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Protein

Microtubule-associated protein 1B

Gene

MAP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: GO_Central
  • microtubule binding Source: ARUK-UCL
  • structural molecule activity Source: ProtInc
  • tubulin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P46821

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 1B
Short name:
MAP-1B
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131711.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6836 MAP1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
157129 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46821

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4131

Open Targets

More...
OpenTargetsi
ENSG00000131711

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98892 Periventricular nodular heterotopia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30581

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3217382

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373388

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000186042 – 2468Microtubule-associated protein 1BAdd BLAST2467
ChainiPRO_00004183792 – 2206MAP1B heavy chainAdd BLAST2205
ChainiPRO_00000186052207 – 2468MAP1 light chain LC1Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei336PhosphoserineCombined sources1
Modified residuei339PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei527PhosphothreonineBy similarity1
Modified residuei541PhosphoserineCombined sources1
Modified residuei544PhosphoserineBy similarity1
Modified residuei561PhosphoserineBy similarity1
Modified residuei614PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei831PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1
Modified residuei891PhosphoserineBy similarity1
Modified residuei899PhosphothreonineBy similarity1
Modified residuei908PhosphothreonineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei937PhosphoserineCombined sources1
Modified residuei948PhosphothreonineCombined sources1
Modified residuei970PhosphoserineBy similarity1
Modified residuei977PhosphoserineBy similarity1
Modified residuei992PhosphoserineCombined sources1
Modified residuei995PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1
Modified residuei1144PhosphoserineCombined sources1
Modified residuei1154PhosphoserineCombined sources1
Modified residuei1156PhosphoserineCombined sources1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1190PhosphoserineBy similarity1
Modified residuei1208PhosphoserineCombined sources1
Modified residuei1211PhosphoserineBy similarity1
Modified residuei1212PhosphoserineBy similarity1
Modified residuei1229PhosphoserineBy similarity1
Modified residuei1247PhosphoserineBy similarity1
Modified residuei1252PhosphoserineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Modified residuei1258PhosphoserineBy similarity1
Modified residuei1260PhosphoserineCombined sources1
Modified residuei1262PhosphoserineCombined sources1
Modified residuei1265PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1282PhosphothreonineCombined sources1
Modified residuei1298PhosphoserineCombined sources1
Modified residuei1312PhosphoserineBy similarity1
Modified residuei1322PhosphoserineCombined sources1
Modified residuei1324PhosphoserineBy similarity1
Modified residuei1326PhosphoserineBy similarity1
Modified residuei1328PhosphothreonineBy similarity1
Modified residuei1330PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei1376PhosphoserineBy similarity1
Modified residuei1378PhosphoserineCombined sources1
Modified residuei1387PhosphoserineCombined sources1
Modified residuei1389PhosphoserineCombined sources1
Modified residuei1396PhosphoserineCombined sources1
Modified residuei1400PhosphoserineCombined sources1
Modified residuei1408PhosphoserineBy similarity1
Modified residuei1410PhosphotyrosineBy similarity1
Modified residuei1427PhosphoserineCombined sources1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1443PhosphoserineCombined sources1
Modified residuei1501PhosphoserineCombined sources1
Modified residuei1512PhosphoserineBy similarity1
Modified residuei1520PhosphoserineBy similarity1
Modified residuei1522PhosphoserineBy similarity1
Modified residuei1525PhosphothreonineBy similarity1
Modified residuei1527PhosphoserineBy similarity1
Modified residuei1618PhosphoserineCombined sources1
Modified residuei1620PhosphoserineCombined sources1
Modified residuei1625PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1663PhosphoserineBy similarity1
Modified residuei1666PhosphoserineCombined sources1
Modified residuei1690PhosphoserineBy similarity1
Modified residuei1772PhosphoserineBy similarity1
Modified residuei1779PhosphoserineCombined sources1
Modified residuei1782PhosphoserineCombined sources1
Modified residuei1785PhosphoserineCombined sources1
Modified residuei1788PhosphothreonineCombined sources1
Modified residuei1792PhosphoserineBy similarity1
Modified residuei1793PhosphoserineCombined sources1
Modified residuei1796PhosphotyrosineBy similarity1
Modified residuei1797PhosphoserineCombined sources1
Modified residuei1801PhosphoserineBy similarity1
Modified residuei1819PhosphoserineBy similarity1
Modified residuei1881PhosphoserineBy similarity1
Modified residuei1899PhosphoserineCombined sources1
Modified residuei1915PhosphoserineCombined sources1
Modified residuei1917PhosphoserineCombined sources1
Modified residuei1919PhosphoserineCombined sources1
Modified residuei1932PhosphothreonineCombined sources1
Modified residuei1939PhosphoserineCombined sources1
Modified residuei1949PhosphothreonineCombined sources1
Modified residuei1965PhosphoserineCombined sources1
Modified residuei2034PhosphothreonineCombined sources1
Modified residuei2209PhosphoserineCombined sources1
Modified residuei2271PhosphoserineCombined sources1
Modified residuei2289PhosphoserineCombined sources1
Modified residuei2305PhosphothreonineCombined sources1
Modified residuei2414PhosphoserineBy similarity1
Modified residuei2464S-nitrosocysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

