_HUMAN | Transcriptional coactivator YAP1 | YAP1 | 258 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071125 | 139 | P → L1 PublicationCorresponds to variant dbSNP:rs1162286204Ensembl. | 1 | |
Natural variantiVAR_071126 | 227 | S → L1 PublicationCorresponds to variant dbSNP:rs376161041Ensembl. | 1 | |
Natural variantiVAR_071127 | 330 | M → V1 PublicationCorresponds to variant dbSNP:rs777949318Ensembl. | 1 | |
Natural variantiVAR_071128 | 462 | G → E1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045190 | 1 – 178 | Missing in isoform 4. 1 PublicationAdd BLAST | 178 | |
Alternative sequenceiVSP_039053 | 230 – 267 | Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_039054 | 328 – 343 | Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_053483 | 328 | Q → QVRPQ in isoform 7 and isoform 9. 1 Publication | 1 | |
Alternative sequenceiVSP_039055 | 329 – 343 | AMRNI…NSPKC → VRP in isoform 3 and isoform 8. 1 PublicationAdd BLAST | 15 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000282441; ENSP00000282441; ENSG00000137693 ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7] ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4] ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5] ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2] ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8] ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9] ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3] |
GeneIDi | 10413 |
KEGGi | hsa:10413 |
MANE-Selecti | ENST00000282441.10; ENSP00000282441.5; NM_001130145.3; NP_001123617.1 |
UCSCi | uc001pgt.3, human [P46937-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Protein Spotlight Shaping life - Issue 175 of January 2016 |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JMQ | NMR | - | A | 165-210 | [»] | |
1K5R | NMR | - | A | 165-204 | [»] | |
1K9Q | NMR | - | A | 165-204 | [»] | |
1K9R | NMR | - | A | 165-204 | [»] | |
2LAW | NMR | - | A | 230-263 | [»] | |
2LAX | NMR | - | A | 170-205 | [»] | |
2LAY | NMR | - | A | 170-205 | [»] | |
2LTV | NMR | - | A | 230-265 | [»] | |
2LTW | NMR | - | A | 170-205 | [»] | |
3KYS | X-ray | 2.80 | B/D | 50-171 | [»] | |
3MHR | X-ray | 1.15 | P | 124-133 | [»] | |
4RE1 | X-ray | 2.20 | C/D | 50-171 | [»] | |
4REX | X-ray | 1.60 | A | 165-209 | [»] | |
5OAQ | X-ray | 1.95 | L | 60-100 | [»] | |
5YDX | NMR | - | A | 164-218 | [»] | |
5YDY | NMR | - | A | 229-287 | [»] | |
6G6X | X-ray | 1.13 | P | 124-133 | [»] | |
6G8I | X-ray | 1.60 | P | 125-133 | [»] | |
6G8J | X-ray | 1.47 | P | 124-133 | [»] | |
6G8K | X-ray | 1.25 | P | 124-133 | [»] | |
6G8L | X-ray | 1.37 | P | 124-133 | [»] | |
6G8P | X-ray | 1.90 | P | 124-133 | [»] | |
6G8Q | X-ray | 1.85 | P | 124-132 | [»] | |
6GE3 | X-ray | 1.85 | L | 60-100 | [»] | |
6GE4 | X-ray | 1.97 | L | 60-100 | [»] | |
6GE5 | X-ray | 2.05 | L | 60-100 | [»] | |
6GE6 | X-ray | 1.80 | L | 60-100 | [»] | |
6GEC | X-ray | 1.70 | L | 60-99 | [»] | |
6GEE | X-ray | 1.96 | L | 60-99 | [»] | |
6GEG | X-ray | 2.23 | L | 60-99 | [»] | |
6GEI | X-ray | 1.65 | L | 60-100 | [»] | |
6GEK | X-ray | 2.28 | L/M | 60-100 | [»] | |
6HIK | X-ray | 1.65 | L | 60-99 | [»] | |
6HIL | X-ray | 2.30 | L/M/N/O | 60-100 | [»] | |
6Q2X | X-ray | 2.10 | L | 60-100 | [»] | |
SMRi | P46937 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115684, 689 interactors |
ComplexPortali | CPX-256, YAP1-TEAD1 complex |
CORUMi | P46937 |
DIPi | DIP-40839N |
ELMi | P46937 |
IntActi | P46937, 117 interactors |
MINTi | P46937 |
STRINGi | 9606.ENSP00000478927 |
Chemistry databases
ChEMBLi | CHEMBL3334415 |
PTM databases
GlyGeni | P46937, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P46937 |
MetOSitei | P46937 |
PhosphoSitePlusi | P46937 |
Genetic variation databases
BioMutai | YAP1 |
DMDMi | 294862479 |
Proteomic databases
EPDi | P46937 |
jPOSTi | P46937 |
MassIVEi | P46937 |
MaxQBi | P46937 |
PaxDbi | P46937 |
PeptideAtlasi | P46937 |
PRIDEi | P46937 |
ProteomicsDBi | 23425 25812 5134 55772 [P46937-1] 55773 [P46937-2] 55774 [P46937-3] |
Protocols and materials databases
Antibodypediai | 3994, 947 antibodies from 43 providers |
DNASUi | 10413 |
Genome annotation databases
Organism-specific databases
CTDi | 10413 |
DisGeNETi | 10413 |
GeneCardsi | YAP1 |
HGNCi | HGNC:16262, YAP1 |
HPAi | ENSG00000137693, Low tissue specificity |
MalaCardsi | YAP1 |
MIMi | 120433, phenotype 606608, gene |
neXtProti | NX_P46937 |
OpenTargetsi | ENSG00000137693 |
Orphaneti | 157791, Epithelioid hemangioendothelioma 1473, Uveal coloboma-cleft lip and palate-intellectual disability |
PharmGKBi | PA38103 |
VEuPathDBi | HostDB:ENSG00000137693 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0940, Eukaryota |
GeneTreei | ENSGT00510000046760 |
HOGENOMi | CLU_041917_0_1_1 |
InParanoidi | P46937 |
OMAi | DPNQHNP |
OrthoDBi | 1006566at2759 |
PhylomeDBi | P46937 |
TreeFami | TF326941 |
Enzyme and pathway databases
PathwayCommonsi | P46937 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-2028269, Signaling by Hippo R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P46937 |
SIGNORi | P46937 |
Miscellaneous databases
BioGRID-ORCSi | 10413, 147 hits in 1040 CRISPR screens |
ChiTaRSi | YAP1, human |
EvolutionaryTracei | P46937 |
GeneWikii | YAP1 |
GenomeRNAii | 10413 |
Pharosi | P46937, Tbio |
PROi | PR:P46937 |
RNActi | P46937, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137693, Expressed in pigmented layer of retina and 236 other tissues |
ExpressionAtlasi | P46937, baseline and differential |
Genevisiblei | P46937, HS |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
DisProti | DP00702 |
IDEALi | IID00304 |
InterProi | View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00397, WW, 2 hits |
SMARTi | View protein in SMART SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | YAP1_HUMAN | |
Accessioni | P46937Primary (citable) accession number: P46937 Secondary accession number(s): B4DTY1 Q8IUY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 23, 2022 | |
This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries