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Protein

Unconventional myosin-Ib

Gene

Myo1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 115ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ib
Alternative name(s):
MIH-L
Myosin I alpha
Short name:
MMI-alpha
Short name:
MMIa
Gene namesi
Name:Myo1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107752 Myo1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234431 – 1107Unconventional myosin-IbAdd BLAST1107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP46735
PaxDbiP46735
PeptideAtlasiP46735
PRIDEiP46735

PTM databases

iPTMnetiP46735
PhosphoSitePlusiP46735
SwissPalmiP46735

Expressioni

Tissue specificityi

Prominent expression is seen in the brain, lung and liver. It is also expressed in the heart and testis. A high level expression is seen in virtually all neurons (but not glia) in the postnatal and adult mouse brain and in neuroblasts of the cerebellar external granular layer.

Gene expression databases

BgeeiENSMUSG00000018417 Expressed in 283 organ(s), highest expression level in brain blood vessel
CleanExiMM_MYO1B
ExpressionAtlasiP46735 baseline and differential
GenevisibleiP46735 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201663, 3 interactors
IntActiP46735, 8 interactors
MINTiP46735
STRINGi10090.ENSMUSP00000018561

Structurei

3D structure databases

ProteinModelPortaliP46735
SMRiP46735
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 701Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini704 – 727IQ 1PROSITE-ProRule annotationAdd BLAST24
Domaini728 – 749IQ 2PROSITE-ProRule annotationAdd BLAST22
Domaini750 – 778IQ 3PROSITE-ProRule annotationAdd BLAST29
Domaini780 – 807IQ 4PROSITE-ProRule annotationAdd BLAST28
Domaini808 – 837IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini923 – 1107TH1PROSITE-ProRule annotationAdd BLAST185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni592 – 599Actin-bindingSequence analysis8

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiP46735
KOiK10356
OMAiTIAAFWH

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P46735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKMEVKSSL LDNMIGVGDM VLLEPLNEET FIDNLKKRFD HNEIYTYIGS
60 70 80 90 100
VVISVNPYRS LPIYSPEKVE DYRNRNFYEL SPHIFALSDE AYRSLRDQDK
110 120 130 140 150
DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE
160 170 180 190 200
AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR
210 220 230 240 250
GERNFHVFYQ LLSGASEELL YKLKLERDFS RYNYLSLDSA KVNGVDDAAN
260 270 280 290 300
FRTVRNAMQI VGFLDHEAEA VLEVVAAVLK LGNIEFKPES RVNGLDESKI
310 320 330 340 350
KDKNELKEIC ELTSIDQVVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD
360 370 380 390 400
ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE
410 420 430 440 450
QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE
460 470 480 490 500
NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL
510 520 530 540 550
NDTTLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKAGHSLI
560 570 580 590 600
KSLFPEGNPA KVNLKRPPTA GSQFKASVAT LMRNLQTKNP NYIRCIKPND
610 620 630 640 650
KKAAHIFNES LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK
660 670 680 690 700
QTWPHWKGPA RSGVEVLFNE LEIPVEEHSF GRSKIFIRNP RTLFQLEDLR
710 720 730 740 750
KQRLEDLATL IQKIYRGWKC RTHFLLMKRS QVVIAAWYRR YAQQKRYQQI
760 770 780 790 800
KSSALVIQSY IRGWKARKIL RELKHQKRCK EAATTIAAYW HGTQARRELK
810 820 830 840 850
RLKEEARRKH AVAVIWAYWL GLKVRREYRK FFRANAGKKI YEFTLQRIVQ
860 870 880 890 900
KYLLEMKNKM PSLSPIDKNW PSRPYLFLDS THKELKRIFH LWRCKKYRDQ
910 920 930 940 950
FTDQQKLIYE EKLEASELFK DKKALYPSSV GQPFQGAYLE INKNPKYKKL
960 970 980 990 1000
KDAIEEKIII AEVVNKINRA NGKSTSRIFL LTNNNLLLAD QKSGQIKSEV
1010 1020 1030 1040 1050
PLVDVTKVSM SSQNDGFFAV HLKEGSEAAS KGDFLFSSDH LIEMATKLYR
1060 1070 1080 1090 1100
TTLSQTKQKL NIEISDEFLV QFRQDKVCVK FIQGNQKNGS VPTCKRKNNR

LLEVAVP
Length:1,107
Mass (Da):128,564
Last modified:July 27, 2011 - v3
Checksum:i42B339708CA9B7E6
GO
Isoform 2 (identifier: P46735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     791-819: Missing.

