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Protein

D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2

Gene

DLD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate (PubMed:26774271). In addition to its enzymatic role it could play an important role in the yeast cell morphology (PubMed:10509019).2 Publications

Miscellaneous

Present with 11400 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADCurated

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.11 sec(-1) for (R)-2-hydroxyglutarate oxidation with pyruvate as electron acceptor. kcat is 0.18 sec(-1) for (R)-2-hydroxyglutarate oxidation with DCIP as electron acceptor. kcat is 1.31 sec(-1) for (R)-lactate reduction with DCIP as electron donor.1 Publication
  1. KM=74 µM for (R)-2-hydroxyglutarate1 Publication
  2. KM=5.2 mM for (R)-lactate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • (R)-2-hydroxyglutarate dehydrogenase activity Source: SGD
    • actin binding Source: SGD
    • D-lactate dehydrogenase (cytochrome) activity Source: SGD
    • FAD binding Source: SGD

    GO - Biological processi

    • lactate catabolic process Source: SGD
    • lactate oxidation Source: GO_Central
    • respiratory electron transport chain Source: GO_Central

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    YEAST:YDL178W-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-SCE-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2Curated (EC:1.1.99.401 Publication)
    Short name:
    D-2HG--pyruvate transhydrogenase DLD21 Publication
    Alternative name(s):
    Actin-interacting protein 2
    D-lactate dehydrogenase [cytochrome] 2, mitochondrial (EC:1.1.2.4)
    D-lactate ferricytochrome C oxidoreductase
    Short name:
    D-LCR
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DLD2
    Synonyms:AIP2
    Ordered Locus Names:YDL178W
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

    Organism-specific databases

    Saccharomyces Genome Database

    More...
    SGDi
    S000002337 DLD2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000020429? – 530D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P46681

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P46681

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P46681

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with F-actin.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    31888, 40 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-956N

    Protein interaction database and analysis system

    More...
    IntActi
    P46681, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    4932.YDL178W

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P46681

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 277FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST180

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00550000075086

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000230997

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P46681

    KEGG Orthology (KO)

    More...
    KOi
    K21618

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VYEWTAR

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG092C1XYI

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.45.10, 1 hit
    3.30.43.10, 1 hit
    3.30.465.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016166 FAD-bd_PCMH
    IPR036318 FAD-bd_PCMH-like_sf
    IPR016167 FAD-bd_PCMH_sub1
    IPR016169 FAD-bd_PCMH_sub2
    IPR016164 FAD-linked_Oxase-like_C
    IPR004113 FAD-linked_oxidase_C
    IPR006094 Oxid_FAD_bind_N
    IPR016171 Vanillyl_alc_oxidase_C-sub2

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02913 FAD-oxidase_C, 1 hit
    PF01565 FAD_binding_4, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55103 SSF55103, 1 hit
    SSF56176 SSF56176, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51387 FAD_PCMH, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P46681-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLRNILVRST GSNFKFAGRY MKSSALLGYY RRVNYYSTKI QTRLTSENYP
    60 70 80 90 100
    DVHRDPRFKK LTSDDLNYFK SILSEQEILR ASESEDLSFY NEDWMRKYKG
    110 120 130 140 150
    QSKLVLRPKS VEKVSLILNY CNDEKIAVVP QGGNTGLVGG SVPIFDELIL
    160 170 180 190 200
    SLANLNKIRD FDPVSGILKC DAGVILENAN NYVMEQNYMF PLDLGAKGSC
    210 220 230 240 250
    HVGGVVATNA GGLRLLRYGS LHGSVLGLEV VMPNGQIVNS MHSMRKDNTG
    260 270 280 290 300
    YDLKQLFIGS EGTIGIITGV SILTVPKPKA FNVSYLSVES FEDVQKVFVR
    310 320 330 340 350
    ARQELSEILS AFEFMDAKSQ VLAKSQLKDA AFPLEDEHPF YILIETSGSN
    360 370 380 390 400
    KDHDDSKLET FLENVMEEGI VTDGVVAQDE TELQNLWKWR EMIPEASQAN
    410 420 430 440 450
    GGVYKYDVSL PLKDLYSLVE ATNARLSEAE LVGDSPKPVV GAIGYGHVGD
    460 470 480 490 500
    GNLHLNVAVR EYNKNIEKTL EPFVYEFVSS KHGSVSAEHG LGFQKKNYIG
    510 520 530
    YSKSPEEVKM MKDLKVHYDP NGILNPYKYI
    Length:530
    Mass (Da):59,268
    Last modified:November 1, 1995 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42FDFBE5CA7E11B7
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239N → S in AAU09682 (PubMed:17322287).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U35667 Genomic DNA Translation: AAA79142.1
    Z67750 Genomic DNA Translation: CAA91567.1
    Z74226 Genomic DNA Translation: CAA98752.1
    AY723765 Genomic DNA Translation: AAU09682.1
    BK006938 Genomic DNA Translation: DAA11684.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S61034

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_010103.1, NM_001180238.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    YDL178W_mRNA; YDL178W_mRNA; YDL178W

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    851376

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    sce:YDL178W

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U35667 Genomic DNA Translation: AAA79142.1
    Z67750 Genomic DNA Translation: CAA91567.1
    Z74226 Genomic DNA Translation: CAA98752.1
    AY723765 Genomic DNA Translation: AAU09682.1
    BK006938 Genomic DNA Translation: DAA11684.1
    PIRiS61034
    RefSeqiNP_010103.1, NM_001180238.1

    3D structure databases

    ProteinModelPortaliP46681
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi31888, 40 interactors
    DIPiDIP-956N
    IntActiP46681, 1 interactor
    STRINGi4932.YDL178W

    Proteomic databases

    MaxQBiP46681
    PaxDbiP46681
    PRIDEiP46681

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblFungiiYDL178W_mRNA; YDL178W_mRNA; YDL178W
    GeneIDi851376
    KEGGisce:YDL178W

    Organism-specific databases

    SGDiS000002337 DLD2

    Phylogenomic databases

    GeneTreeiENSGT00550000075086
    HOGENOMiHOG000230997
    InParanoidiP46681
    KOiK21618
    OMAiVYEWTAR
    OrthoDBiEOG092C1XYI

    Enzyme and pathway databases

    BioCyciYEAST:YDL178W-MONOMER
    ReactomeiR-SCE-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P46681

    Family and domain databases

    Gene3Di1.10.45.10, 1 hit
    3.30.43.10, 1 hit
    3.30.465.10, 1 hit
    InterProiView protein in InterPro
    IPR016166 FAD-bd_PCMH
    IPR036318 FAD-bd_PCMH-like_sf
    IPR016167 FAD-bd_PCMH_sub1
    IPR016169 FAD-bd_PCMH_sub2
    IPR016164 FAD-linked_Oxase-like_C
    IPR004113 FAD-linked_oxidase_C
    IPR006094 Oxid_FAD_bind_N
    IPR016171 Vanillyl_alc_oxidase_C-sub2
    PfamiView protein in Pfam
    PF02913 FAD-oxidase_C, 1 hit
    PF01565 FAD_binding_4, 1 hit
    SUPFAMiSSF55103 SSF55103, 1 hit
    SSF56176 SSF56176, 1 hit
    PROSITEiView protein in PROSITE
    PS51387 FAD_PCMH, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLD2_YEAST
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46681
    Secondary accession number(s): D6VRH4, Q66RH8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: December 5, 2018
    This is version 151 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families
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