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Protein

Glutathione S-transferase

Gene
N/A
Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46GlutathioneBy similarity1
Binding sitei77GlutathioneBy similarity1
Binding sitei81GlutathioneBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca
Proteomesi
  • UP000095301 Componenti: Whole Genome Shotgun Assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859191 – 241Glutathione S-transferaseAdd BLAST241

Proteomic databases

PRIDEiP46437

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP46437
SMRiP46437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 117GST N-terminalAdd BLAST78
Domaini119 – 241GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 89Glutathione bindingBy similarity3
Regioni101 – 102Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

KOiK04097

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P46437-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEAPAAPP AEGEAPAAPA EGEAPPPAEG EAPPAEPVKN TYTLFYFNVK
60 70 80 90 100
ALAEPLRYLF AYGGIEYEDV RVTRDEWPAL KPTMPMGQMP VLEVNGKRVH
110 120 130 140 150
QSISMARFLA KTVGLCGATP WEDLQVDIVV DTINDFRLKI AVVSYEPEDE
160 170 180 190 200
IKEKKLVTLN NEVIPFYLEK LEQTVKDNDG HLALNKLTWA DVYFAGILDY
210 220 230 240
MNYMVKRDIL EQYPALRGVV DSVNALEPIK AWIEKRPQTE V
Length:241
Mass (Da):26,964
Last modified:November 1, 1995 - v1
Checksum:i6A8FBD67ADDDEDFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02616 mRNA Translation: AAA03434.1
RefSeqiNP_001273827.1, NM_001286898.1
XP_011295686.1, XM_011297384.2

Genome annotation databases

GeneIDi101890455
KEGGimde:101890455
VectorBaseiMDOA005193-RB; MDOA005193-PB; MDOA005193
MDOA005193-RD; MDOA005193-PD; MDOA005193

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02616 mRNA Translation: AAA03434.1
RefSeqiNP_001273827.1, NM_001286898.1
XP_011295686.1, XM_011297384.2

3D structure databases

ProteinModelPortaliP46437
SMRiP46437
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP46437

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101890455
KEGGimde:101890455
VectorBaseiMDOA005193-RB; MDOA005193-PB; MDOA005193
MDOA005193-RD; MDOA005193-PD; MDOA005193

Organism-specific databases

CTDi101890455

Phylogenomic databases

KOiK04097

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGST_MUSDO
AccessioniPrimary (citable) accession number: P46437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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