Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase NEDD4

Gene

NEDD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).9 Publications
(Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding.1 Publication

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Activity regulationi

Activated by NDFIP1- and NDFIP2-binding.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1286Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • beta-2 adrenergic receptor binding Source: UniProtKB
  • phosphoserine residue binding Source: BHF-UCL
  • phosphothreonine residue binding Source: BHF-UCL
  • proline-rich region binding Source: BHF-UCL
  • protein domain specific binding Source: UniProtKB
  • RNA polymerase binding Source: BHF-UCL
  • sodium channel inhibitor activity Source: BHF-UCL
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin protein ligase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHost-virus interaction, Neurogenesis, Ubl conjugation pathway

Enzyme and pathway databases

BRENDAi2.3.2.B9 2681
6.3.2.19 2681
ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1253288 Downregulation of ERBB4 signaling
R-HSA-8948747 Regulation of PTEN localization
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP46934
SIGNORiP46934
UniPathwayi
UPA00143

Protein family/group databases

TCDBi8.A.30.1.2 the nedd4-family interacting protein-2 (nedd4) family

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase NEDD4 (EC:2.3.2.262 Publications)
Alternative name(s):
Cell proliferation-inducing gene 53 protein
HECT-type E3 ubiquitin transferase NEDD4
Neural precursor cell expressed developmentally down-regulated protein 4
Short name:
NEDD-4
Gene namesi
Name:NEDD4
Synonyms:KIAA0093, NEDD4-1
ORF Names:PIG53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000069869.15
HGNCiHGNC:7727 NEDD4
MIMi602278 gene
neXtProtiNX_P46934

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi795W → A: Abolishes interaction with ARRDC3; when associated with A-868 and A-920. 1 Publication1
Mutagenesisi868W → A: Abolishes interaction with ARRDC3; when associated with A-795 and A-920. 1 Publication1
Mutagenesisi920W → A: Abolishes interaction with ARRDC3; when associated with A-795 and A-868. 1 Publication1

Organism-specific databases

DisGeNETi4734
OpenTargetsiENSG00000069869
PharmGKBiPA31533

Chemistry databases

ChEMBLiCHEMBL3621023

Polymorphism and mutation databases

BioMutaiNEDD4
DMDMi313104311

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203191 – 1319E3 ubiquitin-protein ligase NEDD4Add BLAST1319
Isoform 4 (identifier: P46934-4)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei576PhosphoserineBy similarity1
Modified residuei648PhosphothreonineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei742PhosphoserineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Isoform 4 (identifier: P46934-4)
Modified residuei2N-acetylalanineCombined sources1

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP46934
MaxQBiP46934
PaxDbiP46934
PeptideAtlasiP46934
PRIDEiP46934
ProteomicsDBi55768
55769 [P46934-2]
55770 [P46934-3]
55771 [P46934-4]

PTM databases

iPTMnetiP46934
PhosphoSitePlusiP46934

Expressioni

Gene expression databases

BgeeiENSG00000069869 Expressed in 198 organ(s), highest expression level in biceps brachii
CleanExiHS_NEDD4
ExpressionAtlasiP46934 baseline and differential
GenevisibleiP46934 HS

Organism-specific databases

HPAiCAB001991
CAB072833
HPA039883

Interactioni

Subunit structurei

Interacts with UBE2D2. Binds SCNN1A, SCNN1B and SCNN1G. Binds, in vitro, through the WW2 and WW3 domains, to neural isoforms of ENAH that contain the PPSY motif. Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, PMEPAI and PRRG2 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes (By similarity). Interaction with PTEN is questionable according to PubMed:18562292. Interacts (via C2 domain) with GRB10 (via SH2 domain). Interacts with ERBB4 (By similarity). Interacts with TNIK; the interaction is direct, allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4. Interacts (via WW3 domain) with TNK2; EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via C-terminus). Interacts with OTUD7B. Interacts with ISG15. Interacts (via WW domain) with RAPGEF2; this interaction leads to ubiquitination and degradation via the proteasome pathway. Interacts (via WW domains) with ARRDC3 (via PPXY motifs) (PubMed:20559325, PubMed:24379409). Interacts with LAPTM4B; may play a role in the lysosomal sorting of LAPTM4B (PubMed:22096579). Interacts (via WW domains) with ARRDC1, ARRDC2 and ARRDC3 (PubMed:21191027). Interacts with ZBTB7B (By similarity).By similarity14 Publications
(Microbial infection) Interacts with viral proteins that contain a late-budding motif P-P-P-Y. This interaction is essential for viral particle budding of many retroviruses, like HTLV-1 Gag and MLV Gag. Interacts with Herpes simplex virus 2 (HHV-2) protein UL56; this interaction induces NEDD4 degradation (PubMed:18353951). Interacts with Ebola virus protein VP40 (PubMed:12559917).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110811, 318 interactors
CORUMiP46934
DIPiDIP-29815N
ELMiP46934
IntActiP46934, 38 interactors
MINTiP46934
STRINGi9606.ENSP00000345530

