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Protein

Serine/threonine-protein kinase SULU

Gene

kin-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • feeding behavior Source: WormBase
  • negative regulation of MAP kinase activity Source: WormBase
  • nervous system development Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of meiosis I Source: WormBase
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of pharyngeal pumping Source: WormBase
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP46549

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SULU (EC:2.7.11.1)
Alternative name(s):
Protein kinase 18
Gene namesi
Name:kin-18
Synonyms:sulu
ORF Names:T17E9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT17E9.1a ; CE01405 ; WBGene00002201 ; kin-18
T17E9.1b ; CE32936 ; WBGene00002201 ; kin-18

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5197

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867261 – 982Serine/threonine-protein kinase SULUAdd BLAST982

Proteomic databases

EPDiP46549
PaxDbiP46549
PeptideAtlasiP46549

PTM databases

iPTMnetiP46549

Expressioni

Gene expression databases

BgeeiWBGene00002201

Interactioni

Protein-protein interaction databases

STRINGi6239.T17E9.1a.2

Structurei

3D structure databases

ProteinModelPortaliP46549
SMRiP46549
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST260

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0577 Eukaryota
ENOG410Y259 LUCA
GeneTreeiENSGT00920000148968
HOGENOMiHOG000236358
InParanoidiP46549
KOiK04429
OMAiLRDHTAW
OrthoDBiEOG091G01CN
PhylomeDBiP46549

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P46549-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAVLQKPG VIKDPSIAAL FSNKDPEQRY QDLREIGHGS FGAVYFAYDK
60 70 80 90 100
KNEQTVAIKK MNFSGKQAVE KWNDILKEVS FLNTVVHPHI VDYKACFLKD
110 120 130 140 150
TTCWLVMEYC IGSAADIVDV LRKGMREVEI AAICSQTLDA LRYLHSLKRI
160 170 180 190 200
HRDIKAGNIL LSDHAIVKLA DFGSASLVDP AQTFIGTPFF MAPEVILAMD
210 220 230 240 250
EGHYTDRADI WSLGITCIEL AERRPPLFSM NAMSALYHIA QNDPPTLSPI
260 270 280 290 300
DTSEQPEWSL EFVQFIDKCL RKPAEERMSA EECFRHPFIQ RSRPSDTIQE
310 320 330 340 350
LIQRTKNMVL ELDNFQYKKM RKLMYLDETE GKEGSEGNGA SDDLDFHGNE
360 370 380 390 400
ANSIGRAGDS ASSRSASLTS FRSMQSSGGA GLLVSTNTTG AMDNVHGSSG
410 420 430 440 450
YGNGSSSTTS SARRRPPIPS QMLSSTSTSG VGTMPSHGSV GASITAIAVN
460 470 480 490 500
PTPSPSEPIP TSQPTSKSES SSILETAHDD PLDTSIRAPV KDLHMPHRAV
510 520 530 540 550
KERIATLQNH KFATLRSQRI INQEQEEYTK ENNMYEQMSK YKHLRQAHHK
560 570 580 590 600
ELQQFEERCA LDREQLRVKM DRELEQLTTT YSKEKMRVRC SQNNELDKRK
610 620 630 640 650
KDIEDGEKKM KKTKNSQNQQ QMKLYSAQQL KEYKYNKEAQ KTRLRSLNMP
660 670 680 690 700
RSTYENAMKE VKADLNRVKD ARENDFDEKL RAELEDEIVR YRRQQLSNLH
710 720 730 740 750
QLEEQLDDED VNVQERQMDT RHGLLSKQHE MTRDLEIQHL NELHAMKKRH
760 770 780 790 800
LETQHEAESA SQNEYTQRQQ DELRKKHAMQ SRQQPRDLKI QEAQIRKQYR
810 820 830 840 850
QVVKTQTRQF KLYLTQMVQV VPKDEQKELT SRLKQDQMQK VALLASQYES
860 870 880 890 900
QIKKMVQDKT VKLESWQEDE QRVLSEKLEK ELEELIAYQK KTRATLEEQI
910 920 930 940 950
KKERTALEER IGTRRAMLEQ KIIEEREQMG EMRRLKKEQI RDRHSQERHR
960 970 980
LENHFVRTGS TSRSSGGIAP GVGNSSSIQM AM
Length:982
Mass (Da):112,871
Last modified:November 1, 1995 - v1
Checksum:i745CE1E2F890977D
GO
Isoform b (identifier: P46549-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: ANS → NHG
     354-982: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,010
Checksum:iC78FC46407DFCC8B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020524351 – 353ANS → NHG in isoform b. Curated3
Alternative sequenceiVSP_020525354 – 982Missing in isoform b. CuratedAdd BLAST629

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32275 mRNA Translation: AAA75370.1
FO080363 Genomic DNA Translation: CCD63180.1
FO080363 Genomic DNA Translation: CCD63181.1
PIRiT18576
RefSeqiNP_001022767.1, NM_001027596.2 [P46549-1]
NP_741172.2, NM_171151.3 [P46549-2]
UniGeneiCel.18101

Genome annotation databases

EnsemblMetazoaiT17E9.1a.1; T17E9.1a.1; WBGene00002201 [P46549-1]
T17E9.1a.2; T17E9.1a.2; WBGene00002201 [P46549-1]
GeneIDi175862
KEGGicel:CELE_T17E9.1
UCSCiT17E9.1a c. elegans [P46549-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSULU_CAEEL
AccessioniPrimary (citable) accession number: P46549
Secondary accession number(s): Q8MPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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