UniProtKB - P46686 (TULP2_MOUSE)
Protein
Tubby-related protein 2
Gene
Tulp2
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Was originally thought to be a phosphodiesterase on the basis of spurious sequence similarities.1 Publication
GO - Molecular functioni
- phosphoric diester hydrolase activity Source: MGI
- protein-containing complex binding Source: MGI
GO - Biological processi
- protein localization to cilium Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Tubby-related protein 2Alternative name(s): Protein P4-6 Tubby-like protein 2 |
Gene namesi | Name:Tulp2 Synonyms:Pdet |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1861600, Tulp2 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cytoplasm, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186469 | 1 – 562 | Tubby-related protein 2Add BLAST | 562 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 153 | PhosphoserineCombined sources | 1 | |
Modified residuei | 155 | PhosphoserineCombined sources | 1 | |
Modified residuei | 211 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 213 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P46686 |
PRIDEi | P46686 |
PTM databases
iPTMneti | P46686 |
PhosphoSitePlusi | P46686 |
Expressioni
Tissue specificityi
Expressed in retina and testis.
Gene expression databases
Bgeei | ENSMUSG00000023467, Expressed in testis and 34 other tissues |
Genevisiblei | P46686, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103391 |
Miscellaneous databases
RNActi | P46686, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TUB family.Curated
Phylogenomic databases
eggNOGi | KOG2502, Eukaryota |
GeneTreei | ENSGT00940000161908 |
HOGENOMi | CLU_028236_0_0_1 |
InParanoidi | P46686 |
OMAi | WLWRSCL |
TreeFami | TF314076 |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659, Tubby-like_C IPR000007, Tubby_C IPR018066, Tubby_C_CS IPR005398, Tubby_N |
Pfami | View protein in Pfam PF01167, Tub, 1 hit PF16322, Tub_N, 1 hit |
PRINTSi | PR01573, SUPERTUBBY PR01574, TUBBYPROTEIN |
SUPFAMi | SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200, TUB_1, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P46686-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDREGPRGPR SGASQENEQW KKETLEDEFS GVRLQKLEQQ RQLFEKKQRR
60 70 80 90 100
KRQEPLMVQA NPDATLRHRR PRRGEERFQS DSSWGLGVGS PFLQENVPQA
110 120 130 140 150
HLPSGAHSAL VTMSYVADGS GERAPLLSPR GAVYTRGNGP AVRHHLCWLP
160 170 180 190 200
DSSDSDVEEV TMEDIPVISR PPQTNLANLR RGWLASPGPG ISQEEKEEEV
210 220 230 240 250
GSTDARVEDK TPSPDPDPDP TVNSDGDHGD LAPCKVEENT AQKNTETASG
260 270 280 290 300
IGDEDREKGE VTESTETNYA PVASKVLQGD DGDASNHNAW NMTCPQPRIP
310 320 330 340 350
GPRLGEDMEA YVLLPAPRDH MVQCRIVRNK HGMDKGMFPS YYLYLEAEDG
360 370 380 390 400
VAHFLLAGRK RKRSKTSNYL ISLDPKDMSR NGSNFVGKVR SNVLGTKFTI
410 420 430 440 450
FDNGVNPERS YWVPDSARIR EELGVVCYET NVLGFRGPRK MTVILPGMDS
460 470 480 490 500
RKQRMKVQPQ NDQDSILSRV QKGAGHGLLL LQNKAPSWSD ESGAYVLNFH
510 520 530 540 550
GRVTRASVKN FQIVHPDEPD HLVLQFGRVA PNIFTMDFRY PLCPLQAFAI
560
CLSSFDGKLA FF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z0R4 | D3Z0R4_MOUSE | Tubby-like protein | Tulp2 | 457 | Annotation score: | ||
A0A1B0GRN6 | A0A1B0GRN6_MOUSE | Tubby-related protein 2 | Tulp2 | 457 | Annotation score: | ||
A0A1B0GSC0 | A0A1B0GSC0_MOUSE | Tubby-related protein 2 | Tulp2 | 192 | Annotation score: | ||
A0A1B0GR36 | A0A1B0GR36_MOUSE | Tubby-related protein 2 | Tulp2 | 77 | Annotation score: |
Sequence cautioni
The sequence AAD38452 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC36686 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA49481 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | M → R in AAD38452 (Ref. 1) Curated | 1 | |
Sequence conflicti | 314 | L → V in CAA49481 (PubMed:7509194).Curated | 1 | |
Sequence conflicti | 324 | C → W in AAD38452 (Ref. 1) Curated | 1 | |
Sequence conflicti | 324 | C → W in CAA49481 (PubMed:7509194).Curated | 1 | |
Sequence conflicti | 347 | A → G in AAD38452 (Ref. 1) Curated | 1 | |
Sequence conflicti | 347 | A → G in CAA49481 (PubMed:7509194).Curated | 1 | |
Sequence conflicti | 504 | T → S in CAA49481 (PubMed:7509194).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022197 | 1 – 112 | Missing in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 112 | |
