UniProtKB - P46896 (GTR1_CHICK)
Solute carrier family 2, facilitated glucose transporter member 1
SLC2A1
Functioni
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity).
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (PubMed:25957687).
By similarity1 PublicationCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 160 | D-glucoseBy similarity | 1 | |
Binding sitei | 287 | D-glucoseBy similarity | 1 | |
Binding sitei | 316 | D-glucoseBy similarity | 1 | |
Binding sitei | 379 | D-glucoseBy similarity | 1 | |
Binding sitei | 387 | D-glucoseBy similarity | 1 |
GO - Molecular functioni
- glucose transmembrane transporter activity Source: UniProtKB
- protein self-association Source: UniProtKB
GO - Biological processi
- glucose transmembrane transport Source: UniProtKB
- photoreceptor cell maintenance Source: UniProtKB
- protein-containing complex assembly Source: UniProtKB
- response to dexamethasone Source: AgBase
- response to insulin Source: AgBase
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
Reactomei | R-GGA-352832, Glucose transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 1CuratedAlternative name(s): Glucose transporter type 11 Publication Short name: GLUT-11 Publication Short name: GT11 Publication |
Gene namesi | Name:SLC2A1By similarity Synonyms:GLUT11 Publication |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- Photoreceptor inner segment By similarity
Cytoskeleton
- cortical actin cytoskeleton Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- photoreceptor inner segment Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicBy similarity | 10 | |
Transmembranei | 11 – 32 | Helical; Name=1By similarityAdd BLAST | 22 | |
Topological domaini | 33 – 65 | ExtracellularBy similarityAdd BLAST | 33 | |
Transmembranei | 66 – 86 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 87 – 89 | CytoplasmicBy similarity | 3 | |
Transmembranei | 90 – 111 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 112 – 119 | ExtracellularBy similarity | 8 | |
Transmembranei | 120 – 143 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 144 – 154 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 155 – 175 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 176 – 184 | ExtracellularBy similarity | 9 | |
Transmembranei | 185 – 205 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 206 – 270 | CytoplasmicBy similarityAdd BLAST | 65 | |
Transmembranei | 271 – 292 | Helical; Name=7By similarityAdd BLAST | 22 | |
Topological domaini | 293 – 305 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 306 – 327 | Helical; Name=8By similarityAdd BLAST | 22 | |
Topological domaini | 328 – 333 | CytoplasmicBy similarity | 6 | |
Transmembranei | 334 – 354 | Helical; Name=9By similarityAdd BLAST | 21 | |
Topological domaini | 355 – 364 | ExtracellularBy similarity | 10 | |
Transmembranei | 365 – 387 | Helical; Name=10By similarityAdd BLAST | 23 | |
Topological domaini | 388 – 400 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 401 – 421 | Helical; Name=11By similarityAdd BLAST | 21 | |
Topological domaini | 422 – 428 | ExtracellularBy similarity | 7 | |
Transmembranei | 429 – 449 | Helical; Name=12By similarityAdd BLAST | 21 | |
Topological domaini | 450 – 490 | CytoplasmicBy similarityAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050344 | 1 – 490 | Solute carrier family 2, facilitated glucose transporter member 1Add BLAST | 490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P46896 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with isoform 1 of BSG.
1 PublicationGO - Molecular functioni
- protein self-association Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000007795 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 281 – 282 | D-glucose bindingBy similarity | 2 | |
Regioni | 470 – 490 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
InParanoidi | P46896 |
OrthoDBi | 749998at2759 |
PhylomeDBi | P46896 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002439, Glu_transpt_1 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01190, GLUCTRSPORT1 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MESGSKMTAR LMLAVGGAVL GSLQFGYNTG VINRPQKVIE DFYNHTWLYR
60 70 80 90 100
YEEPISPATL TTLWSLSVAI FSVGGMIGSF SVGLFVNRFG RRNSMLMSNI
110 120 130 140 150
LAFLAAVLMG FSKMALSFEM LILGRFIIGL YSGLTTGFVP MYVGEVSPTA
160 170 180 190 200
LRGALGTFHQ LGIVLGILIA QVFGLDLIMG NDSLWPLLLG FIFVPALLQC
210 220 230 240 250
IILPFAPESP RFLLINRNEE NKAKSVLKKL RGTTDVSSDL QEMKEESRQM
260 270 280 290 300
MREKKVTIME LFRSPMYRQP ILIAIVLQLS QQLSGINAVF YYSTSIFEKS
310 320 330 340 350
GVEQPVYATI GSGVVNTAFT VVSLFVVERA GRRTLHLIGL AGMAGCAILM
360 370 380 390 400
TIALTLLDQM PWMSYLSIVA IFGFVAFFEI GPGPIPWFIV AELFSQGPRP
410 420 430 440 450
AAFAVAGLSN WTSNFIVGMG FQYIAQLCGS YVFIIFTVLL VLFFIFTYFK
460 470 480 490
VPETKGRTFD EIAYRFRQGG ASQSDKTPDE FHSLGADSQV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07300 mRNA Translation: AAB02037.1 |
RefSeqi | NP_990540.1, NM_205209.1 |
Genome annotation databases
GeneIDi | 396130 |
KEGGi | gga:396130 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07300 mRNA Translation: AAB02037.1 |
RefSeqi | NP_990540.1, NM_205209.1 |
3D structure databases
AlphaFoldDBi | P46896 |
SMRi | P46896 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000007795 |
Proteomic databases
PaxDbi | P46896 |
Genome annotation databases
GeneIDi | 396130 |
KEGGi | gga:396130 |
Organism-specific databases
CTDi | 6513 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
InParanoidi | P46896 |
OrthoDBi | 749998at2759 |
PhylomeDBi | P46896 |
Enzyme and pathway databases
Reactomei | R-GGA-352832, Glucose transport |
Miscellaneous databases
PROi | PR:P46896 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002439, Glu_transpt_1 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01190, GLUCTRSPORT1 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR1_CHICK | |
Accessioni | P46896Primary (citable) accession number: P46896 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families