UniProtKB - P46881 (PAOX_ARTGO)
Protein
Phenylethylamine oxidase
Gene
N/A
Organism
Arthrobacter globiformis
Status
Functioni
Catalytic activityi
- EC:1.4.3.21By similarity
Cofactori
Protein has several cofactor binding sites:- Cu cation1 PublicationNote: Binds 1 copper ion per subunit.1 Publication
- L-topaquinone1 PublicationNote: Contains 1 topaquinone per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 298 | Proton acceptorBy similarity | 1 | |
Active sitei | 382 | Schiff-base intermediate with substrate; via topaquinoneBy similarity | 1 | |
Metal bindingi | 431 | Copper; via tele nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 433 | Copper; via tele nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 592 | Copper; via pros nitrogenCombined sources1 Publication | 1 |
GO - Molecular functioni
- aliphatic-amine oxidase activity Source: UniProtKB-EC
- aminoacetone:oxygen oxidoreductase(deaminating) activity Source: UniProtKB-EC
- copper ion binding Source: InterPro
- phenethylamine:oxygen oxidoreductase (deaminating) activity Source: UniProtKB-EC
- primary amine oxidase activity Source: UniProtKB-EC
- quinone binding Source: InterPro
- tryptamine:oxygen oxidoreductase (deaminating) activity Source: UniProtKB-EC
GO - Biological processi
- amine metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Copper, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.4.3.21, 444 |
Names & Taxonomyi
Protein namesi | Recommended name: Phenylethylamine oxidase (EC:1.4.3.21By similarity)Alternative name(s): Primary amine oxidase |
Organismi | Arthrobacter globiformis |
Taxonomic identifieri | 1665 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Micrococcales › Micrococcaceae › Arthrobacter |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 382 | Y → F: Loss of activity. | 1 |
Chemistry databases
DrugBanki | DB02511, 2-Hydroxy-5-({1-[(2-Naphthyloxy)Methyl]-3-Oxoprop-1-Enyl}Amino)Tyrosine DB02537, 2-Hydroxy-5-({1-[(4-Methylphenoxy)Methyl]-3-Oxoprop-1-Enyl}Amino)-L-Tyrosine DB06988, 2-HYDROXY-5-{[(1E)-2-PHENYLETHYLIDENE]AMINO}-L-TYROSINE DB04334, 6-hydroxydopa quinone |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000035681 | 1 – 2 | 2 | ||
ChainiPRO_0000035682 | 3 – 638 | Phenylethylamine oxidaseAdd BLAST | 636 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 317 ↔ 343 | Combined sources1 Publication | ||
Modified residuei | 382 | 2',4',5'-topaquinone1 Publication | 1 |
Post-translational modificationi
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.1 Publication
Keywords - PTMi
Disulfide bond, TPQExpressioni
Inductioni
By phenethylamine.
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P46881 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46881 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 296 – 307 | Substrate bindingBy similarityAdd BLAST | 12 | |
Regioni | 379 – 384 | Substrate bindingBy similarity | 6 |
Sequence similaritiesi
Belongs to the copper/topaquinone oxidase family.Curated
Family and domain databases
Gene3Di | 2.70.98.20, 1 hit |
InterProi | View protein in InterPro IPR000269, Cu_amine_oxidase IPR015798, Cu_amine_oxidase_C IPR036460, Cu_amine_oxidase_C_sf IPR016182, Cu_amine_oxidase_N-reg IPR015802, Cu_amine_oxidase_N3 |
PANTHERi | PTHR10638, PTHR10638, 1 hit |
