YAP1

Functionⁱ

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).6 Publications

Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).1 Publication

GO - Molecular functionⁱ

activating transcription factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 20123905
- 20368466
chromatin binding Source: Ensembl
proline-rich region binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein heterodimerization activity
Source: CAFA
Inferred from physical interactionⁱ
- 20123905
- 20368466
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18158288
- 18280240
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18158288
transcription factor activity, RNA polymerase II transcription factor binding Source: Ensembl
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18280240

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bud elongation involved in lung branching Source: Ensembl
cardiac muscle tissue regeneration Source: Ensembl
cell morphogenesis Source: Ensembl
cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 17974916
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 18280240
cellular response to gamma radiation
Source: UniProtKB
Inferred from direct assayⁱ
- 18280240
cellular response to retinoic acid Source: Ensembl
contact inhibition
Source: UniProtKB
Inferred from direct assayⁱ
- 17974916
embryonic heart tube morphogenesis Source: Ensembl
heart process Source: Ensembl
hippo signaling
Source: UniProtKB
Traceable author statementⁱ
- 18158288
keratinocyte differentiation Source: Ensembl
lateral mesoderm development Source: Ensembl
lung epithelial cell differentiation Source: Ensembl
negative regulation of epithelial cell differentiation Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
negative regulation of stem cell differentiation Source: Ensembl
notochord development Source: Ensembl
paraxial mesoderm development Source: Ensembl
positive regulation of canonical Wnt signaling pathway Source: Ensembl
positive regulation of cardiac muscle cell proliferation Source: Ensembl
positive regulation of intracellular estrogen receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 16772533
positive regulation of stem cell population maintenance Source: Ensembl
positive regulation of transcription, DNA-templated
Source: CAFA
Inferred from direct assayⁱ
- 20368466
positive regulation of transcription by RNA polymerase II
Source: CAFA
Inferred from direct assayⁱ
- 25796446
progesterone receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 16772533
protein-containing complex assembly
Source: CAFA
Inferred from direct assayⁱ
- 20368466
regulation of hematopoietic stem cell differentiation Source: Reactome
regulation of keratinocyte proliferation Source: Ensembl
regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
regulation of neurogenesis
Source: MGI
Inferred from direct assayⁱ
- 25433207
regulation of stem cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 25433207
response to progesterone
Source: UniProtKB
Inferred from direct assayⁱ
- 16772533
somatic stem cell population maintenance Source: Ensembl
tissue homeostasis Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome
vasculogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-2028269 Signaling by Hippo R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973 RUNX2 regulates osteoblast differentiation R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SignaLinkⁱ	P46937
SIGNORⁱ	P46937

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcriptional coactivator YAP1 Short name: Yes-associated protein 1 Alternative name(s): Protein yorkie homolog Yes-associated protein YAP65 homolog
Gene namesⁱ	Name:YAP1 Synonyms:YAP65
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137693.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16262 YAP1
MIMⁱ	606608 gene
neXtProtⁱ	NX_P46937

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid-frequency hearing loss.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	61	S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-109; A-127 and A-164. 1 Publication	1
Mutagenesisⁱ	80	V → A: No change in interaction with TEAD4. Reduced interaction with TEAD4 and transforming ability; when associated with A-84 and A-85. 1 Publication	1
Mutagenesisⁱ	84	V → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-85. 1 Publication	1
Mutagenesisⁱ	85	P → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-84. 1 Publication	1
Mutagenesisⁱ	86	M → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	89	R → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	91	L → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	94	S → A: Loss of interaction with TEAD1, TEAD2, TEAD3 and TEAD4. Loss of transcriptional coactivation activity towards TEAD1, TEAD2, TEAD3 and TEAD4 but no effect on its activity towards RUNX2 and ERBB4. 2 Publications	1
Mutagenesisⁱ	95	F → A: Complete loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	96	F → A: Loss of interaction with TEAD1. 1 Publication	1
Mutagenesisⁱ	109	S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-127 and A-164. 1 Publication	1
Mutagenesisⁱ	122	H → A, R, N or K: Loss of phosphorylation by LATS1. 2 Publications	1
Mutagenesisⁱ	122	H → L or Y: Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB. 2 Publications	1
Mutagenesisⁱ	124	R → A: Loss of phosphorylation by LATS1. 1 Publication	1
Mutagenesisⁱ	127	S → A: Reduced phosphorylation by LATS2, loss of phosphorylation by LATS1, loss of interaction with YWHAB, decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4. In YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109; A-127 and A-164. 4 Publications	1
Mutagenesisⁱ	129	P → D: No effect on phosphorylation but loss of interaction with YWHAB. 1 Publication	1
Mutagenesisⁱ	164	S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109 and A-127. 1 Publication	1
Mutagenesisⁱ	199	W → A: Loss of interaction with ERBB4 and loss of transcriptional coactivation function toward CTF; when associated with A-202. 1 Publication	1
Mutagenesisⁱ	202	P → A: Loss of interaction with ERBB4 and loss of transcriptional coactivation function toward CTF; when associated with A-199. 1 Publication	1
Mutagenesisⁱ	397	S → A: Loss of phosphorylation by LATS1. 1 Publication	1
Mutagenesisⁱ	407	Y → E: Enhanced interaction with TP73. 1 Publication	1
Mutagenesisⁱ	407	Y → F: No phosphorylation by ABL1 and partial loss of binding to TP73. 1 Publication	1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10413
MalaCards human disease database More...MalaCardsⁱ	YAP1
MIMⁱ	120433 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000137693
Orphanetⁱ	1473 Uveal coloboma - cleft lip and palate - intellectual disability
PharmGKBⁱ	PA38103