LC1 is generated from MAP1B by proteolytic processing.1 Publication
S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46821

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P46821

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P46821

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P46821

PeptideAtlas

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PeptideAtlasi
P46821

PRoteomics IDEntifications database

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PRIDEi
P46821

ProteomicsDB human proteome resource

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ProteomicsDBi
55766

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P46821

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46821

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P46821

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131711 Expressed in 243 organ(s), highest expression level in entorhinal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAP1B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46821 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46821 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009792
HPA022275

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674, PubMed:16227972). Interacts (via N-terminus) with DAPK1 (PubMed:18195017). Interacts with TMEM185A (PubMed:15525354). Interacts with MAP1LC3B (PubMed:24089205). Interacts with KIRREL3 (PubMed:25902260).By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110304, 72 interactors

Database of interacting proteins

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DIPi
DIP-33474N

Protein interaction database and analysis system

More...
IntActi
P46821, 39 interactors

Molecular INTeraction database

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MINTi
P46821

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296755

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P46821

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1878 – 1894MAP1B 1Add BLAST17
Repeati1895 – 1911MAP1B 2Add BLAST17
Repeati1912 – 1928MAP1B 3Add BLAST17
Repeati1929 – 1945MAP1B 4Add BLAST17
Repeati1946 – 1962MAP1B 5Add BLAST17
Repeati1963 – 1979MAP1B 6Add BLAST17
Repeati1997 – 2013MAP1B 7Add BLAST17
Repeati2014 – 2030MAP1B 8Add BLAST17
Repeati2031 – 2047MAP1B 9Add BLAST17
Repeati2048 – 2064MAP1B 10Add BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2294 – 2468Mediates interaction with TMEM185A1 PublicationAdd BLAST175

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi589 – 790Lys-rich (highly basic, contains many KKEE and KKEI/V repeats)Add BLAST202

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3592 Eukaryota
ENOG410XRYM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155897

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000063256

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052409

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P46821

KEGG Orthology (KO)

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KOi
K10429

Identification of Orthologs from Complete Genome Data

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OMAi
KPQGRQC

Database of Orthologous Groups

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OrthoDBi
86642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46821

TreeFam database of animal gene trees

More...
TreeFami
TF350229

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026074 MAP1
IPR027321 MAP1B
IPR000102 MAP1B_neuraxin

