E3 ubiquitin-protein ligase NEDD4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:P46934 (NEDD4_HUMAN)

  EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-2 adrenergic receptor binding Source: Ensembl
• ionotropic glutamate receptor binding Source: ParkinsonsUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8."
    Scudder S.L., Goo M.S., Cartier A.E., Molteni A., Schwarz L.A., Wright R., Patrick G.N.
    J. Neurosci. 34:16637-16649(2014) [PubMed] [Europe PMC] [Abstract]
• phosphoserine residue binding Source: BHF-UCLInferred from direct assayⁱ
  • "Function of WW domains as phosphoserine- or phosphothreonine-binding modules."
    Lu P.J., Zhou X.Z., Shen M., Lu K.P.
    Science 283:1325-1328(1999) [PubMed] [Europe PMC] [Abstract]
• phosphothreonine residue binding Source: BHF-UCLInferred from direct assayⁱ
  • "Function of WW domains as phosphoserine- or phosphothreonine-binding modules."
    Lu P.J., Zhou X.Z., Shen M., Lu K.P.
    Science 283:1325-1328(1999) [PubMed] [Europe PMC] [Abstract]
• proline-rich region binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
    Harvey K.F., Shearwin-Whyatt L.M., Fotia A., Parton R.G., Kumar S.
    J. Biol. Chem. 277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]
  • "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II."
    Gavva N.R., Gavva R., Ermekova K., Sudol M., Shen C.J.
    J. Biol. Chem. 272:24105-24108(1997) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: MGI
• protein domain specific binding Source: Ensembl
• RNA polymerase binding Source: Ensembl
• sodium channel inhibitor activity Source: MGIInferred from direct assayⁱ
  • "All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+."
    Harvey K.F., Dinudom A., Komwatana P., Jolliffe C.N., Day M.L., Parasivam G., Cook D.I., Kumar S.
    J. Biol. Chem. 274:12525-12530(1999) [PubMed] [Europe PMC] [Abstract]
• ubiquitin binding Source: Ensembl
• ubiquitin protein ligase activity Source: MGIInferred from direct assayⁱ
  • "Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase."
    Murillas R., Simms K.S., Hatakeyama S., Weissman A.M., Kuehn M.R.
    J. Biol. Chem. 277:2897-2907(2002) [PubMed] [Europe PMC] [Abstract]
  • Ref.3

    "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases."
    Hatakeyama S., Jensen J.P., Weissman A.M.
    J. Biol. Chem. 272:15085-15092(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH UBE2D2.
• ubiquitin-protein transferase activity Source: MGI

