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Protein

26S proteasome regulatory subunit 7

Gene

Psmc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 223ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 7
Alternative name(s):
26S proteasome AAA-ATPase subunit RPT1
Proteasome 26S subunit ATPase 2
Protein MSS1
Gene namesi
Name:Psmc2
Synonyms:Mss1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109555 Psmc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847101 – 43326S proteasome regulatory subunit 7Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei422N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP46471
MaxQBiP46471
PaxDbiP46471
PeptideAtlasiP46471
PRIDEiP46471

2D gel databases

REPRODUCTION-2DPAGEiP46471
SWISS-2DPAGEiP46471

PTM databases

iPTMnetiP46471
PhosphoSitePlusiP46471
SwissPalmiP46471

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80 and SQSTM1. Interacts with PAAF1. Interacts with HIV-1 Tat. Interacts with TRIM5.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP46471, 5 interactors
MINTiP46471
STRINGi10090.ENSMUSP00000030769

Structurei

3D structure databases

ProteinModelPortaliP46471
SMRiP46471
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0729 Eukaryota
COG1222 LUCA
HOVERGENiHBG000109
InParanoidiP46471

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035245 PSMC2
PANTHERiPTHR23073:SF13 PTHR23073:SF13, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P46471-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDYLGADQR KTKEEEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED
60 70 80 90 100
DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK
110 120 130 140 150
IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH
160 170 180 190 200
IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC KEQIEKLREV VETPLLHPER
210 220 230 240 250
FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV IGSELVQKYV
260 270 280 290 300
GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
310 320 330 340 350
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG
360 370 380 390 400
RTHIFKIHAR SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR
410 420 430
RKIATEKDFL EAVNKVIKSY AKFSATPRYM TYN
Length:433
Mass (Da):48,648
Last modified:January 23, 2007 - v5
Checksum:i302E4FA62A48104C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BVQ9Q8BVQ9_MOUSE
26S proteasome regulatory subunit 7
Psmc2
475Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8D → E in AAB51069 (PubMed:9353061).Curated1
Sequence conflicti37 – 40GQST → VQRC in AAB51069 (PubMed:9353061).Curated4
Sequence conflicti37G → A no nucleotide entry (PubMed:8247131).Curated1
Sequence conflicti114N → D in AAB51069 (PubMed:9353061).Curated1
Sequence conflicti122 – 123VV → EE no nucleotide entry (PubMed:8247131).Curated2
Sequence conflicti138M → R in AAB51069 (PubMed:9353061).Curated1
Sequence conflicti148Q → P in AAB51069 (PubMed:9353061).Curated1
Sequence conflicti170P → L no nucleotide entry (PubMed:8247131).Curated1
Sequence conflicti172V → F no nucleotide entry (PubMed:8247131).Curated1
Sequence conflicti188R → L no nucleotide entry (PubMed:8247131).Curated1
Sequence conflicti201F → L no nucleotide entry (PubMed:8247131).Curated1
Sequence conflicti277I → M no nucleotide entry (PubMed:8247131).Curated1
Sequence conflicti369R → G no nucleotide entry (PubMed:8247131).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005083 mRNA Translation: BAB23807.1
AK168548 mRNA Translation: BAE40423.1
BC005462 mRNA Translation: AAH05462.1
U61283 mRNA Translation: AAB51069.1
PIRiS39349
UniGeneiMm.2462

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005083 mRNA Translation: BAB23807.1
AK168548 mRNA Translation: BAE40423.1
BC005462 mRNA Translation: AAH05462.1
U61283 mRNA Translation: AAB51069.1
PIRiS39349
UniGeneiMm.2462

3D structure databases

ProteinModelPortaliP46471
SMRiP46471
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46471, 5 interactors
MINTiP46471
STRINGi10090.ENSMUSP00000030769

PTM databases

iPTMnetiP46471
PhosphoSitePlusiP46471
SwissPalmiP46471

2D gel databases

REPRODUCTION-2DPAGEiP46471
SWISS-2DPAGEiP46471

Proteomic databases

EPDiP46471
MaxQBiP46471
PaxDbiP46471
PeptideAtlasiP46471
PRIDEiP46471

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109555 Psmc2

Phylogenomic databases

eggNOGiKOG0729 Eukaryota
COG1222 LUCA
HOVERGENiHBG000109
InParanoidiP46471

Miscellaneous databases

ChiTaRSiPsmc2 mouse
PROiPR:P46471
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035245 PSMC2
PANTHERiPTHR23073:SF13 PTHR23073:SF13, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRS7_MOUSE
AccessioniPrimary (citable) accession number: P46471
Secondary accession number(s): O08531, Q3TGX5, Q9DBA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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