Polymorphism and mutation databases

BioMutaⁱ	YAP1
DMDMⁱ	294862479

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076071	1 – 504	Transcriptional coactivator YAP1Add BLAST		504

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	61	Phosphoserine; by LATS1 and LATS2Combined sources2 Publications	1
Modified residueⁱ	63	PhosphothreonineCombined sources	1
Modified residueⁱ	105	PhosphoserineBy similarity	1
Modified residueⁱ	109	Phosphoserine; by LATS1 and LATS2Combined sources2 Publications	1
Modified residueⁱ	110	PhosphothreonineBy similarity	1
Modified residueⁱ	119	Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	127	Phosphoserine; by LATS1 and LATS2Combined sources4 Publications	1
Modified residueⁱ	128	PhosphoserineCombined sources	1
Modified residueⁱ	131	PhosphoserineCombined sources	1
Modified residueⁱ	138	Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	154	Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	164	Phosphoserine; by LATS1 and LATS22 Publications	1
Modified residueⁱ	274	PhosphoserineCombined sources	1
Modified residueⁱ	289	PhosphoserineCombined sources	1
Modified residueⁱ	367	Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication	1
Modified residueⁱ	371	PhosphoserineCombined sources	1
Modified residueⁱ	381	PhosphoserineCombined sources	1
Modified residueⁱ	382	PhosphoserineCombined sources	1
Modified residueⁱ	388	PhosphoserineCombined sources	1
Modified residueⁱ	397	Phosphoserine; by LATS1 and LATS24 Publications	1
Modified residueⁱ	400	Phosphoserine; by CK11 Publication	1
Modified residueⁱ	403	Phosphoserine; by CK11 Publication	1
Modified residueⁱ	407	Phosphotyrosine; by ABL11 Publication	1
Modified residueⁱ	412	Phosphothreonine; by MAPK8 and MAPK91 Publication	1

Post-translational modificationⁱ

Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).4 Publications

Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P46937
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P46937
PaxDbⁱ	P46937
PeptideAtlas More...PeptideAtlasⁱ	P46937
PRIDEⁱ	P46937
ProteomicsDBⁱ	55772 55773 [P46937-2] 55774 [P46937-3]

PTM databases

iPTMnetⁱ	P46937
PhosphoSitePlusⁱ	P46937

Expressionⁱ

Tissue specificityⁱ

Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000137693 Expressed in 225 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_YAP1
ExpressionAtlasⁱ	P46937 baseline and differential
Genevisibleⁱ	P46937 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009370 CAB069915 HPA038885 HPA070359

HPAⁱ

CAB009370
CAB069915
HPA038885
HPA070359

Interactionⁱ

Subunit structureⁱ

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916). Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288). Interacts with LATS2 (PubMed:18158288). Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2) (PubMed:12807903). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908). Interacts with TP73 (PubMed:18280240). Interacts with RUNX1 (PubMed:18280240). Interacts with HCK (PubMed:17535448). Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).By similarity10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AXIN1	O15169	11	EBI-1044059,EBI-710484
Axin1	O35625	3	EBI-1044059,EBI-2365912	From Mus musculus.
CTNNB1	P35222	13	EBI-1044059,EBI-491549
DDX17	Q92841	7	EBI-1044059,EBI-746012
ERBB4	Q15303	3	EBI-1044059,EBI-80371
LATS1	O95835	9	EBI-1044059,EBI-444209
MAP2K1	Q02750	3	EBI-1044059,EBI-492564
PRKAA1	Q13131	3	EBI-1044059,EBI-1181405
Prkaa1	Q5EG47	2	EBI-1044059,EBI-7282395	From Mus musculus.
PRRG2	O14669	5	EBI-1044059,EBI-9824765
PTCH1	Q13635	3	EBI-1044059,EBI-8775406
PTPN14	Q15678	7	EBI-1044059,EBI-1237156
RAB11A	P62491	2	EBI-1044059,EBI-745098
RUNX1	Q01196	3	EBI-1044059,EBI-925904
SMAD1	Q15797	3	EBI-1044059,EBI-1567153
SMAD7	O15105	7	EBI-1044059,EBI-3861591
SOCS6	O14544	2	EBI-1044059,EBI-3929549
TBX5	Q99593	4	EBI-1044059,EBI-297043
TEAD1	P28347	10	EBI-1044059,EBI-529156
TEAD2	Q15562	5	EBI-1044059,EBI-6427252
TEAD4	Q15561	10	EBI-1044059,EBI-747736
TP53BP2	Q13625-2	9	EBI-1044059,EBI-287091
TP73	O15350	3	EBI-1044059,EBI-389606
TP73	O15350-1	7	EBI-1044059,EBI-389619
WBP1	Q96G27	3	EBI-1044059,EBI-3867685
Wbp1	P97764	13	EBI-1044059,EBI-6304160	From Mus musculus.
WBP2	Q969T9	7	EBI-1044059,EBI-727055
YWHAB	P31946	6	EBI-1044059,EBI-359815
YWHAE	P62258	5	EBI-1044059,EBI-356498
YWHAZ	P63104	8	EBI-1044059,EBI-347088

