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Entry version 200 (07 Oct 2020)
Sequence version 3 (23 Jan 2007)
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Protein

60S ribosomal protein L5

Gene

RPL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P46777

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

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SIGNORi
P46777

Protein family/group databases

MoonProt database of moonlighting proteins

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MoonProti
P46777

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L5
Alternative name(s):
Large ribosomal subunit protein uL181 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL5
ORF Names:MSTP030
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000122406.12

Human Gene Nomenclature Database

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HGNCi
HGNC:10360, RPL5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603634, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P46777

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 6 (DBA6)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055450140G → S in DBA6. 1 PublicationCorresponds to variant dbSNP:rs121434406EnsemblClinVar.1
Natural variantiVAR_055451285A → V in DBA6. 1 Publication1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
6125

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RPL5

MalaCards human disease database

More...
MalaCardsi
RPL5
MIMi612561, phenotype

Open Targets

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OpenTargetsi
ENSG00000122406

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
124, Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34755

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P46777, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RPL5

Domain mapping of disease mutations (DMDM)

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DMDMi
81175191

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001314312 – 29760S ribosomal protein L5Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycineCombined sources1
Modified residuei5N6-acetyllysineCombined sources1
Modified residuei48N6-acetyllysineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei220N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei232PhosphothreonineCombined sources1
Modified residuei272PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P46777

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P46777

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P46777

MaxQB - The MaxQuant DataBase

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MaxQBi
P46777

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P46777

PeptideAtlas

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PeptideAtlasi
P46777

PRoteomics IDEntifications database

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PRIDEi
P46777

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55759

Consortium for Top Down Proteomics

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TopDownProteomicsi
P46777

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P46777

MetOSite database of methionine sulfoxide sites

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MetOSitei
P46777

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P46777

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P46777

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000122406, Expressed in germinal epithelium of ovary and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P46777, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P46777, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000122406, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit (LSU).

Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868).

Interacts with isoform 1 of NVL in an ATP-dependent manner (PubMed:15469983).

Interacts with RRP1B (PubMed:20926688).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112045, 302 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-5183, 60S cytosolic large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P46777

Database of interacting proteins

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DIPi
DIP-31152N

Protein interaction database and analysis system

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IntActi
P46777, 84 interactors

Molecular INTeraction database

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MINTi
P46777

STRING: functional protein association networks

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STRINGi
9606.ENSP00000359345

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P46777, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46777

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0875, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_056222_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P46777

KEGG Orthology (KO)

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KOi
K02932

Identification of Orthologs from Complete Genome Data

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OMAi
NHGLTNW

Database of Orthologous Groups

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OrthoDBi
999609at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P46777

TreeFam database of animal gene trees

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TreeFami
TF300044

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_01337_A, Ribosomal_L18_A, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005485, Rbsml_L5_euk/L18_arc
IPR025607, Rbsml_L5e/L18P_C

The PANTHER Classification System

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PANTHERi
PTHR23410, PTHR23410, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14204, Ribosomal_L18_c, 1 hit
PF17144, Ribosomal_L5e, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00058, RIBOSOMALL5

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P46777-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR
60 70 80 90 100
MIVRVTNRDI ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC
110 120 130 140 150
TGLLLARRLL NRFGMDKIYE GQVEVTGDEY NVESIDGQPG AFTCYLDAGL
160 170 180 190 200
ARTTTGNKVF GALKGAVDGG LSIPHSTKRF PGYDSESKEF NAEVHRKHIM
210 220 230 240 250
GQNVADYMRY LMEEDEDAYK KQFSQYIKNS VTPDMMEEMY KKAHAAIREN
260 270 280 290
PVYEKKPKKE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES
Length:297
Mass (Da):34,363
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07CA9FBA842BD2A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y4A2A0A2R8Y4A2_HUMAN
60S ribosomal protein L5
RPL5
170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6J3A0A2R8Y6J3_HUMAN
60S ribosomal protein L5
RPL5
238Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T7N0Q5T7N0_HUMAN
60S ribosomal protein L5
RPL5
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNJ2R4GNJ2_HUMAN
60S ribosomal protein L5
RPL5
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78A → R in AAA85654 (PubMed:7772601).Curated1
Sequence conflicti176S → R (PubMed:7937132).Curated1
Sequence conflicti264K → E in BAD96324 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055450140G → S in DBA6. 1 PublicationCorresponds to variant dbSNP:rs121434406EnsemblClinVar.1
Natural variantiVAR_052009210Y → C1 PublicationCorresponds to variant dbSNP:rs11540832EnsemblClinVar.1
Natural variantiVAR_055451285A → V in DBA6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U14966 mRNA Translation: AAA85654.1
AF113210 mRNA Translation: AAG39281.1
AK222604 mRNA Translation: BAD96324.1
AL162740 Genomic DNA No translation available.
BC109370 mRNA Translation: AAI09371.1
U76609 mRNA Translation: AAB18361.1
Z35312 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS741.1