Structurei

Secondary structure

11319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP46934
SMRiP46934
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46934

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini610 – 643WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini767 – 800WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini840 – 873WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini892 – 925WW 4PROSITE-ProRule annotationAdd BLAST34
Domaini984 – 1318HECTPROSITE-ProRule annotationAdd BLAST335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni578 – 981Mediates interaction with TNIKBy similarityAdd BLAST404

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 215Ser-richAdd BLAST148

Domaini

The WW domains mediate interaction with PPxY motif-containing proteins (PubMed:21191027). The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, PMEPAI, NDFIP1 and PRRG2 (By similarity).By similarity1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00760000118966
HOVERGENiHBG004134
InParanoidiP46934
KOiK10591
OMAiFNSLKWI
OrthoDBiEOG091G0SS8
PhylomeDBiP46934
TreeFamiTF323658

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd00201 WW, 4 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF00397 WW, 4 hits
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00456 WW, 4 hits
SUPFAMiSSF51045 SSF51045, 4 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 4 hits
PS50020 WW_DOMAIN_2, 4 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46934-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK
60 70 80 90 100
LTPRQTALAP LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL
110 120 130 140 150
QSSNVLADSD DASFTCILKD GIYSSAVVDN ELNAVNDGHL VSSPAICSGS
160 170 180 190 200
LSNFSTSDNG SYSSNGSDFG SCASITSGGS YTNSVISDSS SYTFPPSDDT
210 220 230 240 250
FLGGNLPSDS TSNRSVPNRN TTPCEIFSRS TSTDPFVQDD LEHGLEIMKL
260 270 280 290 300
PVSRNTKIPL KRYSSLVIFP RSPSTTRPTS PTSLCTLLSK GSYQTSHQFI
310 320 330 340 350
ISPSEIAHNE DGTSAKGFLS TAVNGLRLSK TICTPGEVRD IRPLHRKGSL
360 370 380 390 400
QKKIVLSNNT PRQTVCEKSS EGYSCVSVHF TQRKAATLDC ETTNGDCKPE
410 420 430 440 450
MSEIKLNSDS EYIKLMHRTS ACLPSSQNVD CQININGELE RPHSQMNKNH
460 470 480 490 500
GILRRSISLG GAYPNISCLS SLKHNCSKGG PSQLLIKFAS GNEGKVDNLS
510 520 530 540 550
RDSNRDCTNE LSNSCKTRDD FLGQVDVPLY PLPTENPRLE RPYTFKDFVL
560 570 580 590 600
HPRSHKSRVK GYLRLKMTYL PKTSGSEDDN AEQAEELEPG WVVLDQPDAA
610 620 630 640 650
CHLQQQQEPS PLPPGWEERQ DILGRTYYVN HESRRTQWKR PTPQDNLTDA
660 670 680 690 700
ENGNIQLQAQ RAFTTRRQIS EETESVDNRE SSENWEIIRE DEATMYSNQA
710 720 730 740 750
FPSPPPSSNL DVPTHLAEEL NARLTIFGNS AVSQPASSSN HSSRRGSLQA
760 770 780 790 800
YTFEEQPTLP VLLPTSSGLP PGWEEKQDER GRSYYVDHNS RTTTWTKPTV
810 820 830 840 850
QATVETSQLT SSQSSAGPQS QASTSDSGQQ VTQPSEIEQG FLPKGWEVRH
860 870 880 890 900
APNGRPFFID HNTKTTTWED PRLKIPAHLR GKTSLDTSND LGPLPPGWEE
910 920 930 940 950
RTHTDGRIFY INHNIKRTQW EDPRLENVAI TGPAVPYSRD YKRKYEFFRR
960 970 980 990 1000
KLKKQNDIPN KFEMKLRRAT VLEDSYRRIM GVKRADFLKA RLWIEFDGEK
1010 1020 1030 1040 1050
GLDYGGVARE WFFLISKEMF NPYYGLFEYS ATDNYTLQIN PNSGLCNEDH
1060 1070 1080 1090 1100
LSYFKFIGRV AGMAVYHGKL LDGFFIRPFY KMMLHKPITL HDMESVDSEY
1110 1120 1130 1140 1150
YNSLRWILEN DPTELDLRFI IDEELFGQTH QHELKNGGSE IVVTNKNKKE
1160 1170 1180 1190 1200
YIYLVIQWRF VNRIQKQMAA FKEGFFELIP QDLIKIFDEN ELELLMCGLG
1210 1220 1230 1240 1250
DVDVNDWREH TKYKNGYSAN HQVIQWFWKA VLMMDSEKRI RLLQFVTGTS
1260 1270 1280 1290 1300
RVPMNGFAEL YGSNGPQSFT VEQWGTPEKL PRAHTCFNRL DLPPYESFEE
1310
LWDKLQMAIE NTQGFDGVD
Note: No experimental confirmation available.
Length:1,319
Mass (Da):149,114
Last modified:November 30, 2010 - v4
Checksum:iD56EBBC50A34F13B
GO
Isoform 2 (identifier: P46934-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-604: Missing.