The PANTHER Classification System

More...
PANTHERi
PTHR13843 PTHR13843, 1 hit
PTHR13843:SF5 PTHR13843:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00414 MAP1B_neuraxin, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00230 MAP1B_NEURAXIN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P46821-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVVVEATE PEPSGSIANP AASTSPSLSH RFLDSKFYLL VVVGEIVTEE
60 70 80 90 100
HLRRAIGNIE LGIRSWDTNL IECNLDQELK LFVSRHSARF SPEVPGQKIL
110 120 130 140 150
HHRSDVLETV VLINPSDEAV STEVRLMITD AARHKLLVLT GQCFENTGEL
160 170 180 190 200
ILQSGSFSFQ NFIEIFTDQE IGELLSTTHP ANKASLTLFC PEEGDWKNSN
210 220 230 240 250
LDRHNLQDFI NIKLNSASIL PEMEGLSEFT EYLSESVEVP SPFDILEPPT
260 270 280 290 300
SGGFLKLSKP CCYIFPGGRG DSALFAVNGF NMLINGGSER KSCFWKLIRH
310 320 330 340 350
LDRVDSILLT HIGDDNLPGI NSMLQRKIAE LEEEQSQGST TNSDWMKNLI
360 370 380 390 400
SPDLGVVFLN VPENLKNPEP NIKMKRSIEE ACFTLQYLNK LSMKPEPLFR
410 420 430 440 450
SVGNTIDPVI LFQKMGVGKL EMYVLNPVKS SKEMQYFMQQ WTGTNKDKAE
460 470 480 490 500
FILPNGQEVD LPISYLTSVS SLIVWHPANP AEKIIRVLFP GNSTQYNILE
510 520 530 540 550
GLEKLKHLDF LKQPLATQKD LTGQVPTPVV KQTKLKQRAD SRESLKPAAK
560 570 580 590 600
PLPSKSVRKE SKEETPEVTK VNHVEKPPKV ESKEKVMVKK DKPIKTETKP
610 620 630 640 650
SVTEKEVPSK EEPSPVKAEV AEKQATDVKP KAAKEKTVKK ETKVKPEDKK
660 670 680 690 700
EEKEKPKKEV AKKEDKTPIK KEEKPKKEEV KKEVKKEIKK EEKKEPKKEV
710 720 730 740 750
KKETPPKEVK KEVKKEEKKE VKKEEKEPKK EIKKLPKDAK KSSTPLSEAK
760 770 780 790 800
KPAALKPKVP KKEESVKKDS VAAGKPKEKG KIKVIKKEGK AAEAVAAAVG
810 820 830 840 850
TGATTAAVMA AAGIAAIGPA KELEAERSLM SSPEDLTKDF EELKAEEVDV
860 870 880 890 900
TKDIKPQLEL IEDEEKLKET EPVEAYVIQK EREVTKGPAE SPDEGITTTE
910 920 930 940 950
GEGECEQTPE ELEPVEKQGV DDIEKFEDEG AGFEESSETG DYEEKAETEE
960 970 980 990 1000
AEEPEEDGEE HVCVSASKHS PTEDEESAKA EADAYIREKR ESVASGDDRA
1010 1020 1030 1040 1050
EEDMDEAIEK GEAEQSEEEA DEEDKAEDAR EEEYEPEKME AEDYVMAVVD
1060 1070 1080 1090 1100
KAAEAGGAEE QYGFLTTPTK QLGAQSPGRE PASSIHDETL PGGSESEATA
1110 1120 1130 1140 1150
SDEENREDQP EEFTATSGYT QSTIEISSEP TPMDEMSTPR DVMSDETNNE
1160 1170 1180 1190 1200
ETESPSQEFV NITKYESSLY SQEYSKPADV TPLNGFSEGS KTDATDGKDY
1210 1220 1230 1240 1250
NASASTISPP SSMEEDKFSR SALRDAYCSE VKASTTLDIK DSISAVSSEK
1260 1270 1280 1290 1300
VSPSKSPSLS PSPPSPLEKT PLGERSVNFS LTPNEIKVSA EAEVAPVSPE
1310 1320 1330 1340 1350
VTQEVVEEHC ASPEDKTLEV VSPSQSVTGS AGHTPYYQSP TDEKSSHLPT
1360 1370 1380 1390 1400
EVIEKPPAVP VSFEFSDAKD ENERASVSPM DEPVPDSESP IEKVLSPLRS
1410 1420 1430 1440 1450
PPLIGSESAY ESFLSADDKA SGRGAESPFE EKSGKQGSPD QVSPVSEMTS
1460 1470 1480 1490 1500
TSLYQDKQEG KSTDFAPIKE DFGQEKKTDD VEAMSSQPAL ALDERKLGDV
1510 1520 1530 1540 1550
SPTQIDVSQF GSFKEDTKMS ISEGTVSDKS ATPVDEGVAE DTYSHMEGVA
1560 1570 1580 1590 1600
SVSTASVATS SFPEPTTDDV SPSLHAEVGS PHSTEVDDSL SVSVVQTPTT