Pfami | View protein in Pfam PF01179, Cu_amine_oxid, 1 hit PF02728, Cu_amine_oxidN3, 1 hit |
SUPFAMi | SSF49998, SSF49998, 1 hit SSF54416, SSF54416, 2 hits |
PROSITEi | View protein in PROSITE PS01164, COPPER_AMINE_OXID_1, 1 hit PS01165, COPPER_AMINE_OXID_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P46881-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPSTIQTAS PFRLASAGEI SEVQGILRTA GLLGPEKRIA YLGVLDPARG
60 70 80 90 100
AGSEAEDRRF RVFIHDVSGA RPQEVTVSVT NGTVISAVEL DTAATGELPV
110 120 130 140 150
LEEEFEVVEQ LLATDERWLK ALAARNLDVS KVRVAPLSAG VFEYAEERGR
160 170 180 190 200
RILRGLAFVQ DFPEDSAWAH PVDGLVAYVD VVSKEVTRVI DTGVFPVPAE
210 220 230 240 250
HGNYTDPELT GPLRTTQKPI SITQPEGPSF TVTGGNHIEW EKWSLDVGFD
260 270 280 290 300
VREGVVLHNI AFRDGDRLRP IINRASIAEM VVPYGDPSPI RSWQNYFDTG
310 320 330 340 350
EYLVGQYANS LELGCDCLGD ITYLSPVISD AFGNPREIRN GICMHEEDWG
360 370 380 390 400
ILAKHSDLWS GINYTRRNRR MVISFFTTIG NYDYGFYWYL YLDGTIEFEA
410 420 430 440 450
KATGVVFTSA FPEGGSDNIS QLAPGLGAPF HQHIFSARLD MAIDGFTNRV
460 470 480 490 500
EEEDVVRQTM GPGNERGNAF SRKRTVLTRE SEAVREADAR TGRTWIISNP
510 520 530 540 550
ESKNRLNEPV GYKLHAHNQP TLLADPGSSI ARRAAFATKD LWVTRYADDE
560 570 580 590 600
RYPTGDFVNQ HSGGAGLPSY IAQDRDIDGQ DIVVWHTFGL THFPRVEDWP
610 620 630
IMPVDTVGFK LRPEGFFDRS PVLDVPANPS QSGSHCHG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03517 Unassigned DNA Translation: AAA18114.1 |
PIRi | JC2139 |
Genome annotation databases
KEGGi | ag:AAA18114 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03517 Unassigned DNA Translation: AAA18114.1 |
PIRi | JC2139 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AV4 | X-ray | 2.20 | A | 1-638 | [»] | |
1AVK | X-ray | 2.20 | A | 1-638 | [»] | |
1AVL | X-ray | 2.80 | A | 1-638 | [»] | |
1IQX | X-ray | 2.00 | A/B | 1-638 | [»] | |
1IQY | X-ray | 1.80 | A/B | 1-638 | [»] | |
1IU7 | X-ray | 1.80 | A/B | 1-638 | [»] | |
1IVU | X-ray | 1.90 | A/B | 1-638 | [»] | |
1IVV | X-ray | 2.10 | A/B | 1-638 | [»] | |
1IVW | X-ray | 1.80 | A/B | 1-638 | [»] | |
1IVX | X-ray | 2.20 | A/B | 1-638 | [»] | |
1RJO | X-ray | 1.67 | A | 3-638 | [»] | |
1SIH | X-ray | 1.73 | A | 3-638 | [»] | |
1SII | X-ray | 1.70 | A | 3-638 | [»] | |
1UI7 | X-ray | 2.00 | A/B | 1-638 | [»] | |
1UI8 | X-ray | 1.80 | A/B | 1-638 | [»] | |
1W4N | X-ray | 1.65 | A/B | 3-638 | [»] | |
1W5Z | X-ray | 1.86 | A | 3-638 | [»] | |
1W6C | X-ray | 2.20 | A | 3-638 | [»] | |
1W6G | X-ray | 1.55 | A | 3-638 | [»] | |
1WMN | X-ray | 1.80 | A/B | 1-638 | [»] | |
1WMO | X-ray | 1.80 | A/B | 1-638 | [»] | |
1WMP | X-ray | 2.00 | A/B | 1-638 | [»] | |
2BT3 | X-ray | 1.73 | A | 3-638 | [»] | |
2CFD | X-ray | 1.60 | A/B | 3-638 | [»] | |
2CFG | X-ray | 1.55 | A/B | 3-638 | [»] | |
2CFK | X-ray | 1.80 | A | 3-638 | [»] | |
2CFL | X-ray | 1.80 | A | 3-638 | [»] | |
2CFW | X-ray | 1.74 | A | 3-638 | [»] | |
2CG0 | X-ray | 1.80 | A | 3-638 | [»] | |
2CG1 | X-ray | 1.67 | A | 3-638 | [»] | |
2CWT | X-ray | 1.82 | A/B | 1-638 | [»] | |
2CWU | X-ray | 1.85 | A/B | 1-638 | [»] | |
2CWV | X-ray | 1.85 | A/B | 1-638 | [»] | |
2D1W | X-ray | 1.74 | A/B | 1-638 | [»] | |
2E2T | X-ray | 2.05 | A | 1-638 | [»] | |
2E2U | X-ray | 1.68 | A/B | 1-628 | [»] | |
2E2V | X-ray | 1.80 | A/B | 1-628 | [»] | |
2YX9 | X-ray | 1.68 | A/B | 1-638 | [»] | |
2ZL8 | X-ray | 1.73 | A/B | 1-638 | [»] | |
