UniProtKB - P46462 (TERA_RAT)
Transitional endoplasmic reticulum ATPase
Vcp
Functioni
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER) (PubMed:10930451, PubMed:12411482).
Vesicle budding from the tER is an ATP-dependent process (PubMed:10930451, PubMed:12411482).
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome (PubMed:10930451, PubMed:12411482).
The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of stress granules (SGs) clearance process upon arsenite-induced response (By similarity).
Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (By similarity).
May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity).
May more particularly play a role in caveolins sorting in cells (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (By similarity).
By similarity2 PublicationsCatalytic activityi
- EC:3.6.4.6By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 348 | ATP 1By similarity | 1 | |
Binding sitei | 384 | ATP 1By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 247 – 253 | ATP 1By similarity | 7 | |
Nucleotide bindingi | 521 – 526 | ATP 2By similarity | 6 |
GO - Molecular functioni
- ADP binding Source: RGD
- ATP binding Source: BHF-UCL
- ATP hydrolysis activity Source: RGD
- BAT3 complex binding Source: RGD
- deubiquitinase activator activity Source: RGD
- identical protein binding Source: BHF-UCL
- K48-linked polyubiquitin modification-dependent protein binding Source: RGD
- lipid binding Source: UniProtKB-KW
- MHC class I protein binding Source: RGD
- polyubiquitin modification-dependent protein binding Source: RGD
- protein-containing complex binding Source: RGD
- protein domain specific binding Source: RGD
- protein phosphatase binding Source: RGD
- ubiquitin-like protein ligase binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
- ubiquitin-specific protease binding Source: RGD
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
- aggresome assembly Source: RGD
- ATP metabolic process Source: RGD
- autophagosome maturation Source: UniProtKB
- autophagy Source: UniProtKB
- cellular response to arsenite ion Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to heat Source: UniProtKB
- DNA repair Source: UniProtKB
- double-strand break repair Source: UniProtKB
- endoplasmic reticulum stress-induced pre-emptive quality control Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: RGD
- endosome to lysosome transport via multivesicular body sorting pathway Source: UniProtKB
- ERAD pathway Source: UniProtKB
- ER-associated misfolded protein catabolic process Source: RGD
- flavin adenine dinucleotide catabolic process Source: RGD
- interstrand cross-link repair Source: UniProtKB
- macroautophagy Source: UniProtKB
- mitotic spindle disassembly Source: GO_Central
- NADH metabolic process Source: RGD
- negative regulation of smoothened signaling pathway Source: RGD
- positive regulation of ATP biosynthetic process Source: RGD
- positive regulation of canonical Wnt signaling pathway Source: RGD
- positive regulation of Lys63-specific deubiquitinase activity Source: RGD
- positive regulation of mitochondrial membrane potential Source: RGD
- positive regulation of oxidative phosphorylation Source: RGD
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: RGD
- positive regulation of protein catabolic process Source: RGD
- positive regulation of protein-containing complex assembly Source: RGD
- positive regulation of protein K63-linked deubiquitination Source: RGD
- positive regulation of ubiquitin-dependent protein catabolic process Source: RGD
- proteasomal protein catabolic process Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein-DNA covalent cross-linking repair Source: UniProtKB
- protein ubiquitination Source: UniProtKB
- regulation of aerobic respiration Source: RGD
- regulation of protein localization to chromatin Source: UniProtKB
- regulation of synapse organization Source: SynGO
- retrograde protein transport, ER to cytosol Source: RGD
- stress granule disassembly Source: UniProtKB
- translesion synthesis Source: UniProtKB
- ubiquitin-dependent ERAD pathway Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: RGD
- viral genome replication Source: RGD
Keywordsi
Molecular function | Hydrolase |
Biological process | Autophagy, DNA damage, DNA repair, Transport |
Ligand | ATP-binding, Lipid-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.4.6, 5301 |
