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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.1 Publication

Miscellaneous

RtcA (apo form) crystallized as a disulfide-linked homodimer via Cys-307 (PubMed:10673421) but the covalent RtcA-AMP catalytic intermediate crystallized as a monomer with the shortest distance between Cys-307 side chains of neighboring protomers being 41 Angstroms (PubMed:20399182).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=20 µM for ATP1 Publication
  2. KM=100 µM for GTP1 Publication

    pH dependencei

    Optimum pH is 8.0-8.5.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei103ATP1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei308Tele-AMP-histidine intermediate1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi283 – 287ATP5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • RNA-3'-phosphate cyclase activity Source: EcoCyc

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:G7750-MONOMER
    MetaCyc:G7750-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    6.5.1.4 2026

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
    Short name:
    RNA cyclase
    Short name:
    RNA-3'-phosphate cyclase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:rtcA
    Synonyms:yhgJ, yhgK
    Ordered Locus Names:b4475, JW5688
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    Escherichia coli strain K12 genome database

    More...
    EcoGenei
    EG12938 rtcA

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Disruption of the rtcA gene does not affect growth.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi103Q → A: No effect on RNA cyclase activity and RtcA adenylation. 1 Publication1
    Mutagenesisi128S → A: No effect on RNA cyclase activity and RtcA adenylation. 1 Publication1
    Mutagenesisi130P → G: 33% of wild-type RNA cyclase activity and 13% of wild-type RtcA adenylation. 1 Publication1
    Mutagenesisi134F → A: 3% of wild-type RNA cyclase activity and 2% of wild-type RtcA adenylation. 1 Publication1
    Mutagenesisi250F → A: 28% of wild-type RNA cyclase activity and 38% of wild-type RtcA adenylation. 1 Publication1
    Mutagenesisi269E → A: Nearly no effect on RNA cyclase activity and 2-fold decrease in RtcA adenylation. 1 Publication1
    Mutagenesisi283Y → A: 12% of wild-type RNA cyclase activity and 2% of wild-type RtcA adenylation. 1 Publication1
    Mutagenesisi286D → A: Loss of RNA cyclase activity and RtcA adenylation. 1 Publication1
    Mutagenesisi287Q → A: Loss of RNA cyclase activity and RtcA adenylation. 1 Publication1
    Mutagenesisi308H → A or G: Loss of RNA cyclase activity and RtcA adenylation. 1 Publication1

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB04272 Citric Acid

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001564161 – 338RNA 3'-terminal phosphate cyclaseAdd BLAST338

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P46849

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P46849

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4261186, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    316385.ECDH10B_3594

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1338
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P46849

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P46849

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P46849

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CKX Bacteria
    COG0430 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000015264

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P46849

    KEGG Orthology (KO)

    More...
    KOi
    K01974

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P46849

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.360.20, 1 hit
    3.65.10.20, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00200 RTC, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013791 RNA3'-term_phos_cycl_insert
    IPR023797 RNA3'_phos_cyclase_dom
    IPR037136 RNA3'_phos_cyclase_dom_sf
    IPR000228 RNA3'_term_phos_cyc
    IPR017770 RNA3'_term_phos_cyc_type_1
    IPR020719 RNA3'_term_phos_cycl-like_CS
    IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
    IPR036553 RPTC_insert

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11096 PTHR11096, 1 hit
    PTHR11096:SF0 PTHR11096:SF0, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01137 RTC, 1 hit
    PF05189 RTC_insert, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52913 SSF52913, 1 hit
    SSF55205 SSF55205, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03399 RNA_3prim_cycl, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01287 RTC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P46849-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKRMIALDGA QGEGGGQILR SALSLSMITG QPFTITSIRA GRAKPGLLRQ
    60 70 80 90 100
    HLTAVKAATE ICGATVEGAE LGSQRLLFRP GTVRGGDYRF AIGSAGSCTL
    110 120 130 140 150
    VLQTVLPALW FADGPSRVEV SGGTDNPSAP PADFIRRVLE PLLAKIGIHQ
    160 170 180 190 200
    QTTLLRHGFY PAGGGVVATE VSPVASFNTL QLGERGNIVQ MRGEVLLAGV
    210 220 230 240 250
    PRHVAEREIA TLAGSFSLHE QNIHNLPRDQ GPGNTVSLEV ESENITERFF
    260 270 280 290 300
    VVGEKRVSAE VVAAQLVKEV KRYLASTAAV GEYLADQLVL PMALAGAGEF
    310 320 330
    TVAHPSCHLL TNIAVVERFL PVRFSLIETD GVTRVSIE
    Length:338
    Mass (Da):35,903
    Last modified:December 1, 2000 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3450201CB8E40CE7
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA58217 differs from that shown. Reason: Frameshift at position 122. Produces two separate ORFs.Curated
    The sequence AAA58218 differs from that shown. Reason: Frameshift at position 122. Produces two separate ORFs.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U18997 Genomic DNA Translation: AAA58218.1 Frameshift.
    U18997 Genomic DNA Translation: AAA58217.1 Frameshift.
    U00096 Genomic DNA Translation: AAT48181.1
    AP009048 Genomic DNA Translation: BAE77872.1
    M13585 Genomic DNA Translation: AAA83889.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_001335950.1, NZ_LN832404.1
    YP_026219.1, NC_000913.3

