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Entry version 158 (16 Jan 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Neurogenic locus notch homolog protein 1

Gene

notch1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processAngiogenesis, Differentiation, Notch signaling pathway, Transcription, Transcription regulation
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 1
Short name:
Notch 1
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:notch1a
Synonyms:notch
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990415-173 notch1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1724ExtracellularSequence analysisAdd BLAST1704
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1725 – 1747HelicalSequence analysisAdd BLAST23
Topological domaini1748 – 2437CytoplasmicSequence analysisAdd BLAST690

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000770821 – 2437Neurogenic locus notch homolog protein 1Add BLAST2417
ChainiPRO_00004252001713 – 2437Notch 1 extracellular truncationBy similarityAdd BLAST725
ChainiPRO_00004252011745 – 2437Notch 1 intracellular domainBy similarityAdd BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 35By similarity
Disulfide bondi29 ↔ 45By similarity
Disulfide bondi47 ↔ 56By similarity
Disulfide bondi62 ↔ 73By similarity
Disulfide bondi67 ↔ 86By similarity
Disulfide bondi88 ↔ 97By similarity
Disulfide bondi105 ↔ 116By similarity
Disulfide bondi110 ↔ 126By similarity
Disulfide bondi128 ↔ 137By similarity
Disulfide bondi143 ↔ 154By similarity
Disulfide bondi148 ↔ 163By similarity
Disulfide bondi165 ↔ 174By similarity
Disulfide bondi181 ↔ 194By similarity
Disulfide bondi188 ↔ 203By similarity
Disulfide bondi205 ↔ 214By similarity
Disulfide bondi221 ↔ 232By similarity
Disulfide bondi226 ↔ 242By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi231O-linked (Fuc...) threonine; alternateBy similarity1
Glycosylationi231O-linked (GalNAc...) threonine; alternateBy similarity1
Disulfide bondi244 ↔ 253By similarity
Disulfide bondi260 ↔ 271By similarity
Disulfide bondi265 ↔ 280By similarity
Disulfide bondi282 ↔ 291By similarity
Disulfide bondi298 ↔ 311By similarity
Disulfide bondi305 ↔ 320By similarity
Disulfide bondi322 ↔ 331By similarity
Disulfide bondi338 ↔ 349By similarity
Disulfide bondi343 ↔ 358By similarity
Disulfide bondi360 ↔ 369By similarity
Disulfide bondi375 ↔ 386By similarity
Disulfide bondi380 ↔ 397By similarity
Disulfide bondi399 ↔ 408By similarity
Disulfide bondi415 ↔ 428By similarity
Disulfide bondi422 ↔ 437By similarity
Disulfide bondi439 ↔ 448By similarity
Disulfide bondi455 ↔ 466By similarity
Disulfide bondi460 ↔ 475By similarity
Disulfide bondi477 ↔ 486By similarity
Disulfide bondi493 ↔ 503By similarity
Disulfide bondi498 ↔ 512By similarity
Disulfide bondi514 ↔ 523By similarity
Disulfide bondi530 ↔ 541By similarity
Disulfide bondi535 ↔ 550By similarity
Disulfide bondi552 ↔ 561By similarity
Disulfide bondi568 ↔ 578By similarity
Disulfide bondi573 ↔ 587By similarity
Disulfide bondi589 ↔ 598By similarity
Disulfide bondi605 ↔ 616By similarity
Disulfide bondi610 ↔ 625By similarity
Disulfide bondi627 ↔ 636By similarity
Disulfide bondi643 ↔ 653By similarity
Disulfide bondi648 ↔ 662By similarity
Disulfide bondi664 ↔ 673By similarity
Disulfide bondi680 ↔ 691By similarity
Disulfide bondi685 ↔ 700By similarity
Disulfide bondi702 ↔ 711By similarity