1610 1620 1630 1640 1650
FQETEMSPSK EECPRPMSIS PPDFSPKTAK SRTPVQDHRS EQSSMSIEFG
1660 1670 1680 1690 1700
QESPEQSLAM DFSRQSPDHP TVGAGVLHIT ENGPTEVDYS PSDMQDSSLS
1710 1720 1730 1740 1750
HKIPPMEEPS YTQDNDLSEL ISVSQVEASP STSSAHTPSQ IASPLQEDTL
1760 1770 1780 1790 1800
SDVAPPRDMS LYASLTSEKV QSLEGEKLSP KSDISPLTPR ESSPLYSPTF
1810 1820 1830 1840 1850
SDSTSAVKEK TATCHSSSSP PIDAASAEPY GFRASVLFDT MQHHLALNRD
1860 1870 1880 1890 1900
LSTPGLEKDS GGKTPGDFSY AYQKPEETTR SPDEEDYDYE SYEKTTRTSD
1910 1920 1930 1940 1950
VGGYYYEKIE RTTKSPSDSG YSYETIGKTT KTPEDGDYSY EIIEKTTRTP
1960 1970 1980 1990 2000
EEGGYSYDIS EKTTSPPEVS GYSYEKTERS RRLLDDISNG YDDSEDGGHT
2010 2020 2030 2040 2050
LGDPSYSYET TEKITSFPES EGYSYETSTK TTRTPDTSTY CYETAEKITR
2060 2070 2080 2090 2100
TPQASTYSYE TSDLCYTAEK KSPSEARQDV DLCLVSSCEY KHPKTELSPS
2110 2120 2130 2140 2150
FINPNPLEWF ASEEPTEESE KPLTQSGGAP PPPGGKQQGR QCDETPPTSV
2160 2170 2180 2190 2200
SESAPSQTDS DVPPETEECP SITADANIDS EDESETIPTD KTVTYKHMDP
2210 2220 2230 2240 2250
PPAPVQDRSP SPRHPDVSMV DPEALAIEQN LGKALKKDLK EKTKTKKPGT
2260 2270 2280 2290 2300
KTKSSSPVKK SDGKSKPLAA SPKPAGLKES SDKVSRVASP KKKESVEKAA
2310 2320 2330 2340 2350
KPTTTPEVKA ARGEEKDKET KNAANASASK SAKTATAGPG TTKTTKSSAV
2360 2370 2380 2390 2400
PPGLPVYLDL CYIPNHSNSK NVDVEFFKRV RSSYYVVSGN DPAAEEPSRA
2410 2420 2430 2440 2450
VLDALLEGKA QWGSNMQVTL IPTHDSEVMR EWYQETHEKQ QDLNIMVLAS
2460
SSTVVMQDES FPACKIEL
Length:2,468
Mass (Da):270,634
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FFDCB2E20049A8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA40D6RA40_HUMAN
Microtubule-associated protein 1B
MAP1B
569Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA32D6RA32_HUMAN
Microtubule-associated protein 1B
MAP1B
670Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGJ3D6RGJ3_HUMAN
Microtubule-associated protein 1B
MAP1B
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCL2D6RCL2_HUMAN
Microtubule-associated protein 1B
MAP1B
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036016326R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs766004582Ensembl.1
Natural variantiVAR_036017574V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs369022142Ensembl.1
Natural variantiVAR_024530594I → V3 PublicationsCorresponds to variant dbSNP:rs1866374Ensembl.1
Natural variantiVAR_030347869E → G. Corresponds to variant dbSNP:rs16876070Ensembl.1
Natural variantiVAR_0341051296P → L. Corresponds to variant dbSNP:rs34093016Ensembl.1
Natural variantiVAR_0561231917S → R. Corresponds to variant dbSNP:rs13153166Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L06237 mRNA Translation: AAA18904.1
BN001084 mRNA Translation: CAM06633.1
AC012609 Genomic DNA No translation available.
AC093218 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW95697.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4012.1

