UniProtKB - P46782 (RS5_HUMAN)
Protein
40S ribosomal protein S5
Gene
RPS5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- mRNA binding Source: UniProtKB
- RNA binding Source: UniProtKB
- rRNA binding Source: GO_Central
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- regulation of translational fidelity Source: UniProtKB
- ribosomal small subunit assembly Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P46782 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P46782 |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S5Alternative name(s): Small ribosomal subunit protein uS71 Publication Cleaved into the following chain: |
Gene namesi | Name:RPS5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000083845.8 |
HGNCi | HGNC:10426, RPS5 |
MIMi | 603630, gene |
neXtProti | NX_P46782 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic small ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
Other locations
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- ribonucleoprotein complex Source: MGI
- ribosome Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6193 |
OpenTargetsi | ENSG00000083845 |
PharmGKBi | PA34841 |
Miscellaneous databases
Pharosi | P46782, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Polymorphism and mutation databases
BioMutai | RPS5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000370369 | 1 – 204 | 40S ribosomal protein S5Add BLAST | 204 | |
Initiator methioninei | Removed; alternateCombined sources2 Publications | |||
ChainiPRO_0000124526 | 2 – 204 | 40S ribosomal protein S5, N-terminally processedAdd BLAST | 203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine; in 40S ribosomal protein S5; alternateCombined sources1 Publication | 1 | |
Modified residuei | 2 | N-acetylthreonine; in 40S ribosomal protein S5, N-terminally processedCombined sources2 Publications | 1 | |
Modified residuei | 14 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 47 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 47 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 142 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P46782 |
jPOSTi | P46782 |
MassIVEi | P46782 |
MaxQBi | P46782 |
PaxDbi | P46782 |
PeptideAtlasi | P46782 |
PRIDEi | P46782 |
ProteomicsDBi | 55764 |
TopDownProteomicsi | P46782 |
2D gel databases
SWISS-2DPAGEi | P46782 |
PTM databases
iPTMneti | P46782 |
MetOSitei | P46782 |
PhosphoSitePlusi | P46782 |
SwissPalmi | P46782 |
Expressioni
Gene expression databases
Bgeei | ENSG00000083845, Expressed in epithelium of bronchus and 241 other tissues |
ExpressionAtlasi | P46782, baseline and differential |
Genevisiblei | P46782, HS |
Organism-specific databases
HPAi | ENSG00000083845, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112107, 242 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P46782 |
IntActi | P46782, 58 interactors |
MINTi | P46782 |
STRINGi | 9606.ENSP00000472985 |
Miscellaneous databases
RNActi | P46782, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P46782 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uS7 family.Curated
Phylogenomic databases
eggNOGi | KOG3291, Eukaryota |
GeneTreei | ENSGT00390000010806 |
HOGENOMi | CLU_063975_0_0_1 |
InParanoidi | P46782 |
OrthoDBi | 1532160at2759 |
PhylomeDBi | P46782 |
TreeFami | TF300872 |
Family and domain databases
CDDi | cd14867, uS7_Eukaryote, 1 hit |
Gene3Di | 1.10.455.10, 1 hit |
InterProi | View protein in InterPro IPR000235, Ribosomal_S5/S7 IPR005716, Ribosomal_S5/S7_euk/arc IPR020606, Ribosomal_S7_CS IPR023798, Ribosomal_S7_dom IPR036823, Ribosomal_S7_dom_sf |
PANTHERi | PTHR11205, PTHR11205, 1 hit |
Pfami | View protein in Pfam PF00177, Ribosomal_S7, 1 hit |
PIRSFi | PIRSF002122, RPS7p_RPS7a_RPS5e_RPS7o, 1 hit |
