SLC2A1

Functionⁱ

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	316	MonosaccharideBy similarity		1
Binding siteⁱ	387	MonosaccharideBy similarity		1

GO - Molecular functionⁱ

glucose transmembrane transporter activity Source: UniProtKB
protein self-association Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glucose transmembrane transport Source: UniProtKB
protein-containing complex assembly Source: UniProtKB
response to dexamethasone
Source: AgBase
Inferred from direct assayⁱ
- 22859751
response to insulin
Source: AgBase
Inferred from direct assayⁱ
- 22859751

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sugar transport, Transport

Biological process

Sugar transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-GGA-352832 Glucose transport

Reactomeⁱ

R-GGA-352832 Glucose transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 2, facilitated glucose transporter member 1 Alternative name(s): Glucose transporter type 1 Short name: GLUT-1 Short name: GT1
Gene namesⁱ	Name:SLC2A1 Synonyms:GLUT1
Organismⁱ	Gallus gallus (Chicken)
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Unplaced

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 10	CytoplasmicBy similarity	10
Transmembraneⁱ	11 – 32	Helical; Name=1By similarityAdd BLAST	22
Topological domainⁱ	33 – 65	ExtracellularBy similarityAdd BLAST	33
Transmembraneⁱ	66 – 86	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	87 – 89	CytoplasmicBy similarity	3
Transmembraneⁱ	90 – 111	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	112 – 119	ExtracellularBy similarity	8
Transmembraneⁱ	120 – 143	Helical; Name=4By similarityAdd BLAST	24
Topological domainⁱ	144 – 154	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	155 – 175	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	176 – 184	ExtracellularBy similarity	9
Transmembraneⁱ	185 – 205	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	206 – 270	CytoplasmicBy similarityAdd BLAST	65
Transmembraneⁱ	271 – 292	Helical; Name=7By similarityAdd BLAST	22
Topological domainⁱ	293 – 305	ExtracellularBy similarityAdd BLAST	13
Transmembraneⁱ	306 – 327	Helical; Name=8By similarityAdd BLAST	22
Topological domainⁱ	328 – 333	CytoplasmicBy similarity	6
Transmembraneⁱ	334 – 354	Helical; Name=9By similarityAdd BLAST	21
Topological domainⁱ	355 – 364	ExtracellularBy similarity	10
Transmembraneⁱ	365 – 387	Helical; Name=10By similarityAdd BLAST	23
Topological domainⁱ	388 – 400	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	401 – 421	Helical; Name=11By similarityAdd BLAST	21
Topological domainⁱ	422 – 428	ExtracellularBy similarity	7
Transmembraneⁱ	429 – 449	Helical; Name=12By similarityAdd BLAST	21
Topological domainⁱ	450 – 490	CytoplasmicBy similarityAdd BLAST	41

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050344	1 – 490	Solute carrier family 2, facilitated glucose transporter member 1Add BLAST		490

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	44	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P46896

PaxDbⁱ

P46896

Interactionⁱ

GO - Molecular functionⁱ

protein self-association Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000007795

STRINGⁱ

9031.ENSGALP00000007795

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P46896
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	281 – 287	Monosaccharide bindingBy similarity		7

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0569 Eukaryota COG0477 LUCA
HOGENOMⁱ	HOG000202871
HOVERGENⁱ	HBG014816
InParanoidⁱ	P46896
KEGG Orthology (KO) More...KOⁱ	K07299
PhylomeDBⁱ	P46896

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR002439 Glu_transpt_1 IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR01190 GLUCTRSPORT1 PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P46896-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MESGSKMTAR LMLAVGGAVL GSLQFGYNTG VINRPQKVIE DFYNHTWLYR 
        60         70         80         90        100
YEEPISPATL TTLWSLSVAI FSVGGMIGSF SVGLFVNRFG RRNSMLMSNI 
       110        120        130        140        150
LAFLAAVLMG FSKMALSFEM LILGRFIIGL YSGLTTGFVP MYVGEVSPTA 
       160        170        180        190        200
LRGALGTFHQ LGIVLGILIA QVFGLDLIMG NDSLWPLLLG FIFVPALLQC 
       210        220        230        240        250
IILPFAPESP RFLLINRNEE NKAKSVLKKL RGTTDVSSDL QEMKEESRQM 
       260        270        280        290        300
MREKKVTIME LFRSPMYRQP ILIAIVLQLS QQLSGINAVF YYSTSIFEKS 
       310        320        330        340        350
GVEQPVYATI GSGVVNTAFT VVSLFVVERA GRRTLHLIGL AGMAGCAILM 
       360        370        380        390        400
TIALTLLDQM PWMSYLSIVA IFGFVAFFEI GPGPIPWFIV AELFSQGPRP 
       410        420        430        440        450
AAFAVAGLSN WTSNFIVGMG FQYIAQLCGS YVFIIFTVLL VLFFIFTYFK 
       460        470        480        490
VPETKGRTFD EIAYRFRQGG ASQSDKTPDE FHSLGADSQV

Length:490

Mass (Da):54,087

Last modified:November 1, 1995 - v1

Checksum:ⁱ63BB176812D06104

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07300 mRNA Translation: AAB02037.1
NCBI Reference Sequences More...RefSeqⁱ	NP_990540.1, NM_205209.1
UniGeneⁱ	Gga.1040

Genome annotation databases

GeneIDⁱ	396130
KEGGⁱ	gga:396130

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P46896	Solute carrier family 2, facilitated glucose transporter member 1		CHEMY		584	UniRef90_P46896
Solute carrier family 2, facilitated glucose transporter member 1		Patagioenas fasciata monilis		502
Uncharacterized protein		BAMTH		496
Solute carrier family 2, facilitated glucose transporter member 1		COLLI		495
Uncharacterized protein		ALLMI		491
+77

Protein	Similar proteins		Species	Score	Length	Source
P46896	Solute carrier family 2, facilitated glucose transporter member 1	)	HUMAN		492	UniRef50_P11166
Solute carrier family 2, facilitated glucose transporter member 1		BOVIN		492
Solute carrier family 2, facilitated glucose transporter member 1		RAT		492
Solute carrier family 2, facilitated glucose transporter member 1		RABIT		492
Solute carrier family 2, facilitated glucose transporter member 1		MOUSE		492
+1298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07300 mRNA Translation: AAB02037.1
RefSeqⁱ	NP_990540.1, NM_205209.1
UniGeneⁱ	Gga.1040

3D structure databases

ProteinModelPortalⁱ	P46896
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000007795

STRINGⁱ

9031.ENSGALP00000007795

Proteomic databases

PaxDbⁱ	P46896

PaxDbⁱ

P46896

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	396130
KEGGⁱ	gga:396130

Organism-specific databases

CTDⁱ	6513

CTDⁱ

6513

Phylogenomic databases

eggNOGⁱ	KOG0569 Eukaryota COG0477 LUCA
HOGENOMⁱ	HOG000202871
HOVERGENⁱ	HBG014816
InParanoidⁱ	P46896
KOⁱ	K07299
PhylomeDBⁱ	P46896

Enzyme and pathway databases

Reactomeⁱ	R-GGA-352832 Glucose transport

Reactomeⁱ

R-GGA-352832 Glucose transport

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P46896

PROⁱ

PR:P46896

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR002439 Glu_transpt_1 IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR01190 GLUCTRSPORT1 PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GTR1_CHICK
Accessionⁱ	P46896Primary (citable) accession number: P46896
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P46896 (GTR1_CHICK)

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Solute carrier family 2, facilitated glucose transporter member 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