Disulfide bondi718 ↔ 728By similarity
Disulfide bondi723 ↔ 737By similarity
Disulfide bondi739 ↔ 748By similarity
Disulfide bondi755 ↔ 766By similarity
Disulfide bondi760 ↔ 775By similarity
Disulfide bondi777 ↔ 786By similarity
Disulfide bondi793 ↔ 804By similarity
Disulfide bondi798 ↔ 813By similarity
Disulfide bondi815 ↔ 824By similarity
Disulfide bondi831 ↔ 842By similarity
Disulfide bondi836 ↔ 853By similarity
Disulfide bondi855 ↔ 864By similarity
Disulfide bondi871 ↔ 882By similarity
Disulfide bondi876 ↔ 891By similarity
Disulfide bondi893 ↔ 902By similarity
Disulfide bondi909 ↔ 920By similarity
Disulfide bondi914 ↔ 929By similarity
Disulfide bondi931 ↔ 940By similarity
Disulfide bondi947 ↔ 958By similarity
Disulfide bondi952 ↔ 967By similarity
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi969 ↔ 978By similarity
Disulfide bondi985 ↔ 996By similarity
Disulfide bondi990 ↔ 1005By similarity
Disulfide bondi1007 ↔ 1016By similarity
Disulfide bondi1023 ↔ 1034By similarity
Disulfide bondi1028 ↔ 1043By similarity
Disulfide bondi1045 ↔ 1054By similarity
Disulfide bondi1061 ↔ 1072By similarity
Disulfide bondi1066 ↔ 1081By similarity
Disulfide bondi1083 ↔ 1092By similarity
Disulfide bondi1099 ↔ 1120By similarity
Disulfide bondi1114 ↔ 1129By similarity
Disulfide bondi1131 ↔ 1140By similarity
Disulfide bondi1147 ↔ 1158By similarity
Disulfide bondi1152 ↔ 1167By similarity
Disulfide bondi1169 ↔ 1178By similarity
Glycosylationi1177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1185 ↔ 1196By similarity
Disulfide bondi1190 ↔ 1205By similarity
Disulfide bondi1207 ↔ 1216By similarity
Disulfide bondi1223 ↔ 1242By similarity
Disulfide bondi1236 ↔ 1251By similarity
Disulfide bondi1253 ↔ 1262By similarity
Disulfide bondi1269 ↔ 1282By similarity
Disulfide bondi1274 ↔ 1291By similarity
Disulfide bondi1293 ↔ 1302By similarity
Disulfide bondi1309 ↔ 1320By similarity
Disulfide bondi1314 ↔ 1332By similarity
Disulfide bondi1334 ↔ 1343By similarity
Disulfide bondi1350 ↔ 1361By similarity
Disulfide bondi1355 ↔ 1370By similarity
Disulfide bondi1372 ↔ 1381By similarity
Disulfide bondi1389 ↔ 1400By similarity
Disulfide bondi1394 ↔ 1411By similarity
Glycosylationi1399O-linked (Fuc...) threonine; alternateBy similarity1
Glycosylationi1399O-linked (GalNAc...) threonine; alternateBy similarity1
Disulfide bondi1413 ↔ 1422By similarity
Disulfide bondi1447 ↔ 1470By similarity
Disulfide bondi1452 ↔ 1465By similarity
Disulfide bondi1461 ↔ 1477By similarity
Glycosylationi1487N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1488 ↔ 1512By similarity
Disulfide bondi1494 ↔ 1507By similarity
Disulfide bondi1503 ↔ 1519By similarity
Disulfide bondi1526 ↔ 1552By similarity
Disulfide bondi1534 ↔ 1547By similarity
Disulfide bondi1543 ↔ 1559By similarity
Glycosylationi1585N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by adam17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).By similarity
O-glycosylated on the EGF-like domains. Contains both O-linked fucose and O-linked glucose. O-linked glycosylation by galnt11 is involved in determination of left/right symmetry: glycosylation promotes activation of notch1, possibly by promoting cleavage by adam17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1656 – 1657Cleavage; by furin-like proteaseBy similarity2
Sitei1712 – 1713Cleavage; by adam17By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46530

