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UniProtKB - P46937 (YAP1_HUMAN)

Entry version 200 (18 Sep 2019)
Sequence version 2 (20 Apr 2010)
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Protein

Transcriptional coactivator YAP1

Gene

YAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).7 Publications
Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-2028269 Signaling by Hippo
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P46937

SIGNOR Signaling Network Open Resource

More...SIGNORi		P46937

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional coactivator YAP1
Short name:
Yes-associated protein 1
Alternative name(s):
Protein yorkie homolog
Yes-associated protein YAP65 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YAP1
Synonyms:YAP65
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16262 YAP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606608 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P46937

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid-frequency hearing loss.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi61S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-109; A-127 and A-164. 1 Publication1
Mutagenesisi80V → A: No change in interaction with TEAD4. Reduced interaction with TEAD4 and transforming ability; when associated with A-84 and A-85. 1 Publication1
Mutagenesisi84V → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-85. 1 Publication1
Mutagenesisi85P → A: Reduced interaction with TEAD4 and transforming ability; when associated with A-80 and A-84. 1 Publication1
Mutagenesisi86M → A: Complete loss of interaction with TEAD1. 1 Publication1
Mutagenesisi89R → A: Complete loss of interaction with TEAD1. 1 Publication1
Mutagenesisi91L → A: Complete loss of interaction with TEAD1. 1 Publication1
Mutagenesisi94S → A: Loss of interaction with TEAD1, TEAD2, TEAD3 and TEAD4. Loss of transcriptional coactivation activity towards TEAD1, TEAD2, TEAD3 and TEAD4 but no effect on its activity towards RUNX2 and ERBB4. 2 Publications1
Mutagenesisi95F → A: Complete loss of interaction with TEAD1. 1 Publication1
Mutagenesisi96F → A: Loss of interaction with TEAD1. 1 Publication1
Mutagenesisi109S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-127 and A-164. 1 Publication1
Mutagenesisi122H → A, R, N or K: Loss of phosphorylation by LATS1. 2 Publications1
Mutagenesisi122H → L or Y: Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB. 2 Publications1
Mutagenesisi124R → A: Loss of phosphorylation by LATS1. 1 Publication1
Mutagenesisi127S → A: Reduced phosphorylation by LATS2, loss of phosphorylation by LATS1, loss of interaction with YWHAB, decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4. In YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109; A-127 and A-164. 4 Publications1
Mutagenesisi129P → D: No effect on phosphorylation but loss of interaction with YWHAB. 1 Publication1
Mutagenesisi164S → A in YAP-4SA; prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus; when associated with A-61; A-109 and A-127. 1 Publication1
Mutagenesisi199W → A: Loss of interaction with ERBB4 and loss of transcriptional coactivation function toward CTF; when associated with A-202. 1 Publication1
Mutagenesisi202P → A: Loss of interaction with ERBB4 and loss of transcriptional coactivation function toward CTF; when associated with A-199. 1 Publication1
Mutagenesisi397S → A: Loss of phosphorylation by LATS1. 1 Publication1
Mutagenesisi407Y → E: Enhanced interaction with TP73. 1 Publication1
Mutagenesisi407Y → F: No phosphorylation by ABL1 and partial loss of binding to TP73. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		10413

MalaCards human disease database

More...MalaCardsi		YAP1
MIMi120433 phenotype

Open Targets

More...OpenTargetsi		ENSG00000137693

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		157791 Epithelioid hemangioendothelioma
1473 Uveal coloboma-cleft lip and palate-intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38103

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YAP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760711 – 504Transcriptional coactivator YAP1Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei61Phosphoserine; by LATS1 and LATS2Combined sources2 Publications1
Modified residuei63PhosphothreonineCombined sources1
Modified residuei105PhosphoserineBy similarity1
Modified residuei109Phosphoserine; by LATS1 and LATS2Combined sources2 Publications1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei119Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication1
Modified residuei127Phosphoserine; by LATS1 and LATS2Combined sources4 Publications1
Modified residuei128PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei138Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication1
Modified residuei154Phosphothreonine; by MAPK8 and MAPK9Combined sources1 Publication1
Modified residuei164Phosphoserine; by LATS1 and LATS22 Publications1
Modified residuei274PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei367Phosphoserine; by MAPK8 and MAPK9Combined sources1 Publication1
Modified residuei371PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1
Modified residuei397Phosphoserine; by LATS1 and LATS24 Publications1
Modified residuei400Phosphoserine; by CK11 Publication1
Modified residuei403Phosphoserine; by CK11 Publication1
Modified residuei407Phosphotyrosine; by ABL11 Publication1
Modified residuei412Phosphothreonine; by MAPK8 and MAPK91 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).4 Publications
Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P46937

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P46937

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P46937

MaxQB - The MaxQuant DataBase

More...MaxQBi		P46937

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46937

PeptideAtlas

More...PeptideAtlasi		P46937

PRoteomics IDEntifications database

More...PRIDEi		P46937

ProteomicsDB human proteome resource

More...ProteomicsDBi		23425
25812
5134
55772 [P46937-1]
55773 [P46937-2]
55774 [P46937-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P46937

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P46937

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137693 Expressed in 225 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P46937 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P46937 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB009370
CAB069915
HPA038885
HPA070359

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916).

Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288).

Interacts with LATS2 (PubMed:18158288). Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2) (PubMed:12807903).

Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908).

Interacts with TP73 (PubMed:18280240).

Interacts with RUNX1 (PubMed:18280240).

Interacts with HCK (PubMed:17535448).

Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115684, 379 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-256 YAP1-TEAD1 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P46937

Database of interacting proteins

More...DIPi		DIP-40839N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P46937

Protein interaction database and analysis system

More...IntActi		P46937, 113 interactors

Molecular INTeraction database

More...MINTi		P46937

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000478927

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P46937

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P46937

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini171 – 204WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini230 – 263WW 2PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni291 – 504Transactivation domainAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili86 – 1001 PublicationAdd BLAST15
Coiled coili298 – 359Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 49Pro-richAdd BLAST47

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first coiled-coil region mediates most of the interaction with TEAD transcription factors.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the YAP1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0940 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00510000046760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007854

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46937

KEGG Orthology (KO)

More...KOi		K16687

Identification of Orthologs from Complete Genome Data

More...OMAi		VQQNIMN

Database of Orthologous Groups

More...OrthoDBi		1006566at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46937

TreeFam database of animal gene trees

More...TreeFami		TF326941

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201 WW, 2 hits

Database of protein disorder

More...DisProti		DP00702

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00397 WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045 SSF51045, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms of the YAP1-1 form contain only one WW domain.

This entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P46937-1) [UniParc]FASTAAdd to basket
Also known as: YAP1-2gamma, YAP2L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA 
        60         70         80         90        100
GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE 
       110        120        130        140        150
PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG 
       160        170        180        190        200
PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ 
       210        220        230        240        250
DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN 
       260        270        280        290        300
HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
       310        320        330        340        350
NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS 
       360        370        380        390        400
QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS 
       410        420        430        440        450
GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG 
       460        470        480        490        500
TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF 

LTWL
Length:504
Mass (Da):54,462
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6145F7049ED338AE
GO
Isoform 2 (identifier: P46937-2) [UniParc]FASTAAdd to basket
Also known as: YAP1-2alpha, YAP2

The sequence of this isoform differs from the canonical sequence as follows:
     328-343: Missing.

Show »
Length:488
Mass (Da):52,748
Checksum:i675CC207C83A311E
GO
Isoform 3 (identifier: P46937-3) [UniParc]FASTAAdd to basket
Also known as: YAP1-1beta

The sequence of this isoform differs from the canonical sequence as follows:
     230-267: Missing.
     329-343: AMRNINPSTANSPKC → VRP

Show »
Length:454
Mass (Da):48,755
Checksum:i87CB840D3393EFC0
GO
Isoform 4 (identifier: P46937-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):36,232
Checksum:i5C94DABAC6D74ABA
GO
Isoform 5 (identifier: P46937-5) [UniParc]FASTAAdd to basket
Also known as: YAP1-1alpha

The sequence of this isoform differs from the canonical sequence as follows:
     230-267: Missing.
     328-343: Missing.

Show »
Length:450
Mass (Da):48,275
Checksum:i295934FD185E7C59
GO
Isoform 6 (identifier: P46937-6) [UniParc]FASTAAdd to basket
Also known as: YAP1-1gamma

The sequence of this isoform differs from the canonical sequence as follows:
     230-267: Missing.

Show »
Length:466
Mass (Da):49,989
Checksum:iF1E76E6DEB3F93C0
GO
Isoform 7 (identifier: P46937-7) [UniParc]FASTAAdd to basket
Also known as: YAP1-1delta

The sequence of this isoform differs from the canonical sequence as follows:
     230-267: Missing.
     328-328: Q → QVRPQ

Show »
Length:470
Mass (Da):50,469
Checksum:i8935AAD2FA859F62
GO
Isoform 8 (identifier: P46937-8) [UniParc]FASTAAdd to basket
Also known as: YAP1-2beta

The sequence of this isoform differs from the canonical sequence as follows:
     329-343: AMRNINPSTANSPKC → VRP

Show »
Length:492
Mass (Da):53,228
Checksum:i289722956D96193A
GO
Isoform 9 (identifier: P46937-9) [UniParc]FASTAAdd to basket
Also known as: YAP1-2delta

