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UniProtKB - P46734 (MP2K3_HUMAN)

Entry version 213 (29 Sep 2021)
Sequence version 2 (01 Nov 2002)
Previous versions | rss
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Protein

Dual specificity mitogen-activated protein kinase kinase 3

Gene

MAP2K3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by dual phosphorylation on Ser-218 and Thr-222.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei93ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei190Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi70 – 78ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.12.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P46734

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-450302, activated TAK1 mediates p38 MAPK activation
R-HSA-5210891, Uptake and function of anthrax toxins [P46734-3]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P46734

SIGNOR Signaling Network Open Resource

More...SIGNORi		P46734

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 3 (EC:2.7.12.21 Publication)
Short name:
MAP kinase kinase 3
Short name:
MAPKK 3
Alternative name(s):
MAPK/ERK kinase 3
Short name:
MEK 3
Stress-activated protein kinase kinase 2
Short name:
SAPK kinase 2
Short name:
SAPKK-2
Short name:
SAPKK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP2K3
Synonyms:MEK3, MKK3, PRKMK3, SKK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6843, MAP2K3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602315, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P46734

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000034152

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in MAP2K3 may be involved in colon cancer.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi218S → A: Inactivation. 1 Publication1
Mutagenesisi218S → E: Constitutive activation. 1 Publication1
Mutagenesisi222T → A: Inactivation. 1 Publication1
Mutagenesisi222T → E: Constitutive activation. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		5606

Open Targets

More...OpenTargetsi		ENSG00000034152

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30588

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P46734, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2109

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		P46734

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2064

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAP2K3

Domain mapping of disease mutations (DMDM)

More...DMDMi		24638466

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863781 – 347Dual specificity mitogen-activated protein kinase kinase 3Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei218Phosphoserine1 Publication1
Modified residuei222Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118).2 Publications
(Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-814
CPTAC-815

Encyclopedia of Proteome Dynamics

More...EPDi		P46734

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P46734

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P46734

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46734

PeptideAtlas

More...PeptideAtlasi		P46734

PRoteomics IDEntifications database

More...PRIDEi		P46734

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55750 [P46734-1]
55751 [P46734-2]
55752 [P46734-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P46734, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P46734

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P46734

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000034152, Expressed in buccal mucosa cell and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P46734, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P46734, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000034152, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910).

Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity).

Interacts with ARRB1 (PubMed:16709866).

By similarity3 Publications

(Microbial infection) Interacts with Yersinia YopJ.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111592, 199 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P46734

Database of interacting proteins

More...DIPi		DIP-34242N

Protein interaction database and analysis system

More...IntActi		P46734, 94 interactors

Molecular INTeraction database

More...MINTi		P46734

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345083

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P46734

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P46734, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P46734

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0984, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160875

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_63_23_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46734

Identification of Orthologs from Complete Genome Data

More...OMAi		MARFINE

Database of Orthologous Groups

More...OrthoDBi		81952at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46734

TreeFam database of animal gene trees

More...TreeFami		TF350701

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P46734-1) [UniParc]FASTAAdd to basket
Also known as: 3b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI 
        60         70         80         90        100
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN 
       110        120        130        140        150
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF 
       160        170        180        190        200
YRKVLDKNMT IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK 
       210        220        230        240        250
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD 
       260        270        280        290        300
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 
       310        320        330        340 
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
Length:347
Mass (Da):39,318
Last modified:November 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA80BA4FDFF8F75A2
GO
Isoform 1 (identifier: P46734-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:318
Mass (Da):36,173
Checksum:i966821BE4B76E8FA
GO
Isoform 2 (identifier: P46734-3) [UniParc]FASTAAdd to basket
Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MESPASSQPASMPQSK → MGVQGTLMSRDSQTPHLLSIL

Show »
Length:352
Mass (Da):39,940
Checksum:iF59612D9001EA9C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QR49J3QR49_HUMAN
Dual-specificity mitogen-activated ...
MAP2K3
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRZ0E9PRZ0_HUMAN
Dual-specificity mitogen-activated ...
MAP2K3
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMA8E9PMA8_HUMAN
Dual-specificity mitogen-activated ...
MAP2K3
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL77J3QL77_HUMAN
Dual-specificity mitogen-activated ...
MAP2K3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRV4J3KRV4_HUMAN
Dual-specificity mitogen-activated ...
MAP2K3
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RB39X6RB39_HUMAN
Dual-specificity mitogen-activated ...
MAP2K3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti341E → K (PubMed:7839144).Curated1
Sequence conflicti341E → K (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04081726R → T1 Publication1
Natural variantiVAR_04606240P → T. Corresponds to variant dbSNP:rs33911218EnsemblClinVar.1
Natural variantiVAR_06174255R → T. Corresponds to variant dbSNP:rs36047035EnsemblClinVar.1
Natural variantiVAR_04606368S → P1 PublicationCorresponds to variant dbSNP:rs34105301EnsemblClinVar.1
Natural variantiVAR_04606484A → T1 PublicationCorresponds to variant dbSNP:rs2305873EnsemblClinVar.1
Natural variantiVAR_04606590M → I1 PublicationCorresponds to variant dbSNP:rs36076766EnsemblClinVar.1
Natural variantiVAR_04606694R → L1 PublicationCorresponds to variant dbSNP:rs56067280Ensembl.1
Natural variantiVAR_04606796R → W1 PublicationCorresponds to variant dbSNP:rs56216806Ensembl.1
Natural variantiVAR_014208175R → W in colon cancer. 1 PublicationCorresponds to variant dbSNP:rs1339756947Ensembl.1
Natural variantiVAR_014209215L → V in colon cancer. 1 PublicationCorresponds to variant dbSNP:rs989026404Ensembl.1
Natural variantiVAR_046068293R → H1 PublicationCorresponds to variant dbSNP:rs35206134EnsemblClinVar.1
Natural variantiVAR_046069339V → M1 PublicationCorresponds to variant dbSNP:rs2363198EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0048781 – 29Missing in isoform 1. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0048771 – 16MESPA…MPQSK → MGVQGTLMSRDSQTPHLLSI L in isoform 2. CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L36719 mRNA Translation: AAC41718.1
D87116 mRNA Translation: BAA13248.1
U66839 mRNA Translation: AAB40652.1
U66840 Genomic DNA Translation: AAB40653.1
AK093838 mRNA Translation: BAG52769.1
BC032478 mRNA Translation: AAH32478.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11217.1 [P46734-1]
CCDS11218.1 [P46734-2]

