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Protein

Glucosamine-6-phosphate isomerase 1

Gene

GNPDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei72Proton acceptor; for enolization stepBy similarity1
Active sitei141For ring-opening stepBy similarity1
Active sitei143Proton acceptor; for ring-opening stepBy similarity1
Active sitei148For ring-opening stepBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glucosamine-6-phosphate deaminase activity Source: UniProtKB
  • identical protein binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.99.6 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-70171 Glycolysis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P46926

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucosamine-6-phosphate isomerase 1 (EC:3.5.99.6)
Alternative name(s):
Glucosamine-6-phosphate deaminase 1
Short name:
GNPDA 1
Short name:
GlcN6P deaminase 1
Oscillin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNPDA1
Synonyms:GNPI, HLN, KIAA0060
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113552.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4417 GNPDA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601798 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46926

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10007

Open Targets

More...
OpenTargetsi
ENSG00000113552

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28796

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03951 16g
DB02445 2-Deoxy-2-Amino Glucitol-6-Phosphate
DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNPDA1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001601221 – 289Glucosamine-6-phosphate isomerase 1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64N6-acetyllysineCombined sources1
Modified residuei161PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46926

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P46926

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46926

PeptideAtlas

More...
PeptideAtlasi
P46926

PRoteomics IDEntifications database

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PRIDEi
P46926

ProteomicsDB human proteome resource

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ProteomicsDBi
55767

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46926

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46926

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113552 Expressed in 239 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

More...
CleanExi
HS_GNPDA1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46926 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46926 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000499
HPA046891

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115325, 37 interactors

Protein interaction database and analysis system

More...
IntActi
P46926, 5 interactors

Molecular INTeraction database

More...
MINTi
P46926

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311876

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P46926

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46926

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P46926

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3148 Eukaryota
COG0363 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014316

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000064979

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002546

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P46926

KEGG Orthology (KO)

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KOi
K02564

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46926

TreeFam database of animal gene trees

More...
TreeFami
TF300841

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01399 GlcN6P_deaminase, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01241 GlcN6P_deamin, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like

The PANTHER Classification System

More...
PANTHERi
PTHR11280 PTHR11280, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01182 Glucosamine_iso, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00502 nagB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46926-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLIILEHYS QASEWAAKYI RNRIIQFNPG PEKYFTLGLP TGSTPLGCYK
60 70 80 90 100
KLIEYYKNGD LSFKYVKTFN MDEYVGLPRD HPESYHSFMW NNFFKHIDIH
110 120 130 140 150
PENTHILDGN AVDLQAECDA FEEKIKAAGG IELFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRVK TLAMDTILAN ARFFDGELTK VPTMALTVGV GTVMDAREVM
210 220 230 240 250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD EDATLELKVK
260 270 280
TVKYFKGLML VHNKLVDPLY SIKEKETEKS QSSKKPYSD
Length:289
Mass (Da):32,669
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4111F655D574F74F
GO
Isoform 2 (identifier: P46926-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-145: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):24,047
Checksum:i1E7290F5BF06DB34
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFF8D6RFF8_HUMAN
Glucosamine-6-phosphate isomerase
GNPDA1
290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9P4D6R9P4_HUMAN
Glucosamine-6-phosphate isomerase
GNPDA1
274Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAY7D6RAY7_HUMAN
Glucosamine-6-phosphate isomerase
GNPDA1
237Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB13D6RB13_HUMAN
Glucosamine-6-phosphate isomerase
GNPDA1
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R917D6R917_HUMAN
Glucosamine-6-phosphate isomerase 1
GNPDA1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFK5D6RFK5_HUMAN
Glucosamine-6-phosphate isomerase 1
GNPDA1
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA06544 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05701169 – 145Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF048826 mRNA Translation: AAC05123.1
AJ002231 mRNA Translation: CAA05259.1
AF029914 mRNA Translation: AAB84217.1
AF035809
, AF035804, AF035805, AF035806, AF035807, AF035808 Genomic DNA Translation: AAB88748.1
D31766 mRNA Translation: BAA06544.2 Different initiation.
AK296452 mRNA Translation: BAH12360.1
AC005740 Genomic DNA Translation: AAC62119.1
CH471062 Genomic DNA Translation: EAW61890.1
CH471062 Genomic DNA Translation: EAW61891.1
CH471062 Genomic DNA Translation: EAW61892.1
CH471062 Genomic DNA Translation: EAW61893.1
BC012853 mRNA Translation: AAH12853.1
BC020769 mRNA Translation: AAH20769.1
BC022322 mRNA Translation: AAH22322.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4272.1 [P46926-1]

