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Entry version 164 (12 Aug 2020)
Sequence version 2 (01 Oct 1996)
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Protein

Suppressor of mar1-1 protein

Gene

SUM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding protein that specifically binds the regulatory region of middle sporulation genes (MSE). Required for the repression of middle sporulation genes during vegetative growth. Represses expression via the recruitment of histone deacetylase HST1.1 Publication

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processSporulation, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29869-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of mar1-1 protein
Short name:
SUM1-1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUM1
Ordered Locus Names:YDR310C
ORF Names:D9740.19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR310C

Saccharomyces Genome Database

More...
SGDi
S000002718, SUM1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi988T → I: Loss of function. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723112 – 1062Suppressor of mar1-1 proteinAdd BLAST1061

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei697PhosphothreonineCombined sources1
Modified residuei712Phosphoserine; by ATM or ATRCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei817PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P46676

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46676

PRoteomics IDEntifications database

More...
PRIDEi
P46676

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46676

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RFM1. This interaction is required to recruit HST1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32363, 521 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1384, SUM1-RFM1-HST1 histone deacetylase complex

Database of interacting proteins

More...
DIPi
DIP-6438N

Protein interaction database and analysis system

More...
IntActi
P46676, 21 interactors

Molecular INTeraction database

More...
MINTi
P46676

STRING: functional protein association networks

More...
STRINGi
4932.YDR310C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P46676, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi464 – 467Poly-Asn4
Compositional biasi514 – 523Poly-Ala10

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTPX, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012589_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46676

KEGG Orthology (KO)

More...
KOi
K12779

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWRDQSR

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P46676-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSENTTAPSD NITNEQRLPS GPKDDVDTLA LTSAQNQANS LRKLDTDANA
60 70 80 90 100
KALPSITDIP VSDDSDIKRQ VGSGFGSNPL HIKDSEAFPH SSIEALKEGM
110 120 130 140 150
DKVTKQCNDL KTALLSKDTS LTDSVQDLFN SLKVLSHNQS VLENKLDDVM
160 170 180 190 200
KNQVNTDILV NNLNERLNKL STMLQNTSKV NHSNLLIENS SNNTSSQHNT
210 220 230 240 250
SSSRRGPGRP RKDASTSTMN KLVSNAASVN LKSASNQGAP FSPVNITLPT
260 270 280 290 300
AVVQTSKSKR YFVEPSTKQE SLLLSAPSSS RDDADMSLTS VPQRTNNENG
310 320 330 340 350
KERPSTANSS SITPTPVTPN NLIQIKRKRG RPPKKRTVET MISNSTDTID
360 370 380 390 400
KSDASNRIKN EIPINSLLPS SKFHQIPSSP SNPVSQPAPV RTSRSATQEI
410 420 430 440 450
DIKSLELASL ISTNGDPNAE DSNTTDTVHN NVEGKVNVEE NKTEKEKIIT
460 470 480 490 500
IKSSSENSGN NTTNNNNTDN VIKFSANSDI NSDIRRLMVN DQFSLSYDAS
510 520 530 540 550
GNITVKLPPV SSPAAATAAA AAAVTSEMNR QQRELDKRRD SREKMLVNMK
560 570 580 590 600
YNDRDKAKSF MESNKKLLKA MKEEERRKRM TSIIHDNHLN LNLNEISTRS
610 620 630 640 650
KIKSAEKPTT KGSSMSPKPR SASISGISDH QQEGYQPLEQ EKLVDIDNEG
660 670 680 690 700
SNANSDSLKM GLTISAADTV HKVGIQSMLN SGEEAITKEN AEYERKTPGD
710 720 730 740 750
EETTTFVPLE NSQPSDTIRK RTAGDDGALD QTENTSISPK KRRTEDHTKG
760 770 780 790 800
EEDEGERGVG NSGTLATVEN VSGDISADLS KGTSSIHNDT ESANDSSNGN
810 820 830 840 850
GNLGLGTESR NTLLTATPIE LICREGFFYR RDIPDVPITT GAYLEFKFKA
860 870 880 890 900
KEEELINSSI NEEDYAAKSK HEKMNAHFFK PDIQEETELA FEILSKTTLT
910 920 930 940 950
EKYVNSLEYF LMEFRWENKL VGLGLKLRES KRTWQRRKAL FALFEFWRDQ
960 970 980 990 1000
SRDKRRFHNY TILHAVKEME NYRIFINRSV SWFYNHITLL KMILYDLCDN
1010 1020 1030 1040 1050
VTTQWREWMF PHNETLPALG QDGINEDNLN ETIDNMLIFD FLDDGSENNQ
1060
VKYSRIIPPD IR
Length:1,062
Mass (Da):118,201
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08A43263CCCFC1C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 20MSENT…QRLPS → MNRDFRL (PubMed:8754829).CuratedAdd BLAST20
Sequence conflicti30A → R in AAB38222 (PubMed:8754829).Curated1
Sequence conflicti408A → G in AAB38222 (PubMed:8754829).Curated1
Sequence conflicti523Missing in AAB38222 (PubMed:8754829).Curated1
Sequence conflicti826G → A in AAB38222 (PubMed:8754829).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U34832 Genomic DNA Translation: AAB38222.1
U28374 Genomic DNA Translation: AAB64746.1
BK006938 Genomic DNA Translation: DAA12149.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61196

NCBI Reference Sequences

More...
RefSeqi
NP_010596.1, NM_001180618.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR310C_mRNA; YDR310C; YDR310C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR310C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34832 Genomic DNA Translation: AAB38222.1
U28374 Genomic DNA Translation: AAB64746.1
BK006938 Genomic DNA Translation: DAA12149.1
PIRiS61196
RefSeqiNP_010596.1, NM_001180618.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32363, 521 interactors
ComplexPortaliCPX-1384, SUM1-RFM1-HST1 histone deacetylase complex
DIPiDIP-6438N
IntActiP46676, 21 interactors
MINTiP46676
STRINGi4932.YDR310C

PTM databases

iPTMnetiP46676

Proteomic databases

MaxQBiP46676
PaxDbiP46676
PRIDEiP46676

Genome annotation databases

EnsemblFungiiYDR310C_mRNA; YDR310C; YDR310C
GeneIDi851905
KEGGisce:YDR310C

Organism-specific databases

EuPathDBiFungiDB:YDR310C
SGDiS000002718, SUM1

Phylogenomic databases

eggNOGiENOG502QTPX, Eukaryota
HOGENOMiCLU_012589_0_0_1
InParanoidiP46676
KOiK12779
OMAiFWRDQSR

Enzyme and pathway databases

BioCyciYEAST:G3O-29869-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P46676
RNActiP46676, protein

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUM1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46676
Secondary accession number(s): D6VST9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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