SUPFAMi | SSF47973, SSF47973, 1 hit |
TIGRFAMsi | TIGR01028, uS7_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00052, RIBOSOMAL_S7, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P46782-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP
60 70 80 90 100
HSAGRYAAKR FRKAQCPIVE RLTNSMMMHG RNNGKKLMTV RIVKHAFEII
110 120 130 140 150
HLLTGENPLQ VLVNAIINSG PREDSTRIGR AGTVRRQAVD VSPLRRVNQA
160 170 180 190 200
IWLLCTGARE AAFRNIKTIA ECLADELINA AKGSSNSYAI KKKDELERVA
KSNR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R0F0 | M0R0F0_HUMAN | 40S ribosomal protein S5 | RPS5 | 200 | Annotation score: | ||
M0R0R2 | M0R0R2_HUMAN | 40S ribosomal protein S5 | RPS5 | 225 | Annotation score: | ||
M0QZN2 | M0QZN2_HUMAN | 40S ribosomal protein S5 | RPS5 | 134 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 – 60 | KR → NA in AAA85658 (PubMed:7772601).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14970 mRNA Translation: AAA85658.1 AB061853 Genomic DNA Translation: BAB79493.1 AK311938 mRNA Translation: BAG34879.1 CH471135 Genomic DNA Translation: EAW72581.1 BC015405 mRNA Translation: AAH15405.1 BC018151 mRNA Translation: AAH18151.1 AB007149 Genomic DNA Translation: BAA25815.1 |
CCDSi | CCDS12978.1 |
PIRi | S55916 |
RefSeqi | NP_001000.2, NM_001009.3 |
Genome annotation databases
Ensembli | ENST00000196551; ENSP00000196551; ENSG00000083845 ENST00000596046; ENSP00000472985; ENSG00000083845 ENST00000601521; ENSP00000470114; ENSG00000083845 |
GeneIDi | 6193 |
KEGGi | hsa:6193 |
UCSCi | uc002qsn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14970 mRNA Translation: AAA85658.1 AB061853 Genomic DNA Translation: BAB79493.1 AK311938 mRNA Translation: BAG34879.1 CH471135 Genomic DNA Translation: EAW72581.1 BC015405 mRNA Translation: AAH15405.1 BC018151 mRNA Translation: AAH18151.1 AB007149 Genomic DNA Translation: BAA25815.1 |
CCDSi | CCDS12978.1 |
PIRi | S55916 |
RefSeqi | NP_001000.2, NM_001009.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | SF | 1-204 | [»] | |
4V6X | electron microscopy | 5.00 | AF | 1-204 | [»] | |
5A2Q | electron microscopy | 3.90 | F | 1-204 | [»] | |
5AJ0 | electron microscopy | 3.50 | BF | 1-204 | [»] | |
5FLX | electron microscopy | 3.90 | F | 1-204 | [»] | |
5LKS | electron microscopy | 3.60 | SF | 1-204 | [»] | |
5OA3 | electron microscopy | 4.30 | F | 1-204 | [»] | |
5T2C | electron microscopy | 3.60 | As | 1-204 | [»] | |
5VYC | X-ray | 6.00 | F1/F2/F3/F4/F5/F6 | 1-204 | [»] | |
6EK0 | electron microscopy | 2.90 | SF | 1-204 | [»] | |
6FEC | electron microscopy | 6.30 | U | 14-204 | [»] | |
6G18 | electron microscopy | 3.60 | F | 1-204 | [»] | |
6G4S | electron microscopy | 4.00 | F | 1-204 | [»] | |
6G4W | electron microscopy | 4.50 | F | 1-204 | [»] | |
6G51 | electron microscopy | 4.10 | F | 1-204 | [»] | |
6G53 | electron microscopy | 4.50 | F | 1-204 | [»] | |
6G5H | electron microscopy | 3.60 | F | 1-204 | [»] | |
6G5I | electron microscopy | 3.50 | F | 1-204 | [»] | |
6IP5 | electron microscopy | 3.90 | 2r | 1-204 | [»] | |
6IP6 | electron microscopy | 4.50 | 2r | 1-204 | [»] | |
6IP8 | electron microscopy | 3.90 | 2r | 1-204 | [»] | |
6OLE | electron microscopy | 3.10 | SF | 16-204 | [»] | |
6OLF | electron microscopy | 3.90 | SF | 16-204 | [»] | |
6OLG | electron microscopy | 3.40 | BF | 15-204 | [»] | |
6OLI | electron microscopy | 3.50 | SF | 16-204 | [»] | |
6OLZ | electron microscopy | 3.90 | BF | 15-204 | [»] | |
6OM0 | electron microscopy | 3.10 | SF | 16-204 | [»] | |
6OM7 | electron microscopy | 3.70 | SF | 16-204 | [»] | |
6QZP | electron microscopy | 2.90 | SF | 16-204 | [»] | |
6Y0G | electron microscopy | 3.20 | SF | 1-204 | [»] | |
6Y2L | electron microscopy | 3.00 | SF | 1-204 | [»] | |
6Y57 | electron microscopy | 3.50 | SF | 1-204 | [»] | |