Reactomei | R-RNO-110320, Translesion Synthesis by POLH R-RNO-3371511, HSF1 activation R-RNO-382556, ABC-family proteins mediated transport R-RNO-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-RNO-5358346, Hedgehog ligand biogenesis R-RNO-5689877, Josephin domain DUBs R-RNO-5689896, Ovarian tumor domain proteases R-RNO-6798695, Neutrophil degranulation R-RNO-9013407, RHOH GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Transitional endoplasmic reticulum ATPase (EC:3.6.4.6By similarity)Short name: TER ATPase Alternative name(s): 15S Mg(2+)-ATPase p97 subunit Valosin-containing protein Short name: VCP |
Gene namesi | Name:Vcp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621595, Vcp |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- cytosol 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Other locations
- Stress granule By similarity
Note: Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN. Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. Colocalizes with TIA1, ZFAND1 and G3BP1 in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment (By similarity).By similarity
Cytosol
- cytosol Source: ParkinsonsUK-UCL
Endoplasmic reticulum
- Derlin-1 retrotranslocation complex Source: RGD
- endoplasmic reticulum Source: RGD
- endoplasmic reticulum membrane Source: RGD
- VCP-NPL4-UFD1 AAA ATPase complex Source: ParkinsonsUK-UCL
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- ATPase complex Source: RGD
- cytoplasm Source: RGD
- cytoplasmic stress granule Source: UniProtKB
- glutamatergic synapse Source: SynGO
- intracellular membrane-bounded organelle Source: RGD
- lipid droplet Source: RGD
- perinuclear region of cytoplasm Source: RGD
- proteasome complex Source: RGD
- protein-containing complex Source: RGD
- site of double-strand break Source: UniProtKB
- synapse Source: RGD
- VCP-NSFL1C complex Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000084575 | 2 – 806 | Transitional endoplasmic reticulum ATPaseAdd BLAST | 805 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Cross-linki | 18 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Modified residuei | 315 | N6,N6,N6-trimethyllysine; by VCPKMTBy similarity | 1 | |
Modified residuei | 436 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 462 | PhosphoserineBy similarity | 1 | |
Modified residuei | 502 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 505 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 668 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 668 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 702 | PhosphoserineBy similarity | 1 | |
Modified residuei | 754 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 770 | PhosphoserineBy similarity | 1 | |
Modified residuei | 775 | PhosphoserineBy similarity | 1 | |
Modified residuei | 787 | PhosphoserineBy similarity | 1 | |
Modified residuei | 805 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P46462 |
PaxDbi | P46462 |
PRIDEi | P46462 |
2D gel databases
World-2DPAGEi | 0004:P46462 |
PTM databases
iPTMneti | P46462 |
PhosphoSitePlusi | P46462 |
SwissPalmi | P46462 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000034242, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | P46462, RN |
Interactioni
Subunit structurei
Homohexamer.
Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry.
Interacts with NSFL1C-like protein p37; the complex has membrane fusion activity and is required for Golgi and endoplasmic reticulum biogenesis.
Interacts with RHBDD1 (via C-terminal domain).
Interacts with SELENOS and SYVN1, as well as with DERL1 (via SHP-box motif), DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP.
Interacts with SVIP.
Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXN4 and RNF19A.
Interacts with CASR.
Interacts with UBE4B and YOD1.
Interacts with clathrin.
Interacts with RNF103.
Interacts with TRIM13 and TRIM21.
Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmic reticulum-associated degradation (ERAD) of HMGCR.
Interacts directly with AMFR/gp78 (via its VIM).
Interacts with SPRTN; leading to recruitment to stalled replication forks.
Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Binds to a heterodimer of NPLOC4 and UFD1, binding to this heterodimer inhibits Golgi-membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP.
Part of a ternary complex containing NPLOC4, UFD1 and VCP.
Interacts with WASHC5.
Interacts with UBOX5.
Interacts (via N-terminus) with UBXN7, UBXN8, and probably several other UBX domain-containing proteins (via UBX domains); the interactions are mutually exclusive with VIM-dependent interactions such as those with AMFR and SELENOS.
Forms a complex with UBQLN1 and UBXN4 (By similarity).
Interacts (via the PIM motif) with RNF31 (via the PUB domain) (By similarity).
Interacts with DDX58/RIG-I and RNF125; interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (By similarity).
Interacts with BAG6 (By similarity).
Interacts with UBXN10 (By similarity).
Interacts with UBXN6; the interaction with UBXN6 is direct and competitive with UFD1 (By similarity).
Forms a ternary complex with CAV1 and UBXN6.
Interacts with PLAA, UBXN6 and YOD1; may form a complex involved in macroautophagy (By similarity).
Interacts with ANKZF1 (By similarity).
Interacts with ubiquitin-binding protein FAF1 (By similarity).
Interacts with ZFAND2B (via VIM motif); the interaction is direct (By similarity).
Interacts with ZFAND1 (via its ubiquitin-like region); this interaction occurs in an arsenite-dependent manner (By similarity).
Interacts with CCDC47 (By similarity).
Interacts with LMBR1L and UBAC2 (By similarity).
Interacts with ATXN3 (By similarity).
Interacts with TEX264; bridging VCP to covalent DNA-protein cross-links (DPCs) (By similarity).
By similarity4 PublicationsBinary interactionsi
P46462
With | #Exp. | IntAct |
---|---|---|
Nsfl1c [O35987] | 12 | EBI-399011,EBI-1993760 |
GO - Molecular functioni
- identical protein binding Source: BHF-UCL
- K48-linked polyubiquitin modification-dependent protein binding Source: RGD
- MHC class I protein binding Source: RGD
- polyubiquitin modification-dependent protein binding Source: RGD
- protein domain specific binding Source: RGD
- protein phosphatase binding Source: RGD
- ubiquitin-like protein ligase binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
- ubiquitin-specific protease binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 250528, 28 interactors |
ComplexPortali | CPX-138, Vcp-Npl4-Ufd1 AAA ATPase complex CPX-263, Nsfl1c-Vcp complex |
CORUMi | P46462 |
IntActi | P46462, 11 interactors |
MINTi | P46462 |
STRINGi | 10116.ENSRNOP00000040121 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 708 – 727 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 768 – 806 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 797 – 806 | Interaction with UBXN6By similarity | 10 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 802 – 806 | PIM motifBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 768 – 794 | Polar residuesSequence analysisAdd BLAST | 27 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0730, Eukaryota |
GeneTreei | ENSGT00900000141071 |
HOGENOMi | CLU_000688_12_3_1 |
InParanoidi | P46462 |
OMAi | WINPPDF |
OrthoDBi | 194195at2759 |
PhylomeDBi | P46462 |
TreeFami | TF300542 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR005938, AAA_ATPase_CDC48 IPR041569, AAA_lid_3 IPR009010, Asp_de-COase-like_dom_sf IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR004201, Cdc48_dom2 IPR029067, CDC48_domain_2-like_sf IPR003338, CDC4_N-term_subdom IPR027417, P-loop_NTPase IPR015415, Vps4_C |
Pfami | View protein in Pfam PF00004, AAA, 2 hits PF17862, AAA_lid_3, 2 hits PF02933, CDC48_2, 1 hit PF02359, CDC48_N, 1 hit PF09336, Vps4_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01072, CDC48_2, 1 hit SM01073, CDC48_N, 1 hit |
SUPFAMi | SSF50692, SSF50692, 1 hit SSF52540, SSF52540, 2 hits SSF54585, SSF54585, 1 hit |
TIGRFAMsi | TIGR01243, CDC48, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ
60 70 80 90 100
LFRGDTVLLK GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI
110 120 130 140 150
SIQPCPDVKY GKRIHVLPID DTVEGITGNL FEVYLKPYFL EAYRPIRKGD
160 170 180 190 200
IFLVRGGMRA VEFKVVETDP SPYCIVAPDT VIHCEGEPIK REDEEESLNE
210 220 230 240 250
VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG ILLYGPPGTG
260 270 280 290 300
KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI
310 320 330 340 350
IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP
360 370 380 390 400
NSIDPALRRF GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA
410 420 430 440 450
NETHGHVGAD LAALCSEAAL QAIRKKMDLI DLEDETIDAE VMNSLAVTMD
460 470 480 490 500
DFRWALSQSN PSALRETVVE VPQVTWEDIG GLEDVKRELQ ELVQYPVEHP
510 520 530 540 550
DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI SIKGPELLTM
560 570 580 590 600
WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV
610 620 630 640 650
INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE
660 670 680 690 700
KSRVAILKAN LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR
710 720 730 740 750
ESIESEIRRE RERQTNPSAM EVEEDDPVPE IRRDHFEEAM RFARRSVSDN
760 770 780 790 800
DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG AGPSQGSGGG TGGNVYTEDN
DDDLYG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11760 mRNA Translation: AAC52154.1 BC060518 mRNA Translation: AAH60518.1 |
PIRi | A55190 |
RefSeqi | NP_446316.1, NM_053864.2 |
Genome annotation databases
Ensembli | ENSRNOT00000046102; ENSRNOP00000040121; ENSRNOG00000034242 |
GeneIDi | 116643 |
KEGGi | rno:116643 |
UCSCi | RGD:621595, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11760 mRNA Translation: AAC52154.1 BC060518 mRNA Translation: AAH60518.1 |
PIRi | A55190 |
RefSeqi | NP_446316.1, NM_053864.2 |
3D structure databases
SMRi | P46462 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250528, 28 interactors |
ComplexPortali | CPX-138, Vcp-Npl4-Ufd1 AAA ATPase complex CPX-263, Nsfl1c-Vcp complex |
CORUMi | P46462 |
IntActi | P46462, 11 interactors |
MINTi | P46462 |
STRINGi | 10116.ENSRNOP00000040121 |
PTM databases
iPTMneti | P46462 |
PhosphoSitePlusi | P46462 |
SwissPalmi | P46462 |
2D gel databases
World-2DPAGEi | 0004:P46462 |
Proteomic databases
jPOSTi | P46462 |
PaxDbi | P46462 |
PRIDEi | P46462 |
Genome annotation databases
Ensembli | ENSRNOT00000046102; ENSRNOP00000040121; ENSRNOG00000034242 |
GeneIDi | 116643 |
KEGGi | rno:116643 |
UCSCi | RGD:621595, rat |
Organism-specific databases
CTDi | 7415 |
RGDi | 621595, Vcp |
Phylogenomic databases
eggNOGi | KOG0730, Eukaryota |
GeneTreei | ENSGT00900000141071 |
HOGENOMi | CLU_000688_12_3_1 |
InParanoidi | P46462 |
OMAi | WINPPDF |
OrthoDBi | 194195at2759 |
PhylomeDBi | P46462 |
TreeFami | TF300542 |
Enzyme and pathway databases
BRENDAi | 3.6.4.6, 5301 |
Reactomei | R-RNO-110320, Translesion Synthesis by POLH R-RNO-3371511, HSF1 activation R-RNO-382556, ABC-family proteins mediated transport R-RNO-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-RNO-5358346, Hedgehog ligand biogenesis R-RNO-5689877, Josephin domain DUBs R-RNO-5689896, Ovarian tumor domain proteases R-RNO-6798695, Neutrophil degranulation R-RNO-9013407, RHOH GTPase cycle |
Miscellaneous databases
PROi | PR:P46462 |
Gene expression databases
Bgeei | ENSRNOG00000034242, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | P46462, RN |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR005938, AAA_ATPase_CDC48 IPR041569, AAA_lid_3 IPR009010, Asp_de-COase-like_dom_sf IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR004201, Cdc48_dom2 IPR029067, CDC48_domain_2-like_sf IPR003338, CDC4_N-term_subdom IPR027417, P-loop_NTPase IPR015415, Vps4_C |
Pfami | View protein in Pfam PF00004, AAA, 2 hits PF17862, AAA_lid_3, 2 hits PF02933, CDC48_2, 1 hit PF02359, CDC48_N, 1 hit PF09336, Vps4_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01072, CDC48_2, 1 hit SM01073, CDC48_N, 1 hit |
SUPFAMi | SSF50692, SSF50692, 1 hit SSF52540, SSF52540, 2 hits SSF54585, SSF54585, 1 hit |
TIGRFAMsi | TIGR01243, CDC48, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TERA_RAT | |
Accessioni | P46462Primary (citable) accession number: P46462 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families