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Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

SLC2A5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:7980458). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33FructoseBy similarity1
Binding sitei168FructoseBy similarity1
Binding sitei284FructoseBy similarity1
Binding sitei379FructoseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
Fructose transporter
Glucose transporter type 5, small intestine
Short name:
GLUT-5
Gene namesi
Name:SLC2A5
Synonyms:GLUT5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicBy similarityAdd BLAST19
Transmembranei20 – 40Helical; Name=1By similarityAdd BLAST21
Topological domaini41 – 69ExtracellularBy similarityAdd BLAST29
Transmembranei70 – 92Helical; Name=2By similarityAdd BLAST23
Topological domaini93 – 99CytoplasmicBy similarity7
Transmembranei100 – 120Helical; Name=3By similarityAdd BLAST21
Topological domaini121 – 127ExtracellularBy similarity7
Transmembranei128 – 150Helical; Name=4By similarityAdd BLAST23
Topological domaini151 – 162CytoplasmicBy similarityAdd BLAST12
Transmembranei163 – 183Helical; Name=5By similarityAdd BLAST21
Topological domaini184 – 192ExtracellularBy similarity9
Transmembranei193 – 211Helical; Name=6By similarityAdd BLAST19
Topological domaini212 – 274CytoplasmicBy similarityAdd BLAST63
Transmembranei275 – 294Helical; Name=7By similarityAdd BLAST20
Topological domaini295 – 306ExtracellularBy similarityAdd BLAST12
Transmembranei307 – 327Helical; Name=8By similarityAdd BLAST21
Topological domaini328 – 334CytoplasmicBy similarity7
Transmembranei335 – 355Helical; Name=9By similarityAdd BLAST21
Topological domaini356 – 363ExtracellularBy similarity8
Transmembranei364 – 385Helical; Name=10By similarityAdd BLAST22
Topological domaini386 – 402CytoplasmicBy similarityAdd BLAST17
Transmembranei403 – 421Helical; Name=11By similarityAdd BLAST19
Topological domaini422 – 426ExtracellularBy similarity5
Transmembranei427 – 447Helical; Name=12By similarityAdd BLAST21
Topological domaini448 – 486CytoplasmicBy similarityAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503711 – 486Solute carrier family 2, facilitated glucose transporter member 5Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Expressioni

Tissue specificityi

Detected in jejunum. Detected at the intestinal brush-border membrane (at protein level). Detected in duodenum, jejunum and kidney.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP46408
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni292 – 294Fructose bindingBy similarity3
Regioni407 – 408Fructose bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG014816
InParanoidiP46408
KOiK08143

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002442 Fru_transpt_5
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01194 GLUCTRSPORT5
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46408-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQEGQEKKK EGRLTLVLAL RTLIAAFGSS FQYAYNVSVC NSPSELMTEF
60 70 80 90 100
YNDTYYDRTG ELIDEFPLTL LWSVTVSMFP SGGFAGSLLV GPLVNKFGRK
110 120 130 140 150
GALLFNNIFS IVPAILMGCS KVARSFELII ISRLLVGICA GVSSNVVPMY
160 170 180 190 200
LGELAPKNLR GALGVESQLF ITLGILVAQI FGLRSIRQQK GWPILLGLTG
210 220 230 240 250
GPAAAACPPF FPESPRYLLI GQEPRCRQKA LQSLRGWDSV DRELEEIRRE
260 270 280 290 300
DEAARAAGLV SVRALCAMRG LAWQLISVVP LMWQQLSGVN AIYYYDQIYL
310 320 330 340 350
SPLDTDTQYY TAATGAVNVL MTVCTVFVVE SWARLLLLLG FSPLAPTCCV
360 370 380 390 400
LTAALALQDT VSWMPYISIV CIIVYVIGHA IGPAIRSLYT EIFLQSGRPP
410 420 430 440 450
TWWGQVHWLS NFTVGLVFPL IQWAGLYSFI IFGVACLSTT VYTFLIVPET
460 470 480
KGKSFIEIIR RFIRMNKVEV SPDREELKDF PPDVSE
Length:486
Mass (Da):53,854
Last modified:November 1, 1995 - v1
Checksum:i61A141CB2ED5A6BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26482 mRNA Translation: BAA05492.1
PIRiS53322
RefSeqiNP_001075671.1, NM_001082202.1
UniGeneiOcu.2145

Genome annotation databases

KEGGiocu:100008992

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26482 mRNA Translation: BAA05492.1
PIRiS53322
RefSeqiNP_001075671.1, NM_001082202.1
UniGeneiOcu.2145

3D structure databases

ProteinModelPortaliP46408
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiocu:100008992

Phylogenomic databases

HOVERGENiHBG014816
InParanoidiP46408
KOiK08143

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002442 Fru_transpt_5
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01194 GLUCTRSPORT5
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR5_RABIT
AccessioniPrimary (citable) accession number: P46408
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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