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Entry version 106 (08 May 2019)
Sequence version 2 (15 Mar 2004)
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Protein

Putative cell division cycle ATPase

Gene

PF07_0047

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi568 – 575ATPSequence analysis8
Nucleotide bindingi975 – 982ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PF07_0047-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.25.2.1 the symbiont-specific erad-like machinery (selma) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative cell division cycle ATPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF07_0047
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0711000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845931 – 1229Putative cell division cycle ATPaseAdd BLAST1229

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P46468

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P46468

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
1209952, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P46468, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P46468

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46468

KEGG Orthology (KO)

More...
KOi
K13525

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCSIFKA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46468

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR041569 AAA_lid_3
IPR009010 Asp_de-COase-like_dom_sf
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR029067 CDC48_domain_2-like_sf
IPR003338 CDC4_N-term_subdom
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004 AAA, 2 hits
PF17862 AAA_lid_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits
SM01073 CDC48_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50692 SSF50692, 1 hit
SSF52540 SSF52540, 2 hits
SSF54585 SSF54585, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674 AAA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46468-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVRKMHYPL FSFTEYLSCY IILYFFVFLP NYSYAININN YHNKNNLWNI
60 70 80 90 100
NNKWNNQQSN HFSNNRIGHF LWGSKIRKNP LASISTSITT KKLENQKKKT
110 120 130 140 150
NKNESYSNVN DKYEHNNNTA HFVQINYKND QSNDTLSTYK NNNEMTVEGK
160 170 180 190 200
PNNLASGEGK KEIHNTTQKI LEKVDYFKER EKITNSYNNN NNNNKVIVTH
210 220 230 240 250
DNKNHTNYIN KVENKQSDDK IKNLNNKYIK KFKSHILQND ILGTISTMFW
260 270 280 290 300
SGKKNNNGNV KKGIKNVPMD EKSYSPNDHD NNSNNSNNNN NNDNNNSNNN
310 320 330 340 350
NNNNNGGKNN SYYNEKTQKG VNDKETNFLL KALDSGKFPT YCLVENIDEN
360 370 380 390 400
LDNFDIYMSK EKMDELNIND GATVLLKGKK KREMLGIARL DRSLKKHYVV
410 420 430 440 450
ISFAMKKNLR LMHNDIIKIH PFMNAKRIRN VVLSPFSDTI PNLSREELEK
460 470 480 490 500
AVIHPYLKNS YKPLRVNSNI YIYYKNNKIE FKVLKIISEE SENEEFGCIG
510 520 530 540 550
EHSQLTLAEE YLKREDYEEN NDDITYEDLG GMKKQLNKIR ELIELPLKYP
560 570 580 590 600
EIFMSIGISA PKGVLMHGIP GTGKTSIAKA IANESNAYCY IINGPEIMSK
610 620 630 640 650
HIGESEQKLR KIFKKASEKT PCIIFIDEID SIANKRSKSN NELEKRVVSQ
660 670 680 690 700
LLTLMDGLKK NNNVLVLAAT NRPNSIDPAL RRFGRFDREI EIPVPDEQGR
710 720 730 740 750
YEILLTKTKK MKLDPDVNLR KIAKECHGYV GADLAQLCFE AAIQCIKEHI
760 770 780 790 800
HFLDLDEEDF IEFMKISVDE DKKNMGNEPY GSSHTNNSNY INHLTESSNK
810 820 830 840 850
LSYTNMFPLN RKNTLLQNDK NEMNKDSSYD KKTDALDNYK NDSTIDMEKK
860 870 880 890 900
KNKKKSNFFF SNDDEETKNK NKTNVNQKKK KNPNDKLDKN ERRIPAYILN
910 920 930 940 950
KLTIKAKHFQ HALNICNPSS LRERQVQIPT VTWNDIGGMN EVKEQLKETI
960 970 980 990 1000
LYPLEYKHLY NKFNSNYNKG ILLYGPPGCG KTLLAKAIAN ECKANFISVK
1010 1020 1030 1040 1050
GPELLTMWFG ESEANVRDLF DKARAASPCI IFFDEIDSLA KERNSNTNND
1060 1070 1080 1090 1100
ASDRVINQIL TEIDGINEKK TIFIIAATNR PDILDKALTR PGRLDKLIYI
1110 1120 1130 1140 1150
SLPDLKSRYS IFKAILKNTP LNEDVDIHDM AKRTEGFSGA DITNLCQSAV
1160 1170 1180 1190 1200
NEAIKETIHL LNIRKKEQEE QRKKNKNSFK IDDTDTYDPV PTLSKKHFDL
1210 1220
AFKNARISIQ PEDVLKYEKF KEKLSLQDF
Length:1,229
Mass (Da):142,080
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DA03A25EA4E4FA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti834D → N in AAA29520 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844506 Genomic DNA Translation: CAD50861.1
M96757 Genomic DNA Translation: AAA29520.1

NCBI Reference Sequences

More...
RefSeqi
XP_001349023.1, XM_001348987.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD50861; CAD50861; PF3D7_0711000

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0711000.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2655095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0711000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844506 Genomic DNA Translation: CAD50861.1
M96757 Genomic DNA Translation: AAA29520.1
RefSeqiXP_001349023.1, XM_001348987.1

3D structure databases

SMRiP46468
ModBaseiSearch...

Protein-protein interaction databases

BioGridi1209952, 1 interactor
IntActiP46468, 1 interactor

Protein family/group databases

TCDBi3.A.25.2.1 the symbiont-specific erad-like machinery (selma) family

PTM databases

SwissPalmiP46468

Proteomic databases

PRIDEiP46468

Genome annotation databases

EnsemblProtistsiCAD50861; CAD50861; PF3D7_0711000
GeneDBiPF3D7_0711000.1:pep
GeneIDi2655095
KEGGipfa:PF3D7_0711000

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0711000

Phylogenomic databases

InParanoidiP46468
KOiK13525
OMAiRCSIFKA
PhylomeDBiP46468

Enzyme and pathway databases

BioCyciPLASMO:PF07_0047-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR041569 AAA_lid_3
IPR009010 Asp_de-COase-like_dom_sf
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR029067 CDC48_domain_2-like_sf
IPR003338 CDC4_N-term_subdom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 2 hits
PF17862 AAA_lid_3, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM01073 CDC48_N, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF52540 SSF52540, 2 hits
SSF54585 SSF54585, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDAT_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46468
Secondary accession number(s): Q8IBY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 15, 2004
Last modified: May 8, 2019
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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