UniProtKB - P46691 (CXB2_SHEEP)
Protein
Gap junction beta-2 protein
Gene
GJB2
Organism
Ovis aries (Sheep)
Status
Functioni
Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 42 | Calcium; shared with neighboring subunitBy similarity | 1 | |
Metal bindingi | 45 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 47 | CalciumBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- gap junction channel activity Source: UniProtKB
- gap junction channel activity involved in cell communication by electrical coupling Source: Ensembl
- identical protein binding Source: Ensembl
GO - Biological processi
- cell-cell signaling Source: UniProtKB
- gap junction assembly Source: Ensembl
- gap junction-mediated intercellular transport Source: UniProtKB
- sensory perception of sound Source: UniProtKB-KW
Keywordsi
Biological process | Hearing |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction beta-2 proteinAlternative name(s): Connexin-26 Short name: Cx26 |
Gene namesi | Name:GJB2 |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- gap junction By similarity
Note: Colocalizes with GJB4 at gap junction plaques in the cochlea.By similarity
Plasma Membrane
- connexin complex Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Intramembranei | 2 – 13 | By similarityAdd BLAST | 12 | |
Topological domaini | 14 – 20 | CytoplasmicCurated | 7 | |
Transmembranei | 21 – 40 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 41 – 73 | ExtracellularCuratedAdd BLAST | 33 | |
Transmembranei | 74 – 94 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 95 – 135 | CytoplasmicCuratedAdd BLAST | 41 | |
Transmembranei | 136 – 156 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 157 – 189 | ExtracellularCuratedAdd BLAST | 33 | |
Transmembranei | 190 – 210 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 211 – 226 | CytoplasmicCuratedAdd BLAST | 16 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057861 | 1 – 226 | Gap junction beta-2 proteinAdd BLAST | 226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 180 | By similarity | ||
Disulfide bondi | 60 ↔ 174 | By similarity | ||
Disulfide bondi | 64 ↔ 169 | By similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB4.
Interacts with CNST (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000018338 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWM8, Eukaryota |
GeneTreei | ENSGT00990000203622 |
HOGENOMi | CLU_037388_4_1_1 |
OMAi | YAFYFMY |
OrthoDBi | 1043502at2759 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002268, Connexin26 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01139, CONNEXINB2 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P46691-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDWSALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYYRH
110 120 130 140 150
EKKRKFIRGE IKTEFKDIEE IKNQKVRIEG SLWWTYTGSI FFRVIFEAAF
160 170 180 190 200
MYVFYVMYDG FAMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG
210 220
ICILLNVTEL CYLLIRFCSG KSKKPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17592 mRNA Translation: AAA67446.1 |
RefSeqi | NP_001009780.1, NM_001009780.1 |
Genome annotation databases
Ensembli | ENSOART00000018600; ENSOARP00000018338; ENSOARG00000017089 ENSOART00020007702; ENSOARP00020006377; ENSOARG00020005049 |
GeneIDi | 443345 |
KEGGi | oas:443345 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17592 mRNA Translation: AAA67446.1 |
RefSeqi | NP_001009780.1, NM_001009780.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000018338 |
Genome annotation databases
Ensembli | ENSOART00000018600; ENSOARP00000018338; ENSOARG00000017089 ENSOART00020007702; ENSOARP00020006377; ENSOARG00020005049 |
GeneIDi | 443345 |
KEGGi | oas:443345 |
Organism-specific databases
CTDi | 2706 |
Phylogenomic databases
eggNOGi | ENOG502QWM8, Eukaryota |
GeneTreei | ENSGT00990000203622 |
HOGENOMi | CLU_037388_4_1_1 |
OMAi | YAFYFMY |
OrthoDBi | 1043502at2759 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002268, Connexin26 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01139, CONNEXINB2 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXB2_SHEEP | |
Accessioni | P46691Primary (citable) accession number: P46691 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families