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Protein

60S ribosomal protein L21

Gene

RPL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L21
Alternative name(s):
Large ribosomal subunit protein eL211 Publication
Gene namesi
Name:RPL21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000122026.10
HGNCiHGNC:10313 RPL21
MIMi603636 gene
neXtProtiNX_P46778

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Hypotrichosis 12 (HYPT12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent.
See also OMIM:615885
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06603032R → Q in HYPT12; autosomal dominant. 1 PublicationCorresponds to variant dbSNP:rs587777527EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypotrichosis

Organism-specific databases

DisGeNETi6144
MalaCardsiRPL21
MIMi615885 phenotype
OpenTargetsiENSG00000122026
Orphaneti55654 Hypotrichosis simplex
PharmGKBiPA34683

Polymorphism and mutation databases

BioMutaiRPL21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001496692 – 16060S ribosomal protein L21Add BLAST159

Proteomic databases

EPDiP46778
PaxDbiP46778
PeptideAtlasiP46778
PRIDEiP46778
ProteomicsDBi55760
TopDownProteomicsiP46778

2D gel databases

SWISS-2DPAGEiP46778

PTM databases

iPTMnetiP46778
PhosphoSitePlusiP46778
SwissPalmiP46778

Expressioni

Gene expression databases

BgeeiENSG00000122026
CleanExiHS_RPL21
ExpressionAtlasiP46778 baseline and differential
GenevisibleiP46778 HS

Organism-specific databases

HPAiHPA047252

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication3 Publications

Protein-protein interaction databases

BioGridi112064, 149 interactors
CORUMiP46778
IntActiP46778, 49 interactors
MINTiP46778
STRINGi9606.ENSP00000346027

Structurei

3D structure databases

ProteinModelPortaliP46778
SMRiP46778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1732 Eukaryota
COG2139 LUCA
GeneTreeiENSGT00390000001293
HOVERGENiHBG001518
InParanoidiP46778
KOiK02889
OMAiHVKHSKS
OrthoDBiEOG091G0SNM
PhylomeDBiP46778
TreeFamiTF314640

Family and domain databases

Gene3Di2.30.30.70, 1 hit
InterProiView protein in InterPro
IPR036948 Ribosomal_L21_sf
IPR001147 Ribosomal_L21e
IPR018259 Ribosomal_L21e_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR20981 PTHR20981, 1 hit
PfamiView protein in Pfam
PF01157 Ribosomal_L21e, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01171 RIBOSOMAL_L21E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK
60 70 80 90 100
GMPHKCYHGK TGRVYNVTQH AVGIVVNKQV KGKILAKRIN VRIEHIKHSK
110 120 130 140 150
SRDSFLKRVK ENDQKKKEAK EKGTWVQLKR QPAPPREAHF VRTNGKEPEL
160
LEPIPYEFMA
Length:160
Mass (Da):18,565
Last modified:January 23, 2007 - v2
Checksum:iC51D0B5E8EB9D69E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72V → A in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti78K → E in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti104S → N in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti112N → D in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti115K → E in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti120K → Q in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti131Q → H in AAA80462 (PubMed:7951316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03445915F → S. Corresponds to variant dbSNP:rs17085349Ensembl.1
Natural variantiVAR_06603032R → Q in HYPT12; autosomal dominant. 1 PublicationCorresponds to variant dbSNP:rs587777527EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89401 mRNA Translation: CAA61582.1
U14967 mRNA Translation: AAA85655.1
AB061826 Genomic DNA Translation: BAB79464.1
BC001603 mRNA Translation: AAH01603.1
BC007505 mRNA Translation: AAH07505.1
BC062981 mRNA Translation: AAH62981.1
BC070184 mRNA Translation: AAH70184.1
BC070323 mRNA Translation: AAH70323.1
BC070330 mRNA Translation: AAH70330.1
U25789 mRNA Translation: AAA93231.1
L38826 Genomic DNA Translation: AAA80462.1
AB007176 Genomic DNA Translation: BAA25835.1
CCDSiCCDS9320.1
PIRiS55913
RefSeqiNP_000973.2, NM_000982.3
UniGeneiHs.381123
Hs.535873

Genome annotation databases

EnsembliENST00000272274; ENSP00000351021; ENSG00000122026
ENST00000311549; ENSP00000346027; ENSG00000122026
ENST00000319826; ENSP00000370574; ENSG00000122026
ENST00000326092; ENSP00000370569; ENSG00000122026
GeneIDi6144
KEGGihsa:6144

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL21_HUMAN
AccessioniPrimary (citable) accession number: P46778
Secondary accession number(s): Q16699
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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