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Protein

Solute carrier organic anion transporter family member 1A2

Gene

SLCO1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.14 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A2
Alternative name(s):
OATP-A
Organic anion-transporting polypeptide 1
Short name:
OATP-1
Sodium-independent organic anion transporter
Solute carrier family 21 member 3
Gene namesi
Name:SLCO1A2
Synonyms:OATP, OATP1, OATP1A2, SLC21A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000084453.16
HGNCiHGNC:10956 SLCO1A2
MIMi602883 gene
neXtProtiNX_P46721

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 111Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini112 – 155ExtracellularSequence analysisAdd BLAST44
Transmembranei156 – 184Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini185 – 203CytoplasmicSequence analysisAdd BLAST19
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 242ExtracellularSequence analysisAdd BLAST18
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 311CytoplasmicSequence analysisAdd BLAST44
Transmembranei312 – 333Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini334 – 353ExtracellularSequence analysisAdd BLAST20
Transmembranei354 – 377Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini378 – 381CytoplasmicSequence analysis4
Transmembranei382 – 405Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini406 – 513ExtracellularSequence analysisAdd BLAST108
Transmembranei514 – 536Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini537 – 545CytoplasmicSequence analysis9
Transmembranei546 – 571Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini572 – 605ExtracellularSequence analysisAdd BLAST34
Transmembranei606 – 623Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini624 – 670CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6579
OpenTargetsiENSG00000084453
PharmGKBiPA328

Chemistry databases

ChEMBLiCHEMBL1743123
DrugBankiDB04630 Aldosterone
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB00887 Bumetanide
DB00291 Chlorambucil
DB02659 Cholic Acid
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB05804 dehydroepiandrosterone sulfate
DB03619 Deoxycholic Acid
DB01234 Dexamethasone
DB01396 Digitoxin
DB00390 Digoxin
DB00917 Dinoprostone
DB00584 Enalapril
DB00199 Erythromycin
DB00783 Estradiol
DB04573 Estriol
DB00655 Estrone
DB00950 Fexofenadine
DB01016 Glyburide
DB02123 Glycochenodeoxycholic Acid
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB00224 Indinavir
DB00328 Indomethacin
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB02691 N-Cholylglycine
DB01183 Naloxone
DB00788 Naproxen
DB00220 Nelfinavir
DB01092 Ouabain
DB00175 Pravastatin
DB00860 Prednisolone
DB00635 Prednisone
DB01032 Probenecid
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB00503 Ritonavir
DB00728 Rocuronium
DB01098 Rosuvastatin
DB01232 Saquinavir
DB00641 Simvastatin
DB00421 Spironolactone
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB08834 Tauroursodeoxycholic acid
DB08836 Temocapril
DB00624 Testosterone
DB01124 Tolbutamide
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
GuidetoPHARMACOLOGYi1219

Polymorphism and mutation databases

BioMutaiSLCO1A2
DMDMi1171882

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910421 – 670Solute carrier organic anion transporter family member 1A2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP46721
PaxDbiP46721
PeptideAtlasiP46721
PRIDEiP46721
ProteomicsDBi55748
55749 [P46721-2]

PTM databases

iPTMnetiP46721
PhosphoSitePlusiP46721

Expressioni

Gene expression databases

BgeeiENSG00000084453 Expressed in 133 organ(s), highest expression level in corpus callosum
CleanExiHS_SLCO1A2
ExpressionAtlasiP46721 baseline and differential
GenevisibleiP46721 HS

Organism-specific databases

HPAiHPA071152

Interactioni

Protein-protein interaction databases

IntActiP46721, 1 interactor
STRINGi9606.ENSP00000305974

Chemistry databases

BindingDBiP46721

Structurei

3D structure databases

ProteinModelPortaliP46721
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 488Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiP46721
KOiK03460
OMAiFCTRIFA
OrthoDBiEOG091G08QD
PhylomeDBiP46721
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.iShow all

