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Entry version 200 (31 Jul 2019)
Sequence version 2 (23 Jan 2007)
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Protein

60S ribosomal protein L21

Gene

RPL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.1 Publication3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L21
Alternative name(s):
Large ribosomal subunit protein eL211 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10313 RPL21

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603636 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46778

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypotrichosis 12 (HYPT12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06603032R → Q in HYPT12; autosomal dominant. 1 PublicationCorresponds to variant dbSNP:rs587777527EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypotrichosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
6144

MalaCards human disease database

More...
MalaCardsi
RPL21
MIMi615885 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000122026

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
55654 Hypotrichosis simplex

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34683

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPL21

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001496692 – 16060S ribosomal protein L21Add BLAST159

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46778

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P46778

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46778

PeptideAtlas

More...
PeptideAtlasi
P46778

PRoteomics IDEntifications database

More...
PRIDEi
P46778

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55760

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P46778

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P46778

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46778

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46778

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P46778

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122026 Expressed in 92 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46778 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46778 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047252

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit.

1 Publication3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112064, 177 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P46778

Protein interaction database and analysis system

More...
IntActi
P46778, 61 interactors

Molecular INTeraction database

More...
MINTi
P46778

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346027

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46778

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1732 Eukaryota
COG2139 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182922

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46778

KEGG Orthology (KO)

More...
KOi
K02889

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFRKHGP

Database of Orthologous Groups

More...
OrthoDBi
1422066at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46778

TreeFam database of animal gene trees

More...
TreeFami
TF314640

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.70, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036948 Ribosomal_L21_sf
IPR001147 Ribosomal_L21e
IPR018259 Ribosomal_L21e_CS
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR20981 PTHR20981, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01157 Ribosomal_L21e, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50104 SSF50104, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01171 RIBOSOMAL_L21E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P46778-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK
60 70 80 90 100
GMPHKCYHGK TGRVYNVTQH AVGIVVNKQV KGKILAKRIN VRIEHIKHSK
110 120 130 140 150
SRDSFLKRVK ENDQKKKEAK EKGTWVQLKR QPAPPREAHF VRTNGKEPEL
160
LEPIPYEFMA
Length:160
Mass (Da):18,565
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC51D0B5E8EB9D69E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R181M0R181_HUMAN
60S ribosomal protein L21
RPL21
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1B3G3V1B3_HUMAN
60S ribosomal protein L21
RPL21 hCG_2020044
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3I5M0R3I5_HUMAN
60S ribosomal protein L21
RPL21
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72V → A in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti78K → E in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti104S → N in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti112N → D in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti115K → E in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti120K → Q in AAA93231 (PubMed:7581362).Curated1
Sequence conflicti131Q → H in AAA80462 (PubMed:7951316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03445915F → S. Corresponds to variant dbSNP:rs17085349Ensembl.1
Natural variantiVAR_06603032R → Q in HYPT12; autosomal dominant. 1 PublicationCorresponds to variant dbSNP:rs587777527EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X89401 mRNA Translation: CAA61582.1
U14967 mRNA Translation: AAA85655.1
AB061826 Genomic DNA Translation: BAB79464.1
BC001603 mRNA Translation: AAH01603.1
BC007505 mRNA Translation: AAH07505.1
BC062981 mRNA Translation: AAH62981.1
BC070184 mRNA Translation: AAH70184.1
BC070323 mRNA Translation: AAH70323.1
BC070330 mRNA Translation: AAH70330.1
U25789 mRNA Translation: AAA93231.1
L38826 Genomic DNA Translation: AAA80462.1
AB007176 Genomic DNA Translation: BAA25835.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9320.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S55913

NCBI Reference Sequences

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RefSeqi
NP_000973.2, NM_000982.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272274; ENSP00000351021; ENSG00000122026
ENST00000311549; ENSP00000346027; ENSG00000122026
ENST00000319826; ENSP00000370574; ENSG00000122026
ENST00000326092; ENSP00000370569; ENSG00000122026

