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Entry version 161 (12 Aug 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Trimethylamine-N-oxide reductase 2

Gene

torZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency.

Miscellaneous

Expression of torYZ allows E.coli to grow anaerobically on a wider range of substrates than does expression of torCAD.

Caution

Was originally thought to be a biotin sulfoxide reductase.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mo-bis(molybdopterin guanine dinucleotide)By similarityNote: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi176MolybdenumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: EcoCyc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, Molybdenum

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7022-MONOMER
ECOL316407:JW1861-MONOMER
MetaCyc:G7022-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trimethylamine-N-oxide reductase 2 (EC:1.7.2.3)
Short name:
TMAO reductase 2
Short name:
Trimethylamine oxidase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:torZ
Synonyms:bisZ
Ordered Locus Names:b1872, JW1861
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Tat-type signalPROSITE-ProRule annotation1 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001916332 – 809Trimethylamine-N-oxide reductase 2Add BLAST778

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46923

PRoteomics IDEntifications database

More...
PRIDEi
P46923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4263502, 53 interactors

Database of interacting proteins

More...
DIPi
DIP-9226N

Protein interaction database and analysis system

More...
IntActi
P46923, 19 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1872

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P46923

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0243, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000422_13_3_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46923

KEGG Orthology (KO)

More...
KOi
K07812

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46923

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02793, MopB_CT_DMSOR-BSOR-TMAOR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR006658, BisC
IPR041954, CT_DMSOR/BSOR/TMAOR
IPR041460, Molybdopterin_N
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006655, Mopterin_OxRdtase_prok_CS
IPR006311, TAT_signal
IPR019546, TAT_signal_bac_arc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00384, Molybdopterin, 1 hit
PF18364, Molybdopterin_N, 1 hit
PF01568, Molydop_binding, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50692, SSF50692, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00509, bisC_fam, 1 hit
TIGR01409, TAT_signal_seq, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit
PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
PS51318, TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P46923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLTRREFIK HSGIAAGALV VTSAAPLPAW AEEKGGKILT AGRWGAMNVE
60 70 80 90 100
VKDGKIVSST GALAKTIPNS LQSTAADQVH TTARIQHPMV RKSYLDNPLQ
110 120 130 140 150
PAKGRGEDTY VQVSWEQALK LIHEQHDRIR KANGPSAIFA GSYGWRSSGV
160 170 180 190 200
LHKAQTLLQR YMNLAGGYSG HSGDYSTGAA QVIMPHVVGS VEVYEQQTSW
210 220 230 240 250
PLILENSQVV VLWGMNPLNT LKIAWSSTDE QGLEYFHQLK KSGKPVIAID
260 270 280 290 300
PIRSETIEFF DDNATWIAPN MGTDVALMLG IAHTLMTQGK HDKVFLEKYT
310 320 330 340 350
TGYPQFEEYL TGKSDNTPKS AVWAAEITGV PEAQIVKLAE LMAANRTMLM
360 370 380 390 400
AGWGIQRQQY GEQKHWMLVT LAAMLGQIGT PGGGFGFSYH YSNGGNPTRV
410 420 430 440 450
GGVLPEMSAA IAGHASEAAD DGGMTAIPVA RIVDALENPG GKYQHNGKEQ
460 470 480 490 500
TYPNIKMIWW AGGGNFTHHQ DTNRLIKAWQ KPEMIVVSEC YWTAAAKHAD
510 520 530 540 550
IVLPITTSFE RNDLTMTGDY SNQHIVPMKQ AVAPQFEARN DFDVFADLAE
560 570 580 590 600
LLKPGGKEIY TEGKDEMAWL KFFYDAAQKG ARAQRVTMPM FNAFWQQNKL
610 620 630 640 650
IEMRHSEKNE QYVRYGDFRA DPVKNALGTP SGKIEIYSKT LEKFGYKDCP
660 670 680 690 700
AHPTWLAPDE WKGTADEKQL QLLTAHPAHR LHSQLNYAEL RKKYAIADRE
710 720 730 740 750
PITIHTEDAA RFGIANGDLV RVWNKRGQIL TGAVVTDGIK KGVVCVHEGA
760 770 780 790 800
WPDLENGLCK NGSANVLTAD IPSSQLANAC AGNSALVYIE KYTGNAPKLT

AFDQPAVQA
Length:809
Mass (Da):88,964
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44A84F6302531D09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76A → T in AAC44131 (PubMed:8919859).Curated1
Sequence conflicti291 – 292HD → TI in AAC44131 (PubMed:8919859).Curated2
Sequence conflicti299 – 304YTTGYP → TLPGIR in AAC44131 (PubMed:8919859).Curated6
Sequence conflicti406 – 409EMSA → DFSGP in AAC44131 (PubMed:8919859).Curated4
Sequence conflicti801 – 803AFD → GFG in AAC44131 (PubMed:8919859).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U38839 Genomic DNA Translation: AAC44131.1
U00096 Genomic DNA Translation: AAC74942.2
AP009048 Genomic DNA Translation: BAA15682.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H64949

NCBI Reference Sequences

More...
RefSeqi
NP_416386.4, NC_000913.3
WP_000176781.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74942; AAC74942; b1872
BAA15682; BAA15682; BAA15682

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1861
eco:b1872

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38839 Genomic DNA Translation: AAC44131.1
U00096 Genomic DNA Translation: AAC74942.2
AP009048 Genomic DNA Translation: BAA15682.1
PIRiH64949
RefSeqiNP_416386.4, NC_000913.3
WP_000176781.1, NZ_LN832404.1

3D structure databases

SMRiP46923
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4263502, 53 interactors
DIPiDIP-9226N
IntActiP46923, 19 interactors
STRINGi511145.b1872

Proteomic databases

PaxDbiP46923
PRIDEiP46923

Genome annotation databases

EnsemblBacteriaiAAC74942; AAC74942; b1872
BAA15682; BAA15682; BAA15682
GeneIDi946389
KEGGiecj:JW1861
eco:b1872
PATRICifig|1411691.4.peg.376

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3061

Phylogenomic databases

eggNOGiCOG0243, Bacteria
HOGENOMiCLU_000422_13_3_6
InParanoidiP46923
KOiK07812
PhylomeDBiP46923

Enzyme and pathway databases

BioCyciEcoCyc:G7022-MONOMER
ECOL316407:JW1861-MONOMER
MetaCyc:G7022-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P46923

Family and domain databases

CDDicd02793, MopB_CT_DMSOR-BSOR-TMAOR, 1 hit
InterProiView protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR006658, BisC
IPR041954, CT_DMSOR/BSOR/TMAOR
IPR041460, Molybdopterin_N
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006655, Mopterin_OxRdtase_prok_CS
IPR006311, TAT_signal
IPR019546, TAT_signal_bac_arc
PfamiView protein in Pfam
PF00384, Molybdopterin, 1 hit
PF18364, Molybdopterin_N, 1 hit
PF01568, Molydop_binding, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
TIGRFAMsiTIGR00509, bisC_fam, 1 hit
TIGR01409, TAT_signal_seq, 1 hit
PROSITEiView protein in PROSITE
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit
PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
PS51318, TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTORZ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46923
Secondary accession number(s): P76292, P97187
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: August 12, 2020
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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