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UniProtKB - P46837 (YHGF_ECOLI)

Entry version 147 (10 Feb 2021)
Sequence version 3 (15 Jul 1999)
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Protein

Protein YhgF

Gene

yhgF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G7746-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein YhgF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yhgF
Ordered Locus Names:b3407, JW3370
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002151041 – 773Protein YhgFAdd BLAST773

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P46837

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46837

PRoteomics IDEntifications database

More...PRIDEi		P46837

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261725, 54 interactors
852220, 1 interactor

Database of interacting proteins

More...DIPi		DIP-12337N

Protein interaction database and analysis system

More...IntActi		P46837, 10 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3407

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P46837

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini651 – 720S1 motifPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2183, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009833_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46837

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46837

Family and domain databases

Conserved Domains Database

More...CDDi		cd05685, S1_Tex, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.650, 1 hit
1.10.3500.10, 1 hit
3.30.420.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041692, HHH_9
IPR012340, NA-bd_OB-fold
IPR012337, RNaseH-like_sf
IPR010994, RuvA_2-like
IPR022967, S1_dom
IPR003029, S1_domain
IPR044146, S1_Tex
IPR023323, Tex-like_dom_sf
IPR023319, Tex-like_HTH_dom_sf
IPR018974, Tex-like_N
IPR032639, Tex_YqgF
IPR006641, YqgF/RNaseH-like_dom
IPR037027, YqgF/RNaseH-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17674, HHH_9, 1 hit
PF00575, S1, 1 hit
PF09371, Tex_N, 1 hit
PF16921, Tex_YqgF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00316, S1, 1 hit
SM00732, YqgFc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47781, SSF47781, 2 hits
SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50126, S1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNDSFCRII AGEIQARPEQ VDAAVRLLDE GNTVPFIARY RKEITGGLDD 
        60         70         80         90        100
TQLRNLETRL SYLRELEERR QAILKSISEQ GKLTDDLAKA INATLSKTEL 
       110        120        130        140        150
EDLYLPYKPK RRTRGQIAIE AGLEPLADLL WSDPSHTPEV AAAQYVYADK 
       160        170        180        190        200
GVADTKAALD GARYILMERF AEDAALLAKV RDYLWKNAHL VSTVVSGKEE 
       210        220        230        240        250
EGAKFRDYFD HHEPLSTVPS HRALAMFRGR NEGVLQLSLN ADPQFDEPPK 
       260        270        280        290        300
ESYCEQIIMD HLGLRLNNAP ADSWRKGVVS WTWRIKVLMH LETELMGTVR 
       310        320        330        340        350
ERAEDEAINV FARNLHDLLM AAPAGLRATM GLDPGLRTGV KVAVVDATGK 
       360        370        380        390        400
LVATDTIYPH TGQAAKAAMT VAALCEKHNV ELVAIGNGTA SRETERFYLD 
       410        420        430        440        450
VQKQFPKVTA QKVIVSEAGA SVYSASELAA QEFPDLDVSL RGAVSIARRL 
       460        470        480        490        500
QDPLAELVKI DPKSIGVGQY QHDVSQTQLA RKLDAVVEDC VNAVGVDLNT 
       510        520        530        540        550
ASVPLLTRVA GLTRMMAQNI VAWRDENGQF QNRQQLLKVS RLGPKAFEQC 
       560        570        580        590        600
AGFLRINHGD NPLDASTVHP EAYPVVERIL AATQQALKDL MGNSSELRNL 
       610        620        630        640        650
KASDFTDEKF GVPTVTDIIK ELEKPGRDPR PEFKTAQFAD GVETMNDLQP 
       660        670        680        690        700
GMILEGAVTN VTNFGAFVDI GVHQDGLVHI SSLSNKFVED PHTVVKAGDI 
       710        720        730        740        750
VKVKVLEVDL QRKRIALTMR LDEQPGETNA RRGGGNERPQ NNRPAAKPRG 
       760        770 
REAQPAGNSA MMDALAAAMG KKR
Length:773
Mass (Da):85,120
Last modified:July 15, 1999 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA54D9ED952A8229
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58204 differs from that shown. Wrong choice of frame.Curated
The sequence AAA58205 differs from that shown. Reason: Frameshift.Curated
The sequence AAA58205 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti754 – 755QP → HA in AAA58205 (PubMed:9278503).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58204.1 Sequence problems.
U18997 Genomic DNA Translation: AAA58205.1 Sequence problems.
U00096 Genomic DNA Translation: AAC76432.2
AP009048 Genomic DNA Translation: BAE77884.1

Protein sequence database of the Protein Information Resource

More...PIRi		B65136

NCBI Reference Sequences

More...RefSeqi		NP_417866.4, NC_000913.3
WP_000980727.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76432; AAC76432; b3407
BAE77884; BAE77884; BAE77884

Database of genes from NCBI RefSeq genomes

More...GeneIDi		947911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3370
eco:b3407

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3322

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58204.1 Sequence problems.
U18997 Genomic DNA Translation: AAA58205.1 Sequence problems.
U00096 Genomic DNA Translation: AAC76432.2
AP009048 Genomic DNA Translation: BAE77884.1
PIRiB65136
RefSeqiNP_417866.4, NC_000913.3
WP_000980727.1, NZ_LN832404.1

3D structure databases

SMRiP46837
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261725, 54 interactors
852220, 1 interactor
DIPiDIP-12337N
IntActiP46837, 10 interactors
STRINGi511145.b3407

Proteomic databases

jPOSTiP46837
PaxDbiP46837
PRIDEiP46837

Genome annotation databases

EnsemblBacteriaiAAC76432; AAC76432; b3407
BAE77884; BAE77884; BAE77884
GeneIDi947911
KEGGiecj:JW3370
eco:b3407
PATRICifig|1411691.4.peg.3322

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2768

Phylogenomic databases

eggNOGiCOG2183, Bacteria
HOGENOMiCLU_009833_0_2_6
InParanoidiP46837
PhylomeDBiP46837

Enzyme and pathway databases

BioCyciEcoCyc:G7746-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P46837

Family and domain databases

CDDicd05685, S1_Tex, 1 hit
Gene3Di1.10.10.650, 1 hit
1.10.3500.10, 1 hit
3.30.420.140, 1 hit
InterProiView protein in InterPro
IPR041692, HHH_9
IPR012340, NA-bd_OB-fold
IPR012337, RNaseH-like_sf
IPR010994, RuvA_2-like
IPR022967, S1_dom
IPR003029, S1_domain
IPR044146, S1_Tex
IPR023323, Tex-like_dom_sf
IPR023319, Tex-like_HTH_dom_sf
IPR018974, Tex-like_N
IPR032639, Tex_YqgF
IPR006641, YqgF/RNaseH-like_dom
IPR037027, YqgF/RNaseH-like_dom_sf
PfamiView protein in Pfam
PF17674, HHH_9, 1 hit
PF00575, S1, 1 hit
PF09371, Tex_N, 1 hit
PF16921, Tex_YqgF, 1 hit
SMARTiView protein in SMART
SM00316, S1, 1 hit
SM00732, YqgFc, 1 hit
SUPFAMiSSF47781, SSF47781, 2 hits
SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50126, S1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYHGF_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46837
Secondary accession number(s): P76689, Q2M772
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1999
Last modified: February 10, 2021
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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