Note: No experimental confirmation available.
Show »
Length:1,303
Mass (Da):147,384
Checksum:iC40112E4C9BC8416
GO
Isoform 3 (identifier: P46934-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-588: Missing.

Note: No experimental confirmation available.
Show »
Length:1,247
Mass (Da):140,696
Checksum:i827AC55FB4AFB6A3
GO
Isoform 4 (identifier: P46934-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-419: Missing.
     420-516: SACLPSSQNV...CTNELSNSCK → MATCAVEVFG...LFEVFDENRL

Show »
Length:900
Mass (Da):104,217
Checksum:i4303287D3133B1C7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8X6H0Y8X6_HUMAN
E3 ubiquitin-protein ligase NEDD4
NEDD4
910Annotation score:
H0YA37H0YA37_HUMAN
E3 ubiquitin-protein ligase NEDD4
NEDD4
401Annotation score:
H0Y8H4H0Y8H4_HUMAN
E3 ubiquitin-protein ligase NEDD4
NEDD4
35Annotation score:
H0Y9L1H0Y9L1_HUMAN
E3 ubiquitin-protein ligase NEDD4
NEDD4
39Annotation score:

Sequence cautioni

The sequence BAA07655 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59A → T in AL832063 (PubMed:17974005).Curated1
Sequence conflicti407N → H in AL832063 (PubMed:17974005).Curated1
Sequence conflicti620Q → R in AAT52215 (Ref. 4) Curated1
Sequence conflicti620Q → R in AAI44285 (PubMed:15489334).Curated1
Sequence conflicti863T → I in AAI36606 (PubMed:15489334).Curated1
Sequence conflicti863T → I in AAI44285 (PubMed:15489334).Curated1
Sequence conflicti1199L → P in BAG65229 (PubMed:14702039).Curated1
Sequence conflicti1268S → L in AL832063 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06198533M → V. Corresponds to variant dbSNP:rs1912403Ensembl.1
Natural variantiVAR_036472627Y → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047909679R → Q5 PublicationsCorresponds to variant dbSNP:rs2303580Ensembl.1
Natural variantiVAR_047910698N → S5 PublicationsCorresponds to variant dbSNP:rs2303579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0382561 – 419Missing in isoform 4. 4 PublicationsAdd BLAST419
Alternative sequenceiVSP_038257420 – 516SACLP…SNSCK → MATCAVEVFGLLEDEENSRI VRVRVIAGIGLAKKDILGAS DPYVRVTLYDPMNGVLTSVQ TKTIKKSLNPKWNEEILFRV HPQQHRLLFEVFDENRL in isoform 4. 4 PublicationsAdd BLAST97
Alternative sequenceiVSP_038258517 – 588Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_038259589 – 604Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42055 mRNA Translation: BAA07655.1 Different initiation.
AK304394 mRNA Translation: BAG65229.1
AY550969 mRNA Translation: AAT52215.1
AL832063 Genomic DNA No translation available.
AC009997 Genomic DNA No translation available.
AC039057 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77495.1
BC136605 mRNA Translation: AAI36606.1
BC144284 mRNA Translation: AAI44285.1
BC144285 mRNA Translation: AAI44286.1
BC152452 mRNA Translation: AAI52453.1
BC152562 mRNA Translation: AAI52563.1
CCDSiCCDS10156.1 [P46934-3]
CCDS45265.1 [P46934-4]
CCDS61643.1 [P46934-2]
CCDS61644.1 [P46934-1]
RefSeqiNP_001271267.1, NM_001284338.1 [P46934-1]
NP_001271268.1, NM_001284339.1 [P46934-2]
NP_001271269.1, NM_001284340.1
NP_001316141.1, NM_001329212.1
NP_006145.2, NM_006154.3 [P46934-4]
NP_940682.2, NM_198400.3 [P46934-3]
UniGeneiHs.1565