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: Q → QVRPQ

Note: Highest expression in ovary and placenta, lowest in skeletal muscle and brain.
Show »
Length:508
Mass (Da):54,942
Checksum:iCFCC0BD04A27060B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCI3H0YCI3_HUMAN
Transcriptional coactivator YAP1
YAP1
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071125139P → L1 PublicationCorresponds to variant dbSNP:rs1162286204Ensembl.1
Natural variantiVAR_071126227S → L1 PublicationCorresponds to variant dbSNP:rs376161041Ensembl.1
Natural variantiVAR_071127330M → V1 PublicationCorresponds to variant dbSNP:rs777949318Ensembl.1
Natural variantiVAR_071128462G → E1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451901 – 178Missing in isoform 4. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_039053230 – 267Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_039054328 – 343Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_053483328Q → QVRPQ in isoform 7 and isoform 9. 1 Publication1
Alternative sequenceiVSP_039055329 – 343AMRNI…NSPKC → VRP in isoform 3 and isoform 8. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X80507 Genomic DNA Translation: CAA56672.1
AY316529 mRNA Translation: AAP92710.1
AB567720 mRNA Translation: BAJ41471.1
AB567721 mRNA Translation: BAJ41472.1
AK300414 mRNA Translation: BAG62143.1
AK316116 mRNA Translation: BAH14487.1
AP000942 Genomic DNA No translation available.
AP001527 Genomic DNA No translation available.
AP002777 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67011.1
CH471065 Genomic DNA Translation: EAW67015.1
BC038235 mRNA Translation: AAH38235.1
HE864159 mRNA Translation: CCI79618.1
HE864160 mRNA Translation: CCI79619.1
HE864161 mRNA Translation: CCI79620.1
HE864162 mRNA Translation: CCI79621.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44716.1 [P46937-1]
CCDS53699.1 [P46937-2]
CCDS53700.1 [P46937-4]
CCDS60944.1 [P46937-8]
CCDS60945.1 [P46937-3]
CCDS73373.1 [P46937-9]
CCDS73374.1 [P46937-7]
CCDS8314.2 [P46937-5]

Protein sequence database of the Protein Information Resource

More...PIRi		A56954

NCBI Reference Sequences

More...RefSeqi		NP_001123617.1, NM_001130145.2 [P46937-1]
NP_001181973.1, NM_001195044.1 [P46937-2]
NP_001181974.1, NM_001195045.1 [P46937-4]
NP_001269026.1, NM_001282097.1 [P46937-6]
NP_001269027.1, NM_001282098.1 [P46937-3]
NP_001269028.1, NM_001282099.1 [P46937-7]
NP_001269029.1, NM_001282100.1 [P46937-8]
NP_001269030.1, NM_001282101.1 [P46937-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282441; ENSP00000282441; ENSG00000137693 [P46937-1]
ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7]
ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4]
ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5]
ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2]
ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8]
ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9]
ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10413

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10413

UCSC genome browser

More...UCSCi		uc001pgt.3 human [P46937-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Protein Spotlight