GO - Molecular functionⁱ

activating transcription factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 20123905
- 20368466
proline-rich region binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein heterodimerization activity
Source: CAFA
Inferred from physical interactionⁱ
- 20123905
- 20368466

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115684, 271 interactors
ComplexPortalⁱ	CPX-256 YAP1-TEAD1 complex
CORUMⁱ	P46937
Database of interacting proteins More...DIPⁱ	DIP-40839N
ELMⁱ	P46937
IntActⁱ	P46937, 97 interactors
Molecular INTeraction database More...MINTⁱ	P46937
STRINGⁱ	9606.ENSP00000282441

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	52 – 57	Combined sources	6
Helixⁱ	65 – 73	Combined sources	9
Helixⁱ	75 – 77	Combined sources	3
Helixⁱ	86 – 88	Combined sources	3
Helixⁱ	93 – 96	Combined sources	4
Beta strandⁱ	169 – 171	Combined sources	3
Beta strandⁱ	177 – 181	Combined sources	5
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	187 – 191	Combined sources	5
Turnⁱ	192 – 195	Combined sources	4
Beta strandⁱ	196 – 200	Combined sources	5
Helixⁱ	202 – 206	Combined sources	5
Beta strandⁱ	233 – 235	Combined sources	3
Beta strandⁱ	238 – 241	Combined sources	4
Turnⁱ	242 – 244	Combined sources	3
Beta strandⁱ	245 – 250	Combined sources	6
Turnⁱ	251 – 254	Combined sources	4
Beta strandⁱ	255 – 259	Combined sources	5

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00702
ProteinModelPortalⁱ	P46937
SMRⁱ	P46937
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P46937

EvolutionaryTraceⁱ

P46937

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	171 – 204	WW 1PROSITE-ProRule annotationAdd BLAST		34
Domainⁱ	230 – 263	WW 2PROSITE-ProRule annotationAdd BLAST		34

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	291 – 504	Transactivation domainAdd BLAST		214

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	86 – 100	1 PublicationAdd BLAST		15
Coiled coilⁱ	298 – 359	Sequence analysisAdd BLAST		62

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	3 – 49	Pro-richAdd BLAST		47

Domainⁱ

The first coiled-coil region mediates most of the interaction with TEAD transcription factors.1 Publication

Sequence similaritiesⁱ

Belongs to the YAP1 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0940 Eukaryota COG5021 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046760
HOGENOMⁱ	HOG000007854
HOVERGENⁱ	HBG002748
InParanoidⁱ	P46937
KEGG Orthology (KO) More...KOⁱ	K16687
OMAⁱ	DQTTTWQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G095A
PhylomeDBⁱ	P46937
TreeFamⁱ	TF326941

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 2 hits
InterProⁱ	View protein in InterPro IPR001202 WW_dom IPR036020 WW_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00456 WW, 2 hits
SUPFAMⁱ	SSF51045 SSF51045, 2 hits
PROSITEⁱ	View protein in PROSITE PS01159 WW_DOMAIN_1, 2 hits PS50020 WW_DOMAIN_2, 2 hits

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Isoforms of the YAP1-1 form contain only one WW domain.

This entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P46937-1) [UniParc]FASTA Add to basket

Also known as: YAP1-2gamma, YAP2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS 
       360        370        380        390        400
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS 
       410        420        430        440        450
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG 
       460        470        480        490        500
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF 

LTWL

Length:504

Mass (Da):54,462

Last modified:April 20, 2010 - v2

Checksum:ⁱ6145F7049ED338AE

GO

Isoform 2 (identifier: P46937-2) [UniParc]FASTA Add to basket

Also known as: YAP1-2alpha, YAP2

The sequence of this isoform differs from the canonical sequence as follows:
328-343: Missing.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQEL ALRSQLPTLE QDGGTQNPVS 
       360        370        380        390        400
SPGMSQELRT MTTNSSDPFL NSGTYHSRDE STDSGLSMSS YSVPRTPDDF 
       410        420        430        440        450
LNSVDEMDTG DTINQSTLPS QQNRFPDYLE AIPGTNVDLG TLEGDGMNIE 
       460        470        480 
GEELMPSLQE ALSSDILNDM ESVLAATKLD KESFLTWL

Show »

Length:488

Mass (Da):52,748

Checksum:ⁱ675CC207C83A311E

GO

Isoform 3 (identifier: P46937-3) [UniParc]FASTA Add to basket

Also known as: YAP1-1beta

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.
329-343: AMRNINPSTANSPKC → VRP

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ VRPQELALRS 
       310        320        330        340        350
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS 
       360        370        380        390        400
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG 
       410        420        430        440        450
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF 

LTWL

Show »

Length:454

Mass (Da):48,755

Checksum:ⁱ87CB840D3393EFC0

GO

Isoform 4 (identifier: P46937-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-178: Missing.

« Hide

        10         20         30         40         50
MAKTSSGQRY FLNHIDQTTT WQDPRKAMLS QMNVTAPTSP PVQQNMMNSA 
        60         70         80         90        100
SGPLPDGWEQ AMTQDGEIYY INHKNKTTSW LDPRLDPRFA MNQRISQSAP 
       110        120        130        140        150
VKQPPPLAPQ SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ 
       160        170        180        190        200
AMRNINPSTA NSPKCQELAL RSQLPTLEQD GGTQNPVSSP GMSQELRTMT 
       210        220        230        240        250
TNSSDPFLNS GTYHSRDEST DSGLSMSSYS VPRTPDDFLN SVDEMDTGDT 
       260        270        280        290        300
INQSTLPSQQ NRFPDYLEAI PGTNVDLGTL EGDGMNIEGE ELMPSLQEAL 
       310        320 
SSDILNDMES VLAATKLDKE SFLTWL

Note: No experimental confirmation available.

Show »

Length:326

Mass (Da):36,232

Checksum:ⁱ5C94DABAC6D74ABA

GO

Isoform 5 (identifier: P46937-5) [UniParc]FASTA Add to basket

Also known as: YAP1-1alpha

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.
328-343: Missing.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ ELALRSQLPT 
       310        320        330        340        350
LEQDGGTQNP VSSPGMSQEL RTMTTNSSDP FLNSGTYHSR DESTDSGLSM 
       360        370        380        390        400
SSYSVPRTPD DFLNSVDEMD TGDTINQSTL PSQQNRFPDY LEAIPGTNVD 
       410        420        430        440        450
LGTLEGDGMN IEGEELMPSL QEALSSDILN DMESVLAATK LDKESFLTWL

Show »

Length:450

Mass (Da):48,275

Checksum:ⁱ295934FD185E7C59

GO

Isoform 6 (identifier: P46937-6) [UniParc]FASTA Add to basket

Also known as: YAP1-1gamma

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ AMRNINPSTA 
       310        320        330        340        350
NSPKCQELAL RSQLPTLEQD GGTQNPVSSP GMSQELRTMT TNSSDPFLNS 
       360        370        380        390        400
GTYHSRDEST DSGLSMSSYS VPRTPDDFLN SVDEMDTGDT INQSTLPSQQ 
       410        420        430        440        450
NRFPDYLEAI PGTNVDLGTL EGDGMNIEGE ELMPSLQEAL SSDILNDMES 
       460 
VLAATKLDKE SFLTWL

Show »

Length:466

Mass (Da):49,989

Checksum:ⁱF1E76E6DEB3F93C0

GO

Isoform 7 (identifier: P46937-7) [UniParc]FASTA Add to basket

Also known as: YAP1-1delta

The sequence of this isoform differs from the canonical sequence as follows:
230-267: Missing.
328-328: Q → QVRPQ

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASA MNQRISQSAP VKQPPPLAPQ 
       260        270        280        290        300
SPQGGVMGGS NSNQQQQMRL QQLQMEKERL RLKQQELLRQ VRPQAMRNIN 
       310        320        330        340        350
PSTANSPKCQ ELALRSQLPT LEQDGGTQNP VSSPGMSQEL RTMTTNSSDP 
       360        370        380        390        400
FLNSGTYHSR DESTDSGLSM SSYSVPRTPD DFLNSVDEMD TGDTINQSTL 
       410        420        430        440        450
PSQQNRFPDY LEAIPGTNVD LGTLEGDGMN IEGEELMPSL QEALSSDILN 
       460        470
DMESVLAATK LDKESFLTWL

Show »

