Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SULU

Gene

kin-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility (PubMed:23064028). Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division (PubMed:23064028). Might play a role in cell cycle progression (PubMed:23064028). In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation (PubMed:26510792). Plays a role in meiotic recombination events (PubMed:26510792). Involved in pharyngeal pumping (PubMed:11733138).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei59ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi36 – 44ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P46549

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase SULU (EC:2.7.11.1By similarity)
Alternative name(s):
Protein kinase 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kin-18
Synonyms:sulu
ORF Names:T17E9.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
T17E9.1a ; CE01405 ; WBGene00002201 ; kin-18
T17E9.1b ; CE32936 ; WBGene00002201 ; kin-18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown leads to embryonic lethality (PubMed:23064028). Increased and prolonged cortical contractility leading to a more persistent pseudocleavage in surviving embryos (PubMed:23064028). Decrease in rho-1 anterior cortex localization and increase in posterior cortex localization, leading to a loss of asymmetric rho-1 cortex localization during early embryonic cell division (PubMed:23064028). Increased cortical nmy-2 network between the foci, suggesting that the enhanced contractions are due to increased actomyosin contractility (PubMed:23064028). Reduction in the size of the anterior cortex and increase in the size of the posterior cortex during polarity establishment in the early embryo (PubMed:23064028). Leads to a delay in embryonic cell cycle progression (PubMed:23064028). Double RNAi-mediated knockdown with rho-1 results in loss of cortical contractility (PubMed:23064028).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47 – 642Missing in ok395; accelerated prophase I progression, aberrant oocyte development and ectopic apoptosis in the germline. Shorter gonads, reduction in nuclei, increase in mitotic index, decrease in early meiotic nuclei and sterility. Increase in and premature chromosomal loading of rad-51 and cosa-1 during meiosis. Increased and ectopic phosphorylation levels of mapk-1 (isoform a). 1 PublicationAdd BLAST596

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867261 – 982Serine/threonine-protein kinase SULUAdd BLAST982

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46549

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46549

PeptideAtlas

More...
PeptideAtlasi
P46549

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46549

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pharynx, including the pharyngeal muscle of the metacorpus, the isthmus, and the terminal bulb; in the intestine, including the pharyngeointestinal valve between the pharynx and the intestine, a structure near the anus likely to be the anal sphincter and the excretory cell and in several ring neurons.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryogenesis (PubMed:23064028). Expressed in adults (PubMed:11733138).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002201 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T17E9.1a.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P46549

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P46549

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST260

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0577 Eukaryota
ENOG410Y259 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236358

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46549

KEGG Orthology (KO)

More...
KOi
K04429

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRDHTAW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01CN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46549

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: P46549-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAVLQKPG VIKDPSIAAL FSNKDPEQRY QDLREIGHGS FGAVYFAYDK
60 70 80 90 100
KNEQTVAIKK MNFSGKQAVE KWNDILKEVS FLNTVVHPHI VDYKACFLKD
110 120 130 140 150
TTCWLVMEYC IGSAADIVDV LRKGMREVEI AAICSQTLDA LRYLHSLKRI
160 170 180 190 200
HRDIKAGNIL LSDHAIVKLA DFGSASLVDP AQTFIGTPFF MAPEVILAMD
210 220 230 240 250
EGHYTDRADI WSLGITCIEL AERRPPLFSM NAMSALYHIA QNDPPTLSPI
260 270 280 290 300
DTSEQPEWSL EFVQFIDKCL RKPAEERMSA EECFRHPFIQ RSRPSDTIQE
310 320 330 340 350
LIQRTKNMVL ELDNFQYKKM RKLMYLDETE GKEGSEGNGA SDDLDFHGNE
360 370 380 390 400
ANSIGRAGDS ASSRSASLTS FRSMQSSGGA GLLVSTNTTG AMDNVHGSSG
410 420 430 440 450
YGNGSSSTTS SARRRPPIPS QMLSSTSTSG VGTMPSHGSV GASITAIAVN
460 470 480 490 500
PTPSPSEPIP TSQPTSKSES SSILETAHDD PLDTSIRAPV KDLHMPHRAV
510 520 530 540 550
KERIATLQNH KFATLRSQRI INQEQEEYTK ENNMYEQMSK YKHLRQAHHK
560 570 580 590 600
ELQQFEERCA LDREQLRVKM DRELEQLTTT YSKEKMRVRC SQNNELDKRK
610 620 630 640 650
KDIEDGEKKM KKTKNSQNQQ QMKLYSAQQL KEYKYNKEAQ KTRLRSLNMP
660 670 680 690 700
RSTYENAMKE VKADLNRVKD ARENDFDEKL RAELEDEIVR YRRQQLSNLH
710 720 730 740 750
QLEEQLDDED VNVQERQMDT RHGLLSKQHE MTRDLEIQHL NELHAMKKRH
760 770 780 790 800
LETQHEAESA SQNEYTQRQQ DELRKKHAMQ SRQQPRDLKI QEAQIRKQYR
810 820 830 840 850
QVVKTQTRQF KLYLTQMVQV VPKDEQKELT SRLKQDQMQK VALLASQYES
860 870 880 890 900
QIKKMVQDKT VKLESWQEDE QRVLSEKLEK ELEELIAYQK KTRATLEEQI
910 920 930 940 950
KKERTALEER IGTRRAMLEQ KIIEEREQMG EMRRLKKEQI RDRHSQERHR
960 970 980
LENHFVRTGS TSRSSGGIAP GVGNSSSIQM AM
Length:982
Mass (Da):112,871
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i745CE1E2F890977D
GO
Isoform b (identifier: P46549-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: ANS → NHG
     354-982: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,010
Checksum:iC78FC46407DFCC8B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020524351 – 353ANS → NHG in isoform b. Curated3
Alternative sequenceiVSP_020525354 – 982Missing in isoform b. CuratedAdd BLAST629

