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Entry version 161 (16 Oct 2019)
Sequence version 2 (07 Mar 2006)
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Protein

Adenylosuccinate synthetase isozyme 2

Gene

Adss2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=15 µM for GTP1 Publication
  2. KM=12 µM for IMP1 Publication
  3. KM=950 µM for L-aspartate1 Publication

    pH dependencei

    Optimum pH is 6.6-6.9.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: AMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes AMP from IMP.UniRule annotation
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Adenylosuccinate synthetase isozyme 1 (Adssl1), Adenylosuccinate synthetase (Adss), Adenylosuccinate synthetase isozyme 2 (Adss2), Adenylosuccinate synthetase isozyme 2 (Adss), Adenylosuccinate synthetase isozyme 1 (Adss1), Adenylosuccinate synthetase isozyme 1 (Adssl1)
    2. Adenylosuccinate lyase (Adsl), Adenylosuccinate lyase (Adsl), Adenylosuccinate lyase (Adsl)
    This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei40Proton acceptorUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi40MagnesiumUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei40SubstrateUniRule annotation1
    Metal bindingi67Magnesium; via carbonyl oxygenUniRule annotation1
    Active sitei68Proton donorUniRule annotation1
    Binding sitei162IMPUniRule annotation1
    Binding sitei176IMP; shared with dimeric partnerUniRule annotation1
    Binding sitei255IMPUniRule annotation1
    Binding sitei270IMPUniRule annotation1
    Binding sitei334IMPUniRule annotation1
    Binding sitei336GTPUniRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi39 – 45GTPUniRule annotation7
    Nucleotide bindingi67 – 69GTPUniRule annotation3
    Nucleotide bindingi362 – 364GTPUniRule annotation3
    Nucleotide bindingi444 – 447GTPUniRule annotation4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase
    Biological processPurine biosynthesis
    LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-73817 Purine ribonucleoside monophosphate biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00075;UER00335

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Adenylosuccinate synthetase isozyme 2UniRule annotation (EC:6.3.4.4UniRule annotation1 Publication)
    Short name:
    AMPSase 2UniRule annotation
    Short name:
    AdSS 2UniRule annotation
    Alternative name(s):
    Adenylosuccinate synthetase, acidic isozymeUniRule annotation
    Adenylosuccinate synthetase, liver isozymeUniRule annotation
    Short name:
    L-type adenylosuccinate synthetaseUniRule annotation
    IMP--aspartate ligase 2UniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Adss2
    Synonyms:AdssImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:87948 Adss

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000951311 – 456Adenylosuccinate synthetase isozyme 2Add BLAST456

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P46664

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P46664

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P46664

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P46664

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P46664

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    P46664
    Q9CQL9

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P46664

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P46664

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P46664

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000015961 Expressed in 303 organ(s), highest expression level in cornea

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P46664 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P46664 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    UniRule annotation

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    P46664, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    P46664

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000016105

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P46664

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 43IMP bindingUniRule annotation4
    Regioni65 – 68IMP bindingUniRule annotation4
    Regioni330 – 336Substrate bindingUniRule annotation7

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the adenylosuccinate synthetase family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1355 Eukaryota
    COG0104 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000015553

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000260959

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P46664

    KEGG Orthology (KO)

    More...
    KOi
    K01939

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GIAPFYS

    Database of Orthologous Groups

    More...
    OrthoDBi
    1276527at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P46664

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300486

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd03108 AdSS, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.300.10, 1 hit
    3.40.440.10, 1 hit
    3.90.170.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00011 Adenylosucc_synth, 1 hit
    MF_03127 Adenylosucc_synth_vert_acid, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR018220 Adenylosuccin_syn_GTP-bd
    IPR033128 Adenylosuccin_syn_Lys_AS
    IPR042109 Adenylosuccinate_synth_dom1
    IPR042110 Adenylosuccinate_synth_dom2
    IPR042111 Adenylosuccinate_synth_dom3
    IPR001114 Adenylosuccinate_synthetase
    IPR027529 AdSS_2_vert
    IPR027417 P-loop_NTPase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11846 PTHR11846, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00709 Adenylsucc_synt, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00788 Adenylsucc_synt, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00184 purA, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01266 ADENYLOSUCCIN_SYN_1, 1 hit
    PS00513 ADENYLOSUCCIN_SYN_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P46664-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSISESSPAA TSLPNGDCGR PRARSGGNRV TVVLGAQWGD EGKGKVVDLL
    60 70 80 90 100
    AQDADIVCRC QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV
    110 120 130 140 150
    IHLPGLFEEA EKNVQKGKGL DGWEKRLIIS DRAHIVFDFH QAADGIQEQQ
    160 170 180 190 200
    RQEQAGKNLG TTKKGIGPVY SSKAARSGLR MCDLVSDFDG FSERFKVLAN
    210 220 230 240 250
    QYKSIYPTLE IDIEGELQQL KGYMERIKPM VKDGVYFLYE ALHGPPKKIL
    260 270 280 290 300
    VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY
    310 320 330 340 350
    TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVSLKYAH
    360 370 380 390 400
    MINGFTALAL TKLDILDMFT EIKVGVAYKL DGETIPHFPA NQEVLNKVEV
    410 420 430 440 450
    QYKTLPGWNT DISNARTFKE LPVNAQNYVR FIEDELQIPV KWIGVGKSRE

