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UniProtKB - P46859 (GNTK_ECOLI)
Protein
Thermoresistant gluconokinase
Gene
gntK
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:2.7.1.12
: D-gluconate degradation Pathwayi
This protein is involved in the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 22 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- gluconokinase activity Source: EcoCyc
GO - Biological processi
- D-gluconate catabolic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:GLUCONOKINII-MONOMER |
UniPathwayi | UPA00792 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gntK Ordered Locus Names:b3437, JW3400 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
DrugBanki | DB02076, 6-phospho-D-gluconic acid DB03909, Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000087537 | 2 – 175 | Thermoresistant gluconokinaseAdd BLAST | 174 |
Proteomic databases
jPOSTi | P46859 |
PaxDbi | P46859 |
PRIDEi | P46859 |
Interactioni
Protein-protein interaction databases
DIPi | DIP-9820N |
IntActi | P46859, 2 interactors |
STRINGi | 511145.b3437 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P46859 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46859 |
Family & Domainsi
Sequence similaritiesi
Belongs to the gluconokinase GntK/GntV family.Curated
Phylogenomic databases
eggNOGi | COG3265, Bacteria |
HOGENOMi | CLU_077168_1_0_6 |
InParanoidi | P46859 |
PhylomeDBi | P46859 |
Family and domain databases
CDDi | cd02021, GntK, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR031322, Shikimate/glucono_kinase IPR006001, Therm_gnt_kin |
PANTHERi | PTHR43442, PTHR43442, 1 hit |
Pfami | View protein in Pfam PF01202, SKI, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01313, therm_gnt_kin, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P46859-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTNHDHHI YVLMGVSGSG KSAVASEVAH QLHAAFLDGD FLHPRRNIEK
60 70 80 90 100
MASGEPLNDD DRKPWLQALN DAAFAMQRTN KVSLIVCSAL KKHYRDLLRE
110 120 130 140 150
GNPNLSFIYL KGDFDVIESR LKARKGHFFK TQMLVTQFET LQEPGADETD
160 170
VLVVDIDQPL EGVVASTIEV IKKGK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84362 Genomic DNA Translation: BAA12325.1 U18997 Genomic DNA Translation: AAA58235.1 Frameshift. U00096 Genomic DNA Translation: AAC76462.2 AP009048 Genomic DNA Translation: BAE77856.1 |
RefSeqi | NP_417894.2, NC_000913.3 WP_000108330.1, NZ_STEB01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC76462; AAC76462; b3437 BAE77856; BAE77856; BAE77856 |
GeneIDi | 66672680 947937 |
KEGGi | ecj:JW3400 eco:b3437 |
PATRICi | fig|511145.12.peg.3533 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84362 Genomic DNA Translation: BAA12325.1 U18997 Genomic DNA Translation: AAA58235.1 Frameshift. U00096 Genomic DNA Translation: AAC76462.2 AP009048 Genomic DNA Translation: BAE77856.1 |
RefSeqi | NP_417894.2, NC_000913.3 WP_000108330.1, NZ_STEB01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KNQ | X-ray | 2.00 | A/B | 1-175 | [»] | |
1KO1 | X-ray | 2.09 | A/B | 1-175 | [»] | |
1KO4 | X-ray | 2.50 | A/B | 1-175 | [»] | |
1KO5 | X-ray | 2.28 | A/B | 1-175 | [»] | |
1KO8 | X-ray | 2.40 | A/B | 1-175 | [»] | |
1KOF | X-ray | 2.80 | A/B | 1-175 | [»] | |
SMRi | P46859 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-9820N |
IntActi | P46859, 2 interactors |
STRINGi | 511145.b3437 |
Chemistry databases
DrugBanki | DB02076, 6-phospho-D-gluconic acid DB03909, Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate |
Proteomic databases
jPOSTi | P46859 |
PaxDbi | P46859 |
PRIDEi | P46859 |
Genome annotation databases
EnsemblBacteriai | AAC76462; AAC76462; b3437 BAE77856; BAE77856; BAE77856 |
GeneIDi | 66672680 947937 |
KEGGi | ecj:JW3400 eco:b3437 |
PATRICi | fig|511145.12.peg.3533 |
Organism-specific databases
EchoBASEi | EB2513 |
Phylogenomic databases
eggNOGi | COG3265, Bacteria |
HOGENOMi | CLU_077168_1_0_6 |
InParanoidi | P46859 |
PhylomeDBi | P46859 |
Enzyme and pathway databases
UniPathwayi | UPA00792 |
BioCyci | EcoCyc:GLUCONOKINII-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P46859 |
PROi | PR:P46859 |
Family and domain databases
CDDi | cd02021, GntK, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR031322, Shikimate/glucono_kinase IPR006001, Therm_gnt_kin |
PANTHERi | PTHR43442, PTHR43442, 1 hit |
Pfami | View protein in Pfam PF01202, SKI, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01313, therm_gnt_kin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GNTK_ECOLI | |
Accessioni | P46859Primary (citable) accession number: P46859 Secondary accession number(s): P78116, Q2M7A0, Q59404 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families