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32275 mRNA Translation: AAA75370.1
FO080363 Genomic DNA Translation: CCD63180.1
FO080363 Genomic DNA Translation: CCD63181.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18576

NCBI Reference Sequences

More...
RefSeqi
NP_001022767.1, NM_001027596.2 [P46549-1]
NP_741172.2, NM_171151.3 [P46549-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.18101

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T17E9.1a.1; T17E9.1a.1; WBGene00002201 [P46549-1]
T17E9.1a.2; T17E9.1a.2; WBGene00002201 [P46549-1]
T17E9.1b.1; T17E9.1b.1; WBGene00002201 [P46549-2]
T17E9.1b.2; T17E9.1b.2; WBGene00002201 [P46549-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T17E9.1

UCSC genome browser

More...
UCSCi
T17E9.1a c. elegans [P46549-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32275 mRNA Translation: AAA75370.1
FO080363 Genomic DNA Translation: CCD63180.1
FO080363 Genomic DNA Translation: CCD63181.1
PIRiT18576
RefSeqiNP_001022767.1, NM_001027596.2 [P46549-1]
NP_741172.2, NM_171151.3 [P46549-2]
UniGeneiCel.18101

3D structure databases

ProteinModelPortaliP46549
SMRiP46549
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T17E9.1a.2

Chemistry databases

ChEMBLiCHEMBL5197

PTM databases

iPTMnetiP46549

Proteomic databases

EPDiP46549
PaxDbiP46549
PeptideAtlasiP46549

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT17E9.1a.1; T17E9.1a.1; WBGene00002201 [P46549-1]
T17E9.1a.2; T17E9.1a.2; WBGene00002201 [P46549-1]
T17E9.1b.1; T17E9.1b.1; WBGene00002201 [P46549-2]
T17E9.1b.2; T17E9.1b.2; WBGene00002201 [P46549-2]
GeneIDi175862
KEGGicel:CELE_T17E9.1
UCSCiT17E9.1a c. elegans [P46549-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175862
WormBaseiT17E9.1a ; CE01405 ; WBGene00002201 ; kin-18
T17E9.1b ; CE32936 ; WBGene00002201 ; kin-18

Phylogenomic databases

eggNOGiKOG0577 Eukaryota
ENOG410Y259 LUCA
GeneTreeiENSGT00940000168060
HOGENOMiHOG000236358
InParanoidiP46549
KOiK04429
OMAiLRDHTAW
OrthoDBiEOG091G01CN
PhylomeDBiP46549

Enzyme and pathway databases

SignaLinkiP46549

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P46549

Gene expression databases

BgeeiWBGene00002201 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSULU_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46549
Secondary accession number(s): Q8MPX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again