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UniProtKB - P46439 (GSTM5_HUMAN)
Protein
Glutathione S-transferase Mu 5
Gene
GSTM5
Organism
Homo sapiens (Human)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
1 PublicationCatalytic activityi
- EC:2.5.1.181 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- glutathione transferase activity Source: UniProtKB
- identical protein binding Source: IntAct
GO - Biological processi
- glutathione metabolic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 2681 |
PathwayCommonsi | P46439 |
Reactomei | R-HSA-156590, Glutathione conjugation |
SABIO-RKi | P46439 |
SignaLinki | P46439 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase Mu 5 (EC:2.5.1.18)Alternative name(s): GST class-mu 5 GSTM5-5 |
Gene namesi | Name:GSTM5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4637, GSTM5 |
MIMi | 138385, gene |
neXtProti | NX_P46439 |
VEuPathDBi | HostDB:ENSG00000134201 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- intercellular bridge Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 2949 |
OpenTargetsi | ENSG00000134201 |
PharmGKBi | PA29027 |
Miscellaneous databases
Pharosi | P46439, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2819 |
DrugBanki | DB00143, Glutathione DB03310, Glutathione disulfide |
Genetic variation databases
BioMutai | GSTM5 |
DMDMi | 67476963 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185825 | 1 – 218 | Glutathione S-transferase Mu 5Add BLAST | 218 |
Proteomic databases
jPOSTi | P46439 |
MassIVEi | P46439 |
PaxDbi | P46439 |
PeptideAtlasi | P46439 |
PRIDEi | P46439 |
ProteomicsDBi | 55739 |
PTM databases
iPTMneti | P46439 |
PhosphoSitePlusi | P46439 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134201, Expressed in right ovary and 196 other tissues |
ExpressionAtlasi | P46439, baseline and differential |
Genevisiblei | P46439, HS |
Organism-specific databases
HPAi | ENSG00000134201, Tissue enriched (breast) |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
P46439
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 109204, 13 interactors |
IntActi | P46439, 9 interactors |
STRINGi | 9606.ENSP00000256593 |
Miscellaneous databases
RNActi | P46439, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 88 | GST N-terminalAdd BLAST | 87 | |
Domaini | 90 – 207 | GST C-terminalAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 8 | Glutathione bindingBy similarity | 2 | |
Regioni | 46 – 50 | Glutathione bindingBy similarity | 5 | |
Regioni | 59 – 60 | Glutathione bindingBy similarity | 2 | |
Regioni | 72 – 73 | Glutathione bindingBy similarity | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000155416 |
HOGENOMi | CLU_039475_2_0_1 |
InParanoidi | P46439 |
OMAi | RIRMDIL |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P46439 |
TreeFami | TF353040 |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR003081, GST_mu IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01267, GSTRNSFRASEM |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P46439-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPMTLGYWDI RGLAHAIRLL LEYTDSSYVE KKYTLGDAPD YDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGAHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL
110 120 130 140 150
ENQVMDNHME LVRLCYDPDF EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFLA YDVLDMKRIF EPKCLDAFLN LKDFISRFEG LKKISAYMKS
210
SQFLRGLLFG KSATWNSK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T8R1 | Q5T8R1_HUMAN | Glutathione S-transferase | GSTM5 | 218 | Annotation score: | ||
A0A3B3IRM5 | A0A3B3IRM5_HUMAN | Glutathione S-transferase | GSTM5 | 189 | Annotation score: | ||
A0A3B3IU61 | A0A3B3IU61_HUMAN | Glutathione S-transferase Mu 5 | GSTM5 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 | L → M in AAA20040 (PubMed:8473333).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065098 | 67 | A → T2 PublicationsCorresponds to variant dbSNP:rs17854972Ensembl. | 1 | |
Natural variantiVAR_049491 | 179 | L → P. Corresponds to variant dbSNP:rs2227963Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02321 mRNA Translation: AAA20040.1 AK289673 mRNA Translation: BAF82362.1 BC058881 mRNA Translation: AAH58881.1 |
CCDSi | CCDS811.1 |
PIRi | A46048 |
RefSeqi | NP_000842.2, NM_000851.3 XP_005270841.1, XM_005270784.4 |
Genome annotation databases
Ensembli | ENST00000256593; ENSP00000256593; ENSG00000134201 |
GeneIDi | 2949 |
KEGGi | hsa:2949 |
MANE-Selecti | ENST00000256593.8; ENSP00000256593.3; NM_000851.4; NP_000842.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02321 mRNA Translation: AAA20040.1 AK289673 mRNA Translation: BAF82362.1 BC058881 mRNA Translation: AAH58881.1 |
CCDSi | CCDS811.1 |
PIRi | A46048 |
RefSeqi | NP_000842.2, NM_000851.3 XP_005270841.1, XM_005270784.4 |
3D structure databases
SMRi | P46439 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109204, 13 interactors |
IntActi | P46439, 9 interactors |
STRINGi | 9606.ENSP00000256593 |
Chemistry databases
ChEMBLi | CHEMBL2819 |
DrugBanki | DB00143, Glutathione DB03310, Glutathione disulfide |
PTM databases
iPTMneti | P46439 |
PhosphoSitePlusi | P46439 |
Genetic variation databases
BioMutai | GSTM5 |
DMDMi | 67476963 |
Proteomic databases
jPOSTi | P46439 |
MassIVEi | P46439 |
PaxDbi | P46439 |
PeptideAtlasi | P46439 |
PRIDEi | P46439 |
ProteomicsDBi | 55739 |
Protocols and materials databases
Antibodypediai | 20076, 193 antibodies from 30 providers |
DNASUi | 2949 |
Genome annotation databases
Ensembli | ENST00000256593; ENSP00000256593; ENSG00000134201 |
GeneIDi | 2949 |
KEGGi | hsa:2949 |
MANE-Selecti | ENST00000256593.8; ENSP00000256593.3; NM_000851.4; NP_000842.2 |
Organism-specific databases
CTDi | 2949 |
DisGeNETi | 2949 |
GeneCardsi | GSTM5 |
HGNCi | HGNC:4637, GSTM5 |
HPAi | ENSG00000134201, Tissue enriched (breast) |
MIMi | 138385, gene |
neXtProti | NX_P46439 |
OpenTargetsi | ENSG00000134201 |
PharmGKBi | PA29027 |
VEuPathDBi | HostDB:ENSG00000134201 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000155416 |
HOGENOMi | CLU_039475_2_0_1 |
InParanoidi | P46439 |
OMAi | RIRMDIL |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P46439 |
TreeFami | TF353040 |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 2681 |
PathwayCommonsi | P46439 |
Reactomei | R-HSA-156590, Glutathione conjugation |
SABIO-RKi | P46439 |
SignaLinki | P46439 |
Miscellaneous databases
BioGRID-ORCSi | 2949, 3 hits in 1032 CRISPR screens |
GenomeRNAii | 2949 |
Pharosi | P46439, Tbio |
PROi | PR:P46439 |
RNActi | P46439, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134201, Expressed in right ovary and 196 other tissues |
ExpressionAtlasi | P46439, baseline and differential |
Genevisiblei | P46439, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR003081, GST_mu IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01267, GSTRNSFRASEM |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTM5_HUMAN | |
Accessioni | P46439Primary (citable) accession number: P46439 Secondary accession number(s): A8K0V8, Q6PD78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families