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UniProtKB - P46937 (YAP1_HUMAN)
Protein
Transcriptional coactivator YAP1
Gene
YAP1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097).
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288).
Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702).
Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288).
The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).
In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).
By similarity8 PublicationsActivates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
1 PublicationActivates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
1 PublicationGO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription factor binding Source: CAFA
- proline-rich region binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- transcription cis-regulatory region binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- bud elongation involved in lung branching Source: Ensembl
- cardiac muscle tissue regeneration Source: Ensembl
- cell morphogenesis Source: Ensembl
- cell population proliferation Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to gamma radiation Source: UniProtKB
- cellular response to retinoic acid Source: Ensembl
- contact inhibition Source: UniProtKB
- embryonic heart tube morphogenesis Source: Ensembl
- heart process Source: Ensembl
- hippo signaling Source: GO_Central
- interleukin-6-mediated signaling pathway Source: UniProtKB
- intestinal epithelial cell development Source: UniProtKB
- keratinocyte differentiation Source: Ensembl
- lateral mesoderm development Source: Ensembl
- lung epithelial cell differentiation Source: Ensembl
- negative regulation of cilium assembly Source: UniProtKB
- negative regulation of epithelial cell apoptotic process Source: CACAO
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of fat cell differentiation Source: ARUK-UCL
- negative regulation of gene expression Source: CACAO
- negative regulation of stem cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- notochord development Source: Ensembl
- paraxial mesoderm development Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of cardiac muscle cell proliferation Source: Ensembl
- positive regulation of cell growth Source: ComplexPortal
- positive regulation of epithelial cell proliferation Source: CACAO
- positive regulation of gene expression Source: CACAO
- positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of osteoblast differentiation Source: ARUK-UCL
- positive regulation of protein localization to nucleus Source: UniProtKB
- positive regulation of stem cell population maintenance Source: Ensembl
- positive regulation of transcription, DNA-templated Source: CAFA
- positive regulation of transcription by RNA polymerase II Source: CAFA
- progesterone receptor signaling pathway Source: UniProtKB
- protein-containing complex assembly Source: CAFA
- regulation of keratinocyte proliferation Source: Ensembl
- regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
- regulation of neurogenesis Source: MGI
- regulation of stem cell proliferation Source: MGI
- response to progesterone Source: UniProtKB
- somatic stem cell population maintenance Source: Ensembl
- tissue homeostasis Source: Ensembl
- trophectodermal cell differentiation Source: Ensembl
- vasculogenesis Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
| Molecular function | Activator, Repressor |
| Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
| PathwayCommonsi | P46937 |
| Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-2028269, Signaling by Hippo R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| SignaLinki | P46937 |
| SIGNORi | P46937 |
Names & Taxonomyi
| Protein namesi | Recommended name: Transcriptional coactivator YAP1Short name: Yes-associated protein 1 Alternative name(s): Protein yorkie homolog Yes-associated protein YAP65 homolog |
| Gene namesi | Name:YAP1 Synonyms:YAP65 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| HGNCi | HGNC:16262, YAP1 |
| MIMi | 606608, gene |
| neXtProti | NX_P46937 |
| VEuPathDBi | HostDB:ENSG00000137693 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 5 Publications
Nucleus
- Nucleus 9 Publications
Note: Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity).By similarity4 Publications
Cytosol
- cytosol Source: FlyBase
Nucleus
- female germ cell nucleus Source: Ensembl
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- TEAD-YAP complex Source: CAFA
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid-frequency hearing loss.