PRoteomics IDEntifications database

More...
PRIDEi
P46530

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in all cells in pregastrulation stages. During gastrulation is differentially expressed, accumulating predominantly in the prechordal mesoderm and notochord. At the end of gastrulation, expressed along the anterior-posterior axis including the developing neural plate and differentiating mesoderm. Also present in the developing brain and head regions.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
78873, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000046632

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P46530

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P46530

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 57EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini58 – 98EGF-like 2PROSITE-ProRule annotationAdd BLAST41
Domaini101 – 138EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini139 – 175EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini177 – 215EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini217 – 254EGF-like 6PROSITE-ProRule annotationAdd BLAST38
Domaini256 – 292EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini294 – 332EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini334 – 370EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini371 – 409EGF-like 10PROSITE-ProRule annotationAdd BLAST39
Domaini411 – 449EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini451 – 487EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini489 – 524EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini526 – 562EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini564 – 599EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini601 – 637EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini639 – 674EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini676 – 712EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini714 – 749EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini751 – 787EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini789 – 825EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini827 – 865EGF-like 22PROSITE-ProRule annotationAdd BLAST39
Domaini867 – 903EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini905 – 941EGF-like 24; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini943 – 979EGF-like 25; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini981 – 1017EGF-like 26PROSITE-ProRule annotationAdd BLAST37
Domaini1019 – 1055EGF-like 27; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1057 – 1093EGF-like 28PROSITE-ProRule annotationAdd BLAST37
Domaini1095 – 1141EGF-like 29PROSITE-ProRule annotationAdd BLAST47
Domaini1143 – 1179EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1181 – 1217EGF-like 31; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1219 – 1263EGF-like 32; calcium-bindingPROSITE-ProRule annotationAdd BLAST45
Domaini1265 – 1303EGF-like 33PROSITE-ProRule annotationAdd BLAST39
Domaini1305 – 1344EGF-like 34PROSITE-ProRule annotationAdd BLAST40
Domaini1346 – 1382EGF-like 35PROSITE-ProRule annotationAdd BLAST37
Domaini1385 – 1423EGF-like 36PROSITE-ProRule annotationAdd BLAST39
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1447 – 1487LNR 1Add BLAST41
Repeati1488 – 1525LNR 2Add BLAST38
Repeati1526 – 1566LNR 3Add BLAST41
Repeati1867 – 1910ANK 1Add BLAST44
Repeati1915 – 1944ANK 2Add BLAST30
Repeati1948 – 1978ANK 3Add BLAST31
Repeati1982 – 2011ANK 4Add BLAST30
Repeati2015 – 2044ANK 5Add BLAST30
Repeati2048 – 2077ANK 6Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2265 – 2276Poly-Gln (OPA repeat)Add BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.Curated

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD9W Eukaryota
COG0666 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234369

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052650

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46530

KEGG Orthology (KO)