Genome annotation databases

EnsembliENST00000338963; ENSP00000345530; ENSG00000069869 [P46934-3]
ENST00000435532; ENSP00000410613; ENSG00000069869 [P46934-4]
ENST00000506154; ENSP00000422705; ENSG00000069869 [P46934-2]
ENST00000508342; ENSP00000424827; ENSG00000069869 [P46934-1]
GeneIDi4734
KEGGihsa:4734
UCSCiuc002adi.5 human [P46934-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42055 mRNA Translation: BAA07655.1 Different initiation.
AK304394 mRNA Translation: BAG65229.1
AY550969 mRNA Translation: AAT52215.1
AL832063 Genomic DNA No translation available.
AC009997 Genomic DNA No translation available.
AC039057 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77495.1
BC136605 mRNA Translation: AAI36606.1
BC144284 mRNA Translation: AAI44285.1
BC144285 mRNA Translation: AAI44286.1
BC152452 mRNA Translation: AAI52453.1
BC152562 mRNA Translation: AAI52563.1
CCDSiCCDS10156.1 [P46934-3]
CCDS45265.1 [P46934-4]
CCDS61643.1 [P46934-2]
CCDS61644.1 [P46934-1]
RefSeqiNP_001271267.1, NM_001284338.1 [P46934-1]
NP_001271268.1, NM_001284339.1 [P46934-2]
NP_001271269.1, NM_001284340.1
NP_001316141.1, NM_001329212.1
NP_006145.2, NM_006154.3 [P46934-4]
NP_940682.2, NM_198400.3 [P46934-3]
UniGeneiHs.1565

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KPZNMR-A834-878[»]
2KQ0NMR-A834-878[»]
2M3ONMR-W838-877[»]
2XBBX-ray2.68A/B938-1319[»]
2XBFX-ray2.50A938-1319[»]
3B7YX-ray1.80A/B517-571[»]
4BBNX-ray2.51A938-1319[»]
4BE8X-ray3.00A938-1319[»]
4N7FX-ray1.10A/B841-874[»]
4N7HX-ray1.70A840-872[»]
5AHTNMR-A838-877[»]
5C7JX-ray3.00A/B939-1319[»]
5C91X-ray2.44A938-1312[»]
ProteinModelPortaliP46934
SMRiP46934
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110811, 318 interactors
CORUMiP46934
DIPiDIP-29815N
ELMiP46934
IntActiP46934, 38 interactors
MINTiP46934
STRINGi9606.ENSP00000345530

Chemistry databases

ChEMBLiCHEMBL3621023

Protein family/group databases

TCDBi8.A.30.1.2 the nedd4-family interacting protein-2 (nedd4) family

PTM databases

iPTMnetiP46934
PhosphoSitePlusiP46934

Polymorphism and mutation databases

BioMutaiNEDD4
DMDMi313104311

Proteomic databases

EPDiP46934
MaxQBiP46934
PaxDbiP46934
PeptideAtlasiP46934
PRIDEiP46934
ProteomicsDBi55768
55769 [P46934-2]
55770 [P46934-3]
55771 [P46934-4]

Protocols and materials databases

DNASUi4734
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338963; ENSP00000345530; ENSG00000069869 [P46934-3]
ENST00000435532; ENSP00000410613; ENSG00000069869 [P46934-4]
ENST00000506154; ENSP00000422705; ENSG00000069869 [P46934-2]
ENST00000508342; ENSP00000424827; ENSG00000069869 [P46934-1]
GeneIDi4734
KEGGihsa:4734
UCSCiuc002adi.5 human [P46934-1]

Organism-specific databases

CTDi4734
DisGeNETi4734
EuPathDBiHostDB:ENSG00000069869.15
GeneCardsiNEDD4
HGNCiHGNC:7727 NEDD4
HPAiCAB001991
CAB072833
HPA039883
MIMi602278 gene
neXtProtiNX_P46934
OpenTargetsiENSG00000069869
PharmGKBiPA31533
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00760000118966
HOVERGENiHBG004134
InParanoidiP46934
KOiK10591
OMAiFNSLKWI
OrthoDBiEOG091G0SS8
PhylomeDBiP46934
TreeFamiTF323658

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi2.3.2.B9 2681
6.3.2.19 2681
ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1253288 Downregulation of ERBB4 signaling
R-HSA-8948747 Regulation of PTEN localization
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP46934
SIGNORiP46934

Miscellaneous databases

ChiTaRSiNEDD4 human
EvolutionaryTraceiP46934
GeneWikiiNEDD4
GenomeRNAii4734
PROiPR:P46934
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069869 Expressed in 198 organ(s), highest expression level in biceps brachii
CleanExiHS_NEDD4
ExpressionAtlasiP46934 baseline and differential
GenevisibleiP46934 HS

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd00201 WW, 4 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF00397 WW, 4 hits
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00456 WW, 4 hits
SUPFAMiSSF51045 SSF51045, 4 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 4 hits
PS50020 WW_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNEDD4_HUMAN
AccessioniPrimary (citable) accession number: P46934
Secondary accession number(s): A1KY35
, A6ND72, A7MD29, B4E2R7, B7ZM59, B7ZM60, B9EGN5, D6RF89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 30, 2010
Last modified: October 10, 2018
This is version 195 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again