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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi417Magnesium 1By similarity1
Metal bindingi424Magnesium 1By similarity1
Metal bindingi424Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-264-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:ML0233
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0233

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526491 – 507Lysine--tRNA ligaseAdd BLAST507

Proteomic databases

PRIDEiP46861

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0233

Structurei

3D structure databases

ProteinModelPortaliP46861
SMRiP46861
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
HOGENOMiHOG000236578
KOiK04567
OMAiMMNIIPG
OrthoDBiPOG091H0098

Family and domain databases

HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P46861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNADPLETDA ALPEQFRIRR DKRARLLAEG RDPYPVAIER THTLAEVRAA
60 70 80 90 100
YPDLATDSAT DDIVGIAGRV IFARNSGKLC FATLQDGDGT NLQVMISLNK
110 120 130 140 150
VGSETLDAWK VDVDLGDIVY VHGNVISSRS GELSVLADSW QMVSKSLRPL
160 170 180 190 200
PVAHKEMSEE SRVRQRYVDL IVCPQVRIVA HQRIAVIRAI RTALERRGFL
210 220 230 240 250
EVETPMLQTL AGGAAARPFV THSNALDIDL YLRIAPELFL KRCIVGGFDK
260 270 280 290 300
VFELNRVFRN EGADSTHSPE FSMLETYQTY GTYDDSAVVT REIIQEVADE
310 320 330 340 350
AIGTRQLQMP DDSVYDIDGE WETIQMYPSL SAVLGEEITP QTSVDRLRAI
360 370 380 390 400
ADRLGRGIGP EILDKPSYGH GRLVEQLWEY TVGNTLSAPT FVKDFPVETT
410 420 430 440 450
PLTRQHRSIP GVTEKWDLYL RGVELATGYS ELNDPVVQRE RFGQQVRAAA
460 470 480 490 500
AEEDEAMALD EEFLAALEYA MPPCTGTGMG IDRLLMSLTG LSIRETVLFP

IVRPHSN
Length:507
Mass (Da):56,421
Last modified:April 27, 2001 - v2
Checksum:i52BF33D6287C96B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA Translation: CAC29741.1
M67510 Genomic DNA Translation: AAA25350.1
PIRiA43601
A86938
RefSeqiNP_301293.1, NC_002677.1
WP_010907617.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29741; CAC29741; CAC29741
GeneIDi908650
KEGGimle:ML0233
PATRICifig|272631.5.peg.366

Similar proteinsi

Entry informationi

Entry nameiSYK_MYCLE
AccessioniPrimary (citable) accession number: P46861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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