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Protein

Alcohol dehydrogenase class-3

Gene

Fdh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
1-octanol + NAD+ = 1-octanal + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: FlyBase
  • octanol dehydrogenase activity Source: FlyBase
  • S-(hydroxymethyl)glutathione dehydrogenase activity Source: FlyBase
  • S-nitrosoglutathione reductase activity Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • alcohol metabolic process Source: FlyBase
  • ethanol oxidation Source: InterPro
  • regulation of nitric oxide metabolic process Source: FlyBase
  • regulation of peptidyl-cysteine S-nitrosylation Source: FlyBase
  • visual learning Source: FlyBase

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-DME-2161541 Abacavir metabolism
R-DME-5365859 RA biosynthesis pathway
R-DME-71384 Ethanol oxidation
SABIO-RKiP46415

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
Octanol dehydrogenase (EC:1.1.1.73)
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Gene namesi
Name:Fdh
Synonyms:gfd, ODH
ORF Names:CG6598
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0011768 Fdh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00001607692 – 379Alcohol dehydrogenase class-3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP46415
PRIDEiP46415

Expressioni

Gene expression databases

BgeeiFBgn0011768
GenevisibleiP46415 DM

Interactioni

Protein-protein interaction databases

BioGridi66455, 4 interactors
DIPiDIP-23839N
IntActiP46415, 1 interactor
STRINGi7227.FBpp0081767

Structurei

3D structure databases

ProteinModelPortaliP46415
SMRiP46415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
InParanoidiP46415
KOiK00121
OMAiCIGNVNT
OrthoDBiEOG091G08N3
PhylomeDBiP46415

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATEGKVIT CKAAVAWEAK KPLVIEDIEV APPKAHEVRI KITATGVCHT
60 70 80 90 100
DAFTLSGADP EGLFPVVLGH EGAGIVESVG EGVTNFKAGD HVIALYIPQC
110 120 130 140 150
NECKFCKSGK TNLCQKIRLT QGAGVMPEGT SRLSCKGQQL FHFMGTSTFA
160 170 180 190 200
EYTVVADISL TKINEKAPLE KVCLLGCGIS TGYGAALNTA KVEAGSTCAV
210 220 230 240 250
WGLGAVGLAV GLGCKKAGAG KIYGIDINPD KFELAKKFGF TDFVNPKDVA
260 270 280 290 300
DKGSIQNYLI DLTDGGFDYT FECIGNVNTM RSALEATHKG WGTSVVIGVA
310 320 330 340 350
GAGQEISTRP FQLVVGRVWK GSAFGGWRSV SDVPKLVEDY LKKDLLVDEF
360 370
ITHELPLSQI NEAFDLMHKG ESIRSIIKY
Length:379
Mass (Da):40,389
Last modified:January 23, 2007 - v3
Checksum:i7F382E10BFACAAC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07799 Genomic DNA Translation: AAA57187.1
U07641 mRNA Translation: AAB02520.1
AE014297 Genomic DNA Translation: AAF54571.1
AY089518 mRNA Translation: AAL90256.1
AY089615 mRNA Translation: AAL90353.1
PIRiS51357
RefSeqiNP_524310.1, NM_079586.4
UniGeneiDm.1782

Genome annotation databases

EnsemblMetazoaiFBtr0082290; FBpp0081767; FBgn0011768
GeneIDi41311
KEGGidme:Dmel_CG6598

Similar proteinsi

Entry informationi

Entry nameiADHX_DROME
AccessioniPrimary (citable) accession number: P46415
Secondary accession number(s): Q9VGV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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