MAP2K3

Functionⁱ

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Activity regulationⁱ

Activated by dual phosphorylation on Ser-218 and Thr-222.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	93	ATPPROSITE-ProRule annotation		1
Active siteⁱ	190	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	70 – 78	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279118
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
activation of protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cardiac muscle contraction Source: Ensembl
cellular response to vascular endothelial growth factor stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22696064
inflammatory response Source: Ensembl
p38MAPK cascade
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22696064
positive regulation of blood vessel endothelial cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22696064
positive regulation of protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11980910
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 11980910
regulation of cytokine biosynthetic process Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7839144
signal transduction by protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stress-activated protein kinase signaling cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-5210891 Uptake and function of anthrax toxins
SignaLinkⁱ	P46734
SIGNORⁱ	P46734

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity mitogen-activated protein kinase kinase 3 (EC:2.7.12.21 Publication) Short name: MAP kinase kinase 3 Short name: MAPKK 3 Alternative name(s): MAPK/ERK kinase 3 Short name: MEK 3 Stress-activated protein kinase kinase 2 Short name: SAPK kinase 2 Short name: SAPKK-2 Short name: SAPKK2
Gene namesⁱ	Name:MAP2K3 Synonyms:MEK3, MKK3, PRKMK3, SKK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000034152.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6843 MAP2K3
MIMⁱ	602315 gene
neXtProtⁱ	NX_P46734

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in MAP2K3 may be involved in colon cancer.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	218	S → A: Inactivation. 1 Publication	1
Mutagenesisⁱ	218	S → E: Constitutive activation. 1 Publication	1
Mutagenesisⁱ	222	T → A: Inactivation. 1 Publication	1
Mutagenesisⁱ	222	T → E: Constitutive activation. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5606
Open Targets More...OpenTargetsⁱ	ENSG00000034152
PharmGKBⁱ	PA30588

Chemistry databases

ChEMBLⁱ	CHEMBL2109
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2064

Polymorphism and mutation databases

BioMutaⁱ	MAP2K3
DMDMⁱ	24638466

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086378	1 – 347	Dual specificity mitogen-activated protein kinase kinase 3Add BLAST		347

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	3	PhosphoserineCombined sources	1
Modified residueⁱ	15	PhosphoserineCombined sources	1
Modified residueⁱ	218	Phosphoserine1 Publication	1
Modified residueⁱ	222	Phosphothreonine1 Publication	1

Post-translational modificationⁱ

Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118).2 Publications

Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P46734
PaxDbⁱ	P46734
PeptideAtlas More...PeptideAtlasⁱ	P46734
PRIDEⁱ	P46734
ProteomicsDBⁱ	55750 55751 [P46734-2] 55752 [P46734-3]

PTM databases

iPTMnetⁱ	P46734
PhosphoSitePlusⁱ	P46734

Miscellaneous databases

PMAP-CutDBⁱ	P46734

PMAP-CutDBⁱ

P46734

Expressionⁱ

Tissue specificityⁱ

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Gene expression databases

Bgeeⁱ	ENSG00000034152 Expressed in 241 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_MAP2K3
ExpressionAtlasⁱ	P46734 baseline and differential
Genevisibleⁱ	P46734 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB018548

HPAⁱ

CAB018548

Interactionⁱ

Subunit structureⁱ

Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866). Interacts with Yersinia yopJ (PubMed:16728640).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DYRK1B	Q9Y463	2	EBI-602462,EBI-634187
LRRK2	Q5S007	5	EBI-602462,EBI-5323863
MAP3K5	Q99683	4	EBI-602462,EBI-476263
MAPK14	Q16539	2	EBI-602462,EBI-73946
TINF2	Q9BSI4	2	EBI-602462,EBI-717399

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279118

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111592, 38 interactors
Database of interacting proteins More...DIPⁱ	DIP-34242N
IntActⁱ	P46734, 21 interactors
Molecular INTeraction database More...MINTⁱ	P46734
STRINGⁱ	9606.ENSP00000345083