Isoform OATP1a (identifier: P46721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ
60 70 80 90 100
FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC
110 120 130 140 150
FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT
160 170 180 190 200
KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE
210 220 230 240 250
TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL
260 270 280 290 300
ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS
360 370 380 390 400
SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL
410 420 430 440 450
LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW
460 470 480 490 500
DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC
510 520 530 540 550
DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL
560 570 580 590 600
HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
610 620 630 640 650
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE
660 670
CKDIYQKSTV LKDDELKTKL
Length:670
Mass (Da):74,145
Last modified:November 1, 1995 - v1
Checksum:iC3A740CEF1E6F129
GO
Isoform OATP1b (identifier: P46721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MGETEKRIETHRIRCLSKL → MFLTKNCKQEQERVESA
     559-581: AGIPAPIYFGALMDSTCLHWGTL → GKNSYFFPHPIRTILLLLFFITL
     582-670: Missing.

Show »
Length:579
Mass (Da):64,369
Checksum:i6D80DBB0029DC66E
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DJE6B4DJE6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
538Annotation score:
C9JHU9C9JHU9_HUMAN
Solute carrier organic anion transp...
SLCO1A2
147Annotation score:
C9JGK7C9JGK7_HUMAN
Solute carrier organic anion transp...
SLCO1A2
99Annotation score:
C9K059C9K059_HUMAN
Solute carrier organic anion transp...
SLCO1A2
88Annotation score:
C9JTF6C9JTF6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
136Annotation score:
C9JUW6C9JUW6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
91Annotation score:
F5H060F5H060_HUMAN
Solute carrier organic anion transp...
SLCO1A2
95Annotation score:
C9JG34C9JG34_HUMAN
Solute carrier organic anion transp...
SLCO1A2
51Annotation score:
C9JSB7C9JSB7_HUMAN
Solute carrier organic anion transp...
SLCO1A2
71Annotation score:
F5GXY6F5GXY6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
93Annotation score:
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02464413I → T1 PublicationCorresponds to variant dbSNP:rs10841795Ensembl.1
Natural variantiVAR_020289128N → Y1 PublicationCorresponds to variant dbSNP:rs11568567Ensembl.1
Natural variantiVAR_020290135N → I1 PublicationCorresponds to variant dbSNP:rs45502302Ensembl.1
Natural variantiVAR_020291172E → D1 PublicationCorresponds to variant dbSNP:rs11568563Ensembl.1
Natural variantiVAR_036823187A → T1 PublicationCorresponds to variant dbSNP:rs750165758Ensembl.1
Natural variantiVAR_036409220V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020292355I → V. Corresponds to variant dbSNP:rs45628437Ensembl.1
Natural variantiVAR_020293668T → S1 PublicationCorresponds to variant dbSNP:rs11568557Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0061301 – 19MGETE…CLSKL → MFLTKNCKQEQERVESA in isoform OATP1b. CuratedAdd BLAST19
Alternative sequenceiVSP_006131559 – 581AGIPA…HWGTL → GKNSYFFPHPIRTILLLLFF ITL in isoform OATP1b. CuratedAdd BLAST23
Alternative sequenceiVSP_006132582 – 670Missing in isoform OATP1b. CuratedAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21943 mRNA Translation: AAA87732.1
AF085224 mRNA Translation: AAD52694.1
AJ400735
, AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA Translation: CAB97006.1
AF279784 mRNA Translation: AAG30037.1
Y08062 Genomic DNA Translation: CAB64372.1
CCDSiCCDS8686.1 [P46721-1]
RefSeqiNP_066580.1, NM_021094.3 [P46721-1]
NP_602307.1, NM_134431.3 [P46721-1]
XP_005253531.1, XM_005253474.3 [P46721-1]
XP_011519120.1, XM_011520818.1 [P46721-1]
XP_011519121.1, XM_011520819.1 [P46721-1]
UniGeneiHs.46440

Genome annotation databases

EnsembliENST00000307378; ENSP00000305974; ENSG00000084453 [P46721-1]
GeneIDi6579
KEGGihsa:6579
UCSCiuc001res.3 human [P46721-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSO1A2_HUMAN
AccessioniPrimary (citable) accession number: P46721
Secondary accession number(s): Q9UGP7, Q9UL38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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