GO - Biological processⁱ

• adaptive immune response Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells."
    Yang B., Gay D.L., MacLeod M.K., Cao X., Hala T., Sweezer E.M., Kappler J., Marrack P., Oliver P.M.
    Nat. Immunol. 9:1356-1363(2008) [PubMed] [Europe PMC] [Abstract]
• blood vessel morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1."
    Fouladkou F., Lu C., Jiang C., Zhou L., She Y., Walls J.R., Kawabe H., Brose N., Henkelman R.M., Huang A., Bruneau B.G., Rotin D.
    J. Biol. Chem. 285:6770-6780(2010) [PubMed] [Europe PMC] [Abstract]
• development involved in symbiotic interaction Source: Ensembl
• endocardial cushion development Source: MGIInferred from mutant phenotypeⁱ
  • "The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1."
    Fouladkou F., Lu C., Jiang C., Zhou L., She Y., Walls J.R., Kawabe H., Brose N., Henkelman R.M., Huang A., Bruneau B.G., Rotin D.
    J. Biol. Chem. 285:6770-6780(2010) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid receptor signaling pathway Source: Ensembl
• negative regulation of sodium ion transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of sodium ion transport Source: MGIInferred from direct assayⁱ
  • "All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+."
    Harvey K.F., Dinudom A., Komwatana P., Jolliffe C.N., Day M.L., Parasivam G., Cook D.I., Kumar S.
    J. Biol. Chem. 274:12525-12530(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1."
    Fouladkou F., Lu C., Jiang C., Zhou L., She Y., Walls J.R., Kawabe H., Brose N., Henkelman R.M., Huang A., Bruneau B.G., Rotin D.
    J. Biol. Chem. 285:6770-6780(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
• negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation."
    Murdaca J., Treins C., Monthouel-Kartmann M.N., Pontier-Bres R., Kumar S., Van Obberghen E., Giorgetti-Peraldi S.
    J. Biol. Chem. 279:26754-26761(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH GRB10, MUTAGENESIS OF CYS-854.
• neuromuscular junction development Source: MGIInferred from mutant phenotypeⁱ
  • "Abnormal development of the neuromuscular junction in Nedd4-deficient mice."
    Liu Y., Oppenheim R.W., Sugiura Y., Lin W.
    Dev. Biol. 330:153-166(2009) [PubMed] [Europe PMC] [Abstract]
• neuron projection development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1."
    Fouladkou F., Lu C., Jiang C., Zhou L., She Y., Walls J.R., Kawabe H., Brose N., Henkelman R.M., Huang A., Bruneau B.G., Rotin D.
    J. Biol. Chem. 285:6770-6780(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of nucleocytoplasmic transport Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of protein catabolic process Source: MGIInferred from direct assayⁱ
  • "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
    Harvey K.F., Shearwin-Whyatt L.M., Fotia A., Parton R.G., Kumar S.
    J. Biol. Chem. 277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]
• progesterone receptor signaling pathway Source: Ensembl
• proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein K63-linked ubiquitination Source: UniProtKB
• protein monoubiquitination Source: MGIInferred from direct assayⁱ
  • "Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases."
    Van Campenhout C.A., Eitelhuber A., Gloeckner C.J., Giallonardo P., Gegg M., Oller H., Grant S.G., Krappmann D., Ueffing M., Lickert H.
    Dev. Cell 21:479-491(2011) [PubMed] [Europe PMC] [Abstract]
• protein polyubiquitination Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein targeting to lysosome Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein ubiquitination Source: MGIInferred from direct assayⁱ
  • Ref.3

    "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases."
    Hatakeyama S., Jensen J.P., Weissman A.M.
    J. Biol. Chem. 272:15085-15092(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH UBE2D2.
• receptor catabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of dendrite morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.18