Protein sequence database of the Protein Information Resource

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PIRi
S55912

NCBI Reference Sequences

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RefSeqi
NP_000960.2, NM_000969.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370321; ENSP00000359345; ENSG00000122406

Database of genes from NCBI RefSeq genomes

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GeneIDi
6125

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6125

UCSC genome browser

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UCSCi
uc001doz.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14966 mRNA Translation: AAA85654.1
AF113210 mRNA Translation: AAG39281.1
AK222604 mRNA Translation: BAD96324.1
AL162740 Genomic DNA No translation available.
BC109370 mRNA Translation: AAI09371.1
U76609 mRNA Translation: AAB18361.1
Z35312 Genomic DNA No translation available.
CCDSiCCDS741.1
PIRiS55912
RefSeqiNP_000960.2, NM_000969.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LD1-297[»]
4V6Xelectron microscopy5.00CD1-297[»]
5AJ0electron microscopy3.50AD1-297[»]
5LKSelectron microscopy3.60LD1-297[»]
5T2Celectron microscopy3.60G1-297[»]
6EK0electron microscopy2.90LD1-297[»]
6IP5electron microscopy3.901G1-297[»]
6IP6electron microscopy4.501G1-297[»]
6IP8electron microscopy3.901G1-297[»]
6OLEelectron microscopy3.10F4-297[»]
6OLFelectron microscopy3.90F4-297[»]
6OLGelectron microscopy3.40AD4-297[»]
6OLIelectron microscopy3.50F4-297[»]
6OLZelectron microscopy3.90AD4-297[»]
6OM0electron microscopy3.10F4-297[»]
6OM7electron microscopy3.70F4-297[»]
6QZPelectron microscopy2.90LD2-294[»]
6Y0Gelectron microscopy3.20LD1-297[»]
6Y2Lelectron microscopy3.00LD1-297[»]
6Y57electron microscopy3.50LD1-297[»]
6Y6Xelectron microscopy2.80LD2-294[»]
SMRiP46777
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112045, 302 interactors
ComplexPortaliCPX-5183, 60S cytosolic large ribosomal subunit
CORUMiP46777
DIPiDIP-31152N
IntActiP46777, 84 interactors
MINTiP46777
STRINGi9606.ENSP00000359345

Protein family/group databases

MoonProtiP46777

PTM databases

iPTMnetiP46777
MetOSiteiP46777
PhosphoSitePlusiP46777
SwissPalmiP46777

Polymorphism and mutation databases

BioMutaiRPL5
DMDMi81175191

Proteomic databases

EPDiP46777
jPOSTiP46777
MassIVEiP46777
MaxQBiP46777
PaxDbiP46777
PeptideAtlasiP46777
PRIDEiP46777
ProteomicsDBi55759
TopDownProteomicsiP46777

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33652, 298 antibodies

Genome annotation databases

EnsembliENST00000370321; ENSP00000359345; ENSG00000122406
GeneIDi6125
KEGGihsa:6125
UCSCiuc001doz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6125
DisGeNETi6125
EuPathDBiHostDB:ENSG00000122406.12

GeneCards: human genes, protein and diseases

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GeneCardsi
RPL5
GeneReviewsiRPL5
HGNCiHGNC:10360, RPL5
HPAiENSG00000122406, Low tissue specificity
MalaCardsiRPL5
MIMi603634, gene
612561, phenotype
neXtProtiNX_P46777
OpenTargetsiENSG00000122406
Orphaneti124, Blackfan-Diamond anemia
PharmGKBiPA34755

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0875, Eukaryota
GeneTreeiENSGT00950000183210
HOGENOMiCLU_056222_1_0_1
InParanoidiP46777
KOiK02932
OMAiNHGLTNW
OrthoDBi999609at2759
PhylomeDBiP46777
TreeFamiTF300044

Enzyme and pathway databases

PathwayCommonsiP46777
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP46777

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6125, 750 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL5, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Ribosomal_protein_L5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6125
PharosiP46777, Tbio

Protein Ontology

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PROi
PR:P46777
RNActiP46777, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122406, Expressed in germinal epithelium of ovary and 240 other tissues
ExpressionAtlasiP46777, baseline and differential
GenevisibleiP46777, HS

Family and domain databases

HAMAPiMF_01337_A, Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485, Rbsml_L5_euk/L18_arc
IPR025607, Rbsml_L5e/L18P_C
PANTHERiPTHR23410, PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204, Ribosomal_L18_c, 1 hit
PF17144, Ribosomal_L5e, 1 hit
PRINTSiPR00058, RIBOSOMALL5

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46777
Secondary accession number(s): Q32LZ3, Q53HH6, Q9H3F4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 200 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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