    SMIQLF
    Length:456
    Mass (Da):50,021
    Last modified:March 7, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7825B758BC6CDA38
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167G → R in AAA19727 (PubMed:8308018).Curated1
    Sequence conflicti199A → T in AAA19727 (PubMed:8308018).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L24554 mRNA Translation: AAA19727.1
    AK004877 mRNA Translation: BAB23635.1
    AK010263 mRNA Translation: BAB26805.1
    AK028060 mRNA Translation: BAC25730.1
    AK148420 mRNA Translation: BAE28543.1
    AK170279 mRNA Translation: BAE41682.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS15555.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A53162

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_031448.2, NM_007422.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000016105; ENSMUSP00000016105; ENSMUSG00000015961

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    11566

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:11566

    UCSC genome browser

    More...
    UCSCi
    uc007dut.1 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L24554 mRNA Translation: AAA19727.1
    AK004877 mRNA Translation: BAB23635.1
    AK010263 mRNA Translation: BAB26805.1
    AK028060 mRNA Translation: BAC25730.1
    AK148420 mRNA Translation: BAE28543.1
    AK170279 mRNA Translation: BAE41682.1
    CCDSiCCDS15555.1
    PIRiA53162
    RefSeqiNP_031448.2, NM_007422.3

    3D structure databases

    SMRiP46664
    ModBaseiSearch...

    Protein-protein interaction databases

    IntActiP46664, 1 interactor
    MINTiP46664
    STRINGi10090.ENSMUSP00000016105

    PTM databases

    iPTMnetiP46664
    PhosphoSitePlusiP46664
    SwissPalmiP46664

    2D gel databases

    REPRODUCTION-2DPAGEiP46664
    Q9CQL9

    Proteomic databases

    EPDiP46664
    jPOSTiP46664
    MaxQBiP46664
    PaxDbiP46664
    PRIDEiP46664

    Genome annotation databases

    EnsembliENSMUST00000016105; ENSMUSP00000016105; ENSMUSG00000015961
    GeneIDi11566
    KEGGimmu:11566
    UCSCiuc007dut.1 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    159
    MGIiMGI:87948 Adss

    Phylogenomic databases

    eggNOGiKOG1355 Eukaryota
    COG0104 LUCA
    GeneTreeiENSGT00390000015553
    HOGENOMiHOG000260959
    InParanoidiP46664
    KOiK01939
    OMAiGIAPFYS
    OrthoDBi1276527at2759
    PhylomeDBiP46664
    TreeFamiTF300486

    Enzyme and pathway databases

    UniPathwayiUPA00075;UER00335
    ReactomeiR-MMU-73817 Purine ribonucleoside monophosphate biosynthesis

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Adss mouse

    Protein Ontology

    More...
    PROi
    PR:P46664

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000015961 Expressed in 303 organ(s), highest expression level in cornea
    ExpressionAtlasiP46664 baseline and differential
    GenevisibleiP46664 MM

    Family and domain databases

    CDDicd03108 AdSS, 1 hit
    Gene3Di1.10.300.10, 1 hit
    3.40.440.10, 1 hit
    3.90.170.10, 1 hit
    HAMAPiMF_00011 Adenylosucc_synth, 1 hit
    MF_03127 Adenylosucc_synth_vert_acid, 1 hit
    InterProiView protein in InterPro
    IPR018220 Adenylosuccin_syn_GTP-bd
    IPR033128 Adenylosuccin_syn_Lys_AS
    IPR042109 Adenylosuccinate_synth_dom1
    IPR042110 Adenylosuccinate_synth_dom2
    IPR042111 Adenylosuccinate_synth_dom3
    IPR001114 Adenylosuccinate_synthetase
    IPR027529 AdSS_2_vert
    IPR027417 P-loop_NTPase
    PANTHERiPTHR11846 PTHR11846, 1 hit
    PfamiView protein in Pfam
    PF00709 Adenylsucc_synt, 1 hit
    SMARTiView protein in SMART
    SM00788 Adenylsucc_synt, 1 hit
    SUPFAMiSSF52540 SSF52540, 1 hit
    TIGRFAMsiTIGR00184 purA, 1 hit
    PROSITEiView protein in PROSITE
    PS01266 ADENYLOSUCCIN_SYN_1, 1 hit
    PS00513 ADENYLOSUCCIN_SYN_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPURA2_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46664
    Secondary accession number(s): Q9CQL9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: March 7, 2006
    Last modified: October 16, 2019
    This is version 161 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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