    "Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development."
    Kawabe H., Neeb A., Dimova K., Young S.M. Jr., Takeda M., Katsurabayashi S., Mitkovski M., Malakhova O.A., Zhang D.E., Umikawa M., Kariya K., Goebbels S., Nave K.A., Rosenmund C., Jahn O., Rhee J., Brose N.
    Neuron 65:358-372(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAP2A AND TNIK.
• regulation of membrane potential Source: Ensembl
• regulation of postsynaptic neurotransmitter receptor internalization Source: MGI
• regulation of potassium ion transmembrane transporter activity Source: Ensembl
• regulation of protein catabolic process at postsynapse, modulating synaptic transmission Source: MGI
• regulation of synapse organization Source: MGIInferred from mutant phenotypeⁱ
  • "Abnormal development of the neuromuscular junction in Nedd4-deficient mice."
    Liu Y., Oppenheim R.W., Sugiura Y., Lin W.
    Dev. Biol. 330:153-166(2009) [PubMed] [Europe PMC] [Abstract]
• T cell activation Source: MGIInferred from mutant phenotypeⁱ
  • "Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells."
    Yang B., Gay D.L., MacLeod M.K., Cao X., Hala T., Sweezer E.M., Kappler J., Marrack P., Oliver P.M.
    Nat. Immunol. 9:1356-1363(2008) [PubMed] [Europe PMC] [Abstract]
• transmission of virus Source: Ensembl
• ubiquitin-dependent protein catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells."
    Yang B., Gay D.L., MacLeod M.K., Cao X., Hala T., Sweezer E.M., Kappler J., Marrack P., Oliver P.M.
    Nat. Immunol. 9:1356-1363(2008) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-2 adrenergic receptor binding Source: Ensembl
• ionotropic glutamate receptor binding Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8."
    Scudder S.L., Goo M.S., Cartier A.E., Molteni A., Schwarz L.A., Wright R., Patrick G.N.
    J. Neurosci. 34:16637-16649(2014) [PubMed] [Europe PMC] [Abstract]
• phosphoserine residue binding Source: BHF-UCLInferred from direct assayⁱ
  • "Function of WW domains as phosphoserine- or phosphothreonine-binding modules."
    Lu P.J., Zhou X.Z., Shen M., Lu K.P.
    Science 283:1325-1328(1999) [PubMed] [Europe PMC] [Abstract]
• phosphothreonine residue binding Source: BHF-UCLInferred from direct assayⁱ
  • "Function of WW domains as phosphoserine- or phosphothreonine-binding modules."
    Lu P.J., Zhou X.Z., Shen M., Lu K.P.
    Science 283:1325-1328(1999) [PubMed] [Europe PMC] [Abstract]
• proline-rich region binding Source: MGIInferred from physical interactionⁱ
  • "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
    Harvey K.F., Shearwin-Whyatt L.M., Fotia A., Parton R.G., Kumar S.
    J. Biol. Chem. 277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]
  • "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II."
    Gavva N.R., Gavva R., Ermekova K., Sudol M., Shen C.J.
    J. Biol. Chem. 272:24105-24108(1997) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: MGI
• protein domain specific binding Source: Ensembl
• RNA polymerase binding Source: Ensembl
• ubiquitin binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW 
        60         70         80         90        100
ELNPNSLEEE HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD 
       110        120        130        140        150
PYVRVTLYDP MSGILTSVQT KTIKKSLNPK WNEEILFRVL PQRHRILFEV 
       160        170        180        190        200
FDENRLTRDD FLGQVDVPLY PLPTENPRME RPYTFKDFVL HPRSHKSRVK 
       210        220        230        240        250
GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT HLPHPPEPSP 
       260        270        280        290        300
LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 
       310        320        330        340        350
AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV 
       360        370        380        390        400
QTHLAEEFNT RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLPVL 
       410        420        430        440        450
LPTSSGLPPG WEEKQDDRGR SYYVDHNSKT TTWSKPTMQD DPRSKIPAHL 
       460        470        480        490        500
RGKTDSNDLG PLPPGWEERT HTDGRVFFIN HNIKKTQWED PRLQNVAITG 
       510        520        530        540        550
PAVPYSRDYK RKYEFFRRKL KKQTDIPNKF EMKLRRANIL EDSYRRIMGV 
       560        570        580        590        600
KRADLLKARL WIEFDGEKGL DYGGVAREWF FLISKEMFNP YYGLFEYSAT 
       610        620        630        640        650
DNYTLQINPN SGLCNEDHLS YFKFIGRVAG MAVYHGKLLD GFFIRPFYKM 
       660        670        680        690        700
MLQKLITLHD MESVDSEYYS SLRWILENDP TELDLRFIID EELFGQTHQH 
       710        720        730        740        750
ELKTGGSEIV VTNKNKKEYI YLVIQWRFVN RIQKQMAAFK EGFFELIPQD 
       760        770        780        790        800
LIKIFDENEL ELLMCGLGDV DVNDWREHTK YKNGYSMNHQ VIHWFWKAVW 
       810        820        830        840        850
MMDSEKRIRL LQFVTGTSRV PMNGFAELYG SNGPQSFTVE QWGTPDKLPR 
       860        870        880 
AHTCFNRLDL PPYESFDELW DKLQMAIENT QGFDGVD               

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. PATHWAY comments
   Index of metabolic and biosynthesis pathways
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot