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Entry version 170 (22 Apr 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Acetylserotonin O-methyltransferase

Gene

ASMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.1 Publication

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: melatonin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes melatonin from serotonin.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetylserotonin O-methyltransferase (ASMT), Serotonin N-acetyltransferase (AANAT)
  2. no protein annotated in this organism
This subpathway is part of the pathway melatonin biosynthesis, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes melatonin from serotonin, the pathway melatonin biosynthesis and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei147S-adenosyl-L-methionine1
Binding sitei164S-adenosyl-L-methionine1
Binding sitei210S-adenosyl-L-methionine1
Binding sitei252S-adenosyl-L-methionine1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei255Proton donor/acceptor1 Publication1
Binding sitei256Substrate1
Binding sitei302Substrate1
Binding sitei306Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processMelatonin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS09884-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.4 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-209931 Serotonin and melatonin biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00837;UER00815

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetylserotonin O-methyltransferase (EC:2.1.1.4)
Alternative name(s):
Hydroxyindole O-methyltransferase
Short name:
HIOMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:750 ASMT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300015 gene
402500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46597

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11L → F: Reduced enzyme activity. 1 Publication1
Mutagenesisi31L → H: No effect on enzyme activity. 1
Mutagenesisi296T → M: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi318H → D: Reduced enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
438

Open Targets

More...
OpenTargetsi
ENSG00000196433

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25049

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P46597 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01065 Melatonin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASMT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1170276

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839821 – 345Acetylserotonin O-methyltransferaseAdd BLAST345

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P46597

PeptideAtlas

More...
PeptideAtlasi
P46597

PRoteomics IDEntifications database

More...
PRIDEi
P46597

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55743 [P46597-1]
55744 [P46597-2]
55745 [P46597-3]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196433 Expressed in adenohypophysis and 75 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46597 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P46597 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196433 Tissue enhanced (brain, epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P46597
With#Exp.IntAct
itself3EBI-6502097,EBI-6502097

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106930, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370639

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P46597 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46597

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni235 – 237S-adenosyl-L-methionine binding3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005533_4_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P46597

KEGG Orthology (KO)

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KOi
K00543

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYMEGFL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46597

TreeFam database of animal gene trees

More...
TreeFami
TF314574

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031725 ASMT_dimerisation
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_dom
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16864 Dimerisation2, 1 hit
PF00891 Methyltransf_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005739 O-mtase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51683 SAM_OMT_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P46597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA
60 70 80 90 100
AGVRASAHGT ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT
110 120 130 140 150
SQCSMLKYMG RTSYRCWGHL ADAVREGRNQ YLETFGVPAE ELFTAIYRSE
160 170 180 190 200
GERLQFMQAL QEVWSVNGRS VLTAFDLSVF PLMCDLGGGA GALAKECMSL
210 220 230 240 250
YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD PLPEADLYIL
260 270 280 290 300
ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS
310 320 330 340
LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK
Length:345
Mass (Da):38,453
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i187A375E1E2940B7
GO
Isoform 2 (identifier: P46597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-235: Missing.

Show »
Length:298
Mass (Da):33,192
Checksum:iAAFC60D1F8D70E5A
GO
Isoform 3 (identifier: P46597-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-188: G → GTWIKLETIILSKLSQGQKTKHRVFSLIG

Note: Includes part of a LINE-1 element.Curated
Show »
Length:373
Mass (Da):41,661
Checksum:i8CA134BD0BA50FDD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HFW6I7HFW6_HUMAN
Acetylserotonin O-methyltransferase
ASMT
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti302N → S in BAG37430 (PubMed:14702039).Curated1
Isoform 3 (identifier: P46597-3)
Sequence conflicti190W → R in AAA58582 (PubMed:7989373).Curated1
Sequence conflicti190W → R in AAA58583 (PubMed:7989373).Curated1
Sequence conflicti190W → R in AAA75290 (PubMed:7989373).Curated1
Sequence conflicti190W → R in AAA17020 (PubMed:8397829).Curated1
Sequence conflicti190W → R in BAG37430 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06911113N → H Polymorphism; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121918819Ensembl.1
Natural variantiVAR_04599117N → K Functional polymorphism; nearly abolishes enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs17149149Ensembl.1
Natural variantiVAR_06911261E → Q Functional polymorphism; reduced enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs121918823Ensembl.1
Natural variantiVAR_06911381K → E Polymorphism; no effect on enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs117343570EnsemblClinVar.1
Natural variantiVAR_069114111R → K Polymorphism; no effect on enzyme activity. 2 Publications1
Natural variantiVAR_069115115R → W1 PublicationCorresponds to variant dbSNP:rs201053197Ensembl.1
Natural variantiVAR_069116151G → S1 PublicationCorresponds to variant dbSNP:rs192710293Ensembl.1
Natural variantiVAR_069117166V → I1 PublicationCorresponds to variant dbSNP:rs373339042Ensembl.1
Natural variantiVAR_069118171V → M Functional polymorphism; nearly abolishes enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121918820Ensembl.1
Natural variantiVAR_069119179V → G1 Publication1
Natural variantiVAR_069120210D → G Functional polymorphism; nearly abolishes enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs121918824Ensembl.1
Natural variantiVAR_069121211I → M1 PublicationCorresponds to variant dbSNP:rs201316181Ensembl.1
Natural variantiVAR_069122217T → M1 PublicationCorresponds to variant dbSNP:rs148036160Ensembl.1
Natural variantiVAR_069123219K → R Polymorphism; no effect on enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs121918825Ensembl.1
Natural variantiVAR_069124243P → L Functional polymorphism; reduced enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs121918826Ensembl.1
Natural variantiVAR_069125248Y → H Functional polymorphism; nearly abolishes enzyme activity. 2 Publications1
Natural variantiVAR_069126269I → M Functional polymorphism; reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs146121655Ensembl.1
Natural variantiVAR_069127273C → S Functional polymorphism; reduced enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs121918827Ensembl.1
Natural variantiVAR_069128278G → A Functional polymorphism; reduced enzyme activity. 2 Publications1
Natural variantiVAR_069129288E → D Polymorphism; no effect on enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs121918821Ensembl.1
Natural variantiVAR_069130291R → Q Functional polymorphism; nearly abolishes enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs121918828Ensembl.1
Natural variantiVAR_069131298L → F Functional polymorphism; nearly abolishes enzyme activity. 6 PublicationsCorresponds to variant dbSNP:rs121918822Ensembl.1
Natural variantiVAR_069132305V → M Functional polymorphism; reduced enzyme activity. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004284188G → GTWIKLETIILSKLSQGQKT KHRVFSLIG in isoform 3. 2 Publications1
Alternative sequenceiVSP_004285189 – 235Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U11098 U11097 Genomic DNA Translation: AAA75291.1
U11098 U11097 Genomic DNA Translation: AAA75289.1
U11098 U11097 Genomic DNA Translation: AAA75290.1
U11090 mRNA Translation: AAA58582.1
U11091 mRNA Translation: AAA58583.1
M83779 mRNA Translation: AAA17020.1
AK314922 mRNA Translation: BAG37430.1
AL683807 Genomic DNA No translation available.
BC001620 mRNA Translation: AAH01620.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14117.1 [P46597-3]
CCDS55364.1 [P46597-2]

