UniProtKB - P46846 (GNTX_ECOLI)
Protein
DNA utilization protein YhgH
Gene
gntX
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the use of extracellular DNA as a nutrient (PubMed:16707682). Has been suggested to be involved in gluconate metabolism (PubMed:9871335).1 Publication1 Publication
GO - Biological processi
- carbon utilization Source: EcoCyc
- DNA catabolic process Source: EcoCyc
- nucleoside metabolic process Source: InterPro
Enzyme and pathway databases
BioCyci | EcoCyc:G7747-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA utilization protein YhgH1 PublicationAlternative name(s): Protein GntX |
Gene namesi | Name:gntX1 Publication Synonyms:yhgH Ordered Locus Names:b3413, JW5691 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209458 | 1 – 227 | DNA utilization protein YhgHAdd BLAST | 227 |
Proteomic databases
PaxDbi | P46846 |
PRIDEi | P46846 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261222, 7 interactors |
STRINGi | 511145.b3413 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 54 | Cys-richAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the ComF/GntX family.Curated
Phylogenomic databases
eggNOGi | COG1040, Bacteria |
HOGENOMi | CLU_054549_0_2_6 |
InParanoidi | P46846 |
PhylomeDBi | P46846 |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
Gene3Di | 3.40.50.2020, 1 hit |
InterProi | View protein in InterPro IPR005222, Competence_ComF IPR000836, PRibTrfase_dom IPR029057, PRTase-like |
Pfami | View protein in Pfam PF00156, Pribosyltran, 1 hit |
SUPFAMi | SSF53271, SSF53271, 1 hit |
TIGRFAMsi | TIGR00201, comF, 1 hit |
i Sequence
Sequence statusi: Complete.
P46846-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTVPGLCWL CRMPLALGHW GICSVCSRAT RTDKTLCPQC GLPATHSHLP
60 70 80 90 100
CGRCLQKPPP WQRLVTVADY APPLSPLIHQ LKFSRRSEIA SALSRLLLLE
110 120 130 140 150
VLHARRTTGL QLPDRIVSVP LWQRRHWRRG FNQSDLLCQP LSRWLHCQWD
160 170 180 190 200
SEAVTRTRAT ATQHFLSARL RKRNLKNAFR LELPVQGRHM VIVDDVVTTG
210 220
STVAEIAQLL LRNGAAAVQV WCLCRTL
Sequence cautioni
The sequence AAA58211 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58211.1 Different initiation. U00096 Genomic DNA Translation: AAC76438.2 AP009048 Genomic DNA Translation: BAE77878.1 |
PIRi | H65136 |
RefSeqi | NP_417872.2, NC_000913.3 WP_001333371.1, NZ_SSZK01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAC76438; AAC76438; b3413 BAE77878; BAE77878; BAE77878 |
GeneIDi | 947915 |
KEGGi | ecj:JW5691 eco:b3413 |
PATRICi | fig|1411691.4.peg.3315 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58211.1 Different initiation. U00096 Genomic DNA Translation: AAC76438.2 AP009048 Genomic DNA Translation: BAE77878.1 |
PIRi | H65136 |
RefSeqi | NP_417872.2, NC_000913.3 WP_001333371.1, NZ_SSZK01000008.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261222, 7 interactors |
STRINGi | 511145.b3413 |
Proteomic databases
PaxDbi | P46846 |
PRIDEi | P46846 |
Genome annotation databases
EnsemblBacteriai | AAC76438; AAC76438; b3413 BAE77878; BAE77878; BAE77878 |
GeneIDi | 947915 |
KEGGi | ecj:JW5691 eco:b3413 |
PATRICi | fig|1411691.4.peg.3315 |
Organism-specific databases
EchoBASEi | EB2770 |
Phylogenomic databases
eggNOGi | COG1040, Bacteria |
HOGENOMi | CLU_054549_0_2_6 |
InParanoidi | P46846 |
PhylomeDBi | P46846 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7747-MONOMER |
Miscellaneous databases
PROi | PR:P46846 |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
Gene3Di | 3.40.50.2020, 1 hit |
InterProi | View protein in InterPro IPR005222, Competence_ComF IPR000836, PRibTrfase_dom IPR029057, PRTase-like |
Pfami | View protein in Pfam PF00156, Pribosyltran, 1 hit |
SUPFAMi | SSF53271, SSF53271, 1 hit |
TIGRFAMsi | TIGR00201, comF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNTX_ECOLI | |
Accessioni | P46846Primary (citable) accession number: P46846 Secondary accession number(s): Q2M778 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | July 15, 1999 | |
Last modified: | October 7, 2020 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families