Show »
Length:1,078
Mass (Da):125,022
Checksum:iDDC6FAC4197C80ED
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TQD7Q7TQD7_MOUSE
Myo1b protein
Myo1b
1,136Annotation score:
D3YV80D3YV80_MOUSE
Unconventional myosin-Ib
Myo1b
299Annotation score:
E9QNH6E9QNH6_MOUSE
Unconventional myosin-Ib
Myo1b
1,078Annotation score:
E9Q580E9Q580_MOUSE
Unconventional myosin-Ib
Myo1b
1,084Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44I → R in CAA49604 (PubMed:8458427).Curated1
Sequence conflicti260I → Y in CAA49604 (PubMed:8458427).Curated1
Sequence conflicti304N → I in AAA39800 (PubMed:8449986).Curated1
Sequence conflicti307 – 317KEICELTSIDQ → NEKFASRPASVK in AAA39800 (PubMed:8449986).CuratedAdd BLAST11
Sequence conflicti333Q → R in AAA39800 (PubMed:8449986).Curated1
Sequence conflicti546G → D in AAA39800 (PubMed:8449986).Curated1
Sequence conflicti570 – 571AG → RS in CAA49604 (PubMed:8458427).Curated2
Sequence conflicti742A → E in CAA49604 (PubMed:8458427).Curated1
Sequence conflicti809 – 810KH → ND in CAA49604 (PubMed:8458427).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003347791 – 819Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00923 mRNA Translation: AAA39800.1
AK141207 mRNA Translation: BAE24587.1
CH466548 Genomic DNA Translation: EDK99961.1
BC046300 mRNA Translation: AAH46300.1
X69987 mRNA Translation: CAA49604.1
CCDSiCCDS14942.1 [P46735-1]
CCDS69887.1 [P46735-2]
PIRiA45438
RefSeqiNP_034993.2, NM_010863.4 [P46735-1]
UniGeneiMm.3390
Mm.465429

Genome annotation databases

EnsembliENSMUST00000046390; ENSMUSP00000040447; ENSMUSG00000018417 [P46735-1]
GeneIDi17912
KEGGimmu:17912
UCSCiuc007axr.3 mouse [P46735-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00923 mRNA Translation: AAA39800.1
AK141207 mRNA Translation: BAE24587.1
CH466548 Genomic DNA Translation: EDK99961.1
BC046300 mRNA Translation: AAH46300.1
X69987 mRNA Translation: CAA49604.1
CCDSiCCDS14942.1 [P46735-1]
CCDS69887.1 [P46735-2]
PIRiA45438
RefSeqiNP_034993.2, NM_010863.4 [P46735-1]
UniGeneiMm.3390
Mm.465429

3D structure databases

ProteinModelPortaliP46735
SMRiP46735
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201663, 3 interactors
IntActiP46735, 8 interactors
MINTiP46735
STRINGi10090.ENSMUSP00000018561

PTM databases

iPTMnetiP46735
PhosphoSitePlusiP46735
SwissPalmiP46735

Proteomic databases

MaxQBiP46735
PaxDbiP46735
PeptideAtlasiP46735
PRIDEiP46735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046390; ENSMUSP00000040447; ENSMUSG00000018417 [P46735-1]
GeneIDi17912
KEGGimmu:17912
UCSCiuc007axr.3 mouse [P46735-1]

Organism-specific databases

CTDi4430
MGIiMGI:107752 Myo1b

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiP46735
KOiK10356
OMAiTIAAFWH

Miscellaneous databases

ChiTaRSiMyo1b mouse
PROiPR:P46735
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018417 Expressed in 283 organ(s), highest expression level in brain blood vessel
CleanExiMM_MYO1B
ExpressionAtlasiP46735 baseline and differential
GenevisibleiP46735 MM

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1B_MOUSE
AccessioniPrimary (citable) accession number: P46735
Secondary accession number(s): P70244, Q80VD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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