3AMO | X-ray | 2.10 | A/B | 1-638 | [»] | |
3KII | X-ray | 1.90 | A/B | 3-638 | [»] | |
3KN4 | X-ray | 2.05 | A | 3-638 | [»] | |
3WA2 | X-ray | 1.08 | X | 9-629 | [»] | |
3WA3 | X-ray | 1.55 | A/B | 9-629 | [»] | |
3X3X | X-ray | 1.57 | A/B | 9-628 | [»] | |
3X3Y | X-ray | 1.50 | A/B | 9-628 | [»] | |
3X3Z | X-ray | 1.51 | A/B | 9-628 | [»] | |
3X40 | X-ray | 1.85 | A/B | 9-628 | [»] | |
3X41 | X-ray | 1.87 | A/B | 9-628 | [»] | |
3X42 | X-ray | 1.88 | A/B | 9-629 | [»] | |
5ZOU | X-ray | 1.68 | A/B | 9-628 | [»] | |
5ZOW | X-ray | 1.78 | A/B | 9-628 | [»] | |
5ZOX | X-ray | 1.69 | A/B | 9-628 | [»] | |
5ZOY | X-ray | 1.70 | A/B | 9-628 | [»] | |
5ZOZ | X-ray | 1.70 | A/B | 9-628 | [»] | |
5ZP0 | X-ray | 1.74 | A/B | 9-628 | [»] | |
5ZP1 | X-ray | 1.67 | A/B | 9-628 | [»] | |
5ZP2 | X-ray | 1.75 | A/B | 9-628 | [»] | |
5ZP3 | X-ray | 1.78 | A/B | 9-628 | [»] | |
5ZP4 | X-ray | 1.80 | A/B | 9-628 | [»] | |
5ZP5 | X-ray | 1.77 | A/B | 9-628 | [»] | |
5ZP6 | X-ray | 1.69 | A/B | 9-628 | [»] | |
5ZP7 | X-ray | 1.63 | A/B | 9-628 | [»] | |
5ZP8 | X-ray | 1.66 | A/B | 9-628 | [»] | |
5ZP9 | X-ray | 1.70 | A/B | 9-628 | [»] | |
5ZPA | X-ray | 1.69 | A/B | 9-628 | [»] | |
5ZPB | X-ray | 1.79 | A/B | 9-628 | [»] | |
5ZPC | X-ray | 1.74 | A/B | 9-628 | [»] | |
5ZPD | X-ray | 1.67 | A/B | 9-628 | [»] | |
5ZPE | X-ray | 1.69 | A/B | 9-628 | [»] | |
5ZPF | X-ray | 1.76 | A/B | 9-628 | [»] | |
5ZPG | X-ray | 1.65 | A/B | 9-628 | [»] | |
5ZPH | X-ray | 1.72 | A/B | 9-628 | [»] | |
5ZPI | X-ray | 1.75 | A/B | 9-628 | [»] | |
5ZPJ | X-ray | 1.65 | A/B | 9-628 | [»] | |
5ZPK | X-ray | 1.65 | A/B | 9-628 | [»] | |
5ZPL | X-ray | 1.60 | A/B | 9-628 | [»] | |
5ZPM | X-ray | 1.65 | A/B | 9-628 | [»] | |
5ZPN | X-ray | 1.60 | A/B | 9-628 | [»] | |
5ZPO | X-ray | 1.73 | A/B | 9-628 | [»] | |
5ZPP | X-ray | 1.81 | A/B | 9-628 | [»] | |
5ZPQ | X-ray | 1.85 | A/B | 9-628 | [»] | |
5ZPR | X-ray | 1.92 | A/B | 9-628 | [»] | |
5ZPS | X-ray | 1.75 | A/B | 9-628 | [»] | |
5ZPT | X-ray | 1.90 | A/B | 9-628 | [»] | |
6L9C | Other | 1.14 | X | 9-629 | [»] | |
SMRi | P46881 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB02511, 2-Hydroxy-5-({1-[(2-Naphthyloxy)Methyl]-3-Oxoprop-1-Enyl}Amino)Tyrosine DB02537, 2-Hydroxy-5-({1-[(4-Methylphenoxy)Methyl]-3-Oxoprop-1-Enyl}Amino)-L-Tyrosine DB06988, 2-HYDROXY-5-{[(1E)-2-PHENYLETHYLIDENE]AMINO}-L-TYROSINE DB04334, 6-hydroxydopa quinone |
Genome annotation databases
KEGGi | ag:AAA18114 |
Enzyme and pathway databases
BRENDAi | 1.4.3.21, 444 |
Miscellaneous databases
EvolutionaryTracei | P46881 |
Family and domain databases
Gene3Di | 2.70.98.20, 1 hit |
InterProi | View protein in InterPro IPR000269, Cu_amine_oxidase IPR015798, Cu_amine_oxidase_C IPR036460, Cu_amine_oxidase_C_sf IPR016182, Cu_amine_oxidase_N-reg IPR015802, Cu_amine_oxidase_N3 |
PANTHERi | PTHR10638, PTHR10638, 1 hit |
Pfami | View protein in Pfam PF01179, Cu_amine_oxid, 1 hit PF02728, Cu_amine_oxidN3, 1 hit |
SUPFAMi | SSF49998, SSF49998, 1 hit SSF54416, SSF54416, 2 hits |
PROSITEi | View protein in PROSITE PS01164, COPPER_AMINE_OXID_1, 1 hit PS01165, COPPER_AMINE_OXID_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAOX_ARTGO | |
Accessioni | P46881Primary (citable) accession number: P46881 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families