NCBI Reference Sequences

More...
RefSeqi
NP_005900.2, NM_005909.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.335079

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296755; ENSP00000296755; ENSG00000131711

Database of genes from NCBI RefSeq genomes

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GeneIDi
4131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4131

UCSC genome browser

More...
UCSCi
uc003kbw.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06237 mRNA Translation: AAA18904.1
BN001084 mRNA Translation: CAM06633.1
AC012609 Genomic DNA No translation available.
AC093218 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW95697.1
CCDSiCCDS4012.1
RefSeqiNP_005900.2, NM_005909.4
UniGeneiHs.335079

3D structure databases

ProteinModelPortaliP46821
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110304, 72 interactors
DIPiDIP-33474N
IntActiP46821, 39 interactors
MINTiP46821
STRINGi9606.ENSP00000296755

Chemistry databases

ChEMBLiCHEMBL3217382

PTM databases

CarbonylDBiP46821
iPTMnetiP46821
PhosphoSitePlusiP46821

Polymorphism and mutation databases

BioMutaiMAP1B
DMDMi317373388

Proteomic databases

EPDiP46821
jPOSTiP46821
MaxQBiP46821
PaxDbiP46821
PeptideAtlasiP46821
PRIDEiP46821
ProteomicsDBi55766

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4131
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296755; ENSP00000296755; ENSG00000131711
GeneIDi4131
KEGGihsa:4131
UCSCiuc003kbw.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4131
DisGeNETi4131
EuPathDBiHostDB:ENSG00000131711.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAP1B
HGNCiHGNC:6836 MAP1B
HPAiCAB009792
HPA022275
MIMi157129 gene
neXtProtiNX_P46821
OpenTargetsiENSG00000131711
Orphaneti98892 Periventricular nodular heterotopia
PharmGKBiPA30581

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00940000155897
HOGENOMiHOG000063256
HOVERGENiHBG052409
InParanoidiP46821
KOiK10429
OMAiKPQGRQC
OrthoDBi86642at2759
PhylomeDBiP46821
TreeFamiTF350229

Enzyme and pathway databases

SIGNORiP46821

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAP1B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAP1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4131

Protein Ontology

More...
PROi
PR:P46821

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131711 Expressed in 243 organ(s), highest expression level in entorhinal cortex
CleanExiHS_MAP1B
ExpressionAtlasiP46821 baseline and differential
GenevisibleiP46821 HS

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR027321 MAP1B
IPR000102 MAP1B_neuraxin
PANTHERiPTHR13843 PTHR13843, 1 hit
PTHR13843:SF5 PTHR13843:SF5, 1 hit
PfamiView protein in Pfam
PF00414 MAP1B_neuraxin, 6 hits
PROSITEiView protein in PROSITE
PS00230 MAP1B_NEURAXIN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46821
Secondary accession number(s): A2BDK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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