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Protein

40S ribosomal protein SA

Gene

rps-0

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-CEL-72702 Ribosomal scanning and start codon recognition
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
Gene namesi
Name:rps-0UniRule annotation
ORF Names:B0393.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0393.1 ; CE00854 ; WBGene00004469 ; rps-0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001343522 – 27640S ribosomal protein SAAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineUniRule annotation1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP46769
PaxDbiP46769
PeptideAtlasiP46769
PRIDEiP46769

2D gel databases

World-2DPAGEi0020:P46769

PTM databases

iPTMnetiP46769

Expressioni

Developmental stagei

Expressed at a stable level throughout development.1 Publication

Gene expression databases

BgeeiWBGene00004469 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps-21.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
rps-21P491974EBI-313262,EBI-313268

Protein-protein interaction databases

BioGridi40862, 9 interactors
DIPiDIP-26217N
IntActiP46769, 4 interactors
STRINGi6239.B0393.1.2

Structurei

3D structure databases

ProteinModelPortaliP46769
SMRiP46769
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0830 Eukaryota
COG0052 LUCA
GeneTreeiENSGT00390000015036
HOGENOMiHOG000232073
InParanoidiP46769
KOiK02998
OMAiQQKTKDM
OrthoDBiEOG091G0J0Q
PhylomeDBiP46769

Family and domain databases

CDDicd01425 RPS2, 1 hit
HAMAPiMF_03015 Ribosomal_S2_euk, 1 hit
InterProiView protein in InterPro
IPR001865 Ribosomal_S2
IPR018130 Ribosomal_S2_CS
IPR027498 Ribosomal_S2_euk
IPR005707 Ribosomal_S2_euk/arc
IPR023591 Ribosomal_S2_flav_dom_sf
PANTHERiPTHR11489 PTHR11489, 1 hit
PfamiView protein in Pfam
PF00318 Ribosomal_S2, 1 hit
PRINTSiPR00395 RIBOSOMALS2
SUPFAMiSSF52313 SSF52313, 1 hit
TIGRFAMsiTIGR01012 uS2_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00962 RIBOSOMAL_S2_1, 1 hit
PS00963 RIBOSOMAL_S2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGAAHSAL TEEDVMKLLA TQAHLGSTNL NFQMQQYVYK RRFDGPNIIN
60 70 80 90 100
VKKTWEKLLL AARAIAAVEN PADVVVVSAR PYAQRALLKF AAHTGATAIF
110 120 130 140 150
GRFSPGCLTN QIQKTFKEPR LLVISDPRID HQAVTEASYV GVPVISFVNT
160 170 180 190 200
ESPLKLIDIG VPCNNKGERS IGLMWWMLAR EILILRGKIS RQTGFVLEGK
210 220 230 240 250
EIMPDLYFYR DPTETEKEET GAHADVAEAQ EYQQPTDIDF TTQGGKVDDW
260 270
AAETATWTAE TKTTEEWANA PTQSNW
Length:276
Mass (Da):30,703
Last modified:January 23, 2007 - v3
Checksum:i51CB51C5C1B923DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37983 Genomic DNA Translation: CAA86061.1
PIRiT18742
RefSeqiNP_497978.1, NM_065577.5
UniGeneiCel.10142

Genome annotation databases

EnsemblMetazoaiB0393.1.1; B0393.1.1; WBGene00004469
B0393.1.2; B0393.1.2; WBGene00004469
GeneIDi175628
KEGGicel:CELE_B0393.1
UCSCiB0393.1.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37983 Genomic DNA Translation: CAA86061.1
PIRiT18742
RefSeqiNP_497978.1, NM_065577.5
UniGeneiCel.10142

3D structure databases

ProteinModelPortaliP46769
SMRiP46769
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40862, 9 interactors
DIPiDIP-26217N
IntActiP46769, 4 interactors
STRINGi6239.B0393.1.2

PTM databases

iPTMnetiP46769

2D gel databases

World-2DPAGEi0020:P46769

Proteomic databases

EPDiP46769
PaxDbiP46769
PeptideAtlasiP46769
PRIDEiP46769

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0393.1.1; B0393.1.1; WBGene00004469
B0393.1.2; B0393.1.2; WBGene00004469
GeneIDi175628
KEGGicel:CELE_B0393.1
UCSCiB0393.1.1 c. elegans

Organism-specific databases

CTDi175628
WormBaseiB0393.1 ; CE00854 ; WBGene00004469 ; rps-0

Phylogenomic databases

eggNOGiKOG0830 Eukaryota
COG0052 LUCA
GeneTreeiENSGT00390000015036
HOGENOMiHOG000232073
InParanoidiP46769
KOiK02998
OMAiQQKTKDM
OrthoDBiEOG091G0J0Q
PhylomeDBiP46769

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-CEL-72702 Ribosomal scanning and start codon recognition
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PROiPR:P46769

Gene expression databases

BgeeiWBGene00004469 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

CDDicd01425 RPS2, 1 hit
HAMAPiMF_03015 Ribosomal_S2_euk, 1 hit
InterProiView protein in InterPro
IPR001865 Ribosomal_S2
IPR018130 Ribosomal_S2_CS
IPR027498 Ribosomal_S2_euk
IPR005707 Ribosomal_S2_euk/arc
IPR023591 Ribosomal_S2_flav_dom_sf
PANTHERiPTHR11489 PTHR11489, 1 hit
PfamiView protein in Pfam
PF00318 Ribosomal_S2, 1 hit
PRINTSiPR00395 RIBOSOMALS2
SUPFAMiSSF52313 SSF52313, 1 hit
TIGRFAMsiTIGR01012 uS2_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00962 RIBOSOMAL_S2_1, 1 hit
PS00963 RIBOSOMAL_S2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSSA_CAEEL
AccessioniPrimary (citable) accession number: P46769
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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