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Protein

Zinc finger protein ZIC 1

Gene

Zic1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 260C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST36
Zinc fingeri269 – 296C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri302 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri332 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 384C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 1
Alternative name(s):
Zinc finger protein of the cerebellum 1
Gene namesi
Name:Zic1
Synonyms:Zic
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106683 Zic1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show a cell mass decrease of the spinal dorsal horn, hypoplasia and abnormal foliation patterns in the cerebellum.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472451 – 447Zinc finger protein ZIC 1Add BLAST447

Proteomic databases

MaxQBiP46684
PaxDbiP46684
PeptideAtlasiP46684
PRIDEiP46684

PTM databases

iPTMnetiP46684
PhosphoSitePlusiP46684

Expressioni

Tissue specificityi

Expressed in osteoblasts (at protein level). Expressed in the CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Expressed in lumbar spine and iliac crest.3 Publications

Developmental stagei

Expressed in progenitor cells in the dorsal third of the ventricular zone at 12.5 dpc. Expressed in newly emerging pontine gray nucleus (PGN) precursor cells of the extramural migratory stream (ems) between 12.5 and 14.5 dpc. Expressed in precerebellar mossy fiber (MF) neurons of the PGN (located either rostromedially or caudolaterally) persisted through at least P8 after birth (at protein level). In the early embryonic stage, it is expressed in the dorsal half of the neural tube and adjacent mesenchyme, and in the developing cerebellum it is expressed persistently in the granule cell lineage throughout the prenatal and postnatal periods.2 Publications

Gene expression databases

BgeeiENSMUSG00000032368 Expressed in 195 organ(s), highest expression level in habenula
CleanExiMM_ZIC1
GenevisibleiP46684 MM

Interactioni

Subunit structurei

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi204694, 1 interactor
IntActiP46684, 3 interactors
MINTiP46684
STRINGi10090.ENSMUSP00000034927

Structurei

3D structure databases

ProteinModelPortaliP46684
SMRiP46684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 76Poly-Ala4
Compositional biasi79 – 82Poly-His4
Compositional biasi110 – 116Poly-Ala7
Compositional biasi386 – 440Ser-richAdd BLAST55

Domaini

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 260C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST36
Zinc fingeri269 – 296C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri302 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri332 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 384C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
HOGENOMiHOG000232057
HOVERGENiHBG007135
InParanoidiP46684
KOiK09224
OMAiMGAFKIN
OrthoDBiEOG091G0M59
TreeFamiTF351425

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

P46684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN
60 70 80 90 100
PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF
110 120 130 140 150
LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFSGLHEQA
160 170 180 190 200
AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM
210 220 230 240 250
NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH
260 270 280 290 300
ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK
310 320 330 340 350
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK
360 370 380 390 400
KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG
410 420 430 440
YESSTPPTIV SPTTDNPTTS SMSPSSSAVH HTAGHSALSS NFNEWYV
Length:447
Mass (Da):48,331
Last modified:July 27, 2011 - v2
Checksum:iD41F412F44C2AD3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72A → R in BAA06878 (PubMed:7931345).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32167 mRNA Translation: BAA06878.1
AK136977 mRNA Translation: BAE23194.1
CH466560 Genomic DNA Translation: EDL20910.1
BC050889 mRNA Translation: AAH50889.2
BC060247 mRNA Translation: AAH60247.1
BC063247 mRNA Translation: AAH63247.1
CCDSiCCDS23403.1
PIRiI56511
RefSeqiNP_033599.2, NM_009573.3
XP_006511124.1, XM_006511061.1
UniGeneiMm.335350
Mm.477226

Genome annotation databases

EnsembliENSMUST00000034927; ENSMUSP00000034927; ENSMUSG00000032368
ENSMUST00000065360; ENSMUSP00000068858; ENSMUSG00000032368
GeneIDi22771
KEGGimmu:22771
UCSCiuc009raf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZIC1_MOUSE
AccessioniPrimary (citable) accession number: P46684
Secondary accession number(s): Q6PAK5, Q80Y18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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