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Protein

Radiation-inducible immediate-early gene IEX-1

Gene

Ier3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Radiation-inducible immediate-early gene IEX-1
Alternative name(s):
Immediate early protein GLY96
Immediate early response 3 protein
Gene namesi
Name:Ier3
Synonyms:Gly96, Iex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104814 Ier3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 85CytoplasmicSequence analysisAdd BLAST85
Transmembranei86 – 102Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini103 – 153ExtracellularSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841601 – 153Radiation-inducible immediate-early gene IEX-1Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP46694
PeptideAtlasiP46694
PRIDEiP46694

PTM databases

iPTMnetiP46694
PhosphoSitePlusiP46694

Expressioni

Tissue specificityi

Expressed predominantly in the lung, testes and the uterus.

Inductioni

By serum growth factors and TPA.

Gene expression databases

CleanExiMM_IER3

Interactioni

Subunit structurei

Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003635

Family & Domainsi

Sequence similaritiesi

Belongs to the IER3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ8Q Eukaryota
ENOG410Z2E4 LUCA
HOVERGENiHBG000172
InParanoidiP46694
PhylomeDBiP46694

Family and domain databases

InterProiView protein in InterPro
IPR024829 IEX-1
PANTHERiPTHR16915 PTHR16915, 1 hit
PRINTSiPR02100 GENEIEX1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P46694-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHSRNHLHT MTGLRAPSPA PSTGPELRRG SGPEIFTFDP LPERAVVSTA
60 70 80 90 100
RLNTSRGHRK RSRRVLYPRV VRRQLPTEEP NIAKRVLFLL FAIIFCQILM
110 120 130 140 150
AEEGVSQPLA PEDATSAVTP EPISAPITAP PVLEPLNLTS ESSDYALDLK

AFL
Length:153
Mass (Da):16,875
Last modified:November 1, 1995 - v1
Checksum:iF4429E3B0120DE11
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91VZ5Q91VZ5_MOUSE
Gly96 protein
Ier3 mCG_19912
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67644 mRNA No translation available.
PIRiS33363
UniGeneiMm.25613

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67644 mRNA No translation available.
PIRiS33363
UniGeneiMm.25613

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003635

PTM databases

iPTMnetiP46694
PhosphoSitePlusiP46694

Proteomic databases

PaxDbiP46694
PeptideAtlasiP46694
PRIDEiP46694

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104814 Ier3

Phylogenomic databases

eggNOGiENOG410IZ8Q Eukaryota
ENOG410Z2E4 LUCA
HOVERGENiHBG000172
InParanoidiP46694
PhylomeDBiP46694

Miscellaneous databases

ChiTaRSiIer3 mouse
PROiPR:P46694
SOURCEiSearch...

Gene expression databases

CleanExiMM_IER3

Family and domain databases

InterProiView protein in InterPro
IPR024829 IEX-1
PANTHERiPTHR16915 PTHR16915, 1 hit
PRINTSiPR02100 GENEIEX1
ProtoNetiSearch...

Entry informationi

Entry nameiIEX1_MOUSE
AccessioniPrimary (citable) accession number: P46694
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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