Nuclear mRNA export protein SAC3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• actin filament-based process Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Suppressors of yeast actin mutations."
    Novick P., Osmond B.C., Botstein D.
    Genetics 121:659-674(1989) [PubMed] [Europe PMC] [Abstract]
• mitotic cell cycle Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The SAC3 gene encodes a nuclear protein required for normal progression of mitosis."
    Bauer A., Kolling R.
    J Cell Sci 109:1575-1583(1996) [PubMed] [Europe PMC] [Abstract]
• mRNA 3'-end processing Source: SGDInferred from mutant phenotypeⁱ
  • "Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation."
    Saguez C., Schmid M., Olesen J.R., Ghazy M.A., Qu X., Poulsen M.B., Nasser T., Moore C., Jensen T.H.
    Mol Cell 31:91-103(2008) [PubMed] [Europe PMC] [Abstract]
• mRNA export from nucleus Source: SGDInferred from mutant phenotypeⁱ
  • Ref.5

    "The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores."
    Fischer T., Straesser K., Racz A., Rodriguez-Navarro S., Oppizzi M., Ihrig P., Lechner J., Hurt E.
    EMBO J. 21:5843-5852(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MEX67, NUP1, SUB2 AND THP1, SUBCELLULAR LOCATION.
  • "Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex."
    Lei E.P., Stern C.A., Fahrenkrog B., Krebber H., Moy T.I., Aebi U., Silver P.A.
    Mol Biol Cell 14:836-847(2003) [PubMed] [Europe PMC] [Abstract]
• nuclear mRNA surveillance Source: SGDInferred from mutant phenotypeⁱ
  • "Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP."
    Chekanova J.A., Abruzzi K.C., Rosbash M., Belostotsky D.A.
    RNA 14:66-77(2008) [PubMed] [Europe PMC] [Abstract]
• posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGDInferred from mutant phenotypeⁱ
  • "Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP."
    Chekanova J.A., Abruzzi K.C., Rosbash M., Belostotsky D.A.
    RNA 14:66-77(2008) [PubMed] [Europe PMC] [Abstract]
• protein export from nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "SAC3 may link nuclear protein export to cell cycle progression."
    Jones A.L., Quimby B.B., Hood J.K., Ferrigno P., Keshava P.H., Silver P.A., Corbett A.H.
    Proc Natl Acad Sci U S A 97:3224-3229(2000) [PubMed] [Europe PMC] [Abstract]
• ribosomal small subunit biogenesis Source: SGDInferred from mutant phenotypeⁱ
  • "Rational extension of the ribosome biogenesis pathway using network-guided genetics."
    Li Z., Lee I., Moradi E., Hung N.J., Johnson A.W., Marcotte E.M.
    PLoS Biol. 7:E1000213-E1000213(2009) [PubMed] [Europe PMC] [Abstract]
• transcription-coupled nucleotide-excision repair Source: SGDInferred from mutant phenotypeⁱ
  • "A new connection of mRNP biogenesis and export with transcription-coupled repair."
    Gaillard H., Wellinger R.E., Aguilera A.
    Nucleic Acids Res 35:3893-3906(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MNTSFGSVVP STNFNFFKGH GNNDNTSANS TVNNSNFFLN SNETKPSKNV 
        60         70         80         90        100
FMVHSTSQKK SQQPLQNLSH SPSYTENKPD KKKKYMINDA KTIQLVGPLI 
       110        120        130        140        150
SSPDNLGFQK RSHKARELPR FLINQEPQLE KRAFVQDPWD KANQEKMISL 
       160        170        180        190        200
EESIDDLNEL YETLKKMRNT ERSIMEEKGL VDKADSAKDL YDAIVFQGTC 
       210        220        230        240        250
LDMCPTFERS RRNVEYTVYS YEKNQPNDKK ASRTKALKVF ARPAAAAAPP 
       260        270        280        290        300
LPSDVRPPHI LVKTLDYIVD NLLTTLPESE GFLWDRMRSI RQDFTYQNYS 
       310        320        330        340        350
GPEAVDCNER IVRIHLLILH IMVKSNVEFS LQQELEQLHK SLITLSEIYD 
       360        370        380        390        400
DVRSSGGTCP NEAEFRAYAL LSKIRDPQYD ENIQRLPKHI FQDKLVQMAL 
       410        420        430        440        450
CFRRVISNSA YTERGFVKTE NCLNFYARFF QLMQSPSLPL LMGFFLQMHL 
       460        470        480        490        500
TDIRFYALRA LSHTLNKKHK PIPFIYLENM LLFNNRQEII EFCNYYSIEI 
       510        520        530        540        550
INGDAADLKT LQHYSHKLSE TQPLKKTYLT CLERRLQKTT YKGLINGGED 
       560        570        580        590        600
NLASSVYVKD PKKDRIPSIA DQSFLMENFQ NNYNEKLNQN SSVKPQINTS 
       610        620        630        640        650
PKRVATRPNH FPFSQESKQL PQISQSHTLS TNPLLTPQVH GDLSEQKQQQ 
       660        670        680        690        700
IKTVTDGGSP FVFDQSAQNS TVEASKAHMI STTSNGAYDE KLSSEQEEMR 
       710        720        730        740        750
KKEEQRIEEE KTQLKKKQEN ADKQVITEQI ANDLVKEVVN SSVISIVKRE 
       760        770        780        790        800
FSEANYRKDF IDTMTRELYD AFLHERLYLI YMDSRAELKR NSTLKKKFFE 
       810        820        830        840        850
KWQASYSQAK KNRILEEKKR EEIKLVSHQL GVPGFKKSTC LFRTPYKGNV 
       860        870        880        890        900
NSSFMLSSSD KNLIFSPVND EFNKFATHLT KISKLWRPLE MQSIYYDNLT 
       910        920        930        940        950
KKFPSNSLTP ANLFIYAKDW TSLSNRWILS KFNLQTAQDS KKFSNNIISS 
       960        970        980        990       1000
RIICIDDEYE PSDFSDLQLL IFNTGVTNPD IFDLEMKLKD DGEELIKLIT 
      1010       1020       1030       1040       1050
GISLNTNICF SLLIIYWESA ENTLSESTIK HLLKLNRISK NYSSVIERID 
      1060       1070       1080       1090       1100
LMNLTEESPH KCLEDKLSEI SHSYVYKLTE RGKYDKTLRQ KRSLAGIHSR 
      1110       1120       1130       1140       1150
STQLQTTKDI DQKMKKMLEK EKNKYQQQIG ERNTYAHLES HIDASPRSKK 
      1160       1170       1180       1190       1200
RKLPILLSTS HSSQFKTPLA SRLNTSGSST SPPLPSHLAM KFRKNSRVTS 
      1210       1220       1230       1240       1250
LHTVLPVSTP SHSNNIPAAS FSGNNTTDIQ SQQLIENQKS TSVYLNNVSE 
      1260       1270       1280       1290       1300
RILGNQEICQ TPINPVTPVL DGADQGKEDI PDSILELKIL IDSVKKKVNN 

D                                                      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome IV
   Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families