More...
KOi
K02599

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46530

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 23 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 4 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01984 NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 32 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 6 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 23 hits
PS00022 EGF_1, 34 hits
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 22 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P46530-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRFLVKLTL LTAASLATVA QGQRCSEYCQ NGGICEYKPS GEASCRCPAD
60 70 80 90 100
FVGAQCQFPN PCNPSPCRNG GVCRPQMQGN EVGVKCDCVL GFSDRLCLTP
110 120 130 140 150
VNHACMNSPC RNGGTCSLLT LDTFTCRCQP GWSGKTCQLA DPCASNPCAN
160 170 180 190 200
GGQCSAFESH YICTCPPNFH GQTCRQDVNE CAVSPSPCRN GGTCINEVGS
210 220 230 240 250
YLCRCPPEYT GPHCQRLYQP CLPSPCRSGG TCVQTSDTTH TCSCLPGFTG
260 270 280 290 300
QTCEHNVDDC TQHACENGGP CIDGINTYNC HCDKHWTGQY CTEDVDECEL
310 320 330 340 350
SPNACQNGGT CHNTIGGFHC VCVNGWTGDD CSENIDDCAS AACSHGATCH
360 370 380 390 400
DRVASFFCEC PHGRTGLLCH LDDACISNPC QKGSNCDTNP VSGKAICTCP
410 420 430 440 450
PGYTGSACNQ DIDECSLGAN PCEHGGRCLN TKGSFQCKCL QGYEGPRCEM
460 470 480 490 500
DVNECKSNPC QNDATCLDQI GGFHCICMPG YEGVFCQINS DDCASQPCLN
510 520 530 540 550
GKCIDKINSF HCECPKGFSG SLCQVDVDEC ASTPCKNGAK CTDGPNKYTC
560 570 580 590 600
ECTPGFSGIH CELDINECAS SPCHYGVCRD GVASFTCDCR PGYTGRLCET
610 620 630 640 650
NINECLSQPC RNGGTCQDRE NAYICTCPKG TTGVNCEINI DDCKRKPCDY
660 670 680 690 700
GKCIDKINGY ECVCEPGYSG SMCNINIDDC ALNPCHNGGT CIDGVNSFTC
710 720 730 740 750
LCPDGFRDAT CLSQHNECSS NPCIHGSCLD QINSYRCVCE AGWMGRNCDI
760 770 780 790 800
NINECLSNPC VNGGTCKDMT SGYLCTCRAG FSGPNCQMNI NECASNPCLN
810 820 830 840 850
QGSCIDDVAG FKCNCMLPYT GEVCENVLAP CSPRPCKNGG VCRESEDFQS
860 870 880 890 900
FSCNCPAGWQ GQTCEVDINE CVRNPCTNGG VCENLRGGFQ CRCNPGFTGA
910 920 930 940 950
LCENDIDDCE PNPCSNGGVC QDRVNGFVCV CLAGFRGERC AEDIDECVSA
960 970 980 990 1000
PCRNGGNCTD CVNSYTCSCP AGFSGINCEI NTPDCTESSC FNGGTCVDGI
1010 1020 1030 1040 1050
SSFSCVCLPG FTGNYCQHDV NECDSRPCQN GGSCQDGYGT YKCTCPHGYT
1060 1070 1080 1090 1100
GLNCQSLVRW CDSSPCKNGG SCWQQGASFT CQCASGWTGI YCDVPSVSCE
1110 1120 1130 1140 1150
VAARQQGVSV AVLCRHAGQC VDAGNTHLCR CQAGYTGSYC QEQVDECQPN
1160 1170 1180 1190 1200
PCQNGATCTD YLGGYSCECV PGYHGMNCSK EINECLSQPC QNGGTCIDLV
1210 1220 1230 1240 1250
NTYKCSCPRG TQGVHCEIDI DDCSPSVDPL TGEPRCFNGG RCVDRVGGYG
1260 1270 1280 1290 1300
CVCPAGFVGE RCEGDVNECL SDPCDPSGSY NCVQLINDFR CECRTGYTGK
1310 1320 1330 1340 1350
RCETVFNGCK DTPCKNGGTC AVASNTKHGY ICKCQPGYSG SSCEYDSQSC
1360 1370 1380 1390 1400
GSLRCRNGAT CVSGHLSPRC LCAPGFSGHE CQTRMDSPCL VNPCYNGGTC
1410 1420 1430 1440 1450
QPISDAPFYR CSCPANFNGL LCHILDYSFS GGQGRDIAPP VEVEIRCEIA
1460 1470 1480 1490 1500
QCEGRGGNAI CDTQCNNHAC GWDGGDCSLN FDDPWQNCSA ALQCWRYFND
1510 1520 1530 1540 1550
GKCDEQCATA GCLYDGFDCQ RLEGQCNPLY DQYCRDHYAD GHCDQGCNNA
1560 1570 1580 1590 1600
ECEWDGLDCA DDVPQKLAVG SLVLVVHIPP DELRNRSSSF LRELSSLLHT
1610 1620 1630 1640 1650
NVVFRRDANG EALIFPYYGS EHELSKHKRS DWTDPGQLMQ RARRSLTSFL
1660 1670 1680 1690 1700
KPRTRRELDH MEVKGSIVYL EIDNRQCFQQ SDECFQSATD VAAFLGALAS
1710 1720 1730 1740 1750
SGNLNVPYII EAVTSEGGPP KTGEMYPMFL VLLALAVLAL AAVGVVVSRK
1760 1770 1780 1790 1800