Chemistry databases

BindingDBⁱ

P46734

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P46734
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	64 – 325	Protein kinasePROSITE-ProRule annotationAdd BLAST		262

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0984 Eukaryota ENOG410XT3F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	P46734
KEGG Orthology (KO) More...KOⁱ	K04432
OMAⁱ	ACVTIGD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A9H
PhylomeDBⁱ	P46734
TreeFamⁱ	TF350701

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 3 (identifier: P46734-1) [UniParc]FASTA Add to basket

Also known as: 3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI 
        60         70         80         90        100
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN 
       110        120        130        140        150
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF 
       160        170        180        190        200
YRKVLDKNMT IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK 
       210        220        230        240        250
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD 
       260        270        280        290        300
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 
       310        320        330        340 
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS

Length:347

Mass (Da):39,318

Last modified:November 1, 2002 - v2

Checksum:ⁱA80BA4FDFF8F75A2

GO

Isoform 1 (identifier: P46734-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.

« Hide

        10         20         30         40         50
MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE 
        60         70         80         90        100
KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA 
       110        120        130        140        150
LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH 
       160        170        180        190        200
LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP 
       210        220        230        240        250
YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK 
       260        270        280        290        300
QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK 
       310 
TKKTDIAAFV KEILGEDS

Show »

Length:318

Mass (Da):36,173

Checksum:ⁱ966821BE4B76E8FA

GO

Isoform 2 (identifier: P46734-3) [UniParc]FASTA Add to basket

Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
1-16: MESPASSQPASMPQSK → MGVQGTLMSRDSQTPHLLSIL

« Hide

        10         20         30         40         50
MGVQGTLMSR DSQTPHLLSI LGKSKRKKDL RISCMSKPPA PNPTPPRNLD 
        60         70         80         90        100
SRTFITIGDR NFEVEADDLV TISELGRGAY GVVEKVRHAQ SGTIMAVKRI 
       110        120        130        140        150
RATVNSQEQK RLLMDLDINM RTVDCFYTVT FYGALFREGD VWICMELMDT 
       160        170        180        190        200
SLDKFYRKVL DKNMTIPEDI LGEIAVSIVR ALEHLHSKLS VIHRDVKPSN 
       210        220        230        240        250
VLINKEGHVK MCDFGISGYL VDSVAKTMDA GCKPYMAPER INPELNQKGY 
       260        270        280        290        300
NVKSDVWSLG ITMIEMAILR FPYESWGTPF QQLKQVVEEP SPQLPADRFS 
       310        320        330        340        350
PEFVDFTAQC LRKNPAERMS YLELMEHPFF TLHKTKKTDI AAFVKEILGE 

DS

Show »

