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Protein

Heat shock protein 90 homolog

Gene

HSP90

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATPBy similarity1
Binding sitei82ATPBy similarity1
Binding sitei101ATPBy similarity1
Binding sitei127ATP; via amide nitrogenBy similarity1
Binding sitei377ATPBy similarity1

GO - Molecular functioni

  • ATPase activity, coupled Source: CGD
  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90 homolog
Gene namesi
Name:HSP90
Ordered Locus Names:CAALFM_C702030WA
ORF Names:CaJ7.0234, CaO19.13868, CaO19.6515
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000201062 HSP90

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3580503

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629611 – 707Heat shock protein 90 homologAdd BLAST707

Proteomic databases

PRIDEiP46598

2D gel databases

COMPLUYEAST-2DPAGEiP46598

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1220045, 221 interactors

Structurei

3D structure databases

ProteinModelPortaliP46598
SMRiP46598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi703 – 707TPR repeat-binding5

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

InParanoidiP46598
KOiK04079
OMAiVKRHSEF
OrthoDBiEOG092C1GW3

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

P46598-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAKVETHE FTAEISQLMS LIINTVYSNK EIFLRELISN ASDALDKIRY
60 70 80 90 100
QALSDPSQLE SEPELFIRII PQKDQKVLEI RDSGIGMTKA DLVNNLGTIA
110 120 130 140 150
KSGTKSFMEA LSAGADVSMI GQFGVGFYSL FLVADHVQVI SKHNDDEQYV
160 170 180 190 200
WESNAGGKFT VTLDETNERL GRGTMLRLFL KEDQLEYLEE KRIKEVVKKH
210 220 230 240 250
SEFVAYPIQL VVTKEVEKEV PETEEEDKAA EEDDKKPKLE EVKDEEDEKK
260 270 280 290 300
EKKTKTVKEE VTETEELNKT KPLWTRNPSD ITQDEYNAFY KSISNDWEDP
310 320 330 340 350
LAVKHFSVEG QLEFRAILFV PKRAPFDAFE SKKKKNNIKL YVRRVFITDD
360 370 380 390 400
AEELIPEWLS FIKGVVDSED LPLNLSREML QQNKILKVIR KNIVKKMIET
410 420 430 440 450
FNEISEDQEQ FNQFYTAFSK NIKLGIHEDA QNRQSLAKLL RFYSTKSSEE
460 470 480 490 500
MTSLSDYVTR MPEHQKNIYY ITGESIKAVE KSPFLDALKA KNFEVLFMVD
510 520 530 540 550
PIDEYAMTQL KEFEDKKLVD ITKDFELEES DEEKAAREKE IKEYEPLTKA
560 570 580 590 600
LKDILGDQVE KVVVSYKLVD APAAIRTGQF GWSANMERIM KAQALRDTTM
610 620 630 640 650
SSYMSSKKTF EISPSSPIIK ELKKKVETDG AEDKTVKDLT TLLFDTALLT
660 670 680 690 700
SGFTLDEPSN FAHRINRLIA LGLNIDDDSE ETAVEPEATT TASTDEPAGE

SAMEEVD
Length:707
Mass (Da):80,823
Last modified:November 1, 1995 - v1
Checksum:i3BF614C70F2E5446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81025 Genomic DNA Translation: CAA56931.1
AP006852 Genomic DNA Translation: BAE44720.1
CP017629 Genomic DNA Translation: AOW30566.1
RefSeqiXP_721353.1, XM_716260.1

Genome annotation databases

EnsemblFungiiAOW30566; AOW30566; CAALFM_C702030WA
GeneIDi3636951
KEGGical:CAALFM_C702030WA

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81025 Genomic DNA Translation: CAA56931.1
AP006852 Genomic DNA Translation: BAE44720.1
CP017629 Genomic DNA Translation: AOW30566.1
RefSeqiXP_721353.1, XM_716260.1

3D structure databases

ProteinModelPortaliP46598
SMRiP46598
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1220045, 221 interactors

Chemistry databases

ChEMBLiCHEMBL3580503

2D gel databases

COMPLUYEAST-2DPAGEiP46598

Proteomic databases

PRIDEiP46598

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAOW30566; AOW30566; CAALFM_C702030WA
GeneIDi3636951
KEGGical:CAALFM_C702030WA

Organism-specific databases

CGDiCAL0000201062 HSP90

Phylogenomic databases

InParanoidiP46598
KOiK04079
OMAiVKRHSEF
OrthoDBiEOG092C1GW3

Miscellaneous databases

PROiPR:P46598

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP90_CANAL
AccessioniPrimary (citable) accession number: P46598
Secondary accession number(s): A0A1D8PR20, Q3MPE0, Q5AH23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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