RKREHGQLWF PEGFKVNEPK KKRREPVGED SVGLKPLKNS DSSLMDEQLS
1810 1820 1830 1840 1850
EWAEDDTNKR FRFEGQSILE MSGQLDHRQW TQQHLDAADL RLNSMAPTPP
1860 1870 1880 1890 1900
QGQIENDCMD VNVRGPDGFT PLMIASCSGG GLENENGEAE EDPSADVITD
1910 1920 1930 1940 1950
FIYHGANLHN QTDRTGETAL HLAARYARSD AAKRLLESCA DANVQDNMGR
1960 1970 1980 1990 2000
TPLHAAVAAD AQGVFQILIR NRATDLDARM HDGTTPLILA TRLAVEGMVE
2010 2020 2030 2040 2050
ELINCHADPN AVDDSGKSAL HWAAAVNNVD AAVVLLKNGA NKDLQNNKEE
2060 2070 2080 2090 2100
TPLFLAAREG SYETAKVLLD HLANRDIADH LDQLPRDIAH ERMHHDIVRL
2110 2120 2130 2140 2150
LEEYNLVRSP PLPLSPPLCC PNTYLGIKPS PGNNNNTAKK TRKPGGKGVG
2160 2170 2180 2190 2200
GKDSGKDIRT KKKKSGDGKN GGIMEVGVLS PVDSLESPHG YLSDVSSPPM
2210 2220 2230 2240 2250
MTSPFQQSPP ISLNQLQGLA DSHMGGALQG LGKPFDSAPR LSHLPVANNV
2260 2270 2280 2290 2300
GGAQAGACDW LQRVQQQQQQ QQQQQQAGML MPTMLSATNM PQVMGYPTMQ
2310 2320 2330 2340 2350
SSHLGAPSHM IAHQNMAPMQ HQNISHHFLG DLSGLDLQSS SGHAPIQTIL
2360 2370 2380 2390 2400
PQDSQRMAPP ISSTQFLTPP SQHSYSNPMD NTPNHQQVPD HPFLTPSAGS
2410 2420 2430
PDQWSSSSPH SNLSDWSEGI SSPPTSMQMN HIPEAFK
Length:2,437
Mass (Da):262,308
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8C21012AA4CA8FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IW83A0A0R4IW83_DANRE
Neurogenic locus notch homolog prot...
notch1a
1,655Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IT11A0A0R4IT11_DANRE
Neurogenic locus notch homolog prot...
notch1a
2,438Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3IS74I3IS74_DANRE
Neurogenic locus notch homolog prot...
notch1a
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69088 mRNA Translation: CAA48831.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S42612

NCBI Reference Sequences

More...
RefSeqi
NP_571516.1, NM_131441.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.137595
Dr.75753

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30718

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:30718

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69088 mRNA Translation: CAA48831.1
PIRiS42612
RefSeqiNP_571516.1, NM_131441.1
UniGeneiDr.137595
Dr.75753

3D structure databases

ProteinModelPortaliP46530
SMRiP46530
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78873, 3 interactors
STRINGi7955.ENSDARP00000046632

Proteomic databases

PaxDbiP46530
PRIDEiP46530

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30718
KEGGidre:30718

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30718
ZFINiZDB-GENE-990415-173 notch1a

Phylogenomic databases

eggNOGiENOG410KD9W Eukaryota
COG0666 LUCA
HOGENOMiHOG000234369
HOVERGENiHBG052650
InParanoidiP46530
KOiK02599
OrthoDBi7525at2759
PhylomeDBiP46530

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P46530

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 23 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 4 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 32 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 6 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 23 hits
PS00022 EGF_1, 34 hits
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 22 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOTC1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46530
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 16, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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