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Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

SLC2A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei316MonosaccharideBy similarity1
Binding sitei387MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-352832 Glucose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1
Short name:
GLUT-1
Short name:
GT1
Gene namesi
Name:SLC2A1
Synonyms:GLUT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicBy similarity10
Transmembranei11 – 32Helical; Name=1By similarityAdd BLAST22
Topological domaini33 – 65ExtracellularBy similarityAdd BLAST33
Transmembranei66 – 86Helical; Name=2By similarityAdd BLAST21
Topological domaini87 – 89CytoplasmicBy similarity3
Transmembranei90 – 111Helical; Name=3By similarityAdd BLAST22
Topological domaini112 – 119ExtracellularBy similarity8
Transmembranei120 – 143Helical; Name=4By similarityAdd BLAST24
Topological domaini144 – 154CytoplasmicBy similarityAdd BLAST11
Transmembranei155 – 175Helical; Name=5By similarityAdd BLAST21
Topological domaini176 – 184ExtracellularBy similarity9
Transmembranei185 – 205Helical; Name=6By similarityAdd BLAST21
Topological domaini206 – 270CytoplasmicBy similarityAdd BLAST65
Transmembranei271 – 292Helical; Name=7By similarityAdd BLAST22
Topological domaini293 – 305ExtracellularBy similarityAdd BLAST13
Transmembranei306 – 327Helical; Name=8By similarityAdd BLAST22
Topological domaini328 – 333CytoplasmicBy similarity6
Transmembranei334 – 354Helical; Name=9By similarityAdd BLAST21
Topological domaini355 – 364ExtracellularBy similarity10
Transmembranei365 – 387Helical; Name=10By similarityAdd BLAST23
Topological domaini388 – 400CytoplasmicBy similarityAdd BLAST13
Transmembranei401 – 421Helical; Name=11By similarityAdd BLAST21
Topological domaini422 – 428ExtracellularBy similarity7
Transmembranei429 – 449Helical; Name=12By similarityAdd BLAST21
Topological domaini450 – 490CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503441 – 490Solute carrier family 2, facilitated glucose transporter member 1Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP46896

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007795

Structurei

3D structure databases

ProteinModelPortaliP46896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 287Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP46896
KOiK07299
PhylomeDBiP46896

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002439 Glu_transpt_1
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01190 GLUCTRSPORT1
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGSKMTAR LMLAVGGAVL GSLQFGYNTG VINRPQKVIE DFYNHTWLYR
60 70 80 90 100
YEEPISPATL TTLWSLSVAI FSVGGMIGSF SVGLFVNRFG RRNSMLMSNI
110 120 130 140 150
LAFLAAVLMG FSKMALSFEM LILGRFIIGL YSGLTTGFVP MYVGEVSPTA
160 170 180 190 200
LRGALGTFHQ LGIVLGILIA QVFGLDLIMG NDSLWPLLLG FIFVPALLQC
210 220 230 240 250
IILPFAPESP RFLLINRNEE NKAKSVLKKL RGTTDVSSDL QEMKEESRQM
260 270 280 290 300
MREKKVTIME LFRSPMYRQP ILIAIVLQLS QQLSGINAVF YYSTSIFEKS
310 320 330 340 350
GVEQPVYATI GSGVVNTAFT VVSLFVVERA GRRTLHLIGL AGMAGCAILM
360 370 380 390 400
TIALTLLDQM PWMSYLSIVA IFGFVAFFEI GPGPIPWFIV AELFSQGPRP
410 420 430 440 450
AAFAVAGLSN WTSNFIVGMG FQYIAQLCGS YVFIIFTVLL VLFFIFTYFK
460 470 480 490
VPETKGRTFD EIAYRFRQGG ASQSDKTPDE FHSLGADSQV
Length:490
Mass (Da):54,087
Last modified:November 1, 1995 - v1
Checksum:i63BB176812D06104
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07300 mRNA Translation: AAB02037.1
RefSeqiNP_990540.1, NM_205209.1
UniGeneiGga.1040

Genome annotation databases

GeneIDi396130
KEGGigga:396130

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07300 mRNA Translation: AAB02037.1
RefSeqiNP_990540.1, NM_205209.1
UniGeneiGga.1040

3D structure databases

ProteinModelPortaliP46896
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007795

Proteomic databases

PaxDbiP46896

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396130
KEGGigga:396130

Organism-specific databases

CTDi6513

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP46896
KOiK07299
PhylomeDBiP46896

Enzyme and pathway databases

ReactomeiR-GGA-352832 Glucose transport

Miscellaneous databases

PROiPR:P46896

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002439 Glu_transpt_1
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01190 GLUCTRSPORT1
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR1_CHICK
AccessioniPrimary (citable) accession number: P46896
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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