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UniProtKB - P46676 (SUM1_YEAST)
Protein
Suppressor of mar1-1 protein
Gene
SUM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
DNA-binding protein that specifically binds the regulatory region of middle sporulation genes (MSE). Required for the repression of middle sporulation genes during vegetative growth. Represses expression via the recruitment of histone deacetylase HST1.
1 PublicationMiscellaneous
Present with 149 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: SGD
- DNA replication origin binding Source: SGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: SGD
- sequence-specific DNA binding Source: SGD
GO - Biological processi
- negative regulation of meiosis I Source: CACAO
- negative regulation of transcription by competitive promoter binding Source: SGD
- negative regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of DNA-dependent DNA replication initiation Source: SGD
- silent mating-type cassette heterochromatin assembly Source: SGD
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Sporulation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of mar1-1 proteinShort name: SUM1-1 protein |
Gene namesi | Name:SUM1 Ordered Locus Names:YDR310C ORF Names:D9740.19 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002718, SUM1 |
VEuPathDBi | FungiDB:YDR310C |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- histone deacetylase complex Source: ComplexPortal
- nucleus Source: SGD
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 988 | T → I: Loss of function. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000072311 | 2 – 1062 | Suppressor of mar1-1 proteinAdd BLAST | 1061 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 378 | PhosphoserineCombined sources | 1 | |
Modified residuei | 379 | PhosphoserineCombined sources | 1 | |
Modified residuei | 628 | PhosphoserineCombined sources | 1 | |
Modified residuei | 681 | PhosphoserineCombined sources | 1 | |
Modified residuei | 697 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 712 | Phosphoserine; by ATM or ATRCombined sources | 1 | |
Modified residuei | 738 | PhosphoserineCombined sources | 1 | |
Modified residuei | 817 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P46676 |
PaxDbi | P46676 |
PRIDEi | P46676 |
PTM databases
iPTMneti | P46676 |
Interactioni
Subunit structurei
Interacts with RFM1. This interaction is required to recruit HST1.
1 PublicationBinary interactionsi
P46676
With | #Exp. | IntAct |
---|---|---|
HMT1 [P38074] | 2 | EBI-18547,EBI-8394 |
Protein-protein interaction databases
BioGRIDi | 32363, 523 interactors |
ComplexPortali | CPX-1384, SUM1-RFM1-HST1 histone deacetylase complex |
DIPi | DIP-6438N |
IntActi | P46676, 21 interactors |
MINTi | P46676 |
STRINGi | 4932.YDR310C |
Miscellaneous databases
RNActi | P46676, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 188 – 217 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 267 – 337 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 370 – 398 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 595 – 634 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 681 – 804 | DisorderedSequence analysisAdd BLAST | 124 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 188 – 204 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 268 – 322 | Polar residuesSequence analysisAdd BLAST | 55 | |
Compositional biasi | 607 – 634 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 687 – 701 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 704 – 718 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 736 – 758 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 763 – 804 | Polar residuesSequence analysisAdd BLAST | 42 |
Phylogenomic databases
eggNOGi | ENOG502QTPX, Eukaryota |