6Z6L | electron microscopy | 3.00 | SF | 1-204 | [»] | |
6Z6M | electron microscopy | 3.10 | SF | 1-204 | [»] | |
6Z6N | electron microscopy | 2.90 | SF | 1-204 | [»] | |
6ZLW | electron microscopy | 2.60 | K | 1-204 | [»] | |
6ZM7 | electron microscopy | 2.70 | SF | 1-204 | [»] | |
6ZME | electron microscopy | 3.00 | SF | 1-204 | [»] | |
6ZMI | electron microscopy | 2.60 | SF | 1-204 | [»] | |
6ZMO | electron microscopy | 3.10 | SF | 1-204 | [»] | |
6ZMT | electron microscopy | 3.00 | K | 1-204 | [»] | |
6ZN5 | electron microscopy | 3.20 | K | 16-204 | [»] | |
6ZOJ | electron microscopy | 2.80 | F | 1-204 | [»] | |
6ZOL | electron microscopy | 2.80 | F | 1-204 | [»] | |
6ZON | electron microscopy | 3.00 | e | 1-204 | [»] | |
6ZP4 | electron microscopy | 2.90 | e | 1-204 | [»] | |
6ZVH | electron microscopy | 2.90 | F | 16-204 | [»] | |
SMRi | P46782 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112107, 242 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P46782 |
IntActi | P46782, 58 interactors |
MINTi | P46782 |
STRINGi | 9606.ENSP00000472985 |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
iPTMneti | P46782 |
MetOSitei | P46782 |
PhosphoSitePlusi | P46782 |
SwissPalmi | P46782 |
Polymorphism and mutation databases
BioMutai | RPS5 |
2D gel databases
SWISS-2DPAGEi | P46782 |
Proteomic databases
EPDi | P46782 |
jPOSTi | P46782 |
MassIVEi | P46782 |
MaxQBi | P46782 |
PaxDbi | P46782 |
PeptideAtlasi | P46782 |
PRIDEi | P46782 |
ProteomicsDBi | 55764 |
TopDownProteomicsi | P46782 |
Protocols and materials databases
Antibodypediai | 33338, 240 antibodies |
DNASUi | 6193 |
Genome annotation databases
Ensembli | ENST00000196551; ENSP00000196551; ENSG00000083845 ENST00000596046; ENSP00000472985; ENSG00000083845 ENST00000601521; ENSP00000470114; ENSG00000083845 |
GeneIDi | 6193 |
KEGGi | hsa:6193 |
UCSCi | uc002qsn.4, human |
Organism-specific databases
CTDi | 6193 |
DisGeNETi | 6193 |
EuPathDBi | HostDB:ENSG00000083845.8 |
GeneCardsi | RPS5 |
HGNCi | HGNC:10426, RPS5 |
HPAi | ENSG00000083845, Low tissue specificity |
MIMi | 603630, gene |
neXtProti | NX_P46782 |
OpenTargetsi | ENSG00000083845 |
PharmGKBi | PA34841 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3291, Eukaryota |
GeneTreei | ENSGT00390000010806 |
HOGENOMi | CLU_063975_0_0_1 |
InParanoidi | P46782 |
OrthoDBi | 1532160at2759 |
PhylomeDBi | P46782 |
TreeFami | TF300872 |
Enzyme and pathway databases
PathwayCommonsi | P46782 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P46782 |
Miscellaneous databases
BioGRID-ORCSi | 6193, 774 hits in 852 CRISPR screens |
ChiTaRSi | RPS5, human |
GeneWikii | RPS5 |
GenomeRNAii | 6193 |
Pharosi | P46782, Tbio |
PROi | PR:P46782 |
RNActi | P46782, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000083845, Expressed in epithelium of bronchus and 241 other tissues |
ExpressionAtlasi | P46782, baseline and differential |
Genevisiblei | P46782, HS |
Family and domain databases
CDDi | cd14867, uS7_Eukaryote, 1 hit |
Gene3Di | 1.10.455.10, 1 hit |
InterProi | View protein in InterPro IPR000235, Ribosomal_S5/S7 IPR005716, Ribosomal_S5/S7_euk/arc IPR020606, Ribosomal_S7_CS IPR023798, Ribosomal_S7_dom IPR036823, Ribosomal_S7_dom_sf |
PANTHERi | PTHR11205, PTHR11205, 1 hit |
Pfami | View protein in Pfam PF00177, Ribosomal_S7, 1 hit |
PIRSFi | PIRSF002122, RPS7p_RPS7a_RPS5e_RPS7o, 1 hit |
SUPFAMi | SSF47973, SSF47973, 1 hit |
TIGRFAMsi | TIGR01028, uS7_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00052, RIBOSOMAL_S7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS5_HUMAN | |
Accessioni | P46782Primary (citable) accession number: P46782 Secondary accession number(s): B2R4T2, Q96BN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries