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Protein

Glucosamine-6-phosphate isomerase 1

Gene

GNPDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).By similarity

Catalytic activityi

Alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptor; for enolization stepBy similarity1
Active sitei141For ring-opening stepBy similarity1
Active sitei143Proton acceptor; for ring-opening stepBy similarity1
Active sitei148For ring-opening stepBy similarity1

GO - Molecular functioni

  • glucosamine-6-phosphate deaminase activity Source: UniProtKB

GO - Biological processi

  • carbohydrate metabolic process Source: UniProtKB-KW
  • generation of precursor metabolites and energy Source: UniProtKB
  • glucosamine catabolic process Source: UniProtKB
  • N-acetylglucosamine metabolic process Source: InterPro
  • single fertilization Source: ProtInc

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BRENDAi3.5.99.6 2681
ReactomeiR-HSA-70171 Glycolysis
SABIO-RKiP46926

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosamine-6-phosphate isomerase 1 (EC:3.5.99.6)
Alternative name(s):
Glucosamine-6-phosphate deaminase 1
Short name:
GNPDA 1
Short name:
GlcN6P deaminase 1
Oscillin
Gene namesi
Name:GNPDA1
Synonyms:GNPI, HLN, KIAA0060
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113552.15
HGNCiHGNC:4417 GNPDA1
MIMi601798 gene
neXtProtiNX_P46926

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10007
OpenTargetsiENSG00000113552
PharmGKBiPA28796

Chemistry databases

DrugBankiDB03951 16g
DB02445 2-Deoxy-2-Amino Glucitol-6-Phosphate
DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMutaiGNPDA1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001601221 – 289Glucosamine-6-phosphate isomerase 1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64N6-acetyllysineCombined sources1
Modified residuei161PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP46926
MaxQBiP46926
PaxDbiP46926
PeptideAtlasiP46926
PRIDEiP46926
ProteomicsDBi55767

PTM databases

iPTMnetiP46926
PhosphoSitePlusiP46926

Expressioni

Gene expression databases

BgeeiENSG00000113552
CleanExiHS_GNPDA1
ExpressionAtlasiP46926 baseline and differential
GenevisibleiP46926 HS

Organism-specific databases

HPAiHPA000499
HPA046891

Interactioni

Subunit structurei

Homohexamer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115325, 37 interactors
IntActiP46926, 6 interactors
MINTiP46926
STRINGi9606.ENSP00000311876

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi9 – 27Combined sources19
Beta strandi35 – 39Combined sources5
Helixi43 – 57Combined sources15
Beta strandi66 – 74Combined sources9
Helixi85 – 92Combined sources8
Helixi94 – 96Combined sources3
Helixi101 – 103Combined sources3
Helixi114 – 127Combined sources14
Beta strandi132 – 136Combined sources5
Beta strandi157 – 161Combined sources5
Helixi164 – 170Combined sources7
Helixi171 – 173Combined sources3
Turni174 – 176Combined sources3
Helixi178 – 180Combined sources3
Beta strandi183 – 187Combined sources5
Helixi190 – 194Combined sources5
Beta strandi199 – 203Combined sources5
Helixi206 – 208Combined sources3
Helixi209 – 216Combined sources8
Helixi225 – 231Combined sources7
Beta strandi233 – 240Combined sources8
Helixi241 – 244Combined sources4
Helixi249 – 257Combined sources9
Helixi259 – 262Combined sources4
Helixi263 – 265Combined sources3

3D structure databases

ProteinModelPortaliP46926
SMRiP46926
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46926

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
HOVERGENiHBG002546
InParanoidiP46926
KOiK02564
PhylomeDBiP46926
TreeFamiTF300841

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P46926-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLIILEHYS QASEWAAKYI RNRIIQFNPG PEKYFTLGLP TGSTPLGCYK
60 70 80 90 100
KLIEYYKNGD LSFKYVKTFN MDEYVGLPRD HPESYHSFMW NNFFKHIDIH
110 120 130 140 150
PENTHILDGN AVDLQAECDA FEEKIKAAGG IELFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRVK TLAMDTILAN ARFFDGELTK VPTMALTVGV GTVMDAREVM
210 220 230 240 250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD EDATLELKVK
260 270 280
TVKYFKGLML VHNKLVDPLY SIKEKETEKS QSSKKPYSD
Length:289
Mass (Da):32,669
Last modified:November 1, 1995 - v1
Checksum:i4111F655D574F74F
GO
Isoform 2 (identifier: P46926-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-145: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):24,047
Checksum:i1E7290F5BF06DB34
GO

Sequence cautioni

The sequence BAA06544 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05701169 – 145Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048826 mRNA Translation: AAC05123.1
AJ002231 mRNA Translation: CAA05259.1
AF029914 mRNA Translation: AAB84217.1
AF035809
, AF035804, AF035805, AF035806, AF035807, AF035808 Genomic DNA Translation: AAB88748.1
D31766 mRNA Translation: BAA06544.2 Different initiation.
AK296452 mRNA Translation: BAH12360.1
AC005740 Genomic DNA Translation: AAC62119.1
CH471062 Genomic DNA Translation: EAW61890.1
CH471062 Genomic DNA Translation: EAW61891.1
CH471062 Genomic DNA Translation: EAW61892.1
CH471062 Genomic DNA Translation: EAW61893.1
BC012853 mRNA Translation: AAH12853.1
BC020769 mRNA Translation: AAH20769.1
BC022322 mRNA Translation: AAH22322.1
CCDSiCCDS4272.1 [P46926-1]
RefSeqiNP_005462.1, NM_005471.4 [P46926-1]
XP_006714810.1, XM_006714747.2 [P46926-1]
XP_011535839.1, XM_011537537.1 [P46926-1]
UniGeneiHs.633853

Genome annotation databases

EnsembliENST00000311337; ENSP00000311876; ENSG00000113552 [P46926-1]
ENST00000500692; ENSP00000424275; ENSG00000113552 [P46926-1]
ENST00000503794; ENSP00000423485; ENSG00000113552 [P46926-1]
ENST00000508177; ENSP00000423674; ENSG00000113552 [P46926-1]
GeneIDi10007
KEGGihsa:10007
UCSCiuc003lmf.5 human [P46926-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGNPI1_HUMAN
AccessioniPrimary (citable) accession number: P46926
Secondary accession number(s): B7Z3X4, D3DQE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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