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Protein

Solute carrier organic anion transporter family member 1A2

Gene

SLCO1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: GO_Central
  • organic anion transmembrane transporter activity Source: ProtInc
  • sodium-independent organic anion transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159418 Recycling of bile acids and salts
R-HSA-879518 Transport of organic anions

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.14 the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A2
Alternative name(s):
OATP-A
Organic anion-transporting polypeptide 1
Short name:
OATP-1
Sodium-independent organic anion transporter
Solute carrier family 21 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO1A2
Synonyms:OATP, OATP1, OATP1A2, SLC21A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000084453.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10956 SLCO1A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602883 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46721

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 40Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 111Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini112 – 155ExtracellularSequence analysisAdd BLAST44
Transmembranei156 – 184Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini185 – 203CytoplasmicSequence analysisAdd BLAST19
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 242ExtracellularSequence analysisAdd BLAST18
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 311CytoplasmicSequence analysisAdd BLAST44
Transmembranei312 – 333Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini334 – 353ExtracellularSequence analysisAdd BLAST20
Transmembranei354 – 377Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini378 – 381CytoplasmicSequence analysis4
Transmembranei382 – 405Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini406 – 513ExtracellularSequence analysisAdd BLAST108
Transmembranei514 – 536Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini537 – 545CytoplasmicSequence analysis9
Transmembranei546 – 571Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini572 – 605ExtracellularSequence analysisAdd BLAST34
Transmembranei606 – 623Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini624 – 670CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6579

Open Targets

More...
OpenTargetsi
ENSG00000084453

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA328

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743123

Drug and drug target database

More...
DrugBanki
DB04630 Aldosterone
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB00887 Bumetanide
DB00291 Chlorambucil
DB02659 Cholic Acid
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB05804 dehydroepiandrosterone sulfate
DB03619 Deoxycholic Acid
DB01234 Dexamethasone
DB01396 Digitoxin
DB00390 Digoxin
DB00917 Dinoprostone
DB00584 Enalapril
DB00199 Erythromycin
DB00783 Estradiol
DB04573 Estriol
DB00655 Estrone
DB00950 Fexofenadine
DB01016 Glyburide
DB02123 Glycochenodeoxycholic Acid
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB00224 Indinavir
DB00328 Indomethacin
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB02691 N-Cholylglycine
DB01183 Naloxone
DB00788 Naproxen
DB00220 Nelfinavir
DB01092 Ouabain
DB00175 Pravastatin
DB00860 Prednisolone
DB00635 Prednisone
DB01032 Probenecid
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB00503 Ritonavir
DB00728 Rocuronium
DB01098 Rosuvastatin
DB01232 Saquinavir
DB00641 Simvastatin
DB00421 Spironolactone
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB08834 Tauroursodeoxycholic acid
DB08836 Temocapril
DB00624 Testosterone
DB01124 Tolbutamide
DB01586 Ursodeoxycholic acid
DB00661 Verapamil

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1219

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO1A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1171882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910421 – 670Solute carrier organic anion transporter family member 1A2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46721

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46721

PeptideAtlas

More...
PeptideAtlasi
P46721

PRoteomics IDEntifications database

More...
PRIDEi
P46721

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55748
55749 [P46721-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46721

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46721

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084453 Expressed in 133 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLCO1A2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46721 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46721 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071152

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P46721, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305974

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P46721

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P46721

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini433 – 488Kazal-likePROSITE-ProRule annotationAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626 Eukaryota
ENOG410XRSF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231269

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063896

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46721

KEGG Orthology (KO)

More...
KOi
K03460

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHFLMNR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08QD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46721

TreeFam database of animal gene trees

More...
TreeFami
TF317540

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388 PTHR11388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805 oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform OATP1a (identifier: P46721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ
60 70 80 90 100
FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC
110 120 130 140 150
FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT
160 170 180 190 200
KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE
210 220 230 240 250
TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL
260 270 280 290 300
ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS
360 370 380 390 400
SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL
410 420 430 440 450
LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW
460 470 480 490 500
DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC
510 520 530 540 550
DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL
560 570 580 590 600
HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
610 620 630 640 650
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE
660 670
CKDIYQKSTV LKDDELKTKL
Length:670
Mass (Da):74,145
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3A740CEF1E6F129
GO
Isoform OATP1b (identifier: P46721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MGETEKRIETHRIRCLSKL → MFLTKNCKQEQERVESA
     559-581: AGIPAPIYFGALMDSTCLHWGTL → GKNSYFFPHPIRTILLLLFFITL
     582-670: Missing.

