Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L27a

Gene

RPL27A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27a
Alternative name(s):
Large ribosomal subunit protein uL151 Publication
Gene namesi
Name:RPL27A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166441.12
HGNCiHGNC:10329 RPL27A
MIMi603637 gene
neXtProtiNX_P46776

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6157
OpenTargetsiENSG00000166441
PharmGKBiPA34708

Polymorphism and mutation databases

BioMutaiRPL27A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001048791 – 14860S ribosomal protein L27aAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39(3S)-3-hydroxyhistidine1 Publication1
Modified residuei47N6-acetyllysineCombined sources1
Modified residuei55N6-acetyllysineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei110N6-acetyllysineCombined sources1

Post-translational modificationi

Hydroxylated on His-39 by MINA.1 Publication

Keywords - PTMi

Acetylation, Hydroxylation, Phosphoprotein

Proteomic databases

EPDiP46776
MaxQBiP46776
PaxDbiP46776
PeptideAtlasiP46776
PRIDEiP46776
ProteomicsDBi55758
TopDownProteomicsiP46776

2D gel databases

SWISS-2DPAGEiP46776

PTM databases

iPTMnetiP46776
PhosphoSitePlusiP46776
SwissPalmiP46776

Expressioni

Gene expression databases

BgeeiENSG00000166441 Expressed in 131 organ(s), highest expression level in ectocervix
CleanExiHS_RPL27A
ExpressionAtlasiP46776 baseline and differential
GenevisibleiP46776 HS

Organism-specific databases

HPAiHPA060776
HPA063379

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2F2P139842EBI-350581,EBI-1030560

Protein-protein interaction databases

BioGridi112076, 148 interactors
CORUMiP46776
DIPiDIP-33121N
IntActiP46776, 33 interactors
MINTiP46776
STRINGi9606.ENSP00000346015

Structurei

3D structure databases

ProteinModelPortaliP46776
SMRiP46776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1742 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000005534
HOGENOMiHOG000231263
HOVERGENiHBG054587
InParanoidiP46776
KOiK02900
OMAiWGRVGQH
OrthoDBiEOG091G0TQF
PhylomeDBiP46776
TreeFamiTF313742

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR001196 Ribosomal_L15_CS
IPR021131 Ribosomal_L18e/L15P
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS00475 RIBOSOMAL_L15, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P46776-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP
60 70 80 90 100
GYFGKVGMKH YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI
110 120 130 140
IDVVRSGYYK VLGKGKLPKQ PVIVKAKFFS RRAEEKIKSV GGACVLVA
Length:148
Mass (Da):16,561
Last modified:January 23, 2007 - v2
Checksum:iCB5E09C91507798F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLX7E9PLX7_HUMAN
60S ribosomal protein L27a
RPL27A
113Annotation score:
E9PLL6E9PLL6_HUMAN
60S ribosomal protein L27a
RPL27A
108Annotation score:
H0YF34H0YF34_HUMAN
60S ribosomal protein L27a
RPL27A
42Annotation score:
E9PJD9E9PJD9_HUMAN
60S ribosomal protein L27a
RPL27A
91Annotation score:
E9PKT2E9PKT2_HUMAN
60S ribosomal protein L27a
RPL27A
41Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14968 mRNA Translation: AAA85656.1
AB020236 Genomic DNA Translation: BAA77361.1
AK311767 mRNA Translation: BAG34710.1
CH471064 Genomic DNA Translation: EAW68619.1
BC005326 mRNA Translation: AAH05326.1
BC020169 mRNA Translation: AAH20169.1
AB007178 Genomic DNA Translation: BAA25837.1
CCDSiCCDS7790.1
PIRiS55914
RefSeqiNP_000981.1, NM_000990.4
UniGeneiHs.523463

Genome annotation databases

EnsembliENST00000314138; ENSP00000346015; ENSG00000166441
GeneIDi6157
KEGGihsa:6157
UCSCiuc001mgs.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14968 mRNA Translation: AAA85656.1
AB020236 Genomic DNA Translation: BAA77361.1
AK311767 mRNA Translation: BAG34710.1
CH471064 Genomic DNA Translation: EAW68619.1
BC005326 mRNA Translation: AAH05326.1
BC020169 mRNA Translation: AAH20169.1
AB007178 Genomic DNA Translation: BAA25837.1
CCDSiCCDS7790.1
PIRiS55914
RefSeqiNP_000981.1, NM_000990.4
UniGeneiHs.523463

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BXFX-ray2.05C/D32-50[»]
4UG0electron microscopy-La1-148[»]
4V6Xelectron microscopy5.00Ca1-148[»]
5AJ0electron microscopy3.50Aa1-148[»]
5LKSelectron microscopy3.60La1-148[»]
5T2Celectron microscopy3.60U1-148[»]
6EK0electron microscopy2.90La1-148[»]
ProteinModelPortaliP46776
SMRiP46776
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112076, 148 interactors
CORUMiP46776
DIPiDIP-33121N
IntActiP46776, 33 interactors
MINTiP46776
STRINGi9606.ENSP00000346015

PTM databases

iPTMnetiP46776
PhosphoSitePlusiP46776
SwissPalmiP46776

Polymorphism and mutation databases

BioMutaiRPL27A

2D gel databases

SWISS-2DPAGEiP46776

Proteomic databases

EPDiP46776
MaxQBiP46776
PaxDbiP46776
PeptideAtlasiP46776
PRIDEiP46776
ProteomicsDBi55758
TopDownProteomicsiP46776

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314138; ENSP00000346015; ENSG00000166441
GeneIDi6157
KEGGihsa:6157
UCSCiuc001mgs.5 human

Organism-specific databases

CTDi6157
DisGeNETi6157
EuPathDBiHostDB:ENSG00000166441.12
GeneCardsiRPL27A
HGNCiHGNC:10329 RPL27A
HPAiHPA060776
HPA063379
MIMi603637 gene
neXtProtiNX_P46776
OpenTargetsiENSG00000166441
PharmGKBiPA34708
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1742 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000005534
HOGENOMiHOG000231263
HOVERGENiHBG054587
InParanoidiP46776
KOiK02900
OMAiWGRVGQH
OrthoDBiEOG091G0TQF
PhylomeDBiP46776
TreeFamiTF313742

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPL27A human
GeneWikiiRPL27A
GenomeRNAii6157
PROiPR:P46776
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166441 Expressed in 131 organ(s), highest expression level in ectocervix
CleanExiHS_RPL27A
ExpressionAtlasiP46776 baseline and differential
GenevisibleiP46776 HS

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR001196 Ribosomal_L15_CS
IPR021131 Ribosomal_L18e/L15P
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS00475 RIBOSOMAL_L15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL27A_HUMAN
AccessioniPrimary (citable) accession number: P46776
Secondary accession number(s): B2R4B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again