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Protein

Cation-transporting P-type ATPase B

Gene

ctpB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28PROSITE-ProRule annotation1
Metal bindingi31PROSITE-ProRule annotation1
Active sitei4454-aspartylphosphate intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2196-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase B (EC:3.6.3.-)
Gene namesi
Name:ctpB
Ordered Locus Names:ML2000
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2000

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Transmembranei663 – 683HelicalSequence analysisAdd BLAST21
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Transmembranei715 – 735HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461671 – 750Cation-transporting P-type ATPase BAdd BLAST750

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2000

Structurei

3D structure databases

ProteinModelPortaliP46840
SMRiP46840
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 81HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
HOGENOMiHOG000250397
KOiK12949
OMAiKASIYHP
OrthoDBiPOG091H00YH

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR000579 Cation-trans_P-type_ATPase_A/B
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00940 CATPATPASEA
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46840-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASLVEDTN NNHESVRRIQ LDVAGMLCAA CASRVETKLN KIPGVRASVN
60 70 80 90 100
FATRVATIDA VDVAVDELRQ VIEQAGYRAT AHAESAVEEI DPDADYARNL
110 120 130 140 150
LRRLIVAALL FVPLADLSTM FAIVPTNRFP GWGYLLTALA APIVTWAAWP
160 170 180 190 200
FHRVALRNAR YRAASMETLI SAGILAATGW SLSTIFVDKE PRQTHGIWQA
210 220 230 240 250
ILHSDSIYFE VAAGVTVFVL AGRFFEARAK SKAGSALRAL AARGAKNVEV
260 270 280 290 300
LLPNGAELTI PAGELKKQQH FLVRPGETIT ADGVVIDGTA TIDMSAITGE
310 320 330 340 350
ARPVHASPAS TVVGGTTVLD GRLVIEATAV GGDTQFAAMV RLVEDAQVQK
360 370 380 390 400
ARVQHLADRI AAVFVPMVFV IAGLAGASWL LAGASPDRAF SVVLGVLVIA
410 420 430 440 450
CPCTLGLATP TAMMVASGRG AQLGIFIKGY RALETINAID TVVFDKTGTL
460 470 480 490 500
TLGQLSVSTV TSTGGWCSGE VLALASAVEA ASEHSVATAI VAAYADPRPV
510 520 530 540 550
ADFVAFAGCG VSGVVAEHHV KIGKPSWVTR NAPCDVVLES ARREGESRGE
560 570 580 590 600
TVVFVSVDGV ACGAVAIADT VKDSAADAIS ALCSRGLHTI LLTGDNQAAA
610 620 630 640 650
RAVAAQVGID TVIADMLPEA KVDVIQRLRD QGHTVAMVGD GINDGPALAC
660 670 680 690 700
ADLGLAMGRG TDVAIGAADL ILVRDSLGVV PVALDLARAT MRTIRINMIW
710 720 730 740 750
AFGYNVAAIP IASSGLLNPL IAGAAMAFSS FFVVSNSLRL SNFGLSQTSD
Length:750
Mass (Da):78,101
Last modified:April 27, 2001 - v2
Checksum:i1D58477D4A69B00D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti544 – 548EGESR → RRRIT in CAA86363 (PubMed:7476188).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA Translation: CAA86363.1
AL583924 Genomic DNA Translation: CAC30955.1
PIRiC87159
S77653
RefSeqiNP_302350.1, NC_002677.1
WP_010908670.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30955; CAC30955; CAC30955
GeneIDi909077
KEGGimle:ML2000
PATRICifig|272631.5.peg.3760

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA Translation: CAA86363.1
AL583924 Genomic DNA Translation: CAC30955.1
PIRiC87159
S77653
RefSeqiNP_302350.1, NC_002677.1
WP_010908670.1, NC_002677.1

3D structure databases

ProteinModelPortaliP46840
SMRiP46840
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2000

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30955; CAC30955; CAC30955
GeneIDi909077
KEGGimle:ML2000
PATRICifig|272631.5.peg.3760

Organism-specific databases

LepromaiML2000

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
HOGENOMiHOG000250397
KOiK12949
OMAiKASIYHP
OrthoDBiPOG091H00YH

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2196-MONOMER

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR000579 Cation-trans_P-type_ATPase_A/B
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00940 CATPATPASEA
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTPB_MYCLE
AccessioniPrimary (citable) accession number: P46840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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