Related information in OMIMMutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 61 | S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-109; A-127 and A-164. 1 Publication | 1 | |
| Mutagenesisi | 80 | V → A: No change in interaction with TEAD4. Reduced interaction with TEAD4 and transforming ability; when associated with A-84 and A-85. 1 Publication | 1 | |
| Mutagenesisi | 84 | V → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-85. 1 Publication | 1 | |
| Mutagenesisi | 85 | P → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-84. 1 Publication | 1 | |
| Mutagenesisi | 86 | M → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
| Mutagenesisi | 89 | R → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
| Mutagenesisi | 91 | L → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
| Mutagenesisi | 94 | S → A: Loss of interaction with TEAD1, TEAD2, TEAD3 and TEAD4. Loss of transcriptional coactivation activity towards TEAD1, TEAD2, TEAD3 and TEAD4 but no effect on its activity towards RUNX2 and ERBB4. Abolishes suppression of ciliogenesis. 2 Publications | 1 | |
| Mutagenesisi | 95 | F → A: Complete loss of interaction with TEAD1. 1 Publication | 1 | |
| Mutagenesisi | 96 | F → A: Loss of interaction with TEAD1. 1 Publication | 1 | |
| Mutagenesisi | 109 | S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-127 and A-164. 1 Publication | 1 | |
| Mutagenesisi | 122 | H → A, R, N or K: Loss of phosphorylation by LATS1. 2 Publications | 1 | |
| Mutagenesisi | 122 | H → L or Y: Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB. 2 Publications | 1 | |
| Mutagenesisi | 124 | R → A: Loss of phosphorylation by LATS1. 1 Publication | 1 | |
| Mutagenesisi | 127 | S → A: Reduced phosphorylation by LATS2, loss of phosphorylation by LATS1, loss of interaction with YWHAB, decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4. In YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109; A-127 and A-164. 4 Publications | 1 | |
| Mutagenesisi | 129 | P → D: No effect on phosphorylation but loss of interaction with YWHAB. 1 Publication | 1 | |
| Mutagenesisi | 164 | S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109 and A-127. 1 Publication | 1 | |
| Mutagenesisi | 199 | W → A: Loss of interaction with ERBB4, loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4; when associated with A-202. 2 Publications | 1 | |
| Mutagenesisi | 202 | P → A: Loss of interaction with ERBB4, loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4; when associated with A-199. 2 Publications | 1 | |
| Mutagenesisi | 217 | S → A: No effect on interaction with PRRG4. 1 Publication | 1 | |
| Mutagenesisi | 258 | W → A: Reduced interaction with PRRG4; when associated with A-261. 1 Publication | 1 | |
| Mutagenesisi | 261 | P → A: Reduced interaction with PRRG4; when associated with A-258. 1 Publication | 1 | |
| Mutagenesisi | 397 | S → A: Loss of phosphorylation by LATS1. 1 Publication | 1 | |
| Mutagenesisi | 407 | Y → E: Enhanced interaction with TP73. 1 Publication | 1 | |
| Mutagenesisi | 407 | Y → F: No phosphorylation by ABL1 and partial loss of binding to TP73. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
| DisGeNETi | 10413 |
| MalaCardsi | YAP1 |
| MIMi | 120433, phenotype |
| OpenTargetsi | ENSG00000137693 |
| Orphaneti | 157791, Epithelioid hemangioendothelioma 1473, Uveal coloboma-cleft lip and palate-intellectual disability |
| PharmGKBi | PA38103 |
Miscellaneous databases
| Pharosi | P46937, Tbio |
Chemistry databases
| ChEMBLi | CHEMBL3334415 |
Genetic variation databases
| BioMutai | YAP1 |
| DMDMi | 294862479 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000076071 | 1 – 504 | Transcriptional coactivator YAP1Add BLAST | 504 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 61 | Phosphoserine; by LATS1 and LATS2Combined sources2 Publications | 1 | |
| Modified residuei | 63 | PhosphothreonineCombined sources | 1 | |
| Modified residuei | 105 | PhosphoserineBy similarity | 1 | |
| Modified residuei | 109 | Phosphoserine; by LATS1 and LATS2Combined sources2 Publications | 1 | |
| Modified residuei | 110 | PhosphothreonineBy similarity | 1 | |
| Modified residuei | 119 | Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
| Modified residuei | 127 | Phosphoserine; by LATS1 and LATS2Combined sources4 Publications | 1 | |
| Modified residuei | 128 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 138 | Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
| Modified residuei | 154 | Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
| Modified residuei | 164 | Phosphoserine; by LATS1 and LATS22 Publications | 1 | |
| Modified residuei | 274 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 289 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 367 | Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication | 1 | |
| Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 381 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 382 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 388 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 397 | Phosphoserine; by LATS1 and LATS24 Publications | 1 | |
| Modified residuei | 400 | Phosphoserine; by CK11 Publication | 1 | |
| Modified residuei | 403 | Phosphoserine; by CK11 Publication | 1 | |
| Modified residuei | 407 | Phosphotyrosine; by ABL11 Publication | 1 | |
| Modified residuei | 412 | Phosphothreonine; by MAPK8 and MAPK91 Publication | 1 |
Post-translational modificationi
Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).4 Publications
Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
| EPDi | P46937 |
| jPOSTi | P46937 |
| MassIVEi | P46937 |
| MaxQBi | P46937 |
| PaxDbi | P46937 |
| PeptideAtlasi | P46937 |
| PRIDEi | P46937 |
| ProteomicsDBi | 23425 25812 5134 55772 [P46937-1] 55773 [P46937-2] 55774 [P46937-3] |
PTM databases
| GlyGeni | P46937, 1 site, 1 O-linked glycan (1 site) |
| iPTMneti | P46937 |
| MetOSitei | P46937 |
| PhosphoSitePlusi | P46937 |
Expressioni
Tissue specificityi
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).3 Publications
Gene expression databases
| Bgeei | ENSG00000137693, Expressed in pigmented layer of retina and 236 other tissues |
| ExpressionAtlasi | P46937, baseline and differential |
| Genevisiblei | P46937, HS |
Organism-specific databases
| HPAi | ENSG00000137693, Low tissue specificity |
Interactioni
Subunit structurei
Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916).
Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288).
Interacts with LATS2 (PubMed:18158288).
Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908).
Interacts with TP73 (PubMed:18280240).
Interacts with RUNX1 (PubMed:18280240).
Interacts with HCK (PubMed:17535448).
Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).
Interacts (when phosphorylated at Ser-127) with SMAD2, SMAD3 and WWTR1 (By similarity).
Interacts with PRRG2 (via cytoplasmic domain) (PubMed:17502622).
Interacts (via WW domains) with PRRG4 (via cytoplasmic domain) (PubMed:23873930).
By similarity12 PublicationsBinary interactionsi
P46937
Isoform 1 [P46937-1]
| With | #Exp. | IntAct |
|---|---|---|
| PRRG4 [Q9BZD6] | 2 | EBI-26604877,EBI-3918643 |
Isoform 3 [P46937-3]
| With | #Exp. | IntAct |
|---|---|---|
| CTNNB1 [P35222] | 2 | EBI-6558686,EBI-491549 |
| PRRG4 [Q9BZD6] | 3 | EBI-6558686,EBI-3918643 |
GO - Molecular functioni
- DNA-binding transcription factor binding Source: CAFA
- proline-rich region binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
| BioGRIDi | 115684, 689 interactors |
| ComplexPortali | CPX-256, YAP1-TEAD1 complex |
| CORUMi | P46937 |
| DIPi | DIP-40839N |
| ELMi | P46937 |
| IntActi | P46937, 117 interactors |
| MINTi | P46937 |
| STRINGi | 9606.ENSP00000478927 |
Miscellaneous databases
| RNActi | P46937, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| SMRi | P46937 |
| ModBasei | Search... |
| PDBe-KBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | P46937 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 171 – 204 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
| Domaini | 230 – 263 | WW 2PROSITE-ProRule annotationAdd BLAST | 34 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 1 – 59 | DisorderedSequence analysisAdd BLAST | 59 | |
| Regioni | 91 – 114 | DisorderedSequence analysisAdd BLAST | 24 | |
| Regioni | 133 – 158 | DisorderedSequence analysisAdd BLAST | 26 | |
| Regioni | 275 – 309 | DisorderedSequence analysisAdd BLAST | 35 | |
| Regioni | 291 – 504 | Transactivation domainAdd BLAST | 214 | |
| Regioni | 355 – 407 | DisorderedSequence analysisAdd BLAST | 53 |
Coiled coil
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Coiled coili | 86 – 100 | 1 PublicationAdd BLAST | 15 | |
| Coiled coili | 298 – 359 | Sequence analysisAdd BLAST | 62 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Compositional biasi | 1 – 36 | Pro residuesSequence analysisAdd BLAST | 36 | |
| Compositional biasi | 292 – 309 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
The first coiled-coil region mediates most of the interaction with TEAD transcription factors.1 Publication
Sequence similaritiesi
Belongs to the YAP1 family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
| eggNOGi | KOG0940, Eukaryota |
| GeneTreei | ENSGT00510000046760 |
| HOGENOMi | CLU_041917_0_1_1 |
| InParanoidi | P46937 |
| OMAi | DPNQHNP |
| OrthoDBi | 1006566at2759 |
| PhylomeDBi | P46937 |
| TreeFami | TF326941 |
Family and domain databases
| CDDi | cd00201, WW, 2 hits |
| DisProti | DP00702 |
| IDEALi | IID00304 |
| InterProi | View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf |
| Pfami | View protein in Pfam PF00397, WW, 2 hits |
| SMARTi | View protein in SMART SM00456, WW, 2 hits |
| SUPFAMi | SSF51045, SSF51045, 2 hits |
| PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
Sequences (9+)i
Sequence statusi: Complete.