NCBI Reference Sequences

More...
RefSeqi
NP_005462.1, NM_005471.4 [P46926-1]
XP_006714810.1, XM_006714747.2 [P46926-1]
XP_011535839.1, XM_011537537.1 [P46926-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.633853

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311337; ENSP00000311876; ENSG00000113552 [P46926-1]
ENST00000500692; ENSP00000424275; ENSG00000113552 [P46926-1]
ENST00000503794; ENSP00000423485; ENSG00000113552 [P46926-1]
ENST00000508177; ENSP00000423674; ENSG00000113552 [P46926-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10007

UCSC genome browser

More...
UCSCi
uc003lmf.5 human [P46926-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048826 mRNA Translation: AAC05123.1
AJ002231 mRNA Translation: CAA05259.1
AF029914 mRNA Translation: AAB84217.1
AF035809
, AF035804, AF035805, AF035806, AF035807, AF035808 Genomic DNA Translation: AAB88748.1
D31766 mRNA Translation: BAA06544.2 Different initiation.
AK296452 mRNA Translation: BAH12360.1
AC005740 Genomic DNA Translation: AAC62119.1
CH471062 Genomic DNA Translation: EAW61890.1
CH471062 Genomic DNA Translation: EAW61891.1
CH471062 Genomic DNA Translation: EAW61892.1
CH471062 Genomic DNA Translation: EAW61893.1
BC012853 mRNA Translation: AAH12853.1
BC020769 mRNA Translation: AAH20769.1
BC022322 mRNA Translation: AAH22322.1
CCDSiCCDS4272.1 [P46926-1]
RefSeqiNP_005462.1, NM_005471.4 [P46926-1]
XP_006714810.1, XM_006714747.2 [P46926-1]
XP_011535839.1, XM_011537537.1 [P46926-1]
UniGeneiHs.633853

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NE7X-ray1.75A/B/C/D/E/F1-289[»]
ProteinModelPortaliP46926
SMRiP46926
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115325, 37 interactors
IntActiP46926, 5 interactors
MINTiP46926
STRINGi9606.ENSP00000311876

Chemistry databases

DrugBankiDB03951 16g
DB02445 2-Deoxy-2-Amino Glucitol-6-Phosphate
DB02379 Beta-D-Glucose

PTM databases

iPTMnetiP46926
PhosphoSitePlusiP46926

Polymorphism and mutation databases

BioMutaiGNPDA1

Proteomic databases

EPDiP46926
MaxQBiP46926
PaxDbiP46926
PeptideAtlasiP46926
PRIDEiP46926
ProteomicsDBi55767

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10007
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311337; ENSP00000311876; ENSG00000113552 [P46926-1]
ENST00000500692; ENSP00000424275; ENSG00000113552 [P46926-1]
ENST00000503794; ENSP00000423485; ENSG00000113552 [P46926-1]
ENST00000508177; ENSP00000423674; ENSG00000113552 [P46926-1]
GeneIDi10007
KEGGihsa:10007
UCSCiuc003lmf.5 human [P46926-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10007
DisGeNETi10007
EuPathDBiHostDB:ENSG00000113552.15

GeneCards: human genes, protein and diseases

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GeneCardsi
GNPDA1
HGNCiHGNC:4417 GNPDA1
HPAiHPA000499
HPA046891
MIMi601798 gene
neXtProtiNX_P46926
OpenTargetsiENSG00000113552
PharmGKBiPA28796

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
HOVERGENiHBG002546
InParanoidiP46926
KOiK02564
PhylomeDBiP46926
TreeFamiTF300841

Enzyme and pathway databases

BRENDAi3.5.99.6 2681
ReactomeiR-HSA-70171 Glycolysis
SABIO-RKiP46926

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GNPDA1 human
EvolutionaryTraceiP46926

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GNPDA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10007

Protein Ontology

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PROi
PR:P46926

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113552 Expressed in 239 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_GNPDA1
ExpressionAtlasiP46926 baseline and differential
GenevisibleiP46926 HS

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNPI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46926
Secondary accession number(s): B7Z3X4, D3DQE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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