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAT48181; AAT48181; b4475
    BAE77872; BAE77872; BAE77872

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2847707

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW5688
    eco:b4475

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.3309

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U18997 Genomic DNA Translation: AAA58218.1 Frameshift.
    U18997 Genomic DNA Translation: AAA58217.1 Frameshift.
    U00096 Genomic DNA Translation: AAT48181.1
    AP009048 Genomic DNA Translation: BAE77872.1
    M13585 Genomic DNA Translation: AAA83889.1
    RefSeqiWP_001335950.1, NZ_LN832404.1
    YP_026219.1, NC_000913.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1QMHX-ray2.10A/B2-338[»]
    1QMIX-ray2.80A/B/C/D2-338[»]
    3KGDX-ray1.68A/B/C/D1-338[»]
    3TUTX-ray1.58A1-338[»]
    3TUXX-ray1.85A1-338[»]
    3TV1X-ray1.90A/B1-338[»]
    3TW3X-ray2.10A1-338[»]
    ProteinModelPortaliP46849
    SMRiP46849
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi4261186, 4 interactors
    STRINGi316385.ECDH10B_3594

    Chemistry databases

    DrugBankiDB04272 Citric Acid

    Proteomic databases

    PaxDbiP46849
    PRIDEiP46849

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAT48181; AAT48181; b4475
    BAE77872; BAE77872; BAE77872
    GeneIDi2847707
    KEGGiecj:JW5688
    eco:b4475
    PATRICifig|1411691.4.peg.3309

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB2773
    EcoGeneiEG12938 rtcA

    Phylogenomic databases

    eggNOGiENOG4105CKX Bacteria
    COG0430 LUCA
    HOGENOMiHOG000015264
    InParanoidiP46849
    KOiK01974
    PhylomeDBiP46849

    Enzyme and pathway databases

    BioCyciEcoCyc:G7750-MONOMER
    MetaCyc:G7750-MONOMER
    BRENDAi6.5.1.4 2026

    Miscellaneous databases

    EvolutionaryTraceiP46849

    Protein Ontology

    More...
    PROi
    PR:P46849

    Family and domain databases

    Gene3Di3.30.360.20, 1 hit
    3.65.10.20, 1 hit
    HAMAPiMF_00200 RTC, 1 hit
    InterProiView protein in InterPro
    IPR013791 RNA3'-term_phos_cycl_insert
    IPR023797 RNA3'_phos_cyclase_dom
    IPR037136 RNA3'_phos_cyclase_dom_sf
    IPR000228 RNA3'_term_phos_cyc
    IPR017770 RNA3'_term_phos_cyc_type_1
    IPR020719 RNA3'_term_phos_cycl-like_CS
    IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
    IPR036553 RPTC_insert
    PANTHERiPTHR11096 PTHR11096, 1 hit
    PTHR11096:SF0 PTHR11096:SF0, 1 hit
    PfamiView protein in Pfam
    PF01137 RTC, 1 hit
    PF05189 RTC_insert, 1 hit
    PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
    SUPFAMiSSF52913 SSF52913, 1 hit
    SSF55205 SSF55205, 2 hits
    TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit
    PROSITEiView protein in PROSITE
    PS01287 RTC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTCA_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46849
    Secondary accession number(s): P46848, Q2M784, Q47349
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 1, 2000
    Last modified: December 5, 2018
    This is version 145 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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