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UniProtKB - P46468 (CDAT_PLAF7)

Entry version 115 (02 Jun 2021)
Sequence version 2 (15 Mar 2004)
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Protein

Putative cell division cycle ATPase

Gene

PF07_0047

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi568 – 575ATPSequence analysis8
Nucleotide bindingi975 – 982ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.25.2.1, the symbiont-specific erad-like machinery (selma) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative cell division cycle ATPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF07_0047
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		PlasmoDB:PF3D7_0711000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845931 – 1229Putative cell division cycle ATPaseAdd BLAST1229

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P46468

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P46468

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		1209952, 1 interactor

Protein interaction database and analysis system

More...IntActi		P46468, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni252 – 315DisorderedSequence analysisAdd BLAST64
Regioni814 – 837DisorderedSequence analysisAdd BLAST24
Regioni860 – 892DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi278 – 315Polar residuesSequence analysisAdd BLAST38
Compositional biasi823 – 837Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000688_12_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46468

Identification of Orthologs from Complete Genome Data

More...OMAi		RCSIFKA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46468

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR009010, Asp_de-COase-like_dom_sf
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR029067, CDC48_domain_2-like_sf
IPR003338, CDC4_N-term_subdom
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 2 hits
PF17862, AAA_lid_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits
SM01073, CDC48_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50692, SSF50692, 1 hit
SSF52540, SSF52540, 2 hits
SSF54585, SSF54585, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00674, AAA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46468-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVRKMHYPL FSFTEYLSCY IILYFFVFLP NYSYAININN YHNKNNLWNI 
        60         70         80         90        100
NNKWNNQQSN HFSNNRIGHF LWGSKIRKNP LASISTSITT KKLENQKKKT 
       110        120        130        140        150
NKNESYSNVN DKYEHNNNTA HFVQINYKND QSNDTLSTYK NNNEMTVEGK 
       160        170        180        190        200
PNNLASGEGK KEIHNTTQKI LEKVDYFKER EKITNSYNNN NNNNKVIVTH 
       210        220        230        240        250
DNKNHTNYIN KVENKQSDDK IKNLNNKYIK KFKSHILQND ILGTISTMFW 
       260        270        280        290        300
SGKKNNNGNV KKGIKNVPMD EKSYSPNDHD NNSNNSNNNN NNDNNNSNNN 
       310        320        330        340        350
NNNNNGGKNN SYYNEKTQKG VNDKETNFLL KALDSGKFPT YCLVENIDEN 
       360        370        380        390        400
LDNFDIYMSK EKMDELNIND GATVLLKGKK KREMLGIARL DRSLKKHYVV 
       410        420        430        440        450
ISFAMKKNLR LMHNDIIKIH PFMNAKRIRN VVLSPFSDTI PNLSREELEK 
       460        470        480        490        500
AVIHPYLKNS YKPLRVNSNI YIYYKNNKIE FKVLKIISEE SENEEFGCIG 
       510        520        530        540        550
EHSQLTLAEE YLKREDYEEN NDDITYEDLG GMKKQLNKIR ELIELPLKYP 
       560        570        580        590        600
EIFMSIGISA PKGVLMHGIP GTGKTSIAKA IANESNAYCY IINGPEIMSK 
       610        620        630        640        650
HIGESEQKLR KIFKKASEKT PCIIFIDEID SIANKRSKSN NELEKRVVSQ 
       660        670        680        690        700
LLTLMDGLKK NNNVLVLAAT NRPNSIDPAL RRFGRFDREI EIPVPDEQGR 
       710        720        730        740        750
YEILLTKTKK MKLDPDVNLR KIAKECHGYV GADLAQLCFE AAIQCIKEHI 
       760        770        780        790        800
HFLDLDEEDF IEFMKISVDE DKKNMGNEPY GSSHTNNSNY INHLTESSNK 
       810        820        830        840        850
LSYTNMFPLN RKNTLLQNDK NEMNKDSSYD KKTDALDNYK NDSTIDMEKK 
       860        870        880        890        900
KNKKKSNFFF SNDDEETKNK NKTNVNQKKK KNPNDKLDKN ERRIPAYILN 
       910        920        930        940        950
KLTIKAKHFQ HALNICNPSS LRERQVQIPT VTWNDIGGMN EVKEQLKETI 
       960        970        980        990       1000
LYPLEYKHLY NKFNSNYNKG ILLYGPPGCG KTLLAKAIAN ECKANFISVK 
      1010       1020       1030       1040       1050
GPELLTMWFG ESEANVRDLF DKARAASPCI IFFDEIDSLA KERNSNTNND 
      1060       1070       1080       1090       1100
ASDRVINQIL TEIDGINEKK TIFIIAATNR PDILDKALTR PGRLDKLIYI 
      1110       1120       1130       1140       1150
SLPDLKSRYS IFKAILKNTP LNEDVDIHDM AKRTEGFSGA DITNLCQSAV 
      1160       1170       1180       1190       1200
NEAIKETIHL LNIRKKEQEE QRKKNKNSFK IDDTDTYDPV PTLSKKHFDL 
      1210       1220 
AFKNARISIQ PEDVLKYEKF KEKLSLQDF
Length:1,229
Mass (Da):142,080
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DA03A25EA4E4FA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti834D → N in AAA29520 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL844506 Genomic DNA Translation: CAD50861.1
M96757 Genomic DNA Translation: AAA29520.1

NCBI Reference Sequences

More...RefSeqi		XP_001349023.1, XM_001348987.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CAD50861; CAD50861; PF3D7_0711000

GeneDB pathogen genome database from Sanger Institute

More...GeneDBi		PF3D7_0711000.1:pep

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2655095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pfa:PF3D7_0711000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844506 Genomic DNA Translation: CAD50861.1
M96757 Genomic DNA Translation: AAA29520.1
RefSeqiXP_001349023.1, XM_001348987.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi1209952, 1 interactor
IntActiP46468, 1 interactor

Protein family/group databases

TCDBi3.A.25.2.1, the symbiont-specific erad-like machinery (selma) family

PTM databases

SwissPalmiP46468

Proteomic databases

PRIDEiP46468

Genome annotation databases

EnsemblProtistsiCAD50861; CAD50861; PF3D7_0711000
GeneDBiPF3D7_0711000.1:pep
GeneIDi2655095
KEGGipfa:PF3D7_0711000

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0711000

Phylogenomic databases

HOGENOMiCLU_000688_12_3_1
InParanoidiP46468
OMAiRCSIFKA
PhylomeDBiP46468

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR009010, Asp_de-COase-like_dom_sf
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR029067, CDC48_domain_2-like_sf
IPR003338, CDC4_N-term_subdom
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 2 hits
PF17862, AAA_lid_3, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SM01073, CDC48_N, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
SSF52540, SSF52540, 2 hits
SSF54585, SSF54585, 1 hit
PROSITEiView protein in PROSITE
PS00674, AAA, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDAT_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46468
Secondary accession number(s): Q8IBY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 15, 2004
Last modified: June 2, 2021
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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