UniProtKB - P46412 (GPX3_MOUSE)
Protein
Glutathione peroxidase 3
Gene
Gpx3
Organism
Mus musculus (Mouse)
Status
Functioni
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: MGI
- identical protein binding Source: UniProtKB
- peroxidase activity Source: GO_Central
- selenium binding Source: UniProtKB
GO - Biological processi
- glutathione metabolic process Source: MGI
- hydrogen peroxide catabolic process Source: MGI
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-MMU-3299685, Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3711, MmGPx03 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione peroxidase 3 (EC:1.11.1.9)Short name: GPx-3 Short name: GSHPx-3 Alternative name(s): Plasma glutathione peroxidase Short name: GPx-P Short name: GSHPx-P |
Gene namesi | Name:Gpx3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105102, Gpx3 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000013063 | 25 – 226 | Glutathione peroxidase 3Add BLAST | 202 |
Proteomic databases
CPTACi | non-CPTAC-3540 |
jPOSTi | P46412 |
MaxQBi | P46412 |
PaxDbi | P46412 |
PeptideAtlasi | P46412 |
PRIDEi | P46412 |
ProteomicsDBi | 271014 |
PTM databases
iPTMneti | P46412 |
PhosphoSitePlusi | P46412 |
Expressioni
Tissue specificityi
Secreted in plasma.
Gene expression databases
Bgeei | ENSMUSG00000018339, Expressed in adult mammalian kidney and 343 other tissues |
ExpressionAtlasi | P46412, baseline and differential |
Genevisiblei | P46412, MM |
Interactioni
Subunit structurei
Homotetramer.
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200040, 3 interactors |
IntActi | P46412, 4 interactors |
MINTi | P46412 |
STRINGi | 10090.ENSMUSP00000081011 |
Miscellaneous databases
RNActi | P46412, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1651, Eukaryota |
GeneTreei | ENSGT00940000161754 |
InParanoidi | P46412 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | P46412 |
TreeFami | TF105318 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P46412-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARILRASCL LSLLLAGFVP PGRGQEKSKT DCHGGMSGTI YEYGALTIDG
60 70 80 90 100
EEYIPFKQYA GKYILFVNVA SYUGLTDQYL ELNALQEELG PFGLVILGFP
110 120 130 140 150
SNQFGKQEPG ENSEILPSLK YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT
160 170 180 190 200
FLKNSCPPTA ELLGSPGRLF WEPMKIHDIR WNFEKFLVGP DGIPVMRWYH
210 220
RTTVSNVKMD ILSYMRRQAA LSARGK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1C7ZMZ5 | A0A1C7ZMZ5_MOUSE | Glutathione peroxidase | Gpx3 | 199 | Annotation score: | ||
A0A1C7ZMZ7 | A0A1C7ZMZ7_MOUSE | Glutathione peroxidase 3 | Gpx3 | 217 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 – 7 | RA → Q (PubMed:8566787).Curated | 2 | |
Sequence conflicti | 21 | P → A (PubMed:8566787).Curated | 1 | |
Sequence conflicti | 24 – 29 | GQEKSK → DKRSLR (PubMed:8566787).Curated | 6 |
Non-standard residue
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-standard residuei | 73 | Selenocysteine | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13705 mRNA Translation: AAA62283.2 AK002219 mRNA Translation: BAC55243.1 AK004942 mRNA Translation: BAC55250.1 AK146760 mRNA Translation: BAE27413.1 BC003339 mRNA Translation: AAH03339.1 BC037027 mRNA Translation: AAH37027.1 BC049235 mRNA Translation: AAH49235.1 BC061950 mRNA Translation: AAH61950.1 X84742 Genomic DNA No translation available. |
CCDSi | CCDS24703.1 |
PIRi | A55086 |
RefSeqi | NP_001316789.1, NM_001329860.1 NP_032187.2, NM_008161.4 |
Genome annotation databases
Ensembli | ENSMUST00000082430; ENSMUSP00000081011; ENSMUSG00000018339 |
GeneIDi | 14778 |
KEGGi | mmu:14778 |
UCSCi | uc007iyk.2, mouse |
Keywords - Coding sequence diversityi
SelenocysteineSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13705 mRNA Translation: AAA62283.2 AK002219 mRNA Translation: BAC55243.1 AK004942 mRNA Translation: BAC55250.1 AK146760 mRNA Translation: BAE27413.1 BC003339 mRNA Translation: AAH03339.1 BC037027 mRNA Translation: AAH37027.1 BC049235 mRNA Translation: AAH49235.1 BC061950 mRNA Translation: AAH61950.1 X84742 Genomic DNA No translation available. |
CCDSi | CCDS24703.1 |
PIRi | A55086 |
RefSeqi | NP_001316789.1, NM_001329860.1 NP_032187.2, NM_008161.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 200040, 3 interactors |
IntActi | P46412, 4 interactors |
MINTi | P46412 |
STRINGi | 10090.ENSMUSP00000081011 |
Protein family/group databases
PeroxiBasei | 3711, MmGPx03 |
PTM databases
iPTMneti | P46412 |
PhosphoSitePlusi | P46412 |
Proteomic databases
CPTACi | non-CPTAC-3540 |
jPOSTi | P46412 |
MaxQBi | P46412 |
PaxDbi | P46412 |
PeptideAtlasi | P46412 |
PRIDEi | P46412 |
ProteomicsDBi | 271014 |
Protocols and materials databases
Antibodypediai | 8091, 262 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000082430; ENSMUSP00000081011; ENSMUSG00000018339 |
GeneIDi | 14778 |
KEGGi | mmu:14778 |
UCSCi | uc007iyk.2, mouse |
Organism-specific databases
CTDi | 2878 |
MGIi | MGI:105102, Gpx3 |
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
GeneTreei | ENSGT00940000161754 |
InParanoidi | P46412 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | P46412 |
TreeFami | TF105318 |
Enzyme and pathway databases
Reactomei | R-MMU-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
BioGRID-ORCSi | 14778, 2 hits in 53 CRISPR screens |
ChiTaRSi | Gpx3, mouse |
PROi | PR:P46412 |
RNActi | P46412, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018339, Expressed in adult mammalian kidney and 343 other tissues |
ExpressionAtlasi | P46412, baseline and differential |
Genevisiblei | P46412, MM |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX3_MOUSE | |
Accessioni | P46412Primary (citable) accession number: P46412 Secondary accession number(s): Q5XKR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families