Alternative sequenceiVSP_022198 | 121 – 132 | Missing in isoform 4. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_022199 | 561 – 562 | FF → CE in isoform 2, isoform 3 and isoform 4. 4 Publications | 2 | |
Alternative sequenceiVSP_022200 | 561 – 562 | Missing in isoform 5. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF105712 mRNA Translation: AAD38452.1 Different initiation. AK077200 mRNA Translation: BAC36678.1 AK077211 mRNA Translation: BAC36686.1 Different initiation. AK161165 mRNA Translation: BAE36223.1 BC089545 mRNA Translation: AAH89545.1 X69827 mRNA Translation: CAA49481.1 Different initiation. |
CCDSi | CCDS39953.1 [P46686-1] CCDS39954.1 [P46686-2] CCDS71960.1 [P46686-3] CCDS80720.1 [P46686-4] |
RefSeqi | NP_001039020.1, NM_001045555.2 [P46686-1] NP_001277927.1, NM_001290998.2 [P46686-4] NP_001277928.1, NM_001290999.2 [P46686-3] NP_032833.2, NM_008807.3 [P46686-2] XP_006541088.1, XM_006541025.3 [P46686-5] |
Genome annotation databases
Ensembli | ENSMUST00000024233; ENSMUSP00000024233; ENSMUSG00000023467 [P46686-2] ENSMUST00000085331; ENSMUSP00000082438; ENSMUSG00000023467 [P46686-4] ENSMUST00000107759; ENSMUSP00000103388; ENSMUSG00000023467 [P46686-3] ENSMUST00000107762; ENSMUSP00000103391; ENSMUSG00000023467 [P46686-1] ENSMUST00000210868; ENSMUSP00000147710; ENSMUSG00000023467 [P46686-5] |
GeneIDi | 56734 |
KEGGi | mmu:56734 |
UCSCi | uc009gvk.2, mouse [P46686-3] uc009gvp.2, mouse [P46686-2] uc009gvq.2, mouse [P46686-1] uc009gvr.2, mouse [P46686-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF105712 mRNA Translation: AAD38452.1 Different initiation. AK077200 mRNA Translation: BAC36678.1 AK077211 mRNA Translation: BAC36686.1 Different initiation. AK161165 mRNA Translation: BAE36223.1 BC089545 mRNA Translation: AAH89545.1 X69827 mRNA Translation: CAA49481.1 Different initiation. |
CCDSi | CCDS39953.1 [P46686-1] CCDS39954.1 [P46686-2] CCDS71960.1 [P46686-3] CCDS80720.1 [P46686-4] |
RefSeqi | NP_001039020.1, NM_001045555.2 [P46686-1] NP_001277927.1, NM_001290998.2 [P46686-4] NP_001277928.1, NM_001290999.2 [P46686-3] NP_032833.2, NM_008807.3 [P46686-2] XP_006541088.1, XM_006541025.3 [P46686-5] |
3D structure databases
SMRi | P46686 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103391 |
PTM databases
iPTMneti | P46686 |
PhosphoSitePlusi | P46686 |
Proteomic databases
PaxDbi | P46686 |
PRIDEi | P46686 |
Protocols and materials databases
Antibodypediai | 31829, 179 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000024233; ENSMUSP00000024233; ENSMUSG00000023467 [P46686-2] ENSMUST00000085331; ENSMUSP00000082438; ENSMUSG00000023467 [P46686-4] ENSMUST00000107759; ENSMUSP00000103388; ENSMUSG00000023467 [P46686-3] ENSMUST00000107762; ENSMUSP00000103391; ENSMUSG00000023467 [P46686-1] ENSMUST00000210868; ENSMUSP00000147710; ENSMUSG00000023467 [P46686-5] |
GeneIDi | 56734 |
KEGGi | mmu:56734 |
UCSCi | uc009gvk.2, mouse [P46686-3] uc009gvp.2, mouse [P46686-2] uc009gvq.2, mouse [P46686-1] uc009gvr.2, mouse [P46686-4] |
Organism-specific databases
CTDi | 7288 |
MGIi | MGI:1861600, Tulp2 |
Phylogenomic databases
eggNOGi | KOG2502, Eukaryota |
GeneTreei | ENSGT00940000161908 |
HOGENOMi | CLU_028236_0_0_1 |
InParanoidi | P46686 |
OMAi | WLWRSCL |
TreeFami | TF314076 |
Miscellaneous databases
BioGRID-ORCSi | 56734, 1 hit in 12 CRISPR screens |
ChiTaRSi | Tulp2, mouse |
PROi | PR:P46686 |
RNActi | P46686, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023467, Expressed in testis and 34 other tissues |
Genevisiblei | P46686, MM |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659, Tubby-like_C IPR000007, Tubby_C IPR018066, Tubby_C_CS IPR005398, Tubby_N |
Pfami | View protein in Pfam PF01167, Tub, 1 hit PF16322, Tub_N, 1 hit |
PRINTSi | PR01573, SUPERTUBBY PR01574, TUBBYPROTEIN |
SUPFAMi | SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200, TUB_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TULP2_MOUSE | |
Accessioni | P46686Primary (citable) accession number: P46686 Secondary accession number(s): Q3TTV1 Q9R1I8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 9, 2007 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families