Database of genes from NCBI RefSeq genomes

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GeneIDi
6144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6144

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89401 mRNA Translation: CAA61582.1
U14967 mRNA Translation: AAA85655.1
AB061826 Genomic DNA Translation: BAB79464.1
BC001603 mRNA Translation: AAH01603.1
BC007505 mRNA Translation: AAH07505.1
BC062981 mRNA Translation: AAH62981.1
BC070184 mRNA Translation: AAH70184.1
BC070323 mRNA Translation: AAH70323.1
BC070330 mRNA Translation: AAH70330.1
U25789 mRNA Translation: AAA93231.1
L38826 Genomic DNA Translation: AAA80462.1
AB007176 Genomic DNA Translation: BAA25835.1
CCDSiCCDS9320.1
PIRiS55913
RefSeqiNP_000973.2, NM_000982.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LT1-160[»]
4V6Xelectron microscopy5.00CT1-160[»]
5AJ0electron microscopy3.50AT1-160[»]
5LKSelectron microscopy3.60LT1-160[»]
5T2Celectron microscopy3.60N1-160[»]
6EK0electron microscopy2.90LT1-160[»]
6IP5electron microscopy3.902N1-160[»]
6IP6electron microscopy4.502N1-160[»]
6IP8electron microscopy3.902N1-160[»]
6OLEelectron microscopy3.10U2-158[»]
6OLFelectron microscopy3.90U2-158[»]
6OLGelectron microscopy3.40AT2-158[»]
6OLIelectron microscopy3.50U2-158[»]
6OLZelectron microscopy3.90AT2-158[»]
6OM0electron microscopy3.10U2-158[»]
6OM7electron microscopy3.70U2-158[»]
6QZPelectron microscopy2.90LT2-160[»]
SMRiP46778
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112064, 177 interactors
CORUMiP46778
IntActiP46778, 61 interactors
MINTiP46778
STRINGi9606.ENSP00000346027

PTM databases

iPTMnetiP46778
PhosphoSitePlusiP46778
SwissPalmiP46778

Polymorphism and mutation databases

BioMutaiRPL21

2D gel databases

SWISS-2DPAGEiP46778

Proteomic databases

EPDiP46778
jPOSTiP46778
PaxDbiP46778
PeptideAtlasiP46778
PRIDEiP46778
ProteomicsDBi55760
TopDownProteomicsiP46778

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272274; ENSP00000351021; ENSG00000122026
ENST00000311549; ENSP00000346027; ENSG00000122026
ENST00000319826; ENSP00000370574; ENSG00000122026
ENST00000326092; ENSP00000370569; ENSG00000122026
GeneIDi6144
KEGGihsa:6144

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6144
DisGeNETi6144

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPL21
HGNCiHGNC:10313 RPL21
HPAiHPA047252
MalaCardsiRPL21
MIMi603636 gene
615885 phenotype
neXtProtiNX_P46778
OpenTargetsiENSG00000122026
Orphaneti55654 Hypotrichosis simplex
PharmGKBiPA34683

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1732 Eukaryota
COG2139 LUCA
GeneTreeiENSGT00950000182922
InParanoidiP46778
KOiK02889
OMAiPFRKHGP
OrthoDBi1422066at2759
PhylomeDBiP46778
TreeFamiTF314640

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL21 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPL21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6144

Protein Ontology

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PROi
PR:P46778

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000122026 Expressed in 92 organ(s), highest expression level in body of pancreas
ExpressionAtlasiP46778 baseline and differential
GenevisibleiP46778 HS

Family and domain databases

Gene3Di2.30.30.70, 1 hit
InterProiView protein in InterPro
IPR036948 Ribosomal_L21_sf
IPR001147 Ribosomal_L21e
IPR018259 Ribosomal_L21e_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR20981 PTHR20981, 1 hit
PfamiView protein in Pfam
PF01157 Ribosomal_L21e, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01171 RIBOSOMAL_L21E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46778
Secondary accession number(s): Q16699
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 31, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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