Length:352

Mass (Da):39,940

Checksum:ⁱF59612D9001EA9C5

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PRZ0	E9PRZ0_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 3	MAP2K3	160	Annotation score:
J3QR49	J3QR49_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 3	MAP2K3	173	Annotation score:
J3KRV4	J3KRV4_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 3	MAP2K3	136	Annotation score:
E9PMA8	E9PMA8_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 3	MAP2K3	101	Annotation score:
J3QL77	J3QL77_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 3	MAP2K3	46	Annotation score:
X6RB39	X6RB39_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 3	MAP2K3	46	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	341	E → K (PubMed:7839144).Curated		1
Sequence conflictⁱ	341	E → K (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040817	26	R → T1 Publication	1
Natural variantⁱVAR_046062	40	P → T. Corresponds to variant dbSNP:rs33911218Ensembl.	1
Natural variantⁱVAR_061742	55	R → T. Corresponds to variant dbSNP:rs36047035Ensembl.	1
Natural variantⁱVAR_046063	68	S → P1 PublicationCorresponds to variant dbSNP:rs34105301Ensembl.	1
Natural variantⁱVAR_046064	84	A → T1 PublicationCorresponds to variant dbSNP:rs2305873Ensembl.	1
Natural variantⁱVAR_046065	90	M → I1 PublicationCorresponds to variant dbSNP:rs36076766Ensembl.	1
Natural variantⁱVAR_046066	94	R → L1 PublicationCorresponds to variant dbSNP:rs56067280Ensembl.	1
Natural variantⁱVAR_046067	96	R → W1 PublicationCorresponds to variant dbSNP:rs56216806Ensembl.	1
Natural variantⁱVAR_014208	175	R → W in colon cancer. 1 Publication	1
Natural variantⁱVAR_014209	215	L → V in colon cancer. 1 Publication	1
Natural variantⁱVAR_046068	293	R → H1 PublicationCorresponds to variant dbSNP:rs35206134Ensembl.	1
Natural variantⁱVAR_046069	339	V → M1 PublicationCorresponds to variant dbSNP:rs2363198Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004878	1 – 29	Missing in isoform 1. 2 PublicationsAdd BLAST		29
Alternative sequenceⁱVSP_004877	1 – 16	MESPA…MPQSK → MGVQGTLMSRDSQTPHLLSI L in isoform 2. CuratedAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L36719 mRNA Translation: AAC41718.1 D87116 mRNA Translation: BAA13248.1 U66839 mRNA Translation: AAB40652.1 U66840 Genomic DNA Translation: AAB40653.1 AK093838 mRNA Translation: BAG52769.1 BC032478 mRNA Translation: AAH32478.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11217.1 [P46734-1] CCDS11218.1 [P46734-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001303261.1, NM_001316332.1 [P46734-2] NP_002747.2, NM_002756.4 [P46734-2] NP_659731.1, NM_145109.2 [P46734-1] XP_005256780.1, XM_005256723.2 [P46734-2] XP_011522261.1, XM_011523959.1 [P46734-2] XP_016880347.1, XM_017024858.1 [P46734-2] XP_016880348.1, XM_017024859.1 [P46734-2]
UniGeneⁱ	Hs.514012

Genome annotation databases

Ensemblⁱ	ENST00000316920; ENSP00000319139; ENSG00000034152 [P46734-2] ENST00000342679; ENSP00000345083; ENSG00000034152 [P46734-1] ENST00000361818; ENSP00000355081; ENSG00000034152 [P46734-2] ENST00000613338; ENSP00000478619; ENSG00000034152 [P46734-2]
GeneIDⁱ	5606
KEGGⁱ	hsa:5606
UCSC genome browser More...UCSCⁱ	uc021tsq.2 human [P46734-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P46734	MAP2K3 protein		HUMAN		347	UniRef100_P46734
Mitogen-activated protein kinase kinase 3		PANTR		347
Dual specificity mitogen-activated protein kinase kinase 3 isoform B		MACMU		347
MAP2K3 isoform 1		PONAB		347
Uncharacterized protein		COLAP		347
+6
P46734-2	Uncharacterized protein		MACMU		359	UniRef100_F7GLY8
MAP2K3 isoform 3		PONAB		318
Uncharacterized protein		CERAT		318
Uncharacterized protein		MACFA		318
Uncharacterized protein		MACNE		318
+2

Protein	Similar proteins		Species	Score	Length	Source
P46734	Dual specificity mitogen-activated protein kinase kinase 3	)	MOUSE		347	UniRef90_P46734
MAP2K3 protein		HUMAN		347
Mitogen-activated protein kinase kinase 3		PANTR		347
Dual specificity mitogen-activated protein kinase kinase 3 isoform B		MACMU		347
MAP2K3 isoform 1		PONAB		347
+126

Protein	Similar proteins		Species	Score	Length	Source
P46734	Dual specificity mitogen-activated protein kinase kinase 3	)	MOUSE		347	UniRef50_P46734
MAP2K3 protein		HUMAN		347
Mitogen-activated protein kinase kinase 3		PANTR		347
Dual specificity mitogen-activated protein kinase kinase 3 isoform B		MACMU		347
MAP2K3 isoform 1		PONAB		347
+159