Show »
Length:579
Mass (Da):64,369
Checksum:i6D80DBB0029DC66E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DJE6B4DJE6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
538Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHU9C9JHU9_HUMAN
Solute carrier organic anion transp...
SLCO1A2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGK7C9JGK7_HUMAN
Solute carrier organic anion transp...
SLCO1A2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTF6C9JTF6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K059C9K059_HUMAN
Solute carrier organic anion transp...
SLCO1A2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUW6C9JUW6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG34C9JG34_HUMAN
Solute carrier organic anion transp...
SLCO1A2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H060F5H060_HUMAN
Solute carrier organic anion transp...
SLCO1A2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSB7C9JSB7_HUMAN
Solute carrier organic anion transp...
SLCO1A2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXY6F5GXY6_HUMAN
Solute carrier organic anion transp...
SLCO1A2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02464413I → T1 PublicationCorresponds to variant dbSNP:rs10841795Ensembl.1
Natural variantiVAR_020289128N → Y1 PublicationCorresponds to variant dbSNP:rs11568567Ensembl.1
Natural variantiVAR_020290135N → I1 PublicationCorresponds to variant dbSNP:rs45502302Ensembl.1
Natural variantiVAR_020291172E → D1 PublicationCorresponds to variant dbSNP:rs11568563Ensembl.1
Natural variantiVAR_036823187A → T1 PublicationCorresponds to variant dbSNP:rs750165758Ensembl.1
Natural variantiVAR_036409220V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020292355I → V. Corresponds to variant dbSNP:rs45628437Ensembl.1
Natural variantiVAR_020293668T → S1 PublicationCorresponds to variant dbSNP:rs11568557Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0061301 – 19MGETE…CLSKL → MFLTKNCKQEQERVESA in isoform OATP1b. CuratedAdd BLAST19
Alternative sequenceiVSP_006131559 – 581AGIPA…HWGTL → GKNSYFFPHPIRTILLLLFF ITL in isoform OATP1b. CuratedAdd BLAST23
Alternative sequenceiVSP_006132582 – 670Missing in isoform OATP1b. CuratedAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U21943 mRNA Translation: AAA87732.1
AF085224 mRNA Translation: AAD52694.1
AJ400735
, AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA Translation: CAB97006.1
AF279784 mRNA Translation: AAG30037.1
Y08062 Genomic DNA Translation: CAB64372.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8686.1 [P46721-1]

NCBI Reference Sequences

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RefSeqi
NP_066580.1, NM_021094.3 [P46721-1]
NP_602307.1, NM_134431.3 [P46721-1]
XP_005253531.1, XM_005253474.3 [P46721-1]
XP_011519120.1, XM_011520818.1 [P46721-1]
XP_011519121.1, XM_011520819.1 [P46721-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.46440

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307378; ENSP00000305974; ENSG00000084453 [P46721-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6579

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6579

UCSC genome browser

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UCSCi
uc001res.3 human [P46721-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21943 mRNA Translation: AAA87732.1
AF085224 mRNA Translation: AAD52694.1
AJ400735
, AJ400736, AJ400737, AJ400738, AJ400739, AJ400740, AJ400741, AJ400742, AJ400743, AJ400744, AJ400745, AJ400746, AJ400747, AJ400748 Genomic DNA Translation: CAB97006.1
AF279784 mRNA Translation: AAG30037.1
Y08062 Genomic DNA Translation: CAB64372.1
CCDSiCCDS8686.1 [P46721-1]
RefSeqiNP_066580.1, NM_021094.3 [P46721-1]
NP_602307.1, NM_134431.3 [P46721-1]
XP_005253531.1, XM_005253474.3 [P46721-1]
XP_011519120.1, XM_011520818.1 [P46721-1]
XP_011519121.1, XM_011520819.1 [P46721-1]
UniGeneiHs.46440

3D structure databases

ProteinModelPortaliP46721
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46721, 1 interactor
STRINGi9606.ENSP00000305974

Chemistry databases

BindingDBiP46721
ChEMBLiCHEMBL1743123
DrugBankiDB04630 Aldosterone
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB00887 Bumetanide
DB00291 Chlorambucil
DB02659 Cholic Acid
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB05804 dehydroepiandrosterone sulfate
DB03619 Deoxycholic Acid
DB01234 Dexamethasone
DB01396 Digitoxin
DB00390 Digoxin
DB00917 Dinoprostone
DB00584 Enalapril
DB00199 Erythromycin
DB00783 Estradiol
DB04573 Estriol
DB00655 Estrone
DB00950 Fexofenadine
DB01016 Glyburide
DB02123 Glycochenodeoxycholic Acid
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB00224 Indinavir
DB00328 Indomethacin
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB02691 N-Cholylglycine
DB01183 Naloxone
DB00788 Naproxen
DB00220 Nelfinavir
DB01092 Ouabain
DB00175 Pravastatin
DB00860 Prednisolone
DB00635 Prednisone
DB01032 Probenecid
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB00503 Ritonavir
DB00728 Rocuronium
DB01098 Rosuvastatin
DB01232 Saquinavir
DB00641 Simvastatin
DB00421 Spironolactone
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB08834 Tauroursodeoxycholic acid
DB08836 Temocapril
DB00624 Testosterone
DB01124 Tolbutamide
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
GuidetoPHARMACOLOGYi1219

Protein family/group databases

TCDBi2.A.60.1.14 the organo anion transporter (oat) family

PTM databases

iPTMnetiP46721
PhosphoSitePlusiP46721

Polymorphism and mutation databases

BioMutaiSLCO1A2
DMDMi1171882

Proteomic databases

EPDiP46721
PaxDbiP46721
PeptideAtlasiP46721
PRIDEiP46721
ProteomicsDBi55748
55749 [P46721-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307378; ENSP00000305974; ENSG00000084453 [P46721-1]
GeneIDi6579
KEGGihsa:6579
UCSCiuc001res.3 human [P46721-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6579
DisGeNETi6579
EuPathDBiHostDB:ENSG00000084453.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLCO1A2
HGNCiHGNC:10956 SLCO1A2
HPAiHPA071152
MIMi602883 gene
neXtProtiNX_P46721
OpenTargetsiENSG00000084453
PharmGKBiPA328

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00940000153279
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiP46721
KOiK03460
OMAiPHFLMNR
OrthoDBiEOG091G08QD
PhylomeDBiP46721
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLCO1A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLCO1A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6579

Protein Ontology

More...
PROi
PR:P46721

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084453 Expressed in 133 organ(s), highest expression level in corpus callosum
CleanExiHS_SLCO1A2
ExpressionAtlasiP46721 baseline and differential
GenevisibleiP46721 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO1A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46721
Secondary accession number(s): Q9UGP7, Q9UL38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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