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Entry version 190 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

60S ribosomal protein L28

Gene

RPL28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L28
Alternative name(s):
Large ribosomal subunit protein eL281 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10330 RPL28

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603638 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46779

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6158

Open Targets

More...
OpenTargetsi
ENSG00000108107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34710

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P46779

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPL28

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001223892 – 13760S ribosomal protein L28Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei115PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P46779

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P46779

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P46779

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P46779

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46779

PeptideAtlas

More...
PeptideAtlasi
P46779

PRoteomics IDEntifications database

More...
PRIDEi
P46779

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19127
33973
55761 [P46779-1]
55762 [P46779-2]
9416

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P46779-1 [P46779-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P46779

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46779

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P46779

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P46779

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108107 Expressed in 231 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46779 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46779 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050459

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112077, 196 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P46779

Protein interaction database and analysis system

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IntActi
P46779, 114 interactors

Molecular INTeraction database

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MINTi
P46779

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000452909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3412 Eukaryota
ENOG4111T32 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000200513

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P46779

KEGG Orthology (KO)

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KOi
K02903

Identification of Orthologs from Complete Genome Data

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OMAi
WMIIRNN

Database of Orthologous Groups

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OrthoDBi
1593474at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P46779

TreeFam database of animal gene trees

More...
TreeFami
TF300173

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029004 L28e/Mak16
IPR002672 Ribosomal_L28e

The PANTHER Classification System

More...
PANTHERi
PTHR10544 PTHR10544, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01778 Ribosomal_L28e, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46779-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAHLQWMVV RNCSSFLIKR NKQTYSTEPN NLKARNSFRY NGLIHRKTVG
60 70 80 90 100
VEPAADGKGV VVVIKRRSGQ RKPATSYVRT TINKNARATL SSIRHMIRKN
110 120 130
KYRPDLRMAA IRRASAILRS QKPVMVKRKR TRPTKSS
Length:137
Mass (Da):15,748
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44DCDE45473D7C7B
GO
Isoform 2 (identifier: P46779-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-137: AAIRRASAILRSQKPVMVKRKRTRPTKSS → VSWGLGIRLG...PRGRLVECMG

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,430
Checksum:i1C9BD1FA0A0E14EE
GO
Isoform 3 (identifier: P46779-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-137: AAIRRASAILRSQKPVMVKRKRTRPTKSS → DMLASTGSGL...QNLLDCAHKS

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):19,148
Checksum:iD4D6E5C7F4116D16
GO
Isoform 4 (identifier: P46779-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-137: GQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS → E

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:69
Mass (Da):7,888
Checksum:iEDE20EE54DFE31FE
GO
Isoform 5 (identifier: P46779-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-137: QRKPATSYVR...RKRTRPTKSS → EFCLVWARERPLSRVWEL

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:87
Mass (Da):10,088
Checksum:i791604CE95F509E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLP6H0YLP6_HUMAN
60S ribosomal protein L28
RPL28
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKD8H0YKD8_HUMAN
60S ribosomal protein L28
RPL28
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMF4H0YMF4_HUMAN
60S ribosomal protein L28
RPL28
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84K → R in AAH10182 (PubMed:15489334).Curated1
Sequence conflicti120S → T in AAA85657 (PubMed:7772601).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03446066R → L. Corresponds to variant dbSNP:rs13502Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04702669 – 137GQRKP…PTKSS → E in isoform 4. CuratedAdd BLAST69
Alternative sequenceiVSP_04702770 – 137QRKPA…PTKSS → EFCLVWARERPLSRVWEL in isoform 5. CuratedAdd BLAST68
Alternative sequenceiVSP_043026109 – 137AAIRR…PTKSS → VSWGLGIRLGETGQCCGEGP PTTGCNMGWRGMDSCFQPTP HTQHWPRGRLVECMG in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_046173109 – 137AAIRR…PTKSS → DMLASTGSGLCCSVAVQPWA SSSTSLCLRTLICNMRVDRP YYSGLMRRLNVQNLLDCAHK S in isoform 3. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U14969 mRNA Translation: AAA85657.1
CR457024 mRNA Translation: CAG33305.1
AK311760 mRNA Translation: BAG34703.1
AK293736 mRNA Translation: BAG57160.1
AC020922 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72374.1
CH471135 Genomic DNA Translation: EAW72375.1
CH471135 Genomic DNA Translation: EAW72376.1
BC010173 mRNA Translation: AAH10173.1
BC010182 mRNA Translation: AAH10182.1
BC011582 mRNA Translation: AAH11582.1
BG777550 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12924.1 [P46779-1]
CCDS46189.1 [P46779-3]
CCDS46190.1 [P46779-2]
CCDS46191.1 [P46779-4]
CCDS46192.1 [P46779-5]

Protein sequence database of the Protein Information Resource

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PIRi
S55915

NCBI Reference Sequences

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RefSeqi
NP_000982.2, NM_000991.4 [P46779-1]
NP_001129606.1, NM_001136134.1 [P46779-2]
NP_001129607.1, NM_001136135.1 [P46779-3]
NP_001129608.1, NM_001136136.1 [P46779-5]
NP_001129609.1, NM_001136137.1 [P46779-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344063; ENSP00000342787; ENSG00000108107 [P46779-1]
ENST00000428193; ENSP00000391665; ENSG00000108107 [P46779-4]
ENST00000431533; ENSP00000400596; ENSG00000108107 [P46779-5]
ENST00000558815; ENSP00000452909; ENSG00000108107 [P46779-3]
ENST00000559463; ENSP00000453319; ENSG00000108107 [P46779-1]
ENST00000560583; ENSP00000453029; ENSG00000108107 [P46779-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6158