Shaping life - Issue 175 of January 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80507 Genomic DNA Translation: CAA56672.1
AY316529 mRNA Translation: AAP92710.1
AB567720 mRNA Translation: BAJ41471.1
AB567721 mRNA Translation: BAJ41472.1
AK300414 mRNA Translation: BAG62143.1
AK316116 mRNA Translation: BAH14487.1
AP000942 Genomic DNA No translation available.
AP001527 Genomic DNA No translation available.
AP002777 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67011.1
CH471065 Genomic DNA Translation: EAW67015.1
BC038235 mRNA Translation: AAH38235.1
HE864159 mRNA Translation: CCI79618.1
HE864160 mRNA Translation: CCI79619.1
HE864161 mRNA Translation: CCI79620.1
HE864162 mRNA Translation: CCI79621.1
CCDSiCCDS44716.1 [P46937-1]
CCDS53699.1 [P46937-2]
CCDS53700.1 [P46937-4]
CCDS60944.1 [P46937-8]
CCDS60945.1 [P46937-3]
CCDS73373.1 [P46937-9]
CCDS73374.1 [P46937-7]
CCDS8314.2 [P46937-5]
PIRiA56954
RefSeqiNP_001123617.1, NM_001130145.2 [P46937-1]
NP_001181973.1, NM_001195044.1 [P46937-2]
NP_001181974.1, NM_001195045.1 [P46937-4]
NP_001269026.1, NM_001282097.1 [P46937-6]
NP_001269027.1, NM_001282098.1 [P46937-3]
NP_001269028.1, NM_001282099.1 [P46937-7]
NP_001269029.1, NM_001282100.1 [P46937-8]
NP_001269030.1, NM_001282101.1 [P46937-9]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMQNMR-A165-210[»]
1K5RNMR-A165-204[»]
1K9QNMR-A165-204[»]
1K9RNMR-A165-204[»]
2LAWNMR-A230-263[»]
2LAXNMR-A170-205[»]
2LAYNMR-A170-205[»]
2LTVNMR-A230-265[»]
2LTWNMR-A170-205[»]
3KYSX-ray2.80B/D50-171[»]
3MHRX-ray1.15P124-133[»]
4RE1X-ray2.20C/D50-171[»]
4REXX-ray1.60A165-209[»]
5OAQX-ray1.95L60-100[»]
5YDXNMR-A164-218[»]
5YDYNMR-A229-287[»]
6G6XX-ray1.13P124-133[»]
6G8IX-ray1.60P125-133[»]
6G8JX-ray1.47P124-133[»]
6G8KX-ray1.25P124-133[»]
6G8LX-ray1.37P124-133[»]
6G8PX-ray1.90P124-133[»]
6G8QX-ray1.85P124-132[»]
6GE3X-ray1.85L60-100[»]
6GE4X-ray1.97L60-100[»]
6GE5X-ray2.05L60-100[»]
6GE6X-ray1.80L60-100[»]
6GECX-ray1.70L60-99[»]
6GEEX-ray1.96L60-99[»]
6GEGX-ray2.23L60-99[»]
6GEIX-ray1.65L60-100[»]
6GEKX-ray2.28L/M60-100[»]
6HIKX-ray1.65L60-99[»]
6HILX-ray2.30L/M/N/O60-100[»]
6Q2XX-ray2.10L60-100[»]
SMRiP46937
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115684, 379 interactors
ComplexPortaliCPX-256 YAP1-TEAD1 complex
CORUMiP46937
DIPiDIP-40839N
ELMiP46937
IntActiP46937, 113 interactors
MINTiP46937
STRINGi9606.ENSP00000478927

PTM databases

iPTMnetiP46937
PhosphoSitePlusiP46937

Polymorphism and mutation databases

BioMutaiYAP1
DMDMi294862479

Proteomic databases

EPDiP46937
jPOSTiP46937
MassIVEiP46937
MaxQBiP46937
PaxDbiP46937
PeptideAtlasiP46937
PRIDEiP46937
ProteomicsDBi23425
25812
5134
55772 [P46937-1]
55773 [P46937-2]
55774 [P46937-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282441; ENSP00000282441; ENSG00000137693 [P46937-1]
ENST00000345877; ENSP00000331023; ENSG00000137693 [P46937-7]
ENST00000524575; ENSP00000435602; ENSG00000137693 [P46937-4]
ENST00000526343; ENSP00000434134; ENSG00000137693 [P46937-5]
ENST00000531439; ENSP00000431574; ENSG00000137693 [P46937-2]
ENST00000537274; ENSP00000445635; ENSG00000137693 [P46937-8]
ENST00000615667; ENSP00000478927; ENSG00000137693 [P46937-9]
ENST00000629586; ENSP00000487519; ENSG00000137693 [P46937-3]
GeneIDi10413
KEGGihsa:10413
UCSCiuc001pgt.3 human [P46937-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10413
DisGeNETi10413

GeneCards: human genes, protein and diseases

More...GeneCardsi		YAP1
HGNCiHGNC:16262 YAP1
HPAiCAB009370
CAB069915
HPA038885
HPA070359
MalaCardsiYAP1
MIMi120433 phenotype
606608 gene
neXtProtiNX_P46937
OpenTargetsiENSG00000137693
Orphaneti157791 Epithelioid hemangioendothelioma
1473 Uveal coloboma-cleft lip and palate-intellectual disability
PharmGKBiPA38103

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00510000046760
HOGENOMiHOG000007854
InParanoidiP46937
KOiK16687
OMAiVQQNIMN
OrthoDBi1006566at2759
PhylomeDBiP46937
TreeFamiTF326941

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-2028269 Signaling by Hippo
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SignaLinkiP46937
SIGNORiP46937

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YAP1 human
EvolutionaryTraceiP46937

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10413

Pharos

More...Pharosi		P46937

Protein Ontology

More...PROi		PR:P46937

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137693 Expressed in 225 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiP46937 baseline and differential
GenevisibleiP46937 HS

Family and domain databases

CDDicd00201 WW, 2 hits
DisProtiDP00702
InterProiView protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46937
Secondary accession number(s): B4DTY1
, B7ZA01, E3WEB5, E3WEB6, E9PRV2, F5H202, K0KQ18, K0KYZ8, K0L195, K0L1G3, Q7Z574, Q8IUY9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 20, 2010
Last modified: September 18, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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