Protein sequence database of the Protein Information Resource

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PIRi
I37463

NCBI Reference Sequences

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RefSeqi
NP_001164509.1, NM_001171038.1 [P46597-3]
NP_001164510.1, NM_001171039.1 [P46597-2]
NP_004034.2, NM_004043.2 [P46597-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000381229; ENSP00000370627; ENSG00000196433 [P46597-1]
ENST00000381233; ENSP00000370631; ENSG00000196433 [P46597-2]
ENST00000381241; ENSP00000370639; ENSG00000196433 [P46597-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
438

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:438

UCSC genome browser

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UCSCi
uc010ncy.4 human [P46597-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

5-hydroxyindole-O-methyltransferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11098 U11097 Genomic DNA Translation: AAA75291.1
U11098 U11097 Genomic DNA Translation: AAA75289.1
U11098 U11097 Genomic DNA Translation: AAA75290.1
U11090 mRNA Translation: AAA58582.1
U11091 mRNA Translation: AAA58583.1
M83779 mRNA Translation: AAA17020.1
AK314922 mRNA Translation: BAG37430.1
AL683807 Genomic DNA No translation available.
BC001620 mRNA Translation: AAH01620.1
CCDSiCCDS14117.1 [P46597-3]
CCDS55364.1 [P46597-2]
PIRiI37463
RefSeqiNP_001164509.1, NM_001171038.1 [P46597-3]
NP_001164510.1, NM_001171039.1 [P46597-2]
NP_004034.2, NM_004043.2 [P46597-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A6DX-ray2.40A1-345[»]
4A6EX-ray2.70A1-345[»]
SMRiP46597
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106930, 1 interactor
STRINGi9606.ENSP00000370639

Chemistry databases

DrugBankiDB01065 Melatonin

Polymorphism and mutation databases

BioMutaiASMT
DMDMi1170276

Proteomic databases

MassIVEiP46597
PeptideAtlasiP46597
PRIDEiP46597
ProteomicsDBi55743 [P46597-1]
55744 [P46597-2]
55745 [P46597-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
35250 158 antibodies

The DNASU plasmid repository

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DNASUi
438

Genome annotation databases

EnsembliENST00000381229; ENSP00000370627; ENSG00000196433 [P46597-1]
ENST00000381233; ENSP00000370631; ENSG00000196433 [P46597-2]
ENST00000381241; ENSP00000370639; ENSG00000196433 [P46597-3]
GeneIDi438
KEGGihsa:438
UCSCiuc010ncy.4 human [P46597-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
438
DisGeNETi438

GeneCards: human genes, protein and diseases

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GeneCardsi
ASMT
HGNCiHGNC:750 ASMT
HPAiENSG00000196433 Tissue enhanced (brain, epididymis)
MIMi300015 gene
402500 gene
neXtProtiNX_P46597
OpenTargetsiENSG00000196433
PharmGKBiPA25049

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000161561
HOGENOMiCLU_005533_4_2_1
InParanoidiP46597
KOiK00543
OMAiEYMEGFL
PhylomeDBiP46597
TreeFamiTF314574

Enzyme and pathway databases

UniPathwayiUPA00837;UER00815
BioCyciMetaCyc:HS09884-MONOMER
BRENDAi2.1.1.4 2681
ReactomeiR-HSA-209931 Serotonin and melatonin biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ASMT human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Acetylserotonin_O-methyltransferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
438
PharosiP46597 Tbio

Protein Ontology

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PROi
PR:P46597
RNActiP46597 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196433 Expressed in adenohypophysis and 75 other tissues
ExpressionAtlasiP46597 baseline and differential
GenevisibleiP46597 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR031725 ASMT_dimerisation
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_dom
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF16864 Dimerisation2, 1 hit
PF00891 Methyltransf_2, 1 hit
PIRSFiPIRSF005739 O-mtase, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51683 SAM_OMT_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASMT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46597
Secondary accession number(s): B2RC33
, Q16598, Q5JQ72, Q5JQ73
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 22, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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