This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basketNote: Isoforms of the YAP1-1 form contain only one WW domain.
This entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P46937-1) [UniParc]FASTAAdd to basket
Also known as: YAP1-2gamma, YAP2L
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA
60 70 80 90 100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE
110 120 130 140 150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG
160 170 180 190 200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ
210 220 230 240 250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN
260 270 280 290 300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS
310 320 330 340 350
NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS
360 370 380 390 400
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS
410 420 430 440 450
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG
460 470 480 490 500
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF
LTWL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket| H0YCI3 | H0YCI3_HUMAN | Transcriptional coactivator YAP1 | YAP1 | 258 | Annotation score: |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_071125 | 139 | P → L1 PublicationCorresponds to variant dbSNP:rs1162286204Ensembl. | 1 | |
| Natural variantiVAR_071126 | 227 | S → L1 PublicationCorresponds to variant dbSNP:rs376161041Ensembl. | 1 | |
| Natural variantiVAR_071127 | 330 | M → V1 PublicationCorresponds to variant dbSNP:rs777949318Ensembl. | 1 | |
| Natural variantiVAR_071128 | 462 | G → E1 Publication | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_045190 | 1 – 178 | Missing in isoform 4. 1 PublicationAdd BLAST | 178 | |
| Alternative sequenceiVSP_039053 | 230 – 267 | Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 38 | |
| Alternative sequenceiVSP_039054 | 328 – 343 | Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST | 16 | |
| Alternative sequenceiVSP_053483 | 328 | Q → QVRPQ in isoform 7 and isoform 9. 1 Publication | 1 | |
| Alternative sequenceiVSP_039055 | 329 – 343 | AMRNI…NSPKC → VRP in isoform 3 and isoform 8. 1 PublicationAdd BLAST | 15 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
| Atlas of Genetics and Cytogenetics in Oncology and Haematology |
| Protein Spotlight Shaping life - Issue 175 of January 2016 |
Sequence databases
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1JMQ | NMR | - | A | 165-210 | [»] | |
| 1K5R | NMR | - | A | 165-204 | [»] | |
| 1K9Q | NMR | - | A | 165-204 | [»] | |
| 1K9R | NMR | - | A | 165-204 | [»] | |
| 2LAW | NMR | - | A | 230-263 | [»] | |
| 2LAX | NMR | - | A | 170-205 | [»] | |
| 2LAY | NMR | - | A | 170-205 | [»] | |
| 2LTV | NMR | - | A | 230-265 | [»] | |
| 2LTW | NMR | - | A | 170-205 | [»] | |
| 3KYS | X-ray | 2.80 | B/D | 50-171 | [»] | |
| 3MHR | X-ray | 1.15 | P | 124-133 | [»] | |
| 4RE1 | X-ray | 2.20 | C/D | 50-171 | [»] | |
| 4REX | X-ray | 1.60 | A | 165-209 | [»] | |
| 5OAQ | X-ray | 1.95 | L | 60-100 | [»] | |
| 5YDX | NMR | - | A | 164-218 | [»] | |
| 5YDY | NMR | - | A | 229-287 | [»] | |
| 6G6X | X-ray | 1.13 | P | 124-133 | [»] | |
| 6G8I | X-ray | 1.60 | P | 125-133 | [»] | |
| 6G8J | X-ray | 1.47 | P | 124-133 | [»] | |
| 6G8K | X-ray | 1.25 | P | 124-133 | [»] | |
| 6G8L | X-ray | 1.37 | P | 124-133 | [»] | |
| 6G8P | X-ray | 1.90 | P | 124-133 | [»] | |
| 6G8Q | X-ray | 1.85 | P | 124-132 | [»] | |
| 6GE3 | X-ray | 1.85 | L | 60-100 | [»] | |
| 6GE4 | X-ray | 1.97 | L | 60-100 | [»] | |
| 6GE5 | X-ray | 2.05 | L | 60-100 | [»] | |
| 6GE6 | X-ray | 1.80 | L | 60-100 | [»] | |