NCBI Reference Sequences

More...RefSeqi		NP_001303261.1, NM_001316332.1 [P46734-2]
NP_002747.2, NM_002756.4 [P46734-2]
NP_659731.1, NM_145109.2 [P46734-1]
XP_005256780.1, XM_005256723.2 [P46734-2]
XP_011522261.1, XM_011523959.1 [P46734-2]
XP_016880347.1, XM_017024858.1 [P46734-2]
XP_016880348.1, XM_017024859.1 [P46734-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316920; ENSP00000319139; ENSG00000034152 [P46734-2]
ENST00000342679; ENSP00000345083; ENSG00000034152 [P46734-1]
ENST00000361818; ENSP00000355081; ENSG00000034152 [P46734-2]
ENST00000613338; ENSP00000478619; ENSG00000034152 [P46734-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5606

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5606

UCSC genome browser

More...UCSCi		uc021tsq.2, human [P46734-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36719 mRNA Translation: AAC41718.1
D87116 mRNA Translation: BAA13248.1
U66839 mRNA Translation: AAB40652.1
U66840 Genomic DNA Translation: AAB40653.1
AK093838 mRNA Translation: BAG52769.1
BC032478 mRNA Translation: AAH32478.1
CCDSiCCDS11217.1 [P46734-1]
CCDS11218.1 [P46734-2]
RefSeqiNP_001303261.1, NM_001316332.1 [P46734-2]
NP_002747.2, NM_002756.4 [P46734-2]
NP_659731.1, NM_145109.2 [P46734-1]
XP_005256780.1, XM_005256723.2 [P46734-2]
XP_011522261.1, XM_011523959.1 [P46734-2]
XP_016880347.1, XM_017024858.1 [P46734-2]
XP_016880348.1, XM_017024859.1 [P46734-2]

3D structure databases

SMRiP46734
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111592, 199 interactors
CORUMiP46734
DIPiDIP-34242N
IntActiP46734, 94 interactors
MINTiP46734
STRINGi9606.ENSP00000345083

Chemistry databases

BindingDBiP46734
ChEMBLiCHEMBL2109
DrugBankiDB12010, Fostamatinib
DrugCentraliP46734
GuidetoPHARMACOLOGYi2064

PTM databases

GlyGeniP46734, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP46734
PhosphoSitePlusiP46734

Genetic variation databases

BioMutaiMAP2K3
DMDMi24638466

Proteomic databases

CPTACiCPTAC-814
CPTAC-815
EPDiP46734
jPOSTiP46734
MassIVEiP46734
PaxDbiP46734
PeptideAtlasiP46734
PRIDEiP46734
ProteomicsDBi55750 [P46734-1]
55751 [P46734-2]
55752 [P46734-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4342, 1394 antibodies

The DNASU plasmid repository

More...DNASUi		5606

Genome annotation databases

EnsembliENST00000316920; ENSP00000319139; ENSG00000034152 [P46734-2]
ENST00000342679; ENSP00000345083; ENSG00000034152 [P46734-1]
ENST00000361818; ENSP00000355081; ENSG00000034152 [P46734-2]
ENST00000613338; ENSP00000478619; ENSG00000034152 [P46734-2]
GeneIDi5606
KEGGihsa:5606
UCSCiuc021tsq.2, human [P46734-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5606
DisGeNETi5606

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP2K3
HGNCiHGNC:6843, MAP2K3
HPAiENSG00000034152, Low tissue specificity
MIMi602315, gene
neXtProtiNX_P46734
OpenTargetsiENSG00000034152
PharmGKBiPA30588
VEuPathDBiHostDB:ENSG00000034152

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0984, Eukaryota
GeneTreeiENSGT00940000160875
HOGENOMiCLU_000288_63_23_1
InParanoidiP46734
OMAiMARFINE
OrthoDBi81952at2759
PhylomeDBiP46734
TreeFamiTF350701

Enzyme and pathway databases

BRENDAi2.7.12.2, 2681
PathwayCommonsiP46734
ReactomeiR-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-450302, activated TAK1 mediates p38 MAPK activation
R-HSA-5210891, Uptake and function of anthrax toxins [P46734-3]
SignaLinkiP46734
SIGNORiP46734

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5606, 52 hits in 1061 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAP2K3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAP2K3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5606
PharosiP46734, Tchem

Protein Ontology

More...PROi		PR:P46734
RNActiP46734, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000034152, Expressed in buccal mucosa cell and 254 other tissues
ExpressionAtlasiP46734, baseline and differential
GenevisibleiP46734, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMP2K3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46734
Secondary accession number(s): B3KSK7
, Q99441, Q9UE71, Q9UE72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 2002
Last modified: September 29, 2021
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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