Length:470

Mass (Da):50,469

Checksum:ⁱ8935AAD2FA859F62

GO

Isoform 8 (identifier: P46937-8) [UniParc]FASTA Add to basket

Also known as: YAP1-2beta

The sequence of this isoform differs from the canonical sequence as follows:
329-343: AMRNINPSTANSPKC → VRP

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQVR PQELALRSQL PTLEQDGGTQ 
       360        370        380        390        400
NPVSSPGMSQ ELRTMTTNSS DPFLNSGTYH SRDESTDSGL SMSSYSVPRT 
       410        420        430        440        450
PDDFLNSVDE MDTGDTINQS TLPSQQNRFP DYLEAIPGTN VDLGTLEGDG 
       460        470        480        490 
MNIEGEELMP SLQEALSSDI LNDMESVLAA TKLDKESFLT WL

Show »

Length:492

Mass (Da):53,228

Checksum:ⁱ289722956D96193A

GO

Isoform 9 (identifier: P46937-9) [UniParc]FASTA Add to basket

Also known as: YAP1-2delta

The sequence of this isoform differs from the canonical sequence as follows:
328-328: Q → QVRPQ

« Hide

        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQVR PQAMRNINPS TANSPKCQEL 
       360        370        380        390        400
ALRSQLPTLE QDGGTQNPVS SPGMSQELRT MTTNSSDPFL NSGTYHSRDE 
       410        420        430        440        450
STDSGLSMSS YSVPRTPDDF LNSVDEMDTG DTINQSTLPS QQNRFPDYLE 
       460        470        480        490        500
AIPGTNVDLG TLEGDGMNIE GEELMPSLQE ALSSDILNDM ESVLAATKLD 

KESFLTWL

Note: Highest expression in ovary and placenta, lowest in skeletal muscle and brain.

Show »

Length:508

Mass (Da):54,942

Checksum:ⁱCFCC0BD04A27060B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YCI3	H0YCI3_HUMAN		Transcriptional coactivator YAP1 Transcriptional coactivator YAP1	YAP1	258	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071125	139	P → L1 PublicationCorresponds to variant dbSNP:rs1162286204Ensembl.	1
Natural variantⁱVAR_071126	227	S → L1 PublicationCorresponds to variant dbSNP:rs376161041Ensembl.	1
Natural variantⁱVAR_071127	330	M → V1 PublicationCorresponds to variant dbSNP:rs777949318Ensembl.	1
Natural variantⁱVAR_071128	462	G → E1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045190	1 – 178	Missing in isoform 4. 1 PublicationAdd BLAST	178
Alternative sequenceⁱVSP_039053	230 – 267	Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST	38
Alternative sequenceⁱVSP_039054	328 – 343	Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_053483	328	Q → QVRPQ in isoform 7 and isoform 9. 1 Publication	1
Alternative sequenceⁱVSP_039055	329 – 343	AMRNI…NSPKC → VRP in isoform 3 and isoform 8. 1 PublicationAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80507 Genomic DNA Translation: CAA56672.1 AY316529 mRNA Translation: AAP92710.1 AB567720 mRNA Translation: BAJ41471.1 AB567721 mRNA Translation: BAJ41472.1 AK300414 mRNA Translation: BAG62143.1 AK316116 mRNA Translation: BAH14487.1 AP000942 Genomic DNA No translation available. AP001527 Genomic DNA No translation available. AP002777 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67011.1 CH471065 Genomic DNA Translation: EAW67015.1 BC038235 mRNA Translation: AAH38235.1 HE864159 mRNA Translation: CCI79618.1 HE864160 mRNA Translation: CCI79619.1 HE864161 mRNA Translation: CCI79620.1 HE864162 mRNA Translation: CCI79621.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44716.1 [P46937-1] CCDS53699.1 [P46937-2] CCDS53700.1 [P46937-4] CCDS60944.1 [P46937-8] CCDS60945.1 [P46937-3] CCDS73373.1 [P46937-9] CCDS73374.1 [P46937-7] CCDS8314.2 [P46937-5]
PIRⁱ	A56954
NCBI Reference Sequences More...RefSeqⁱ	NP_001123617.1, NM_001130145.2 [P46937-1] NP_001181973.1, NM_001195044.1 [P46937-2] NP_001181974.1, NM_001195045.1 [P46937-4] NP_001269026.1, NM_001282097.1 [P46937-6] NP_001269027.1, NM_001282098.1 [P46937-3] NP_001269028.1, NM_001282099.1 [P46937-7] NP_001269029.1, NM_001282100.1 [P46937-8] NP_001269030.1, NM_001282101.1 [P46937-9]
UniGeneⁱ	Hs.503692

