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Protein

Fructose-bisphosphate aldolase 2

Gene

aldo-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpi-1), Glucose-6-phosphate isomerase (gpi-1)
  3. ATP-dependent 6-phosphofructokinase 1 (pfk-1.1), ATP-dependent 6-phosphofructokinase 2 (pfk-1.2)
  4. Fructose-bisphosphate aldolase (aldo-2), Fructose-bisphosphate aldolase 2 (aldo-2), Fructose-bisphosphate aldolase 1 (aldo-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateBy similarity1
Binding sitei150SubstrateBy similarity1
Active sitei191Proton acceptorBy similarity1
Active sitei233Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei366Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation
R-CEL-6798695 Neutrophil degranulation
R-CEL-70171 Glycolysis
R-CEL-70263 Gluconeogenesis
R-CEL-70350 Fructose catabolism
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
Alternative name(s):
Aldolase CE-2
Short name:
CE2
Gene namesi
Name:aldo-2
ORF Names:F01F1.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF01F1.12a ; CE01225 ; WBGene00017166 ; aldo-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169291 – 366Fructose-bisphosphate aldolase 2Add BLAST366

Proteomic databases

EPDiP46563
PaxDbiP46563
PeptideAtlasiP46563
PRIDEiP46563

PTM databases

iPTMnetiP46563

Expressioni

Developmental stagei

Restricted to the embryo and early larval stages.

Gene expression databases

BgeeiWBGene00017166
ExpressionAtlasiP46563 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi41049, 7 interactors
DIPiDIP-24398N
IntActiP46563, 8 interactors
STRINGi6239.F01F1.12a.1

Structurei

3D structure databases

ProteinModelPortaliP46563
SMRiP46563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
InParanoidiP46563
OMAiFHQSTDK
OrthoDBiEOG091G0A9T
PhylomeDBiP46563

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

P46563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVGGAFKD SLTQAQKDEL HQIALKIVQD GKGILAADES TGTIGKRLDA
60 70 80 90 100
INLENNETNR QKYRQLLFTT PNLNQHISGV ILYEETFHQS TDKGEKFTDL
110 120 130 140 150
LIKQGIVPGI KLDLGVVPLA GTIGEGTTQG LDKLAERAAA FKKGGCGFAK
160 170 180 190 200
WRCVLNIGTH TPSHLGMLEN ANVLARYASI CQANGLVPIV EPEVLCDGEH
210 220 230 240 250
DLARAQKVTE QVLAFVYKAL ADHHVYLEGT LLKPNMVTPG QSSASKASHE
260 270 280 290 300
AIGLATVTAL RRGVPAAVPG ITFLSGGQSE LDATANLNAI NSVQLGKPWK
310 320 330 340 350
LTFSYGRALQ ASVLKAWGGK DENIAAAQKT LLHRSKANGD ASLGKYAGED
360
AAGAAAESLF VAKHSY
Length:366
Mass (Da):38,846
Last modified:November 1, 1995 - v1
Checksum:iD6BD9D1469E69834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83739 mRNA Translation: BAA12092.1
FO080705 Genomic DNA Translation: CCD65997.1
PIRiT15951
RefSeqiNP_001021240.1, NM_001026069.5
UniGeneiCel.18124

Genome annotation databases

EnsemblMetazoaiF01F1.12a.1; F01F1.12a.1; WBGene00017166
F01F1.12a.2; F01F1.12a.2; WBGene00017166
GeneIDi175827
UCSCiF01F1.12a c. elegans

Similar proteinsi

Entry informationi

Entry nameiALF2_CAEEL
AccessioniPrimary (citable) accession number: P46563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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