| 6GEC | X-ray | 1.70 | L | 60-99 | [»] | |
| 6GEE | X-ray | 1.96 | L | 60-99 | [»] | |
| 6GEG | X-ray | 2.23 | L | 60-99 | [»] | |
| 6GEI | X-ray | 1.65 | L | 60-100 | [»] | |
| 6GEK | X-ray | 2.28 | L/M | 60-100 | [»] | |
| 6HIK | X-ray | 1.65 | L | 60-99 | [»] | |
| 6HIL | X-ray | 2.30 | L/M/N/O | 60-100 | [»] | |
| 6Q2X | X-ray | 2.10 | L | 60-100 | [»] | |
| SMRi | P46937 | |||||
| ModBasei | Search... | |||||
| PDBe-KBi | Search... | |||||
Protein-protein interaction databases
| BioGRIDi | 115684, 689 interactors |
| ComplexPortali | CPX-256, YAP1-TEAD1 complex |
| CORUMi | P46937 |
| DIPi | DIP-40839N |
| ELMi | P46937 |
| IntActi | P46937, 117 interactors |
| MINTi | P46937 |
| STRINGi | 9606.ENSP00000478927 |
Chemistry databases
| ChEMBLi | CHEMBL3334415 |
PTM databases
| GlyGeni | P46937, 1 site, 1 O-linked glycan (1 site) |
| iPTMneti | P46937 |
| MetOSitei | P46937 |
| PhosphoSitePlusi | P46937 |
Genetic variation databases
| BioMutai | YAP1 |
| DMDMi | 294862479 |
Proteomic databases
| EPDi | P46937 |
| jPOSTi | P46937 |
| MassIVEi | P46937 |
| MaxQBi | P46937 |
| PaxDbi | P46937 |
| PeptideAtlasi | P46937 |
| PRIDEi | P46937 |
| ProteomicsDBi | 23425 25812 5134 55772 [P46937-1] 55773 [P46937-2] 55774 [P46937-3] |
Protocols and materials databases
| Antibodypediai | 3994, 947 antibodies from 43 providers |
| DNASUi | 10413 |
Genome annotation databases
Organism-specific databases
| CTDi | 10413 |
| DisGeNETi | 10413 |
| GeneCardsi | YAP1 |
| HGNCi | HGNC:16262, YAP1 |
| HPAi | ENSG00000137693, Low tissue specificity |
| MalaCardsi | YAP1 |
| MIMi | 120433, phenotype 606608, gene |
| neXtProti | NX_P46937 |
| OpenTargetsi | ENSG00000137693 |
| Orphaneti | 157791, Epithelioid hemangioendothelioma 1473, Uveal coloboma-cleft lip and palate-intellectual disability |
| PharmGKBi | PA38103 |
| VEuPathDBi | HostDB:ENSG00000137693 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG0940, Eukaryota |
| GeneTreei | ENSGT00510000046760 |
| HOGENOMi | CLU_041917_0_1_1 |
| InParanoidi | P46937 |
| OMAi | DPNQHNP |
| OrthoDBi | 1006566at2759 |
| PhylomeDBi | P46937 |
| TreeFami | TF326941 |
Enzyme and pathway databases
| PathwayCommonsi | P46937 |
| Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-2028269, Signaling by Hippo R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| SignaLinki | P46937 |
| SIGNORi | P46937 |
Miscellaneous databases
| BioGRID-ORCSi | 10413, 147 hits in 1040 CRISPR screens |
| ChiTaRSi | YAP1, human |
| EvolutionaryTracei | P46937 |
| GeneWikii | YAP1 |
| GenomeRNAii | 10413 |
| Pharosi | P46937, Tbio |
| PROi | PR:P46937 |
| RNActi | P46937, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000137693, Expressed in pigmented layer of retina and 236 other tissues |
| ExpressionAtlasi | P46937, baseline and differential |
| Genevisiblei | P46937, HS |
Family and domain databases
| CDDi | cd00201, WW, 2 hits |
| DisProti | DP00702 |
| IDEALi | IID00304 |
| InterProi | View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf |
| Pfami | View protein in Pfam PF00397, WW, 2 hits |
| SMARTi | View protein in SMART SM00456, WW, 2 hits |
| SUPFAMi | SSF51045, SSF51045, 2 hits |
| PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
| MobiDBi | Search... |
Entry informationi
| Entry namei | YAP1_HUMAN | |
| Accessioni | P46937Primary (citable) accession number: P46937 Secondary accession number(s): B4DTY1 Q8IUY9 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
| Last sequence update: | April 20, 2010 | |
| Last modified: | February 23, 2022 | |
| This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