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L36719 mRNA Translation: AAC41718.1 D87116 mRNA Translation: BAA13248.1 U66839 mRNA Translation: AAB40652.1 U66840 Genomic DNA Translation: AAB40653.1 AK093838 mRNA Translation: BAG52769.1 BC032478 mRNA Translation: AAH32478.1
CCDSⁱ	CCDS11217.1 [P46734-1] CCDS11218.1 [P46734-2]
RefSeqⁱ	NP_001303261.1, NM_001316332.1 [P46734-2] NP_002747.2, NM_002756.4 [P46734-2] NP_659731.1, NM_145109.2 [P46734-1] XP_005256780.1, XM_005256723.2 [P46734-2] XP_011522261.1, XM_011523959.1 [P46734-2] XP_016880347.1, XM_017024858.1 [P46734-2] XP_016880348.1, XM_017024859.1 [P46734-2]
UniGeneⁱ	Hs.514012

3D structure databases

ProteinModelPortalⁱ	P46734
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111592, 38 interactors
DIPⁱ	DIP-34242N
IntActⁱ	P46734, 21 interactors
MINTⁱ	P46734
STRINGⁱ	9606.ENSP00000345083

Chemistry databases

BindingDBⁱ	P46734
ChEMBLⁱ	CHEMBL2109
GuidetoPHARMACOLOGYⁱ	2064

PTM databases

iPTMnetⁱ	P46734
PhosphoSitePlusⁱ	P46734

Polymorphism and mutation databases

BioMutaⁱ	MAP2K3
DMDMⁱ	24638466

Proteomic databases

EPDⁱ	P46734
PaxDbⁱ	P46734
PeptideAtlasⁱ	P46734
PRIDEⁱ	P46734
ProteomicsDBⁱ	55750 55751 [P46734-2] 55752 [P46734-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5606
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316920; ENSP00000319139; ENSG00000034152 [P46734-2] ENST00000342679; ENSP00000345083; ENSG00000034152 [P46734-1] ENST00000361818; ENSP00000355081; ENSG00000034152 [P46734-2] ENST00000613338; ENSP00000478619; ENSG00000034152 [P46734-2]
GeneIDⁱ	5606
KEGGⁱ	hsa:5606
UCSCⁱ	uc021tsq.2 human [P46734-1]

Organism-specific databases

CTDⁱ	5606
DisGeNETⁱ	5606
EuPathDBⁱ	HostDB:ENSG00000034152.18
GeneCardsⁱ	MAP2K3
HGNCⁱ	HGNC:6843 MAP2K3
HPAⁱ	CAB018548
MIMⁱ	602315 gene
neXtProtⁱ	NX_P46734
OpenTargetsⁱ	ENSG00000034152
PharmGKBⁱ	PA30588
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0984 Eukaryota ENOG410XT3F LUCA
GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	P46734
KOⁱ	K04432
OMAⁱ	ACVTIGD
OrthoDBⁱ	EOG091G0A9H
PhylomeDBⁱ	P46734
TreeFamⁱ	TF350701

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-5210891 Uptake and function of anthrax toxins
SignaLinkⁱ	P46734
SIGNORⁱ	P46734

Miscellaneous databases

ChiTaRSⁱ	MAP2K3 human
GeneWikiⁱ	MAP2K3
GenomeRNAiⁱ	5606
PMAP-CutDBⁱ	P46734
Protein Ontology More...PROⁱ	PR:P46734
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000034152 Expressed in 241 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_MAP2K3
ExpressionAtlasⁱ	P46734 baseline and differential
Genevisibleⁱ	P46734 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MP2K3_HUMAN
Accessionⁱ	P46734Primary (citable) accession number: P46734 Secondary accession number(s): B3KSK7 , Q99441, Q9UE71, Q9UE72
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 2002
	Last modified:	November 7, 2018
	This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P46734 (MP2K3_HUMAN)

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Dual specificity mitogen-activated protein kinase kinase 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