HOGENOMi | CLU_012589_0_0_1 |
InParanoidi | P46676 |
OMAi | FALFEFW |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P46676-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSENTTAPSD NITNEQRLPS GPKDDVDTLA LTSAQNQANS LRKLDTDANA
60 70 80 90 100
KALPSITDIP VSDDSDIKRQ VGSGFGSNPL HIKDSEAFPH SSIEALKEGM
110 120 130 140 150
DKVTKQCNDL KTALLSKDTS LTDSVQDLFN SLKVLSHNQS VLENKLDDVM
160 170 180 190 200
KNQVNTDILV NNLNERLNKL STMLQNTSKV NHSNLLIENS SNNTSSQHNT
210 220 230 240 250
SSSRRGPGRP RKDASTSTMN KLVSNAASVN LKSASNQGAP FSPVNITLPT
260 270 280 290 300
AVVQTSKSKR YFVEPSTKQE SLLLSAPSSS RDDADMSLTS VPQRTNNENG
310 320 330 340 350
KERPSTANSS SITPTPVTPN NLIQIKRKRG RPPKKRTVET MISNSTDTID
360 370 380 390 400
KSDASNRIKN EIPINSLLPS SKFHQIPSSP SNPVSQPAPV RTSRSATQEI
410 420 430 440 450
DIKSLELASL ISTNGDPNAE DSNTTDTVHN NVEGKVNVEE NKTEKEKIIT
460 470 480 490 500
IKSSSENSGN NTTNNNNTDN VIKFSANSDI NSDIRRLMVN DQFSLSYDAS
510 520 530 540 550
GNITVKLPPV SSPAAATAAA AAAVTSEMNR QQRELDKRRD SREKMLVNMK
560 570 580 590 600
YNDRDKAKSF MESNKKLLKA MKEEERRKRM TSIIHDNHLN LNLNEISTRS
610 620 630 640 650
KIKSAEKPTT KGSSMSPKPR SASISGISDH QQEGYQPLEQ EKLVDIDNEG
660 670 680 690 700
SNANSDSLKM GLTISAADTV HKVGIQSMLN SGEEAITKEN AEYERKTPGD
710 720 730 740 750
EETTTFVPLE NSQPSDTIRK RTAGDDGALD QTENTSISPK KRRTEDHTKG
760 770 780 790 800
EEDEGERGVG NSGTLATVEN VSGDISADLS KGTSSIHNDT ESANDSSNGN
810 820 830 840 850
GNLGLGTESR NTLLTATPIE LICREGFFYR RDIPDVPITT GAYLEFKFKA
860 870 880 890 900
KEEELINSSI NEEDYAAKSK HEKMNAHFFK PDIQEETELA FEILSKTTLT
910 920 930 940 950
EKYVNSLEYF LMEFRWENKL VGLGLKLRES KRTWQRRKAL FALFEFWRDQ
960 970 980 990 1000
SRDKRRFHNY TILHAVKEME NYRIFINRSV SWFYNHITLL KMILYDLCDN
1010 1020 1030 1040 1050
VTTQWREWMF PHNETLPALG QDGINEDNLN ETIDNMLIFD FLDDGSENNQ
1060
VKYSRIIPPD IR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 20 | MSENT…QRLPS → MNRDFRL (PubMed:8754829).CuratedAdd BLAST | 20 | |
Sequence conflicti | 30 | A → R in AAB38222 (PubMed:8754829).Curated | 1 | |
Sequence conflicti | 408 | A → G in AAB38222 (PubMed:8754829).Curated | 1 | |
Sequence conflicti | 523 | Missing in AAB38222 (PubMed:8754829).Curated | 1 | |
Sequence conflicti | 826 | G → A in AAB38222 (PubMed:8754829).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U34832 Genomic DNA Translation: AAB38222.1 U28374 Genomic DNA Translation: AAB64746.1 BK006938 Genomic DNA Translation: DAA12149.1 |
PIRi | S61196 |
RefSeqi | NP_010596.1, NM_001180618.1 |
Genome annotation databases
EnsemblFungii | YDR310C_mRNA; YDR310C; YDR310C |
GeneIDi | 851905 |
KEGGi | sce:YDR310C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U34832 Genomic DNA Translation: AAB38222.1 U28374 Genomic DNA Translation: AAB64746.1 BK006938 Genomic DNA Translation: DAA12149.1 |
PIRi | S61196 |
RefSeqi | NP_010596.1, NM_001180618.1 |
3D structure databases
SMRi | P46676 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32363, 523 interactors |
ComplexPortali | CPX-1384, SUM1-RFM1-HST1 histone deacetylase complex |
DIPi | DIP-6438N |
IntActi | P46676, 21 interactors |
MINTi | P46676 |
STRINGi | 4932.YDR310C |
PTM databases
iPTMneti | P46676 |
Proteomic databases
MaxQBi | P46676 |
PaxDbi | P46676 |
PRIDEi | P46676 |
Genome annotation databases
EnsemblFungii | YDR310C_mRNA; YDR310C; YDR310C |
GeneIDi | 851905 |
KEGGi | sce:YDR310C |
Organism-specific databases
SGDi | S000002718, SUM1 |
VEuPathDBi | FungiDB:YDR310C |
Phylogenomic databases
eggNOGi | ENOG502QTPX, Eukaryota |
HOGENOMi | CLU_012589_0_0_1 |
InParanoidi | P46676 |
OMAi | FALFEFW |
Miscellaneous databases
PROi | PR:P46676 |
RNActi | P46676, protein |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | SUM1_YEAST | |
Accessioni | P46676Primary (citable) accession number: P46676 Secondary accession number(s): D6VST9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names