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6158

UCSC genome browser

More...
UCSCi
uc002qkv.4 human [P46779-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14969 mRNA Translation: AAA85657.1
CR457024 mRNA Translation: CAG33305.1
AK311760 mRNA Translation: BAG34703.1
AK293736 mRNA Translation: BAG57160.1
AC020922 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72374.1
CH471135 Genomic DNA Translation: EAW72375.1
CH471135 Genomic DNA Translation: EAW72376.1
BC010173 mRNA Translation: AAH10173.1
BC010182 mRNA Translation: AAH10182.1
BC011582 mRNA Translation: AAH11582.1
BG777550 mRNA No translation available.
CCDSiCCDS12924.1 [P46779-1]
CCDS46189.1 [P46779-3]
CCDS46190.1 [P46779-2]
CCDS46191.1 [P46779-4]
CCDS46192.1 [P46779-5]
PIRiS55915
RefSeqiNP_000982.2, NM_000991.4 [P46779-1]
NP_001129606.1, NM_001136134.1 [P46779-2]
NP_001129607.1, NM_001136135.1 [P46779-3]
NP_001129608.1, NM_001136136.1 [P46779-5]
NP_001129609.1, NM_001136137.1 [P46779-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lr1-137[»]
4V6Xelectron microscopy5.00Cr1-137[»]
5AJ0electron microscopy3.50At1-137[»]
5LKSelectron microscopy3.60Lr1-137[»]
5T2Celectron microscopy3.60k1-137[»]
6EK0electron microscopy2.90Lr1-137[»]
6IP5electron microscopy3.902k1-137[»]
6IP6electron microscopy4.502k1-137[»]
6IP8electron microscopy3.902k1-137[»]
6OLEelectron microscopy3.10r2-123[»]
6OLFelectron microscopy3.90r2-123[»]
6OLGelectron microscopy3.40At2-123[»]
6OLIelectron microscopy3.50r2-123[»]
6OLZelectron microscopy3.90At2-123[»]
6OM0electron microscopy3.10r2-123[»]
6OM7electron microscopy3.70r2-123[»]
6QZPelectron microscopy2.90Lr2-126[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112077, 196 interactors
CORUMiP46779
IntActiP46779, 114 interactors
MINTiP46779
STRINGi9606.ENSP00000452909

PTM databases

iPTMnetiP46779
PhosphoSitePlusiP46779
SwissPalmiP46779

Polymorphism and mutation databases

BioMutaiRPL28

Proteomic databases

EPDiP46779
jPOSTiP46779
MassIVEiP46779
MaxQBiP46779
PaxDbiP46779
PeptideAtlasiP46779
PRIDEiP46779
ProteomicsDBi19127
33973
55761 [P46779-1]
55762 [P46779-2]
9416
TopDownProteomicsiP46779-1 [P46779-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6158

Genome annotation databases

EnsembliENST00000344063; ENSP00000342787; ENSG00000108107 [P46779-1]
ENST00000428193; ENSP00000391665; ENSG00000108107 [P46779-4]
ENST00000431533; ENSP00000400596; ENSG00000108107 [P46779-5]
ENST00000558815; ENSP00000452909; ENSG00000108107 [P46779-3]
ENST00000559463; ENSP00000453319; ENSG00000108107 [P46779-1]
ENST00000560583; ENSP00000453029; ENSG00000108107 [P46779-2]
GeneIDi6158
KEGGihsa:6158
UCSCiuc002qkv.4 human [P46779-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6158
DisGeNETi6158

GeneCards: human genes, protein and diseases

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GeneCardsi
RPL28
HGNCiHGNC:10330 RPL28
HPAiHPA050459
MIMi603638 gene
neXtProtiNX_P46779
OpenTargetsiENSG00000108107
PharmGKBiPA34710

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3412 Eukaryota
ENOG4111T32 LUCA
GeneTreeiENSGT00390000008732
HOGENOMiHOG000200513
InParanoidiP46779
KOiK02903
OMAiWMIIRNN
OrthoDBi1593474at2759
PhylomeDBiP46779
TreeFamiTF300173

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL28 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
60S_ribosomal_protein_L28

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6158
PharosiP46779
PMAP-CutDBiP46779

Protein Ontology

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PROi
PR:P46779

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108107 Expressed in 231 organ(s), highest expression level in blood
ExpressionAtlasiP46779 baseline and differential
GenevisibleiP46779 HS

Family and domain databases

InterProiView protein in InterPro
IPR029004 L28e/Mak16
IPR002672 Ribosomal_L28e
PANTHERiPTHR10544 PTHR10544, 1 hit
PfamiView protein in Pfam
PF01778 Ribosomal_L28e, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL28_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46779
Secondary accession number(s): B2R4A6
, B4DEP9, C9JB50, E9PB24, G5E9L2, Q6IAY0, Q96FX1, Q9BWQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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