Genome annotation databases

Ensemblⁱ	ENST00000282441; ENSP00000282441; ENSG00000137693 [P46937-1] ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7] ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4] ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5] ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2] ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8] ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9] ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3]
GeneIDⁱ	10413
KEGGⁱ	hsa:10413
UCSC genome browser More...UCSCⁱ	uc001pgt.3 human [P46937-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P46937	YAP1 isoform 2		PANTR		504	UniRef100_P46937
YAP1 isoform 2		PONAB		504
P46937-2	YAP1 isoform 7		PANTR		488	UniRef100_K7CIP4
YAP1 isoform 8		PONAB		488
Uncharacterized protein		MANLE		442
UPI0004F40397		HUMAN		310
UPI0005F3D2C2		MANLE		416
P46937-3	Yes-associated protein 1, 65kDa, isoform CRA_b		HUMAN		454	UniRef100_A0A024R3E4
YAP1 isoform 7		PONAB		454
YAP1 isoform 6		PANTR		454
UPI0006C9B7A2		PANPA		382
UPI0008F48B47		GORGO		276
P46937-4	Uncharacterized protein		MACFA		506	UniRef100_A0A2K5W4U5
Uncharacterized protein		CERAT		506
Uncharacterized protein		MACNE		506
YAP1 isoform 9		PONAB		326
YAP1 isoform 8		PANTR		326
+3
P46937-5	YAP1 isoform 4		PANTR		450	UniRef100_K7BI95
YAP1 isoform 4		PONAB		450
UPI0006C9A493		PANPA		378
UPI0008F4B0DA		GORGO		272
P46937-7	YAP1 isoform 3		PANTR		470	UniRef100_A0A2I3RHJ4
YAP1 isoform 3		PONAB		470
UPI0008F463EB		GORGO		292
UPI0006C95E11		PANPA		398
P46937-8	YAP1 isoform 1		PANTR		492	UniRef100_K7DF44
YAP1 isoform 1		PONAB		492
UPI0006C9C16C		PANPA		420
UPI0004F42385		RHIBE		314
P46937-9	YAP1 isoform 5		PANTR		508	UniRef100_H2Q4M4
YAP1 isoform 5		PONAB		508

Protein	Similar proteins		Species	Score	Length	Source
P46937	YAP1 isoform 2		PANTR		504	UniRef90_P46937
YAP1 isoform 2		PONAB		504
transcriptional coactivator YAP1 isoform X4		PHYCD		505
transcriptional coactivator YAP1 isoform X4		TURTR		505
Uncharacterized protein		PROCO		504
+11
P46937-2	Uncharacterized protein		PELSI		475	UniRef90_K7FW13
transcriptional coactivator YAP1 isoform X7		DELLE		491
transcriptional coactivator YAP1 isoform X7		PHYCD		491
transcriptional coactivator YAP1 isoform X7		TURTR		491
Uncharacterized protein		MACFA		490
+100
P46937-3	Isoform 6 of Transcriptional coactivator YAP1		HUMAN		466	UniRef90_P46937-6
transcriptional coactivator YAP1 isoform X9		TURTR		471
YAP1 isoform 3		PANTR		470
YAP1 isoform 3		PONAB		470
Uncharacterized protein		PROCO		470
+82
P46937-4	Uncharacterized protein		PAPAN		506	UniRef90_A0A2I3MM76
Uncharacterized protein		MACFA		506
Uncharacterized protein		CERAT		506
Uncharacterized protein		MACNE		506
YAP1 isoform 9		PONAB		326
+20
P46937-5	Transcriptional coactivator YAP1		CHICK		447	UniRef90_A0A1D5NXI5
yorkie homolog isoform X3		LIPVE		459
transcriptional coactivator YAP1 isoform X12		TURTR		451
YAP1 isoform 4		PANTR		450
YAP1 isoform 4		PONAB		450
+28
P46937-6	transcriptional coactivator YAP1 isoform X9		TURTR		471	UniRef90_P46937-6
YAP1 isoform 3		PANTR		470
YAP1 isoform 3		PONAB		470
Isoform 7 of Transcriptional coactivator YAP1		HUMAN		470
Uncharacterized protein		PROCO		470
+82
P46937-7	Isoform 6 of Transcriptional coactivator YAP1		HUMAN		466	UniRef90_P46937-6
transcriptional coactivator YAP1 isoform X9		TURTR		471
YAP1 isoform 3		PANTR		470
YAP1 isoform 3		PONAB		470
Uncharacterized protein		PROCO		470
+82
P46937-8	Uncharacterized protein		MANLE		497	UniRef90_A0A2K6A3S4
Uncharacterized protein		PANPA		512
YAP1 isoform 11 (Fragment)		PONAB		257
YAP1 isoform 10 (Fragment)		PANTR		257
Yes-associated protein isoform 9 (Fragment)		HUMAN		168
+42
P46937-9	YAP1 isoform 5		PANTR		508	UniRef90_H2Q4M4
YAP1 isoform 5		PONAB		508
transcriptional coactivator YAP1 isoform X1		DELLE		511
transcriptional coactivator YAP1 isoform X1		PHYCD		511
transcriptional coactivator YAP1 isoform X1		TURTR		511
+204

Protein	Similar proteins		Species	Score	Length	Source
P46937	YAP1 isoform 2		PANTR		504	UniRef50_P46937
YAP1 isoform 2		PONAB		504
transcriptional coactivator YAP1 isoform X4		PHYCD		505
transcriptional coactivator YAP1 isoform X4		TURTR		505
Uncharacterized protein		PROCO		504
+40
P46937-2	Isoform 2 of Transcriptional coactivator YAP1		MOUSE		472	UniRef50_P46938-2
Transcriptional coactivator YAP1		RAT		469
Uncharacterized protein		NOMLE		402
Yes associated protein 1		LOXAF		492
Uncharacterized protein		ICTTR		397
+219
P46937-3	Isoform 6 of Transcriptional coactivator YAP1		HUMAN		466	UniRef50_P46937-6
Transcriptional coactivator YAP1		DANRE		442
Transcriptional coactivator YAP1-A		XENLA		459
transcriptional coactivator YAP1 isoform X9		TURTR		471
Uncharacterized protein		MACMU		470
+145
P46937-4	Transcriptional coactivator YAP1	)	MOUSE		488	UniRef50_P46938
Transcriptional coactivator YAP1		RAT		428
Uncharacterized protein		PANPA		512
YAP1 isoform 11 (Fragment)		PONAB		257
YAP1 isoform 10 (Fragment)		PANTR		257
+312
P46937-5	Isoform 2 of Transcriptional coactivator YAP1		MOUSE		472	UniRef50_P46938-2
Transcriptional coactivator YAP1		RAT		469
Uncharacterized protein		NOMLE		402
Yes associated protein 1		LOXAF		492
Uncharacterized protein		ICTTR		397
+219
P46937-6	Transcriptional coactivator YAP1		DANRE		442	UniRef50_P46937-6
Transcriptional coactivator YAP1-A		XENLA		459
transcriptional coactivator YAP1 isoform X9		TURTR		471
Uncharacterized protein		MACMU		470
transcriptional coactivator YAP1 isoform X5		Florida manatee		470
+145
P46937-7	Isoform 6 of Transcriptional coactivator YAP1		HUMAN		466	UniRef50_P46937-6
Transcriptional coactivator YAP1		DANRE		442
Transcriptional coactivator YAP1-A		XENLA		459
transcriptional coactivator YAP1 isoform X9		TURTR		471
Uncharacterized protein		MACMU		470
+145
P46937-8	Transcriptional coactivator YAP1	)	MOUSE		488	UniRef50_P46938
Transcriptional coactivator YAP1		RAT		428
Uncharacterized protein		PANPA		512
YAP1 isoform 11 (Fragment)		PONAB		257
YAP1 isoform 10 (Fragment)		PANTR		257
+312
P46937-9	Transcriptional coactivator YAP1	)	MOUSE		488	UniRef50_P46938
Transcriptional coactivator YAP1		RAT		428
Uncharacterized protein		PANPA		512
YAP1 isoform 11 (Fragment)		PONAB		257
YAP1 isoform 10 (Fragment)		PANTR		257
+312

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Protein Spotlight

Shaping life - Issue 175 of January 2016

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80507 Genomic DNA Translation: CAA56672.1 AY316529 mRNA Translation: AAP92710.1 AB567720 mRNA Translation: BAJ41471.1 AB567721 mRNA Translation: BAJ41472.1 AK300414 mRNA Translation: BAG62143.1 AK316116 mRNA Translation: BAH14487.1 AP000942 Genomic DNA No translation available. AP001527 Genomic DNA No translation available. AP002777 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67011.1 CH471065 Genomic DNA Translation: EAW67015.1 BC038235 mRNA Translation: AAH38235.1 HE864159 mRNA Translation: CCI79618.1 HE864160 mRNA Translation: CCI79619.1 HE864161 mRNA Translation: CCI79620.1 HE864162 mRNA Translation: CCI79621.1
CCDSⁱ	CCDS44716.1 [P46937-1] CCDS53699.1 [P46937-2] CCDS53700.1 [P46937-4] CCDS60944.1 [P46937-8] CCDS60945.1 [P46937-3] CCDS73373.1 [P46937-9] CCDS73374.1 [P46937-7] CCDS8314.2 [P46937-5]
PIRⁱ	A56954
RefSeqⁱ	NP_001123617.1, NM_001130145.2 [P46937-1] NP_001181973.1, NM_001195044.1 [P46937-2] NP_001181974.1, NM_001195045.1 [P46937-4] NP_001269026.1, NM_001282097.1 [P46937-6] NP_001269027.1, NM_001282098.1 [P46937-3] NP_001269028.1, NM_001282099.1 [P46937-7] NP_001269029.1, NM_001282100.1 [P46937-8] NP_001269030.1, NM_001282101.1 [P46937-9]
UniGeneⁱ	Hs.503692

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JMQ	NMR	-	A	165-210	[»]
	1K5R	NMR	-	A	165-204	[»]
	1K9Q	NMR	-	A	165-204	[»]
	1K9R	NMR	-	A	165-204	[»]
	2LAW	NMR	-	A	230-263	[»]
	2LAX	NMR	-	A	170-205	[»]
	2LAY	NMR	-	A	170-205	[»]
	2LTV	NMR	-	A	230-265	[»]
	2LTW	NMR	-	A	170-205	[»]
	3KYS	X-ray	2.80	B/D	50-171	[»]
	3MHR	X-ray	1.15	P	124-133	[»]
	4RE1	X-ray	2.20	C/D	50-171	[»]
	4REX	X-ray	1.60	A	165-209	[»]
	5OAQ	X-ray	1.95	L	60-100	[»]
	5YDX	NMR	-	A	164-218	[»]
	5YDY	NMR	-	A	229-287	[»]
DisProtⁱ	DP00702
ProteinModelPortalⁱ	P46937
SMRⁱ	P46937
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115684, 271 interactors
ComplexPortalⁱ	CPX-256 YAP1-TEAD1 complex
CORUMⁱ	P46937
DIPⁱ	DIP-40839N
ELMⁱ	P46937
IntActⁱ	P46937, 97 interactors
MINTⁱ	P46937
STRINGⁱ	9606.ENSP00000282441

PTM databases

iPTMnetⁱ	P46937
PhosphoSitePlusⁱ	P46937

Polymorphism and mutation databases

BioMutaⁱ	YAP1
DMDMⁱ	294862479

Proteomic databases

EPDⁱ	P46937
MaxQBⁱ	P46937
PaxDbⁱ	P46937
PeptideAtlasⁱ	P46937
PRIDEⁱ	P46937
ProteomicsDBⁱ	55772 55773 [P46937-2] 55774 [P46937-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000282441; ENSP00000282441; ENSG00000137693 [P46937-1] ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7] ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4] ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5] ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2] ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8] ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9] ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3]
GeneIDⁱ	10413
KEGGⁱ	hsa:10413
UCSCⁱ	uc001pgt.3 human [P46937-1]

Organism-specific databases

CTDⁱ	10413
DisGeNETⁱ	10413
EuPathDBⁱ	HostDB:ENSG00000137693.13
GeneCardsⁱ	YAP1
HGNCⁱ	HGNC:16262 YAP1
HPAⁱ	CAB009370 CAB069915 HPA038885 HPA070359
MalaCardsⁱ	YAP1
MIMⁱ	120433 phenotype 606608 gene
neXtProtⁱ	NX_P46937
OpenTargetsⁱ	ENSG00000137693
Orphanetⁱ	1473 Uveal coloboma - cleft lip and palate - intellectual disability
PharmGKBⁱ	PA38103
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0940 Eukaryota COG5021 LUCA
GeneTreeⁱ	ENSGT00510000046760
HOGENOMⁱ	HOG000007854
HOVERGENⁱ	HBG002748
InParanoidⁱ	P46937
KOⁱ	K16687
OMAⁱ	DQTTTWQ
OrthoDBⁱ	EOG091G095A
PhylomeDBⁱ	P46937
TreeFamⁱ	TF326941

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-2028269 Signaling by Hippo R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973 RUNX2 regulates osteoblast differentiation R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SignaLinkⁱ	P46937
SIGNORⁱ	P46937

Miscellaneous databases

ChiTaRSⁱ	YAP1 human
EvolutionaryTraceⁱ	P46937
GeneWikiⁱ	YAP1
GenomeRNAiⁱ	10413
Protein Ontology More...PROⁱ	PR:P46937
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137693 Expressed in 225 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_YAP1
ExpressionAtlasⁱ	P46937 baseline and differential
Genevisibleⁱ	P46937 HS

Family and domain databases

CDDⁱ	cd00201 WW, 2 hits
InterProⁱ	View protein in InterPro IPR001202 WW_dom IPR036020 WW_dom_sf
Pfamⁱ	View protein in Pfam PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00456 WW, 2 hits
SUPFAMⁱ	SSF51045 SSF51045, 2 hits
PROSITEⁱ	View protein in PROSITE PS01159 WW_DOMAIN_1, 2 hits PS50020 WW_DOMAIN_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YAP1_HUMAN
Accessionⁱ	P46937Primary (citable) accession number: P46937 Secondary accession number(s): B4DTY1 Q8IUY9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	April 20, 2010
	Last modified:	October 10, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P46937 (YAP1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcriptional coactivator YAP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